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Primary Health Care Directorate



Research Output


Articles in peer-reviewed journals


Havenaar, J.M., Geerlings, M.I., Vivian, L., Collinson, M. and Robertson, B. 2008. Common mental health problems in historically disadvantaged urban and rural communities in South Africa: prevalence and risk factors. Social Psychiatry Psychiatric Epidemiology, 43: 209-215.


Wellcome Trust funding for HIV and TB initiatives




Wellcome Trust Fellows Associate Professor Robert Wilkinson (left) and Dr Graeme Meintjes (right) with senior students at UCT’s Institute of Infectious Disease and Molecular Medicine.


The fight against HIV and TB received a boost in 2008 when the Wellcome Trust granted a consortium of researchers, led by Associate Professor Robert Wilkinson, £3 million (R45 million) to establish a Centre for Clinical Infectious Disease Research at UCT. The grant was part of a £20-million investment by the Trust in research and training in Africa, aimed at ensuring that researchers are equipped to tackle the most pressing problems in their respective regions. The UCT centre will focus on HIV and TB, which are among the main causes of death in Sub-Saharan Africa. Approximately 25 entry positions in research will be established to develop the skills of scientists working in southern Africa so that they can compete better for their own funding. In addition, the capacity to conduct clinical and laboratory research will be enhanced.


Contact Details

Tel: +27 21 406 6761

Fax: +27 21 448 5653

E-mail: cha.johnston@uct.ac.za

Web: www.primaryhealthcare.uct.ac.za


Department of Psychiatry and Mental Health


Research Output


Authored books


Stein, D.J. 2008. Philosophy of Psychopharmacology. Cambridge, UK: Cambridge University Press. 210pp. ISBN 978 0 521 85652 2.


Chapters in books


Joska, J. and Stein, D.J. 2007. Mood disorders. In R.E. Hales, S.C. Yudofsky and G.O. Gabbard (eds), Textbook of Psychiatry, pp. 505-504. Fifth Edition. America: The American Psychiatric Publishing. ISBN 978 1 58562 257 3.


Articles in Peer-reviewed Journals


Brand, L., Groenewald, I., Stein, D.J., Wegener, G. and Harvey, B. 2008. Stress and re-stress increases conditioned taste aversion learning in rats: Possible frontal cortical and hippocampal muscarinic receptor involvement . European Journal of Pharmacology, 586(1-3): 205-211.


Carter, C., Jacobson, S., Molteno, C.D. and Jacobson, J. 2007. Fetal alcohol exposure, iron-deficiency anemia, and infant growth. Pediatrics, 120(3): 559-567.


Combrinck, M.I. and Joska, J. 2008. Inflammation, immunity and Alzheimer's Disease. Current Allergy & Clinical Immunology, 21(3): 132-136.


Corrigall, J., Lund, C., Patel, V., Plagerson, S. and Funk, M. 2008. Poverty and mental illness: fact or fiction? A commentary on Das, Do, Friedman, McKenzie & Scott. Social Science & Medicine, 66: 2061-2063.


Corrigall, J., Plagerson, S., Lund, C. and Myers, J.E. 2008. Global trade and mental health. Global Social Policy: An Interdisciplinary Journal of Public Policy and Social Development, 8(3): 335-358.


Daniels, W., Uys, J., Van Vuuren, P. and Stein, D.J. 2008. The development of behavioral and endocrine abnormalities in rats after repeated exposure to direct and indirect stress. Neuropsychiatric Disease and Treatment, 4(2): 451-464.


Davidson, J., Baldwin, D.S., Stein, D.J., Pedersen, R., Ahmed, A., Musgnung, M., Benattia, I. and Rothbaum, B.O. 2008. Effects of venlafaxine extended release on resilience in posttraumatic stress disorder: an item analysis of the Connor-Davidson Resillience Scale. International Clinical Psychopharmacology, 23(5): 299-303.


Degenhardt, L., Chiu, W., Sampson, N., Kessler, R., Anthony, J.C., Angermeyer, M., Bruffaerts, R., De Girolamo, G., Gureje, O., Huang, Y., Karam, A., Kostyuchenko, S., Lepine, J., Mora, M.E.M., Neumark, Y., Ormel, J., Pinto-Meza, A., Posada-Villa, J., Stein, D.J., Takeshima, T. and Wells, J.E. 2008. Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys. PloS Medicine, 5(7): 1053-1067.


Fincham, D., Smit, J., Carey, P., Stein, D.J. and Seedat, S. 2008. The relationship between behavioural inhibition, anxiety disorders, depression and CD4 counts in HIV-positive adults: a cross-sectional controlled study. Aids Care, 20(10): 1279-1283.


Franklin, M.E., Flessner, C.A., Woods, D.W., Keuthen, N.J., Piacentini, J., Moore, P., Stein, D.J., Cohen, S., Wilson, M.A. and Trichotillomania Learning Centre-Scientific Advisory Board. 2008. The Child and Adolescent Tricholtillomania Impact project: Descriptive psychopathology, comorbidity, functional impairment, and treatment uilization. Journal of Developmental and Behavioral Pediatrics, 26(6): 493-500.


Frenkel, L. 2008. A support group for parents of burned children: a South African Children's Hospital Burns Unit. Burns, 34: 565-569.


Ganasen, K.A., Fincham, D., Smit, J., Seedat, S. and Stein, D.J. 2008. Utility of the HIV Dementia Scale (HDS) in identifying HIV dementia in a South African sample. Journal of the Neurological Sciences, 269: 62-64.


Ganasen, K.A., Parker, S., Hugo, C., Stein, D.J., Emsley, R. and Seedat, S. 2008. Mental health literacy: focus on developing countries. African Journal of Psychiatry (Previously South African Psychiatry Review), 11(1): 23-28.


Gupta, J., Silverman, J.G., Hemenway, D., Acevedo-Garcia, D., Stein, D.J. and Williams, D.R. 2008. Physical violence against intimate partners and related exposures to violence among South African men. Canadian Medical Association Journal, 179(6): 535-541.


Gureje, O., Von Korff, M., Kola, N., Demyttenaere, K., He, Y., Posada-Villa, J., Lepine, J., Angermeyer, M., Levinson, D., De Girolamo, G., Iwata, N., Karam, A., Borgers, G., De Graaf, R., Browne, M., Stein, D.J., Haro, J., Bromet, E., Kessler, R. and Alonso, J. 2008. The relation between multiple pains and mental disorders: Results from the World Mental Health Surveys. Pain, 135(1-2): 82-91.


Hahn, B., Wolkenberg, F.A., Ross, T.J., Myers, C.S., Heishman, S.J., Stein, D.J., Kurup, P.K. and Stein, E. 2008. Divided versus selective attention: Evidence for common processing mechanisms. Brain Research, 1215: 137-146.


Havenaar, J.M., Geerlings, M.I., Vivian, L.M.H., Collinson, M. and Robertson, B.A. 2008. Common mental health problems in historically disadvantaged urban and rural communities in South Africa: prevalence and risk factors. Social Psychiatry and Psychiatric Epidemiology, 43: 209-215.


Ipser, J.C., Kariuki, C. and Stein, D.J. 2008. Pharmacotherapy for social anxiety disorder: a systematic review. Expert Reviews. Neurotherapeutics, 2(2): 235-257.


Jacobson, S., Stanton, M.E., Molteno, C.D., Burden, M.J., Fuller, D.S., Hoyme, E., Robinson, L.K., Khaole, N. and Jacobson, J. 2008. Impaired eyeblink conditioning in children with Fetal Alcohol Syndrome. Alcoholism-Clinical and Experimental Research, 32(2): 365-372.


Jaspan, H.B., Soka, N.F., Strode, A.E., Mathews, C., Mark, D., Flisher, A.J., Wood, R. and Bekker, L. 2008. Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa. Vaccine, 26: 5679-5683.


Joe, S., Stein, D.J., Seedat, S., Herman, A. and Williams, D.R. 2008. Non-fatal suicidal behavior among South Africans. Social Psychiatry and Psychiatric Epidemiology, 43(6): 454-461.


Joe, S., Stein, D.J., Seedat, S., Herman, A. and Williams, D.R. 2008. Prevalence and correlates of non-fatal suicidal behaviour among South Africans. British Journal of Psychiatry, 192: 310-311.


Joska, J., Kaliski, S.Z. and Benatar, S.R. 2008. Patients with severe mental illness: A new approach to testing for HIV. SAMJ South African Medical Journal, 98(3): 213-217.


Joska, J., Stein, D.J. and Flisher, A.J. 2008. HIV/AIDS and psychiatry: Towards the establishment of a pilot programme for detection and treatment of common mental disorders in people living with HIV/AIDS in Cape Town. South African Journal of Psychiatry, 14(4): 122-124.


Kaminer, D.B., Grimsrud, A., Myer, L., Stein, D.J. and Williams, D.R. 2008. Risk for post-traumatic stress disorder associated with different forms of interpersonal violence in South Africa. Social Science & Medicine, 67: 1589-1595.


Kessler, R., Angermeyer, M., Anthony, J.C., De Graaf, R., Demyttenaere, K., Gasquet, I., De Girolamo, G., Gluzman, S., Gureje, O., Haro, J., Kawakami, N., Karam, A., Levinson, D., Medina-Mora, M.E., Browne, M., Posada-Villa, J., Stein, D.J., Tsang, C.H.A., Aguilar-Gaxiola, S., Alonso, J., Lee, S., Heeringa, S.G., Pennell, B.E., Berglund, P., Gruber, M.J., Petukhova, M., Chatterji, S. and Üstün, T. 2008. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Health Surveys. World Psychiatry, 6(3): 168-176.


Korff, S., Stein, D.J. and Harvey, B. 2008. Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive-compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32(2): 348-355.


Liebowitz, M.R., Schneier, F., Stein, D.J. and Davidson, J. 2008. Easing the burden of social anxiety disorder. Journal of Clinical Psychiatry, 69(9): 1485-1496.


Lochner, C., Hemmings, S.M.J., Kinnear, C.J., Nel, D., Seedat, S., Moolman-Smook, J.C. and Stein, D.J. 2008. Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes. Israel Journal of Psychiatry and Related Sciences, 45(3): 164-176.


Lund, C., Stein, D.J., Corrigal, J., Bradshaw, D., Schneider, M. and Flisher, A.J. 2008. Mental health is integral to public health: a call to scale up evidence-based services and develop mental health research. SAMJ South African Medical Journal, 98(6): 444-446.


Marais, L., Van Rensburg, S.J., Van Zyl, M.J., Stein, D.J. and Daniels, W.M. 2008. Maternal separation of rat pups increases risk of depressive-like behaviour after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neuroscience Research, 61(1): 106-112.


Matsunaga, H., Maebayashi, K., Hayashida, K., Okino, K., Matsui, T., Iketani, T., Kiriike, N. and Stein, D.J. 2008. Symptom structure in Japanese patients with Obsessive-Compulsive Disorder. American Journal of Psychiatry, 165(2): 251-253.


Mertens, J.R., Flisher, A.J., Satre, D.D. and Weisner, C. 2008. The role of medical conditions and primary care services in 5-year substance use outcomes among chemical dependency treatment patients. Drug and Alcohol Dependence, 98: 45-53.


Mlisa, N., Ward, C., Flisher, A.J. and Lombard, C. 2008. Bullying at rural high schools in the Eastern Cape Province, South Africa: prevalence, risk and protective factors at school and in the family. Journal of Psychology in Africa, 18: 261-268.


Möller, H.-J., Baldwin, D.S., Goodwin, G., Kasper, S., Okasha, A., Stein, D.J., Tandon, R. and Versiani, M. 2008. Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement. European Archives of Psychiatry and Clinical Neuroscience, 258(3): 3-23.


Myer, L., Smit, J., Le Roux, L., Parker, S. and Stein, D.J. 2008. Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales. AIDS Patient Care and STDs, 22(2): 147-158.


Myer, L., Stein, D.J., Grimsrud, A., Seedat, S. and Williams, D.R. 2008. Social determinants of psychological distress in a nationally-representative sample of South African adults. Social Science & Medicine, 66(8): 1828-1840.


Palen, L.A., Graham, J., Smith, E., Caldwell, L., Mathews, C. and Flisher, A.J. 2008. Rates of missing responses in personal digital assistant (PDA) versus paper assessments. Evaluation Review, 32(3): 257-272.


Palen, L.A., Smith, E., Caldwell, L., Flisher, A.J., Wegner, L. and Vergnani, T. 2008. Inconsistent reports of sexual intercourse among South African high school students. Journal of Adolescent Health, 42: 221-227.


Patel, V., Flisher, A.J., Nikapota, A. and Malhotra, S. 2008. Promoting child and adolescent mental health in low and middle income countries. Journal of Child Psychology and Psychiatry, 49 (3): 313-334.


Pienaar, I.S., Kellaway, L.A., Russell, V.A., Smith, A., Stein, D.J., Zigmond, M. and Daniels, W.M.U. 2008. Maternal separation exaggerates the toxic effects of 6-hydroxydopamine in rats: Implications for neurodegenerative disorders. Stress-The International Journal on the Biology of Stress, 11(6): 448-456.


Plüddemann, A., Flisher, A.J., Mathews, C., Carney, T. and Lombard, C. 2008. Adolescent methamphetamine use and sexual risk behaviour in secondary school students in Cape Town, South Africa. Drug and Alcohol Review, 27: 1-6.


Plüddemann, A., Parry, C., Flisher, A.J. and Jordaan, E. 2008. Heroine users in Cape Town, South Africa: injecting practices, HIV-related risk behaviors, and other health consequences. Journal of Psychoactive Drugs, 40(3): 273-279.


Savitz, J., Van der Merwe, L., Newman, T.K., Solms, M., Stein, D.J. and Ramesar, R. 2007. The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity? International Journal of Neuropsychopharmacology, 11: 149-161.


Savitz, J., Van der Merwe, L., Stein, D.J., Solms, M. and Ramesar, R. 2008. Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma. Bipolar Disorders, 10: 479-494.


Seedat, S., Haskis, A. and Stein, D.J. 2008. Benefits of consumer psychoeducation: a pilot program in South Africa. International Journal of Psychiatry in Medicine, 38(1): 31-42.


Seedat, S., Stein, D.J., Herman, A., Kessler, R., Sonnega, J., Heeringa, S.G., Williams, S.L. and Williams, D.R. 2008. Twelve-month treatment of psychiatric disorders in the South African Stress and Health Study (World Mental Health Survey Initiative). Social Psychiatry and Psychiatric Epidemiology, 43: 889-897.


Smith, E., Palen, L.A., Caldwell, L., Flisher, A.J., Graham, J., Mathews, C., Wegner, L. and Vergnani, T. 2008. Substance use and sexual risk prevention in Cape Town, South Africa: an evaluation of the HealthWise Program. Prevention Science, 9: 311-321


Stein, D.J. 2008. Classification of anxiety disorders: dimensional assessments, intermediate phenotypes, and psychobiological bases. Current Psychiatry Reports, 10: 287-289.


Stein, D.J. 2008. Classifying hypersexual disorders: compulsive, impulsive and addictive models. Psychiatric Clinics of North America, 31(4): 587-591.


Stein, D.J. 2008. Depression, anhedonia, and psychomotor symptoms: the role of dopminergic neurocircuitry. CNS Spectrums, 13(7): 561-565.


Stein, D.J. 2008. Emotional regulation: implications for the psychobiology of psychotherapy. CNS Spectrums, 13(3): 195-198.


Stein, D.J. 2008. Is disorder X in categrory of spectrum Y? General considerations and application to the relationship between obsessive-compulsive disorder and anxiety disorders. Depression and Anxiety, 25(4): 330-335.


Stein, D.J. 2008. Panic disorder: The psychobiology of external threat and interoceptive distress. CNS Spectrums, 13(1): 26-30.


Stein, D.J. 2008. Pharmacotherapy of anxious depression. Current Psychiatry Reports, 10(4): 295-296.


Stein, D.J. 2008. Psychobiology of anxiety disorders and obsessive-compulsive spectrum disorders. CNS Spectrums, 13(9): 23-28.


Stein, D.J. and Muller, J.E. 2008. Cognitive-affective neuroscience of somatization disorder and functional somatic syndromes: reconceptualizing the triad of depression-anxiety-somatic symptoms. CNS Spectrums, 13(5): 379-384.


Stein, D.J., Ahokas, A.A. and De Bodinat, C. 2008. Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology, 28(5): 561-566.


Stein, D.J., Baldwin, D.S., Baldinetti, F. and Mandel, F. 2008. Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: A pooled analysis of 6 studies. European Neuropsychopharmacology, 18(6): 422-430.


Stein, D.J., Carey, P., Lochner, C., Seedat, S., Fineberg, N.A. and Andersen, E.W. 2008. Escitalopram in Obsessive-Compulsive Disorder: response of symptom dimensions to pharmacotherapy. CNS Spectrums, 13(6): 492-498.


Stein, D.J., Ives-Deliperi, V. and Thomas, K. 2008. Psychobiology of mindfulness. CNS Spectrums, 13(9): 752-756.


Stein, D.J., Muller, J.E., Wentzel, I. and Nel, D.G. 2008. Depression and anxiety in multisomatoform disorder: prevalence and clinical predictors in primary care. SAMJ South African Medical Journal, 98(6): 473-476.


Stein, D.J., Pedersen, R., Rothbaum, B.O., Baldwin, D.S., Ahmed, A., Musgnung, M. and Davidson, J. 2008. Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis. International Journal of Neuropsychopharmacology, 11: 1-9.


Stein, D.J., Seedat, S., Herman, A., Moomal, H., Heeringa, S.G., Kessler, R. and Williams, D.R. 2008. Lifetime prevalence of psychiatric disorders in South Africa. British Journal of Psychiatry, 192: 112-117.


Stein, D.J., Seedat, S., Kaminer, D.B., Moomal, H., Herman, A., Sonnega, J. and Williams, D.R. 2008. The impact of the Truth and Reconcilliation Commission on psychological distress and forgiveness in South Africa. Social Psychiatry and Psychiatric Epidemiology, 43: 462-468.


Stein, M.B. and Stein, D.J. 2008. Social anxiety disorder. Lancet, 371(9618): 1115-1125.


Suliman, S., Stein, D.J., Williams, D.R. and Seedat, S. 2008. DSM-IV personality disorders and their axis I correlates in South African population. Psychopathology, 41(6): 356-364.


Tandon, R., Belmaker, R.H., Gattaz, W.F., Lopez-ibor, J.J., Okasha, A., Singh, B., Stein, D.J., Olie, J.-P., Fleischacker, W. and Moeller, H.-J. 2008. World Psychiatric Association Pharmacotherapy Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia. Schizophrenia Research, 100(1-3): 20-38.


Temmingh, H.S. and Oosthuizen, P. 2008. Pathways to care and treatment delays in first and multi episode psychosis. Findings from a developing country. Social Psychiatry and Psychiatric Epidemiology, 43(9): 727-735.


Thornton, H.B., Nel, D., Thornton, D., Van Honk, J., Baker, G. and Stein, D.J. 2008. The neuropsychiatry and neuropsychology of lipoid proteinosis. Journal of Neuropsychiatry and Clinical Neurosciences, 20(1): 86-92.


Tolin, D.F., Diefenbach, G.J., Flessner, C.A., Franklin, M.E., Keuthen, N.J., Moore, P., Piacentini, J., Stein, D.J. and Woods, D.W. 2008. The Trichotillomania Scale for children: development and validation. Child Psychiatry & Human Development, 39(3): 331-349.


Townsend, L., Flisher, A.J., Chikobvu, P., Lombard, C. and King, G. 2008. The relationship between bullying behaviours and high school dropout in Cape Town, South Africa. South African Journal of Psychology, 38: 21-32.


Uys, J., Hattingh, S.M., Stein, D.J. and Daniels, W.M.U. 2008. Large scale hippocampal cellular distress may explain the behavioral consequences of repetitive traumatic experiences - a proteomic approach. Neurochemical Research, 33(9): 1724-1734.


Vythilingum, B. 2008. Anxiety disorders in pregnancy. Current Psychiatry Reports, 10(4): 331-335.


Ward, C.L., Mertens, J., Flisher, A.J., Bresick, G., Sterling, S., Little, F. and Weisner, C. 2008. Prevalence and correlates of substance use among South African primary care clinic patients. Substance Use & Misuse, 43: 1395-1410.


Warwick, J., Carey, P., Jordaan, G.P., Dupont, P. and Stein, D.J. 2008. Resting brain perfusion in social anxiety disorder: a voxel-wise whole brain comparison with healthy control subjects. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32(5): 1251-1256.


Williams, D.R., Gonzalez, H.M., Williams, S.L., Mohammed, S.A., Moomal, H. and Stein, D.J. 2008. Perceived discrimination, race and health in South Africa. Social Science & Medicine, 67(3): 441-452.


Contact Details

Tel: +27 21 404 2164 or 447 5450

Fax: +27 21 448 8158

E-mail: sandra.swart@uct.ac.za

Psychiatric medications examined through a philosophical lens




With rapid developments in the field of cosmetic psychopharmacology, Professor Dan Stein's new book, Philosophy of Pharmacology: Smart Pills, Happy Pills and Pep Pills, published by Cambridge University Press, poses interesting philosophical questions about the implications of developments in neuroscience for our understanding of human beings.


Mental disorders are a leading cause of disability worldwide, and are relatively underdiagnosed and undertreated. At the same time, there have been significant advances in psychopharmacology, and critical questions have been raised about the medicalisation of normal distress. Stein's new work sets out a conceptual framework, pulling in theory and data from modern neuroscience, for examining these issues.


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