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Fax: +27 21 689 1287



Obsessive-compulsive disorder growing among children

Obsessive-compulsive disorder (OCD) is a common psychiatric problem. ‘It's considered one of the most disabling of all medical disorders’, says psychology master's student Lara Hoppe, whose new study on OCD among children shows that it is growing within this group in South Africa. Hoppe's research looks at the phenomenology of OCD and how the symptoms affect children and adolescents on a daily basis. Although there is a paucity of literature in this area, evidence suggests that impairment caused by OCD is significant in a number of domains, and that OCD-related functional impairment in childhood or adolescence may differ across cultures.

It is hoped that her study will inform the future diagnosis and treatment of South African children and adolescents with OCD. Thus far her findings indicate that parents believe that their children's OCD-related problems affect them mainly at school. But the children say their OCD ‘outfall’ extends into both the school and social domains. The study also shows that parents and children differ when it comes to rating the most significant individual functional problems. The findings differ from those of North American and European studies, providing the rationale for further research into the effect of culture on childhood OCD-related functional impairment. This work will have important implications for the diagnosis and treatment of children with OCD in South Africa.

Department of Clinical Laboratory Sciences

(Including the following Divisions/Institutes: Anatomical Pathology, Chemical Pathology, Forensic Medicine and Toxicology, Haematology and UCT Leukaemia Unit, Human Genetics, Immunology, Medical Biochemistry, Medical Microbiology and Medical Virology.

Research Output

Edited books

Smythe, D.L. and Artz, L.M. (eds) 2008. Should We Consent? 282pp. Wetton, Cape Town: Juta & Co Limited. ISBN 978 0 7 21 7938 9.

Chapters in books

Beighton, P. 2007. Genetic deafness and blindness. In O. Mayo and C. Leach (eds), Fifty Years of Human Genetics, Festschrift and Liber Amicorum, Dr George R Fraser, pp. 133-141. Australia: Wakefield Press. ISBN 9781862547537.

Brown, G.D. and Graham, L. 2008. Innate recognition of Aspergillus fumigatus by the mammalian immune system. In J.-P. Latge and W.J. Steinbach (eds), Aspergillus Fumigatus and Aspergillosis, pp. 279-289. United States of America: ASM Press. ISBN 978 1 55581 438 0.

Mendelson, M. 2008. Gastroenterology. In M. Eddleston, R. Davidson, A. Brent and R. Wilkinson (eds), Oxford Handbook of Tropical Medicine, pp. 269-327. 3rd Edition. Oxford: Oxford University Press. ISBN 978 0 19 920409 0.

Nicol, M.P. 2008. Multi-system disease and infection (rickettsial infection and brucellosis). In M. Eddleston, R. Davidson, A. Brent and R. Wilkinson (eds), Oxford Handbook of Tropical Medicine, pp. 686-687. 3rd Edition. Oxford: Oxford University Press. ISBN 978 0 19 920409 0.

Smythe, D., Artz, L.M., Combrinck, H., Doolan, K. and Martin, L.J. 2008. Caught between policy and practice: health and justice responses to gender-based violence. In A. van Niekerk, S. Suffla and M. Seedat (eds), Crime, Violence and Injury Prevention in South Africa: Data to Action, pp. 150-172. Tygerberg, South Africa: MRC-UNISA Crime, Violence and Injury Lead Programme. ISBN 1 920015 08 6.

Smythe, D.L. and Artz, L.M. 2008. Introduction: Should we consent. In L. Artz and D. Smythe (eds), Should We Consent? pp. 1-21. Wetton, Cape Town: Juta & Co Limited. ISBN 978 0 7 21 7938 9.

Encyclopaedia entries

Martin, D.P., Shepherd, D. and Rybicki, E.P. 2008. Maize streak virus. In B.W.J. Mahy and M.H.V. van Regenmortel (eds), Encyclopedia of Virology, pp. 263-272. Oxford, U.K.: Academic Press, Elsevier. ISBN 9780123739353.

Articles in Peer-reviewed Journals

Abrahams, A., Mowla, S., Parker, M.I., Goding, C. and Prince, S. 2008. UV-mediated regulation of the anti-senescence factor Tbx2. Journal of Biological Chemistry, 283(4): 2223-2230.

Abrahams, N., Martin, L.J., Jewkes, R., Mathews, S., Vetten, L. and Lombard, C. 2008. The epidemiology and the pathology of suspected rape homicide in South Africa. Forensic Science International, 178: 132-138.

Adams, E.L., Rice, P.J., Graves, G., Ensley, H.E., Yu, H., Brown, G.D., Gordon, S., Monteiro, M.A., Papp-Szabo, E., Lowman, D.W., Power, T.D., Wemper, M.F. and Williams, D.L. 2008. Differential high affinity interaction of Dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side chain branching. Journal of Pharmacology and Experimental Therapeutics, 325: 115-123.

Allan, B.R., Marais, D.J., Hoffman, M., Shapiro, S. and Williamson, A.-L. 2008. Cervical Human Papillomavirus (HPV) infection in South African women: implications for HPV screening and vaccine strategies. Journal of Clinical Microbiology, 46(2): 740-742.

Allie, N., Alexopoulou, L., Quesniaux, V., Fick, L., Kranidioti, K., Kollias, G., Ryffel, B. and Jacobs, M. 2008. Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection. Immunology, 125: 522-534.

Anderson, D.W., Goldberg, P.A., Algar, U., Felix, R. and Ramesar, R. 2007. Mobile colonoscopic surveillance provides quality care for hereditary nonpolyposis colorectal carcinoma families in South Africa. Colorectal Disease, 9: 509-514.

Andrews, S., Mendelson, M., Hefer, E., Venter, W.D.F., Variava, E. and Wulfsohn, A. 2008. Post-exposure prophylaxis. Southern African Journal of HIV Medicine, 9(3): 36-46.

Appelbe, W., Auerbach, A.D., Becker, K., Bodmer, W., Boone, D.J., Boulyjenkov, V., Brahmachari, S., Brody, L., Brookes, A., Brown, A.F., Byers, P., Cantu, J.M., Cassiman, J., Claustres, M., Concannon, P., Cotton, R.G.H., den Dunnen, J.T., Flicek, P., Gibbs, R., Hall, J., Hasler, J., Katz, M., Kwok, P.Y., Laradi, S., Lindblom, A., Maglott, D., Marsh, S., Masimirembwa, C.M., Minoshima, S., Oller de Ramirez, A.M., Pagon, R., Ramesar, R., Ravine, D., Richards, S., Rimoin, D., Ring, H.Z., Scriver, C.R., Sherry, S., Shimizu, N., Stein, L., Tadmouri, G.O., Taylor, G. and Watson, M. 2007. Recommendations of the 2006 Human Variome Project meeting. Nature Genetics, 39(4): 433-436.

Auerswald, L., Freier, U., Lopata, A.L. and Meyer, B. 2008. Physiological and morphological colour change in Antarctic krill, Euphausia superba: a field study in the Lazarev Sea. Journal of Experimental Biology, 211: 3850-3858.

Balyasnikova, I.V., Metzger, R., Franke, F., Conrad, N., Towbin, H., Schwartz, D.E., Sturrock, E.D. and Danilov, S.M. 2008. Epitope mapping of mAbs to denatured human testicular ACE (CD143). Tissue Antigens, 72: 354-368.

Banaiee, N., January, V., Barthus, C., Lambrick, M., Roditi, D.O.J., Behr, M., Jacobs, W. and Steyn, L.M. 2008. evaluation of a semi-automated reporter phage assy for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa. Tuberculosis, 88: 64-68.

Bandawe, G.P., Martin, D.P., Treurnicht, F., Mlisana, K., Abdool Karim, S.S., Williamson, C. and Caprisa 002 Acute Infection Study Team T. 2008. Conserved positive selection signals in HIV-1 gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection. Virology Journal, 5(1): 141. [Online].

Barbi, J., Brombacher, F. and Satoskar, A. 2008. T cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. Journal of Immunology, 181: 4613-4620.

Barkhuizen, M., Magez, S., Ryffel, B. and Brombacher, F. 2008. Interleukin-12p70 deficiency increases survival and diminishes pathology in trypanosoma congolense infection. Journal of Infectious Diseases, 198: 1284-1291.

Bebell, L.M., Passmore, J.S., Williamson, C., Mlisana, K., Iriogbe, I., Van Loggerenberg, F., Abdool Karim, Q. and Abdool Karim, S. 2008. Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection. Journal of Infectious Diseases, 198: 710-714.

Beck, I.A., Crowell, C., Kittoe, K., Bredell, H., Machaba, M.T., Williamson, C., Janssens, W., Jallow, S., Van der Groen, G., Shao, Y., Jacob, M., Samuel, N.M., De Rivera, I.L., Ngo-Giang-Huong, N., Cassol, S., Alemnji, G. and Frenkel, L.M. 2008. Optimization of the oligonucleotide ligation assay, a rapid and inexpensive test for detection of HIV-1 drug resistance mutations, for non-North American variants. JAIDS-Journal of Acquired Immune Deficiency Syndromes, 48(4): 418-427.

Beeton-Kempen, N., Shoko, A. and Blackburn, J. 2008. Personalizing protein-drug interactions. Pure and Applied Chemistry, 80(8): 1811-1820.

Blokhuis, M., Goldberg, P.A., Pietersen, G.E., Algar, U., Vorster, A.A., Govender, D. and Ramesar, R. 2008. The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation. Familial Cancer, 7: 191-198.

Brown, G.D. 2008. Sensing necrosis with Mincle. Nature Immunology, 9(10): 1099-1100.

Brown, G.D. and Kimberg, M. 2008. Dectin-1 and its role in antifungal immunity. Medical Mycology, 46(7): 1-6.

Burgers, W., Shephard, E.G., Monroe, J.E., Greenhalgh, T., Binder, A.B., Hurter, E., Van Harmelen, J.H., Williamson, C. and Williamson, A.-L. 2008. Construction, characterization, and immunogenicity of a multigene modified vaccinia ankara (MVA) vaccine based on HIV type 1 subtype C. AIDS Research and Human Retroviruses, 24(2): 195-206.

Burn, J., Bishop, D.J., Mecklin, J.P., Macrae, F., Mslein, G., Olschwang, S., Bisgaard, S., Ramesar, R., Eccles, D., Maher, E.R., Bertario, L., Jarvinen, H.J., Lindblom, A., Evans, D.G., Lubinski, J., Morrison, J., Ho, J.W.C., Vasen, H.F.A., Side, L., Thomas, H.J.W., Scott, R.J., Dunlop, M., Barker, G., Elliot, F., Jass, J.R., Fodde, R., Lynch, H.T. and Mathers, J.C. 2008. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch Syndrome. New England Journal of Medicine, 359(24): 2567-2578.

Campbell, J.C., Abrahams, N. and Martin, L.J. 2008. Perpetration of violence against intimate partners: health care implications from global data. Canadian Medical Association Journal, 179(6): 511-512.

Carvill, G., Mamedov, T.G., Pienaar, E., Whitney, S.E., TerMaat, J.R., Goliath, R., Subramanian, A. and Viljoen, H. 2008. A fundamental study of the PCR amplification of GC-rich DNA templates. Computational Biology and Chemistry, 32: 452-457.

Chege, G., Shephard, E.G., Meyers, A.E., Van Harmelen, J.H., Williamson, C., Lynch, A.G., Gray, C., Rybicki, E.P. and Williamson, A.-L. 2008. HIV-1 subtype C Pr55 gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine. Journal of General Virology, 89(9): 2214-2227.

Chege, G., Warren, R.M., Gey van Pittius, N.C., Burgers, W., Wilkinson, R.J., Shephard, E.G. and Williamson, A.-L. 2008. Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak. BMC Microbiology, 8:27.

Chipungu, G., Christians, S. and Oliver, S.P. 2008. Cutaneous cryptococcosis erroneously diagnosed as histoplasma capsulatum infection. SAMJ South African Medical Journal, 98(2): 85.

Chopera, D., Woodman, Z., Mlisana, K., Mlotshwa, M., Martin, D., Seoighe, C., Treurnicht, F., De Rosa, D., Hide, W., Karim, S., Gray, C. and Williamson, A.-L. 2008. Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage. PLoS Pathogens, 4(3): e1000033.

Clarke, I.J., Sari, I.P., Qi, Y., Smith, J.T., Parkington, H.C., Ubuka, T., Iqbal, J., Li, Q., Tilbrook, A., Morgan, K., Pawson, A., Tsutsui, K., Millar, R.P. and Bentley, G.E. 2008. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology, 149(11): 5811-5821.

Coetsee, M., Millar, R.P., Flanagan, C.A. and Lu, Z. 2008. Identification of Tyr290(6.58) of the Human Gonadotropin-Releasing Hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activation. Biochemistry, 47: 10305-10313.

Copley, L., Van der Watt, P., Wirtz, K.W., Parker, M.I. and Leaner, V.D. 2008. Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis. International Journal of Biochemistry & Cell Biology, 40: 227-235.

Corcoran, C., Rebe, K., Van der Plas, H., Myer, L. and Hardie, D.R. 2008. The predictive value of cerebrospinal fluid Epstein-Barr viral load as a marker of primary central nervous system lymphoma in HIV-infected persons. Journal of Clinical Virology, 42(4): 433-436.

Cotton, M., Wasserman, E., Smit, J., Whitelaw, A.C. and Zar, H.J. 2008. High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South Africa. BMC Infectious Diseases, 8:40.

Cotton, R.G.H., Auerbach, A.D., Axton, M., Barash, C.I., Berkovic, S.F., Brookes, A., Burn, J., Cutting, G., Den Dunnen, J.T., Flicek, P., Freimer, N., Greenblatt, M.S., Howard, H.J., Katz, M., Macrae, F.A., Maglott, D., Moslein, G., Povey, S., Ramesar, R., Richards, S., Seminara, D., Smith, T.D., Sobrido, M.J., Solbakk, J.H., Tanzi, R.E., Tavtigian, S.V., Taylor, G., Utsunomiya, J. and Watson, M. 2008. Genetics - the Human Variome Project. Science, 322(5903): 861-862.

Cowley, D., Govender, D., February, B.L., Steyn, L.M., Evans, J., Wilkinson, R.J., Nicol, M.P. and Wolfe, M. 2008. Recent and rapid emergence of W-Beijing strains of mycobacterium tuberculosis in Cape Town, South Africa. Clinical Infectious Diseases, 47: 1252-1259.

Dakshinamurthy, A.G., Ramesar, R., Goldberg, P.A. and Blackburn, J. 2008. Infrequent and low expression of cancer-testis antigens located on the X chromosome in colorectal cancer: Implications for immunotherapy in South African populations. Biotechnology Journal, 3(11): 1417-1423.

Dambuza, I., Allie, N., Fick, L., Johnston, N., Fremond, C., Mitchell, J., Quesniaux, V., Ryffel, B. and Jacobs, M. 2008. Efficacy of membrane TNF mediated host resistance is dependent on mycobacterial virulence. Tuberculosis, 88(3): 221-234.

Davis, E., Teng, H., Bilican, B., Parker, M.I., Liu, B., Carriera, S., Goding, C. and Prince, S. 2008. Ectopic Tbx2 expression results in polyploidy and cisplatin resistance. Oncogene, 27(7): 976-984.

Dennehy, K.M., Ferwerda, G., Willment, J.A., Taylor, P., Kerrigan, A., Tsoni, S.V., Gordon, S., Wentrup, F.M., Gosse, A.J., Kullberg, B.J., Schweighoffer, E., Tybulewicz, V., Mora-Montes, H.M., Gow, N.A.R., Williams, D., Netea, M.G., Brown, G.D., Faro-Trindale, I. and Pyz, E. 2008. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. European Journal of Immunology, 38: 500-506.

Denny, L.A., Boa, R., Williamson, A.-L., Allan, B.R., Hardie, D.R., Ress, S.R. and Myer, L. 2008. Human Papillomavirus infection and cervical disease in Human Immunodeficiency Virus-1 - infected women. Obstetrics and Gynecology, 111(6): 1380-1387.

Donninger, H., Binder, A.B., Bohm, L. and Parker, M.I. 2008. Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells. Biological Chemistry, 389: 57-67.

Du Preez, J., Matolweni, L.O., Greenberg, L.J.H.L., Mntla, P., Adeyemo, A.A. and Mayosi, B.M. 2008. The Q2C Del322-325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans. Cardiovascular Journal of Africa, 19(1): 15-16.

Fromme, B.J., Coetsee, M., Van der Watt, P., Chan, M., Sperling, K.M., Katz, A.A. and Flanagan, C.A. 2008. High-affinity binding of southern African HIV type 1 subtype C envelope protein, gp120, to the CCR5 coreceptor. AIDS Research and Human Retroviruses, 24(12): 1527-1536.

Govan, V.A. 2008. A novel vaccine for cervical cancer: quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil). Therapeutics and Clinical Risk Management, 4(1): 65-70.

Govan, V.A., Rybicki, E.P. and Williamson, A.-L. 2008. Therapeutic immunisation of rabbits with cottontail rabbit papillomavirus (CRPV) virus-like particles (VLP) induces regression of established papillomas. Virology Journal, 5(45): 1-5. [Online].

Gumbi, P., Nkwanyana, N., Bere, A., Burgers, W., Gray, C., Williamson, A.-L., Hoffman, M., Coetzee, D.J., Denny, L.A. and Passmore, J.S. 2008. Impact of mucosal inflammation on cervical Human Immunodeficiency Virus (HIV-1)- specific CD8 T-cell responses in the female genital tract during chronic HIV infection. Journal of Virology, 82(17): 8259-8536.

Halsey, R., Tanzer, F.L., Meyers, A.E., Pillay, S., Lynch, A.G., Shephard, E.G., Williamson, A.-L. and Rybicki, E.P. 2008. Chimaeric HIV-1 subtype C gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles. Virus Research, 133(2): 259-268.

Hardy, B.J., Seguin, B., Ramesar, R., Singer, P. and Daar, A. 2008. South Africa: from species cradle to genomic applications. Nature Reviews Genetics, Suppl 1: S19-23.

Heinsbroek, S., Taylor, P., Martinez, F.O., Pomares, L., Brown, G.D. and Gordon, S. 2008. Stage-specific sampling by pattern recognition receptors during candida albicans phagocytosis. PLoS Pathogens, 4(11): e1000218.

Hiller, R. and Blackburn, J. 2008. Integrating high throughput technologies to advance genomic and proteomic research in South Africa. Biotechnology Journal, 3: 1351-1354.

Hobbs, H., Dix-Peek, S., Dunn, R.N., Wieselthaler, N. and Hoffman, E.B. 2007. Physeal bar resection for partial growth plate arrest. SA Orthopaedic Journal, Summer: 52-60.

Horsnell, W. and Brombacher, F. 2008. Key roles for specific and nonspecific antibody in intestinal nematode expulsion. Cell Host & Microbe, 4(4): 303-305.

Hunter, R., Kaschula, C.H., Parker, M.I., Caira, M.R., Richards, P., Travis, S., Taute, C. and Qwebani, T. 2008. Substituted ajoenes as novel anti-cancer agents. Bioorganic & Medicinal Chemistry Letters, 18: 5277-5279.

Huysamen, C., Willment, J.A., Dennehy, K.M. and Brown, G.D. 2008. CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. Journal of Biological Chemistry, 283(24): 16693-16701.

Ibirogba, S., Algar, U., Goldberg, P.A., Duffield, M., Vorster, A.A. and Ramesar, R. 2008. The clinical and pathological features of hereditary mixed polyposis syndrome: report on a South African family. South African Journal of Surgery, 46(3): 90-92.

Jaspan, H.B.; Huang, L., Cotton, M., Whitelaw, A.C. and Myer, L. 2008. Bacterial disease and antimicrobial susceptibility patterns in HIV infected, hospitalized children: a retrospective cohort study. PLoS ONE, 3(9):e3260. [Online]

Jeebhay, M.F., Robins, T., Miller, M., Bateman, E.D., Smuts, M., Baatjies, R. and Lopata, A.L. 2008. Occupational allergy and asthma among salt water fish processing workers. American Journal of Industrial Medicine, 51(12): 899-910.

Jimenez-A, M., Viriyakosol, S., Walls, L., Datta, S.K., Kirkland, T., Heinsbroek, S., Brown, G.D. and Fierer, J. 2008. Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a). Genes and Immunity, 9: 338-348.

Johnson, L.F. and Lewis, D.A. 2008. The effect of genital tract infections on HIV-1 shedding in the genital tract: a systematic review and meta-analysis. Sexually Transmitted Diseases, 35(11): 946-959.

Jonas, N.E., Fagan, J.J., Wu, H. and Taylor, D.A. 2008. Neuroendocrine small cell carcinoma of the larynx. Internet Journal of Otorhinolaryngology, 8(1): 6.

Kaleebu, P., Abimiku, A., El-Halabi, S., Koulla-Shiro, S., Mamotte, N., Mboup, S., Mugurwa, R., Nkengasong, J., Toure-Kane, C., Tucker, T., Wassenaar, D. and Williamson, C. 2008. African AIDS vaccine programme for a coordinated and collaborative vaccine development effort on the continent. PloS Medicine, 5(12): 1653-1657.

Kulkarni, A., Pillay, N., Kellaway, L.A. and Kotwal, G.J. 2008. Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test. Biogerontology, 9(6): 405-420.

Larke, N., Im, E.J., Wagner, R., Williamson, A.-L., Williamson, C., McMichael, A.J. and Hanke, T. 2007. Combined single-clade candidate HIV-1 vaccines induce T cell responses limited by multiple forms of in vivo immune interference. European Journal of Immunology, 37(2): 566-577.

Latif, M.L. and Pillay, T. 2008. Differential detection of phosphorylated glycogen synthase kinase 3 and depending on blocking conditions. Analytical Biochemistry, 379(1): 136-137.

Learmonth, G.M., Willemse, S., Pillay, K., Venter, F. and Gopolang, F. 2007. Cytomorphology of cells on conventional cervical smears from HIV-infected women. Acta Cytologica, 51(3): 488-489.

Leibundgut-Landmann, S., Osorio, F., Brown, G.D. and Reis e Sousa, C. 2008. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood, 112: 4971-4980.

Li, D., Dandara, C., Walther, G. and Parker, M.I. 2008. Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer. Clinical Chemistry and Laboratory Medicine, 46(3): 323-328.

Lopata, A.L. 2008. Laboratory methods in allergology. Current Allergy & Clinical Immunology, 21(3): 146-147.

Magez, S., Schwegmann, A., Atkinson, R.A., Claes, F., Drennan, M., De Baetselier, P. and Brombacher, F. 2008. The role of B-cells and IgM antibodies in parasitemia, anemia and VSG switching in trypanosoma brucei-infected Mice. PLoS Pathogens, 4(8): e1000122.

Majalija, S., Segal, H., Ejobi, F. and Elisha, B.G. 2008. Shiga toxin gene-containing Escherichia coli from cattle and diarrheic children in the pastoral systems of Southwestern Uganda. Journal of Clinical Microbiology, 46(1): 352-354.

Marais, D.J., Constant, D.A., Allan, B.R., Carrara, H., Hoffman, M., Shapiro, S., Morroni, C. and Williamson, A.-L. 2008. Cervical Human Papillomavirus (HPV) infection and HPV type 16 antibodies in South African women. Journal of Clinical Microbiology, 46(2): 732-739.

Marais, D.J., Passmore, J.S., Denny, L.A., Sampson, C.C., Allan, B.R. and Williamson, A.-L. 2008. Cervical and oral Human Papillomavirus Types in HIV-1 positive and negative women with cervical disease in South Africa. Journal of Medical Virology, 80(6): 953-959.

Marillier, R., Michels, C., Smith, E., Fick, L., Leeto, M., Dewals, B., Horsnell, W. and Brombacher, F. 2008. IL-4 /IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunology, 9:11.

Mathews, S., Abrahams, N., Jewkes, R., Martin, L.J., Lombard, C. and Vetten, L. 2008. Intimate femicide-suicide in South Africa: a cross-sectional study. Bulletin of the World Health Organization: The International Journal of Public Health, 86(7): 552-558.

Mbulawa, Z., Williamson, A.-L., Stewart, D., Passmore, J.S., Denny, L.A., Allan, B.R. and Marais, D.J. 2008. Association of serum and mucosal neutralizing antibodies to human papillomavirus type 16 (HPV-16) with HPV-16 infection and cervical disease. Journal of General Virology, 89: 910-914.

McIntosh, D.B., Montigny, C. and Champeil, P. 2008. Unexpected phosphoryl transfer from Asp351 to fluorescein attached to Lys 515 in sarcoplasmic reticulum Ca+2 -ATPase. Biochemistry, 47(24): 6386-6393.

Mearns, H., Horsnell, W., Hoving, J., Dewals, B., Cutler, A., Kirstein, F., Myburgh, E., Arendse, B. and Brombacher, F. 2008. Interleukin-4-promoted T helper 2 responses enhance nippostrongylus brazilliensis-induced pulmonary pathology. Infection and Immunity, 76(12): 5535-5542.

Meintjes, G., Wilkinson, K., Rangaka, M.X., Skolimowska, K., Van Veen, K., Abrahams, M., Seldon, R., Pepper, D.J., Rebe, K., Mouton, P., Van Cutsem, G., Nicol, M.P., Maartens, G. and Wilkinson, R.J. 2008. Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome. American Journal of Respiratory and Critical Care Medicine, 178: 1083-1089.

Mendelson, M. 2007. Diagnosing tuberculosis in HIV-infected patients: challenges and future prospects. British Medical Bulletin, 81-82(1): 149-165.

Meyers, A.E., Chakauya, E., Shephard, E.G., Tanzer, F.L., Maclean, J., Lynch, A.G., Williamson, A.-L. and Rybicki, E.P. 2008. Expression of HIV-1 antigens in plants as potential subunit vaccines. BMC Biotechnology, 8(53): 1-15. [Online].

Mlisana, K., Auld, S.C., Grobler, A., Van Loggerenberg, F., Williamson, C., Iriogbe, I., Sobieszczyk, M.E., Abdool Karim, S.S. for the CAPRISA Acute Infection Study Team. 2008. Anaemia in Acute HIV-1 Subtype C Infection. PLoS ONE. Feb 20;3(2):e1626. [Online].

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