Скачать 0.74 Mb.
c. Sensory Perception
Sensory impairment is considered by many researchers to be a defining characteristic of autism (Gillberg and Coleman, 1992; Williams, 1996). Baranek (1999) detected sensory-motor problems - touch aversion, poor non-social visual attention, excessive mouthing of objects, and delayed response to name - in 9-12 month old infants later diagnosed with autism, and suggests that these impairments both underlie later social deficits and serve to differentiate ASD from mental retardation and typical controls. Besides sensitivity to sound, as previously noted, ASD often involves insensitivity to pain, even to a burning stove (Gillberg & Coleman, 1992), while on the other hand there may be an overreaction to stimuli, so that even light to moderate touches are painful. Pinprick tests are usually normal. Children with autism have been described as “stiff to hold,” and one of the earliest signs reported by mothers is an aversion to being touched (Gillberg & Coleman, 1992). Abnormal sensation in the extremities and mouth are common. Toe-walking is frequently seen. Oral sensitivity often results in feeding difficulties (Gillberg & Coleman, 1992, p.31). Autistic children frequently have vestibular impairments and difficulty orienting themselves in space (Grandin, 1996; Ornitz, 1987).
As in ASD, sensory issues are reported in nearly all cases of mercury toxicity, and serve to demonstrate the similarities between the two conditions. Paresthesia, or abnormal sensation, tingling, and numbness around the mouth and in the extremities, is the most common sensory disturbance in Hg poisoning, and is usually the first sign of toxicity (Fagala and Wigg, 1992; Joselow et al, 1972; Matheson et al, 1980; Amin-Zaki, 1979). In Japanese who ate contaminated fish, there was numbness in the extremities, face and tongue (Snyder, 1972; Tokuomi et al, 1982). Iraqi children who ate bread experienced sensory changes including numbness in the mouth, hands and feet, and a feeling that there were “ants crawling under the skin.” These children could still feel a pinprick (Amin-Zaki, 1978). Loss of position in space has also been noted (Dales, 1972). Acrodynia sufferers describe excessive pain when bumping limbs, numbness, and poor circulation (Farnesworth, 1997). One adult acrodynia victim described himself as a boy as “shying away from people wanting to touch me” due to extreme touch sensitivity (Neville Recollection, Pink Disease Support Group). Iraqi babies exposed to mercury prenatally showed excessive crying, irritability, and exaggerated reaction to stimulation such as sudden noise or when touched (Amin-Zaki et al, 1974 and 1979).
Table IV: Summary of Sensory Abnormalities
in Mercury Poisoning & Autism
d. Movement/Motor Function
Nearly all cases of autism include disorders of physical movement. Movement disturbances have been detected in infants as young as four to six months old who were later diagnosed as autistic: Teitelbaum et al (1998) have observed that these children do not lie, roll over, sit up or crawl like normal infants; impairment in motor control sometimes caused these babies to fall over while sitting, consistently to avoid using one of their arms, or to rest on their elbows for stability while crawling. Later, when trying to walk their gait was abnormal, and some degree of asymmetry, mostly right-sided, was present in all cases studied. Kanner noted in several of his subjects the absence of crawling and a failure to assume an anticipatory posture preparatory to being picked up in infancy (Kanner, 1943). Arm flapping, abnormal posture, jumping, and hand-finger mannerisms (choreiform movements) are common (Tsai, 1996). Many individuals with Asperger’s syndrome are typically characterized as uncoordinated or clumsy (Kugler, 1998). Other autism movement disorders include praxis (problems with intentional movement), stereotypies, circling or spinning, rocking, myoclonal jerks, difficulty swallowing and chewing, difficulty writing with or even holding a pen, limb apraxia, and poor eye-hand coordination (Caesaroni and Garber, 1991; Gillberg and Coleman, 1992; Filipek et al, 1999).
Like ASD, movement disorders have been a feature of virtually all descriptions of mercury poisoning in humans (Snyder, 1972). Even children prenatally exposed to “safe” levels of methylmercury had deficits in motor function (Grandjean et al, 1998). The movement-related behaviors are extremely diverse: Iraqi infants and children exposed postnatally, for example, developed ataxia that ranged from clumsiness and gait disturbances to an “inability to stand or even sit” (Amin-Zaki et al, 1978). The various movement behaviors are listed more fully in Table VI (Adams et al, 1983; Kark et al, 1971; Pierce et al, 1972; Snyder, 1972; O’Carroll et al, 1995; Tokuomi et al, 1982; Amin-Zaki, 1979; Florentine and Sanfilippo, 1991; Rohyans et al, 1984; Fagala and Wigg, 1992; Smith, 1977; Grandjean et al, 1998; Farnesworth, 1997; Dales, 1972; Matheson et al, 1980; Lowell et al, 1996; O’Kusky et al, 1988; Vroom and Greer, 1972; Warkany and Hubbard, 1953).
Noteworthy because of similarities to movement disorders in autism are reports in the Hg literature of (a) an infant with “peculiar tremulous movements of the extremities which were principally proximal and can best be described as flapping in nature” (Pierce et al, 1972; Snyder, 1972); (b) “jerking movements of the upper extremities” in a man injected with thimerosal (Lowell et al, 1996); (c) “constant choreiform movements affecting the fingers and face” in mercury vapor intoxication (Kark et al, 1971); (d) myoclonal jerks, associated with epilepsy (Amin-Zaki et al, 1978); (e) poor coordination and clumsiness among victims of acrodynia (Farnesworth, 1997); (f) rocking among infants with acrodynia (Warkany and Hubbard, 1953); and (g) unusual postures observed in both acrodynia and mercury vapor poisoning (Vroom and Greer, 1972; Warkany and Hubbard, 1953). In animal studies, cats exposed to mercury by eating fish developed circling movements” (Snyder, 1972), and subcutaneous administration of methylmercury to rats during postnatal development has resulted in postural disorders (O’Kusky et al, 1988). As summarized in Table V, movement similarities in autism and Hg poisoning are clear.
|Arrizabalaga, Heidi Pattern and Palette Sourcebook a complete Guide to Choosing the Perfect Color and Pattern in Design / Heidi Arrizabalaga. Rockport|
Цветочный орнамент / textes Clara Schmidt, Helene Franchi; William Wheeler; O. L. and Co.; Najjia Zegoudh; Olga Nazarova. L'Aventurine,...
|The ghost of Roger Casement Is beating on the door. W. B. Yeats, “The Ghost of Roger Casement” What symbol are you in this dance of death? What is your relevance?|
|C. V. of Roger L. Boyell, Page of Roger L. Boyell, electronics analyst||Pygmalion by George Bernard Shaw|
|Chakats © Bernard Doove/Chakat Goldfur used with permission||The Project Gutenberg ebook of George Bernard Shaw, by Gilbert K. Chesterton|
|Take a look at Roger Ebert's 2002||) stars as a very animated Heidi who is unfairly separated from her loving grandfather (Burl Ives), and forced to live with a gaggle of despicable relatives in|
|Roger Stelljes. Smashwords Edition||Translated by Albert Tezla|