Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ»




НазваниеСтатья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ»
страница4/4
Дата22.09.2012
Размер2.8 Mb.
ТипСтатья
1   2   3   4
Заключение

Природа создала огромный запас геннокодированных ИПЗ, очень разнообразных как по строению, так и по биологической активности. Исследование ИЗП стремительно развивается, и очевидно, что данный пептид – привлекательный кандидат для противомикробной терапии, который можетобеспечить нас потенциальными образцами для разработки как противомикробных, так и иммуномодуляторных препаратов, с возможностью объединения обоих видов активности в одной молекуле. ИЗП и их миметики могут синергически использоваться одновременно с традиционными антибиотиками, а также для воздействия на устойчивые патогенны, где традиционные антибиотики уже бессильны. Важно то, что иммуномодуляторное ИЗП, действие которых в большей мере нацелено на организм хозяина, нежели на патоген, также предоставляет отличную возможность для минимизации рисков формирования резистентности патогенов по отношению к этим соединениям. Будущие фундаментальные и клинические исследования покажут, станет ли это новое мощное “биологическое оружие” частью боевого арсенала работников здравоохранения, а также, когда это произойдет. Особенно важно, чтобы в будущей исследовательской работе использовались преимущества ИЗП, ведь природа ИЗП очень многообразна; при этом ученым следует придерживаться условий физиологического соответствия для окончательного подтверждения in vivo полезных функций ИЗП в борьбе против патогенов.




Просим давать следующую ссылку на данную статью в прессе: Steinstraesser, L., et al., Host defense peptides and their antimicrobial-immunomodulatory duality. Immuno-biology (2010), doi:10.1016/j.imbio.2010.07.003




References


Aarbiou, J., Rabe, K.F., Hiemstra, P.S., 2002. Role of defensins in inflammatory lung disease. Ann. Med. 34, 96.

Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jornvall, H., Wigzell, H., Gudmundsson, G.H., 2000. The human antimicrobial and chemo- tactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96, 3086.

Andres, E., Dimarcq, J.L., 2007. Cationic antimicrobial peptides: from innate immu- nity study to drug development. Up date. Med. Mal. Infect. 37, 194.

Andreu, D., Rivas, L., 1998. Animal antimicrobial peptides: an overview. Biopolymers

47, 415.

Bahri, R., Saidane-Mosbahi, D., Rouabhia, M., 2010. Candida famata modulates toll-like receptor, beta-defensin, and proinflammatory cytokine expression by normal human epithelial cells. J. Cell. Physiol. 222 (1), 209.

Bals, R., Wilson, J.M., 2003. Cathelicidins—a family of multifunctional antimicrobial peptides. Cell. Mol. Life Sci. 60, 711.

Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V., Zasloff, M., Wilson, J.M., 1998. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102, 874.

Bals, R., Weiner, D.J., Moscioni, A.D., Meegalla, R.L., Wilson, J.M., 1999. Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. Infect. Immun. 67, 6084.

Bandholtz, L., Ekman, G.J., Vilhelmsson, M., Buentke, E., Agerberth, B., Scheynius, A., Gudmundsson, G.H., 2006. Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype. Scand. J. Immunol. 63,

410.

Barlow, P.G., Beaumont, P.E., Cosseau, C., Mackellar, A., Wilkinson, T.S., Hancock, R.E., Haslett, C., Govan, J.R., Simpson, A.J., Davidson, D.J., 2010. The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium. Am. J. Respir. Cell Mol. Biol. [Epub ahead of print].

Benko, S., Philpott, D.J., Girardin, S.E., 2008. The microbial and danger signals that activate Nod-like receptors. Cytokine 43, 368.

Bensch, K.W., Raida, M., Magert, H.J., Schulz-Knappe, P., Forssmann, W.G., 1995. hBD-

1: a novel beta-defensin from human plasma. FEBS Lett. 368, 331.

Bhat, S., Milner, S., 2007. Antimicrobial peptides in burns and wounds. Curr. Protein

Pept. Sci. 8, 506.

Birchler, T., Seibl, R., Buchner, K., Loeliger, S., Seger, R., Hossle, J.P., Aguzzi, A., Lauener, R.P., 2001. Human Toll-like receptor 2 mediates induction of the antimicro- bial peptide human beta-defensin 2 in response to bacterial lipoprotein. Eur. J. Immunol. 31, 3131.

Boman, H.G., 2003. Antibacterial peptides: basic facts and emerging concepts. J.

Intern. Med. 254, 197.

Bose, S.K., Gibson, W., Bullard, R.S., Donald, C.D., 2009. PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer. Mol. Immunol. 46, 1140.

Bowdish, D.M., Davidson, D.J., Lau, Y.E., Lee, K., Scott, M.G., Hancock, R.E., 2005.

Impact of LL-37 on anti-infective immunity. J. Leukoc. Biol. 77, 451.

Braff, M.H., Bardan, A., Nizet, V., Gallo, R.L., 2005a. Cutaneous defense mechanisms by antimicrobial peptides. J. Invest. Dermatol. 125, 9.

Braff, M.H., Zaiou, M., Fierer, J., Nizet, V., Gallo, R.L., 2005b. Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens. Infect. Immun. 73, 6771.

Braff, M.H., Jones, A.L., Skerrett, S.J., Rubens, C.E., 2007. Staphylococcus aureus exploits cathelicidin antimicrobial peptides produced during early pneumo- nia to promote staphylokinase-dependent fibrinolysis. J. Infect. Dis. 195,

1365.

Brahmachary, M., Krishnan, S.P., Koh, J.L., Khan, A.M., Seah, S.H., Tan, T.W., Brusic, V., Bajic, V.B., 2004. ANTIMIC: a database of antimicrobial sequences. Nucleic Acids Res. 32, D586.

Butmarc, J., Yufit, T., Carson, P., Falanga, V., 2004. Human beta-defensin-2 expression is increased in chronic wounds. Wound Repair Regen. 12, 439.

Campopiano, D.J., Clarke, D.J., Polfer, N.C., Barran, P.E., Langley, R.J., Govan, J.R., Maxwell, A., Dorin, J.R., 2004. Structure–activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity. J. Biol. Chem. 279, 48671.

Chan, Y.R., Gallo, R.L., 1998. PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas). J. Biol. Chem. 273, 28978.

Charp, P.A., Rice, W.G., Raynor, R.L., Reimund, E., Kinkade Jr., J.M., Ganz, T., Selsted, M.E., Lehrer, R.I., Kuo, J.F., 1988. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochem. Pharmacol. 37, 951.

Chen, X., Niyonsaba, F., Ushio, H., Okuda, D., Nagaoka, I., Ikeda, S., Okumura, K., Ogawa, H., 2005. Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J. Dermatol. Sci. 40, 123.

Chertov, O., Michiel, D.F., Xu, L., Wang, J.M., Tani, K., Murphy, W.J., Longo, D.L., Taub, D.D., Oppenheim, J.J., 1996. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-

8-stimulated neutrophils. J. Biol. Chem. 271, 2935.

Chertov, O., Yang, D., Howard, O.M., Oppenheim, J.J., 2000. Leukocyte granule pro- teins mobilize innate host defenses and adaptive immune responses. Immunol. Rev. 177, 68.

Chromek, M., Slamova, Z., Bergman, P., Kovacs, L., Podracka, L., Ehren, I., Hokfelt, T., Gudmundsson, G.H., Gallo, R.L., Agerberth, B., Brauner, A., 2006. The antimi- crobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med. 12, 636.

C
Просим давать следующую ссылку на данную статью в прессе: Steinstraesser, L., et al., Host defense peptides and their antimicrobial-immunomodulatory duality. Immunobiology (2010), doi:10.1016/j.imbio.2010.07.003


huang,
C.M., Monie, A., Wu, A., Mao, C.P., Hung, C.F., 2009. Treatment with LL-

37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer. Hum. Gene Ther. 20, 303.

Coffelt, S.B., Waterman, R.S., Florez, L., Honer zu Bentrup, K., Zwezdaryk, K.J., Tom- chuck, S.L., LaMarca, H.L., Danka, E.S., Morris, C.A., Scandurro, A.B., 2008. Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-

37 increases ovarian cancer cell proliferation and invasion. Int. J. Cancer. 122,

1030.

Coffelt, S.B., Tomchuck, S.L., Zwezdaryk, K.J., Danka, E.S., Scandurro, A.B., 2009.

Leucine leucine-37 uses formyl peptide receptor-like 1 to activate signal trans- duction pathways, stimulate oncogenic gene expression, and enhance the invasiveness of ovarian cancer cells. Mol. Cancer Res. 7, 907.

Crovella, S., Antcheva, N., Zelezetsky, I., Boniotto, M., Pacor, S., Verga Falzacappa, M.V., Tossi, A., 2005. Primate beta-defensins—structure, function and evolution. Curr. Protein Pept. Sci. 6, 7.

Dalpke, A.H., Lehner, M.D., Hartung, T., Heeg, K., 2005. Differential effects of CpG- DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology

116, 203.

De, Y., Chen, Q., Schmidt, A.P., Anderson, G.M., Wang, J.M., Wooters, J., Oppenheim, J.J., Chertov, O., 2000. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 192, 1069.

De Smet, K., Contreras, R., 2005. Human antimicrobial peptides: defensins, catheli- cidins and histatins. Biotechnol. Lett. 27, 1337.

Deans, K.J., Haley, M., Natanson, C., Eichacker, P.Q., Minneci, P.C., 2005. Novel ther- apies for sepsis: a review. J. Trauma 58, 867.

Di Nardo, A., Yamasaki, K., Dorschner, R.A., Lai, Y., Gallo, R.L., 2008. Mast cell cathe- licidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J. Immunol. 180, 7565.

Diamond, G., Kaiser, V., Rhodes, J., Russell, J.P., Bevins, C.L., 2000. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect. Immun. 68, 113.

Dorschner, R.A., Pestonjamasp, V.K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G.H., Gallo, R.L., 2001. Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Strep- tococcus. J. Invest. Dermatol. 117, 91.

Dorschner, R.A., Lopez-Garcia, B., Peschel, A., Kraus, D., Morikawa, K., Nizet, V., Gallo, R.L., 2006. The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides. FASEB J. 20, 35.

Duits, L.A., Ravensbergen, B., Rademaker, M., Hiemstra, P.S., Nibbering, P.H., 2002.

Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106, 517.

Dunsche, A., Acil, Y., Dommisch, H., Siebert, R., Schroder, J.M., Jepsen, S., 2002. The novel human beta-defensin-3 is widely expressed in oral tissues. Eur. J. Oral Sci.

110, 121.

Elssner, A., Duncan, M., Gavrilin, M., Wewers, M.D., 2004. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta pro- cessing and release. J. Immunol. 172, 4987.

Fang, X.M., Shu, Q., Chen, Q.X., Book, M., Sahl, H.G., Hoeft, A., Stuber, F., 2003. Differ- ential expression of alpha- and beta-defensins in human peripheral blood. Eur. J. Clin. Invest. 33, 82.

Finlay, B.B., Hancock, R.E., 2004. Can innate immunity be enhanced to treat microbial infections? Nat. Rev. Microbiol. 2, 497.

Fjell, C.D., Hancock, R.E., Cherkasov, A., 2007. AMPer: a database and an automated discovery tool for antimicrobial peptides. Bioinformatics 23, 1148.

Fritz, J.H., Ferrero, R.L., Philpott, D.J., Girardin, S.E., 2006. Nod-like proteins in immu- nity, inflammation and disease. Nat. Immunol. 7, 1250.

Froy, O., Hananel, A., Chapnik, N., Madar, Z., 2007. Differential effect of insulin treat- ment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Mol. Immunol. 44, 796.

Gallo, R.L., 2000. Proteoglycans and cutaneous vascular defense and repair. J. Invest.

Dermatol. Symp. Proc. 5, 55.

Gallo, R.L., Ono, M., Povsic, T., Page, C., Eriksson, E., Klagsbrun, M., Bernfield, M.,

1994. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc. Natl. Acad. Sci. U.S.A. 91,

11035.

Gallo, R.L., Murakami, M., Ohtake, T., Zaiou, M., 2002. Biology and clinical relevance of naturally occurring antimicrobial peptides. J. Allergy Clin. Immunol. 110, 823. Ganguly, D., Chamilos, G., Lande, R., Gregorio, J., Meller, S., Facchinetti, V., Homey, B., Barrat, F.J., Zal, T., Gilliet, M., 2009. Self-RNA-antimicrobial peptide com- plexes activate human dendritic cells through TLR7 and TLR8. J. Exp. Med. 206,

1983.

Ganz, T., 2003. Defensins: antimicrobial peptides of innate immunity. Nat. Rev.

Immunol. 3, 710.

Ganz, T., 2004. Antimicrobial polypeptides. J. Leukoc. Biol. 75, 34.

Ganz, T., 2005. Defensins and other antimicrobial peptides: a historical perspective and an update. Comb. Chem. High Throughput Screen. 8, 209.

Ganz, T., Lehrer, R.I., 1999. Antibiotic peptides from higher eukaryotes: biology and applications. Mol. Med. Today 5, 292.

Garcia, J.R., Jaumann, F., Schulz, S., Krause, A., Rodriguez-Jimenez, J., Forssmann, U., Adermann, K., Kluver, E., Vogelmeier, C., Becker, D., Hedrich, R., Forssmann, W.G., Bals, R., 2001a. Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattrac- tion. Cell Tissue Res. 306, 257.




Garcia, J.R., Krause, A., Schulz, S., Rodriguez-Jimenez, F.J., Kluver, E., Adermann, K., Forssmann, U., Frimpong-Boateng, A., Bals, R., Forssmann, W.G., 2001b. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spec- trum of antimicrobial activity. FASEB J. 15, 1819.

Garcia, A.E., Osapay, G., Tran, P.A., Yuan, J., Selsted, M.E., 2008. Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect. Immun. 76, 5883.

Glaser, R., Harder, J., Lange, H., Bartels, J., Christophers, E., Schroder, J.M., 2005.

Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli

infection. Nat. Immunol. 6, 57.

Groeneveld, T.W., Ramwadhdoebe, T.H., Trouw, L.A., van den Ham, D.L., van der Borden, V., Drijfhout, J.W., Hiemstra, P.S., Daha, M.R., Roos, A., 2007. Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of com- plement activation. Mol. Immunol. 44, 3608.

Hale, J.D., Hancock, R.E., 2007. Alternative mechanisms of action of cationic antimi- crobial peptides on bacteria. Expert. Rev. Anti Infect. Ther. 5, 951.

Hancock, R.E., 1997. Peptide antibiotics. Lancet 349, 418.

Hancock, R.E., 2001. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect. Dis. 1, 156.

Hancock, R.E., Sahl, H.G., 2006. Antimicrobial and host-defense peptides as new anti- infective therapeutic strategies. Nat. Biotechnol. 24, 1551.

Hancock, R.E., Scott, M.G., 2000. The role of antimicrobial peptides in animal defenses. Proc. Natl. Acad. Sci. U.S.A. 97, 8856.

Harder, J., Schroder, J.M., 2002. RNase 7, a novel innate immune defense antimicro- bial protein of healthy human skin. J. Biol. Chem. 277, 46779.

Harder, J., Bartels, J., Christophers, E., Schroder, J.M., 1997. A peptide antibiotic from human skin. Nature 387, 861.

Harder, J., Meyer-Hoffert, U., Teran, L.M., Schwichtenberg, L., Bartels, J., Maune, S., Schroder, J.M., 2000. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-

1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am. J. Respir. Cell Mol. Biol. 22, 714.

Harder, J., Bartels, J., Christophers, E., Schroder, J.M., 2001. Isolation and characteri- zation of human beta -defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276, 5707.

Harder, J., Meyer-Hoffert, U., Wehkamp, K., Schwichtenberg, L., Schroder, J.M., 2004.

Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid. J. Invest. Dermatol. 123, 522.

Hata, T.R., Gallo, R.L., 2008. Antimicrobial peptides, skin infections, and atopic der- matitis. Semin. Cutan. Med. Surg. 27, 144.

Hegedus, C.M., Skibola, C.F., Warner, M., Skibola, D.R., Alexander, D., Lim, S., Dan- gleben, N.L., Zhang, L., Clark, M., Pfeiffer, R.M., Steinmaus, C., Smith, A.H., Smith, M.T., Moore, L.E., 2008. Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol. Sci. 106, 74.

Heilborn, J.D., Nilsson, M.F., Kratz, G., Weber, G., Sorensen, O., Borregaard, N., Stahle- Backdahl, M., 2003. The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J. Invest. Dermatol. 120, 379.

Hirsch, T., Jacobsen, F., Steinau, H.U., Steinstraesser, L., 2008. Host defense peptides and the new line of defence against multiresistant infections. Protein Pept. Lett.

15, 238.

Hirsch, T., Spielmann, M., Zuhaili, B., Fossum, M., Metzig, M., Koehler, T., Steinau, H.U., Yao, F., Onderdonk, A.B., Steinstraesser, L., Eriksson, E., 2009. Human beta- defensin-3 promotes wound healing in infected diabetic wounds. J. Genet. Med.

11, 220.

Hollox, E.J., 2008. Copy number variation of beta-defensins and relevance to disease.

Cytogenet. Genome Res. 123, 148.

Jacobsen, F., Mittler, D., Hirsch, T., Gerhards, A., Lehnhardt, M., Voss, B., Steinau, H.U., Steinstraesser, L., 2005a. Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections. Gene Ther. 12, 1494.

Jacobsen, F., Baraniskin, A., Mertens, J., Mittler, D., Mohammadi-Tabrisi, A., Schu- bert, S., Soltau, M., Lehnhardt, M., Behnke, B., Gatermann, S., Steinau, H.U., Steinstraesser, L., 2005b. Activity of histone H1.2 in infected burn wounds. J. Antimicrob. Chemother. 55, 735.

Jenssen, H., Hamill, P., Hancock, R.E., 2006. Peptide antimicrobial agents. Clin. Micro- biol. Rev. 19, 491.

Ji, S., Shin, J.E., Kim, Y.S., Oh, J.E., Min, B.M., Choi, Y., 2009. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect. Immun. 77, 1044.

Jo, E.K., 2008. Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs. Curr. Opin. Infect. Dis. 21, 279.

Johansson, J., Gudmundsson, G.H., Rottenberg, M.E., Berndt, K.D., Agerberth, B.,

1998. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 273, 3718.

Kandler, K., Shaykhiev, R., Kleemann, P., Klescz, F., Lohoff, M., Vogelmeier, C., Bals, R.,

2006. The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands. Int. Immunol. 18, 1729.

Kaus, A., Jacobsen, F., Sorkin, M., Rittig, A., Voss, B., Daigeler, A., Sudhoff, H., Steinau, H.U., Steinstraesser, L., 2008. Host defence peptides in human burns. Burns 34,

32.

Kawai, K., Shimura, H., Minagawa, M., Ito, A., Tomiyama, K., Ito, M., 2002. Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J. Dermatol. Sci. 30, 185.

Kesting, M.R., Loeffelbein, D.J., Hasler, R.J., Wolff, K.D., Rittig, A., Schulte, M., Hirsch, T., Wagenpfeil, S., Jacobsen, F., Steinstraesser, L., 2009. Expression profile of human beta-defensin 3 in oral squamous cell carcinoma. Cancer Invest. 27, 575.

K
Просим давать следующую ссылку на данную статью в прессе: Steinstraesser, L., et al., Host defense peptides and their antimicrobial-immunomodulatory duality. Immunobiology (2010), doi:10.1016/j.imbio.2010.07.003


im,
J.Y., Park, S.C., Hwang, I., Cheong, H., Nah, J.W., Hahm, K.S., Park, Y., 2009.

Protease inhibitors from plants with antimicrobial activity. Int. J. Mol. Sci. 10,

2860.

Kisich, K.O., Howell, M.D., Boguniewicz, M., Heizer, H.R., Watson, N.U., Leung, D.Y.,

2007. The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-Defensin 3. J. Invest. Dermatol..

Klotman, M.E., Chang, T.L., 2006. Defensins in innate antiviral immunity. Nat. Rev.

Immunol. 6, 447.

Koczulla, A.R., Bals, R., 2003. Antimicrobial peptides: current status and therapeutic potential. Drugs 63, 389.

Koczulla, R., von Degenfeld, G., Kupatt, C., Krotz, F., Zahler, S., Gloe, T., Issbrucker, K., Unterberger, P., Zaiou, M., Lebherz, C., Karl, A., Raake, P., Pfosser, A., Boek- stegers, P., Welsch, U., Hiemstra, P.S., Vogelmeier, C., Gallo, R.L., Clauss, M., Bals, R., 2003. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 111, 1665.

Kougias, P., Chai, H., Lin, P.H., Yao, Q., Lumsden, A.B., Chen, C., 2005. Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis. J. Cell. Mol. Med. 9, 3.

Krisanaprakornkit, S., Kimball, J.R., Dale, B.A., 2002. Regulation of human beta- defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family. J. Immunol. 168, 316.

Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.H., Homey, B., Cao, W., Su, B., Nestle, F.O., Zal, T., Mellman, I., Schroder, J.M., Liu, Y.J., Gilliet, M., 2007. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564.

Larrick, J.W., Hirata, M., Balint, R.F., Lee, J., Zhong, J., Wright, S.C., 1995. Human CAP18:

a novel antimicrobial lipopolysaccharide-binding protein. Infect. Immun. 63,

1291.

Lee, P.H., Ohtake, T., Zaiou, M., Murakami, M., Rudisill, J.A., Lin, K.H., Gallo, R.L., 2005.

Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection. Proc. Natl. Acad. Sci. U.S.A. 102, 3750.

Lee, H.Y., Kim, S.D., Shim, J.W., Lee, S.Y., Yun, J., Bae, Y.S., 2009. LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils. Exp. Mol. Med. 41,

325.

Lehrer, R.I., Lichtenstein, A.K., Ganz, T., 1993. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11, 105.

Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., Hoffmann, J.A., 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973.

Leung, D.Y., Boguniewicz, M., Howell, M.D., Nomura, I., Hamid, Q.A., 2004. New insights into atopic dermatitis. J. Clin. Invest. 113, 651.

Linde, A., Mosier, D., Blecha, F., Melgarejo, T., 2007. Innate immunity and inflammation—new frontiers in comparative cardiovascular pathology. Cardio- vasc. Res. 73, 26.

Liu, A.Y., Destoumieux, D., Wong, A.V., Park, C.H., Valore, E.V., Liu, L., Ganz, T.,

2002. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J. Invest. Dermatol.

118, 275.

Liu, L., Roberts, A.A., Ganz, T., 2003. By IL-1 signaling, monocyte-derived cells dra- matically enhance the epidermal antimicrobial response to lipopolysaccharide. J. Immunol. 170, 575.

Liu, P.T., Schenk, M., Walker, V.P., Dempsey, P.W., Kanchanapoomi, M., Wheel- wright, M., Vazirnia, A., Zhang, X., Steinmeyer, A., Zugel, U., Hollis, B.W., Cheng, G., Modlin, R.L., 2009. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One 4, e5810.

Maemoto, A., Qu, X., Rosengren, K.J., Tanabe, H., Henschen-Edman, A., Craik, D.J., Ouellette, A.J., 2004. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J. Biol. Chem. 279, 44188.

Maisetta, G., Batoni, G., Esin, S., Florio, W., Bottai, D., Favilli, F., Campa, M., 2006. In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob. Agents Chemother. 50, 806.

Martinon, F., Tschopp, J., 2007. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 14, 10.

Matsuzaki, K., 1999. Why and how are peptide-lipid interactions utilized for self- defense? Magainins and tachyplesins as archetypes. Biochim. Biophys. Acta

1462, 1.

Matzinger, P., 1994. Tolerance, danger, and the extended family. Annu. Rev.

Immunol. 12, 991.

Matzinger, P., 2007. Friendly and dangerous signals: is the tissue in control? Nat.

Immunol. 8, 11.

Menzies, B.E., Kenoyer, A., 2006. Signal transduction and nuclear responses in staphylococcus aureus-induced expression of human {beta}-defensin-3 in skin keratinocytes. Infect. Immun..

Milner, S.M., Ortega, M.R., 1999. Reduced antimicrobial peptide expression in human burn wounds. Burns 25, 411.

Morioka, Y., Yamasaki, K., Leung, D., Gallo, R.L., 2008. Cathelicidin antimicrobial pep- tides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis. J. Immunol. 181, 3915.

Morrison, G., Kilanowski, F., Davidson, D., Dorin, J., 2002. Characterization of the mouse beta defensin 1, Defb1, mutant mouse model. Infect. Immun. 70,

3053.

Nagaoka, I., Niyonsaba, F., Tsutsumi-Ishii, Y., Tamura, H., Hirata, M., 2008. Evaluation of the effect of human beta-defensins on neutrophil apoptosis. Int. Immunol. 20,

543.




Nassar, H., Lavi, E., Akkawi, S., Bdeir, K., Heyman, S.N., Raghunath, P.N., Tomaszewski, J., Higazi, A.A., 2007. alpha-Defensin: link between inflammation and atheroscle- rosis. Atherosclerosis 194, 452.

Nguyen, T.X., Cole, A.M., Lehrer, R.I., 2003. Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides 24, 1647.

Niyonsaba, F., Ogawa, H., 2005. Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J. Dermatol. Sci. 40, 157.

Niyonsaba, F., Iwabuchi, K., Matsuda, H., Ogawa, H., Nagaoka, I., 2002. Epithe- lial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway. Int. Immunol. 14, 421.

Niyonsaba, F., Ushio, H., Nagaoka, I., Okumura, K., Ogawa, H., 2005. The Human

{beta}-Defensins (-1, -2, -3, -4) and Cathelicidin LL-37 Induce IL-18 Secretion through p38 and ERK MAPK Activation in Primary Human Keratinocytes. J. Immunol. 175, 1776.

Niyonsaba, F., Ushio, H., Nakano, N., Ng, W., Sayama, K., Hashimoto, K., Nagaoka, I., Okumura, K., Ogawa, H., 2006. Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J. Invest. Dermatol..

Niyonsaba, F., Suzuki, A., Ushio, H., Nagaoka, I., Ogawa, H., Okumura, K., 2009. The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br. J. Dermatol. 160, 243.

Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R.A., Pestonja- masp, V., Piraino, J., Huttner, K., Gallo, R.L., 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414, 454.

Ohlsen, K., Dandekar, G., Schwarz, R., Dandekar, T., 2008. New trends in pharma- cogenomic strategies against resistance development in microbial infections. Pharmacogenomics 9, 1711.

O’Neil, D.A., Porter, E.M., Elewaut, D., Anderson, G.M., Eckmann, L., Ganz, T., Kagnoff, M.F., 1999. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J. Immunol. 163, 6718.

Ong, P.Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R.L., Leung, D.Y., 2002. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347, 1151.

Onomoto, K., Yoneyama, M., Fujita, T., 2007. Regulation of antiviral innate immune responses by RIG-I family of RNA helicases. Curr. Top. Microbiol. Immunol. 316,

193.

Oono, T., Shirafuji, Y., Huh, W.K., Akiyama, H., Iwatsuki, K., 2002. Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts. Arch. Dermatol. Res. 294, 185.

Oppenheim, J.J., Biragyn, A., Kwak, L.W., Yang, D., 2003. Roles of antimicrobial pep- tides such as defensins in innate and adaptive immunity. Ann. Rheum. Dis. 62 (Suppl. 2), ii17.

Oren, Z., Lerman, J.C., Gudmundsson, G.H., Agerberth, B., Shai, Y., 1999. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochem. J. 341 (Pt 3), 501.

Oren, A., Ganz, T., Liu, L., Meerloo, T., 2003. In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp. Mol. Pathol. 74, 180.

Otte, J.M., Zdebik, A.E., Brand, S., Chromik, A.M., Strauss, S., Schmitz, F., Steinstraesser, L., Schmidt, W.E., 2009. Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity. Regul. Pept. 156, 104.

Panyutich, A., Ganz, T., 1991. Activated alpha 2-macroglobulin is a principal defensin-binding protein. Am. J. Respir. Cell Mol. Biol. 5, 101.

Panyutich, A.V., Voitenok, N.N., Lehrer, R.I., Ganz, T., 1991. An enzyme immunoassay for human defensins. J. Immunol. Methods 141, 149.

Panyutich, A.V., Panyutich, E.A., Krapivin, V.A., Baturevich, E.A., Ganz, T., 1993. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J. Lab. Clin. Med. 122, 202.

Panyutich, A.V., Szold, O., Poon, P.H., Tseng, Y., Ganz, T., 1994. Identification of defensin binding to C1 complement. FEBS Lett. 356, 169.

Poindexter, B.J., Bhat, S., Buja, L.M., Bick, R.J., Milner, S.M., 2006. Localization of antimicrobial peptides in normal and burned skin. Burns.

Porter, E.M., van Dam, E., Valore, E.V., Ganz, T., 1997. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65, 2396.

Proud, D., Sanders, S.P., Wiehler, S., 2004. Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo. J. Immunol. 172, 4637.

Proudfoot, A.E., Fritchley, S., Borlat, F., Shaw, J.P., Vilbois, F., Zwahlen, C., Trkola, A., Marchant, D., Clapham, P.R., Wells, T.N., 2001. The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity. J. Biol. Chem.

276, 10620.

Rieg, S., Steffen, H., Seeber, S., Humeny, A., Kalbacher, H., Dietz, K., Garbe, C., Schittek, B., 2005. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. J. Immunol. 174, 8003.

Robinson, M.J., Sancho, D., Slack, E.C., LeibundGut-Landmann, S., Reis e Sousa, C.,

2006. Myeloid C-type lectins in innate immunity. Nat. Immunol. 7, 1258. Sallum, U.W., Chen, T.T., 2008. Inducible resistance of fish bacterial pathogens to the

antimicrobial peptide cecropin B. Antimicrob. Agents Chemother. 52, 3006. Sawamura, D., Goto, M., Shibaki, A., Akiyama, M., McMillan, J.R., Abiko, Y., Shimizu,

H., 2005. Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection. Gene Ther..

Schittek, B., Hipfel, R., Sauer, B., Bauer, J., Kalbacher, H., Stevanovic, S., Schirle, M., Schroeder, K., Blin, N., Meier, F., Rassner, G., Garbe, C., 2001. Dermcidin:

a
Просим давать следующую ссылку на данную статью в прессе: Steinstraesser, L., et al., Host defense peptides and their antimicrobial-immunomodulatory duality. Immunobiology (2010), doi:10.1016/j.imbio.2010.07.003


novel human antibiotic peptide secreted by sweat glands. Nat. Immunol. 2,

1133.

Schmid, P., Grenet, O., Medina, J., Chibout, S.D., Osborne, C., Cox, D.A., 2001. An intrinsic antibiotic mechanism in wounds and tissue-engineered skin. J. Invest. Dermatol. 116, 471.

Schroder, J.M., Harder, J., 1999. Human beta-defensin-2. Int. J. Biochem. Cell Biol. 31,

645.

Schroder, J.M., Harder, J., 2006. Antimicrobial skin peptides and proteins. Cell. Mol.

Life Sci. 63, 469.

Scott, M.G., Hancock, R.E., 2000. Cationic antimicrobial peptides and their multifunc- tional role in the immune system. Crit. Rev. Immunol. 20, 407.

Scott, A.M., Saleh, M., 2007. The inflammatory caspases: guardians against infections and sepsis. Cell Death Differ. 14, 23.

Scott, M.G., Davidson, D.J., Gold, M.R., Bowdish, D., Hancock, R.E., 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J. Immunol. 169, 3883.

Selsted, M.E., 2004. Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins. Curr. Protein Pept. Sci. 5, 365.

Selsted, M.E., Ouellette, A.J., 2005. Mammalian defensins in the antimicrobial immune response. Nat. Immunol. 6, 551.

Seong, S.Y., Matzinger, P., 2004. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol.

4, 469.

Shai, Y., 1999. Mechanism of the binding, insertion and destabilization of phospho- lipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim. Biophys. Acta 1462, 55.

Shaykhiev, R., Beisswenger, C., Kandler, K., Senske, J., Puchner, A., Damm, T., Behr, J., Bals, R., 2005. Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am. J. Physiol. Lung Cell. Mol. Physiol. 289, L842.

Sima, P., Trebichavsky, I., Sigler, K., 2003. Mammalian antibiotic peptides. Folia

Microbiol. (Praha) 48, 123.

Singer, A.J., Clark, R.A., 1999. Cutaneous wound healing. N. Engl. J. Med. 341, 738. Singh, P.K., Jia, H.P., Wiles, K., Hesselberth, J., Liu, L., Conway, B.A., Greenberg, E.P.,

Valore, E.V., Welsh, M.J., Ganz, T., Tack, B.F., McCray Jr., P.B., 1998. Production of beta-defensins by human airway epithelia. Proc. Natl. Acad. Sci. U.S.A. 95, 14961. Soehnlein, O., Lindbom, L., Weber, C., 2009. Mechanisms underlying neutrophil-

mediated monocyte recruitment. Blood 114, 4613.

Soong, L.B., Ganz, T., Ellison, A., Caughey, G.H., 1997. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm. Res. 46, 98.

Sorensen, O., Arnljots, K., Cowland, J.B., Bainton, D.F., Borregaard, N., 1997. The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 90,

2796.

Sorensen, O.E., Cowland, J.B., Theilgaard-Monch, K., Liu, L., Ganz, T., Borregaard, N.,

2003. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J. Immunol.

170, 5583.

Sorensen, O.E., Thapa, D.R., Rosenthal, A., Liu, L., Roberts, A.A., Ganz, T., 2005. Differ- ential regulation of beta-defensin expression in human skin by microbial stimuli. J. Immunol. 174, 4870.

Steiner, H., Andreu, D., Merrifield, R.B., 1988. Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects. Biochim. Biophys. Acta

939, 260.

Steinstraesser, L., Oezdogan, Y., Wang, S.C., Steinau, H.U., 2004. Host defense peptides in burns. Burns 30, 619.

Steinstraesser, L., Tippler, B., Mertens, J., Lamme, E., Homann, H.H., Lehnhardt, M., Wildner, O., Steinau, H.U., Uberla, K., 2005. Inhibition of early steps in the lentivi- ral replication cycle by cathelicidin host defense peptides. Retrovirology 2, 2.

Steinstraesser, L., Ring, A., Bals, R., Steinau, H.U., Langer, S., 2006. The human host defense peptide LL37/hCAP accelerates angiogenesis in PEGT/PBT biopolymers. Ann. Plast Surg. 56, 93.

Steinstraesser, L., Koehler, T., Jacobsen, F., Daigeler, A., Goertz, O., Langer, S., Kesting, M., Steinau, H., Eriksson, E., Hirsch, T., 2008. Host defense peptides in wound healing. Mol. Med. 14, 528.

Steinstraesser, L., Kraneburg, U.M., Hirsch, T., Kesting, M., Steinau, H.U., Jacobsen, F., Al-Benna, S., 2009. Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance? Int. J. Mol. Sci. 10 (9),

3951–3970.

Steinstrasser, L., Langer, S., Lehnhardt, M., Steinau, H.U., 2007. Effector molecules of the innate immune system for treatment of wound infections. Chirurg 78, 343. Supp, D.M., Karpinski, A.C., Boyce, S.T., 2004. Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes. Burns

30, 643.

Tani, K., Murphy, W.J., Chertov, O., Salcedo, R., Koh, C.Y., Utsunomiya, I., Funakoshi, S., Asai, O., Herrmann, S.H., Wang, J.M., Kwak, L.W., Oppenheim, J.J., 2000. Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens. Int. Immunol. 12, 691.

Tew, G.N., Clements, D., Tang, H., Arnt, L., Scott, R.W., 2006. Antimicrobial activ- ity of an abiotic host defense peptide mimic. Biochim. Biophys. Acta 1758,

1387.

Thompson, L., Turko, I., Murad, F., 2006. Mass spectrometry-based relative quantifi- cation of human neutrophil peptides 1, 2, and 3 from biological samples. Mol. Immunol. 43, 1485.

Tjabringa, G.S., Aarbiou, J., Ninaber, D.K., Drijfhout, J.W., Sorensen, O.E., Borregaard, N., Rabe, K.F., Hiemstra, P.S., 2003. The antimicrobial peptide LL-37 activates




innate immunity at the airway epithelial surface by transactivation of the epi- dermal growth factor receptor. J. Immunol. 171, 6690.

Tokumaru, S., Sayama, K., Shirakata, Y., Komatsuzawa, H., Ouhara, K., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Nagai, H., Yang, L., Higashiyama, S., Yoshimura, A., Sugai, M., Hashimoto, K., 2005. Induction of keratinocyte migration via trans- activation of the epidermal growth factor receptor by the antimicrobial peptide LL-37. J. Immunol. 175, 4662.

Tomasinsig, L., Zanetti, M., 2005. The cathelicidins—structure, function and evolu- tion. Curr. Protein Pept. Sci. 6, 23.

Tran, D., Tran, P., Roberts, K., Osapay, G., Schaal, J., Ouellette, A., Selsted, M.E.,

2008. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob. Agents Chemother. 52, 944.

Tsutsumi-Ishii, Y., Nagaoka, I., 2002. NF-kappa B-mediated transcriptional regula- tion of human beta-defensin-2 gene following lipopolysaccharide stimulation. J. Leukoc. Biol. 71, 154.

Tsutsumi-Ishii, Y., Nagaoka, I., 2003. Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J. Immunol.

170, 4226.

Turner, J., Cho, Y., Dinh, N.N., Waring, A.J., Lehrer, R.I., 1998. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Ap74 42, 2206. Valore, E.V., Park, C.H., Quayle, A.J., Wiles, K.R., McCray, P.B., Ganz, T., 1998. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest.

101, 1633.

van den Berg, R.H., Faber-Krol, M.C., van Wetering, S., Hiemstra, P.S., Daha, M.R.,

1998. Inhibition of activation of the classical pathway of complement by human neutrophil defensins. Blood 92, 3898.

van ‘t Hof, W., Veerman, E.C., Helmerhorst, E.J., Amerongen, A.V., 2001. Antimicrobial peptides: properties and applicability. Biol. Chem. 382, 597.

Van Wetering, S., Mannesse-Lazeroms, S.P., Van Sterkenburg, M.A., Daha, M.R., Dijk- man, J.H., Hiemstra, P.S., 1997. Effect of defensins on interleukin-8 synthesis in airway epithelial cells. Am. J. Physiol. 272, L888.

von Haussen, J., Koczulla, R., Shaykhiev, R., Herr, C., Pinkenburg, O., Reimer, D., Wiewrodt, R., Biesterfeld, S., Aigner, A., Czubayko, F., Bals, R., 2008. The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells. Lung Cancer 59, 12.

von Kockritz-Blickwede, M., Goldmann, O., Thulin, P., Heinemann, K., Norrby- Teglund, A., Rohde, M., Medina, E., 2008. Phagocytosis-independent antimicro- bial activity of mast cells by means of extracellular trap formation. Blood 111,

3070.

Vora, P., Youdim, A., Thomas, L.S., Fukata, M., Tesfay, S.Y., Lukasek, K., Michelsen, K.S., Wada, A., Hirayama, T., Arditi, M., Abreu, M.T., 2004. Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J. Immunol. 173, 5398.

Wah, J., Wellek, A., Frankenberger, M., Unterberger, P., Welsch, U., Bals, R.,

2006. Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastrointestinal tracts. Cell Tissue Res. 324,

449.

Wang, X., Zhang, Z., Louboutin, J.P., Moser, C., Weiner, D.J., Wilson, J.M., 2003. Air- way epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2. FASEB J. 17, 1727.

Wang, G., Li, X., Wang, Z., 2009. APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res. 37, D933.

Wehkamp, J., Schauber, J., Stange, E.F., 2007. Defensins and cathelicidins in gastroin- testinal infections. Curr. Opin. Gastroenterol. 23, 32.

Wiedow, O., Harder, J., Bartels, J., Streit, V., Christophers, E., 1998. Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes. Biochem. Biophys. Res. Commun. 248, 904.

Wolk, K., Witte, E., Wallace, E., Docke, W.D., Kunz, S., Asadullah, K., Volk, H.D., Sterry, W., Sabat, R., 2006. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36, 1309.

W
Просим давать следующую ссылку на данную статью в прессе: Steinstraesser, L., et al., Host defense peptides and their antimicrobial-immunomodulatory duality. Immunobiology (2010), doi:10.1016/j.imbio.2010.07.003


u,
Z., Hoover, D.M., Yang, D., Boulegue, C., Santamaria, F., Oppenheim, J.J., Lubkowski, J., Lu, W., 2003. Engineering disulfide bridges to dissect antimicro- bial and chemotactic activities of human beta-defensin 3. Proc. Natl. Acad. Sci. U.S.A. 100, 8880.

Xiong, Y.Q., Yeaman, M.R., Bayer, A.S., 1999. In vitro antibacterial activities of platelet microbicidal protein and neutrophil defensin against Staphylococcus aureus are influenced by antibiotics differing in mechanism of action. Antimicrob. Agents Chemother. 43, 1111.

Yacoby, I., Benhar, I., 2007. Targeted anti bacterial therapy. Infect. Disord. Drug

Targets 7, 221.

Yahata, Y., Shirakata, Y., Tokumaru, S., Yang, L., Dai, X., Tohyama, M., Tsuda, T., Sayama, K., Iwai, M., Horiuchi, M., Hashimoto, K., 2006. A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)- like growth factor-mediated EGF receptor transactivation. J. Biol. Chem. 281,

13209.

Yamasaki, K., Di Nardo, A., Bardan, A., Murakami, M., Ohtake, T., Coda, A., Dorschner, R.A., Bonnart, C., Descargues, P., Hovnanian, A., Morhenn, V.B., Gallo, R.L., 2007. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat. Med. 13, 975.

Yang, D., Chertov, O., Bykovskaia, S.N., Chen, Q., Buffo, M.J., Shogan, J., Anderson, M., Schroder, J.M., Wang, J.M., Howard, O.M., Oppenheim, J.J., 1999. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science

286, 525.

Yang, L., Weiss, T.M., Lehrer, R.I., Huang, H.W., 2000. Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys. J. 79, 2002.

Yang, D., Biragyn, A., Kwak, L.W., Oppenheim, J.J., 2002. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol. 23, 291.

Yang, D., Biragyn, A., Hoover, D.M., Lubkowski, J., Oppenheim, J.J., 2004. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu. Rev. Immunol. 22, 181.

Yang, D., Liu, Z.H., Tewary, P., Chen, Q., de la Rosa, G., Oppenheim, J.J., 2007. Defensin participation in innate and adaptive immunity. Curr. Pharm. Des. 13, 3131. Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy,

E., Loo, Y.M., Gale Jr., M., Akira, S., Yonehara, S., Kato, A., Fujita, T., 2005. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175, 2851.

Yu, J., Mookherjee, N., Wee, K., Bowdish, D.M., Pistolic, J., Li, Y., Rehaume, L., Hancock, R.E., 2007. Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways. J. Immunol. 179,

7684.

Zanetti, M., 2004. Cathelicidins, multifunctional peptides of the innate immunity. J.

Leukoc. Biol. 75, 39.

Zasloff, M., 2002. Antimicrobial peptides of multicellular organisms. Nature 415,

389.

Zhang, L., Falla, T.J., 2009. Host defense peptides for use as potential therapeutics.

Curr. Opin. Invest. Drugs 10, 164.

Zhao, C., Wang, I., Lehrer, R.I., 1996. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. Febs Lett. 396, 319.

Zheng, Y., Niyonsaba, F., Ushio, H., Nagaoka, I., Ikeda, S., Okumura, K., Ogawa, H.,

2007. Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br. J. Dermatol. 157, 1124. Zhou, L., Huang, L.Q., Beuerman, R.W., Grigg, M.E., Li, S.F., Chew, F.T., Ang, L., Stern, M.E., Tan, D., 2004a. Proteomic analysis of human tears: defensin expression

after ocular surface surgery. J. Proteome Res. 3, 410.

Zhou, C.X., Zhang, Y.L., Xiao, L., Zheng, M., Leung, K.M., Chan, M.Y., Lo, P.S., Tsang, L.L., Wong, H.Y., Ho, L.S., Chung, Y.W., Chan, H.C., 2004b. An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Nat. Cell. Biol.

6, 458.

Zou, J., Chang, M., Nie, P., Secombes, C.J., 2009. Origin and evolution of the RIG-I like

RNA helicase gene family. BMC Evol. Biol. 9, 85.


Просим давать следующую ссылку на данную статью в прессе: Steinstraesser, L., et al., Host defense peptides and their antimicrobial-immunomodulatory duality. Immunobiology (2010), doi:10.1016/j.imbio.2010.07.003


1   2   3   4

Похожие:

Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconДипломы по экономике и менеджменту
Разработан отделом по управлению качеством и стандартизации ОАО «xxx» (отдел XXX)
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconДипломы по экономике и менеджменту
Разработан отделом по управлению качеством и стандартизации (отдел XXX) ОАО «xxx»
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconПрограмма XXX научной конференции судентов, магистрантов, аспирантов и учащихся лицейных классов
Порядок работы секций XXX научной конференции студентов, магистрантов, аспирантов и учащихся лицейных классов (24 апреля 2003 г)
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconНазвание научного
Тезисы докладов XXX совещания по ядерной спектроскопии и структуре атомного ядра. Ленинград, 1980, с. 209
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» icon152: 481-xxx. Abughrien, B. M., Dore, M. A. 2000. Ciliogenesis in the uterine tube of control and superovulated heifers. Cells, Tissues Organs 166

Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconФестиваль завершится 4 июня 2011 года
Тамбовской области открылся юбилейный XXX междуна­родный музыкальный фестиваль им. С. В. Рахманинова
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconАкты Виленской археографической комиссии
Акты Виленской археографической комиссии: Том XXX акты Трокского подкоморского суда за 1585-1613 годы / М.: Книга по Требованию,...
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconОтчет по результатам диагностики системы управления персоналом ОАО " XXX "
Охватывает не только формы материального стимулирования, но и вообще любые отношения администрации и трудового коллектива. Поэтому...
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» iconРешение от 23 апреля 2009 г. N xxvi/xxix-593
Совета в ред. Решений от 18. 04. 2001 n xxiv/X-187, от 02. 10. 2001 n xxiv/xiii-257, от 11. 09. 2002 n xxiv/xxviii-366, от 17. 12....
Статья в прессе иммунология XXX (2010) XXX-XXX Содержание можно просмотреть на «Сайенс Директ» icon1 апреля- день смеха. Начало 4 четверти
График мероприятий на каникулах можно просмотреть в разделе "воспитательная работа"
Разместите кнопку на своём сайте:
Библиотека


База данных защищена авторским правом ©lib.znate.ru 2014
обратиться к администрации
Библиотека
Главная страница