1956 1960 Maple Heights High School, Maple Heights, Ohio




Название1956 1960 Maple Heights High School, Maple Heights, Ohio
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CURRICULUM VITAE

PERSONAL DATA


Name: Paul F. Hollenberg


EDUCATION


1956 - 1960 Maple Heights High School, Maple Heights, Ohio

1960 - 1964 Wittenberg University, Springfield, Ohio; B.S. in Chemistry

1964 - 1966 University of Michigan, Ann Arbor, Michigan; M.S. (Biological Chemistry; mentor: Minor J. Coon)

1966 - 1969 University of Michigan, Ann Arbor, Michigan; Ph.D. (Biological Chemistry; mentor: Minor J. Coon)


POSTDOCTORAL TRAINING


1969 Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan (Laboratory of Dr. Minor J.Coon)

1969 - 1972 Department of Biochemistry, University of Illinois, Champaign-Urbana, Illinois (Laboratory of Dr. Lowell P. Hager)


ACADEMIC APPOINTMENTS


1972 - 1979 Assistant Professor of Biochemistry, Northwestern University Medical and Dental Schools

1979 - 1981 Assistant Professor of Pathology and Pharmacology (with tenure), Northwestern University Medical and Dental Schools

1981 - 1982 Associate Professor of Pathology and Pharmacology, Northwestern University Medical and Dental Schools

1982 - 1984 Associate Professor of Pathology and Molecular Biology, Northwestern University Medical and Dental Schools

1984 - 1987 Professor of Pathology and Molecular Biology, Northwestern University Medical and Dental Schools

1987 - 1994 Professor and Chairman of Pharmacology, Wayne State University School of Medicine

1990 - 1991 Interim Director, Center for Molecular Biology

1994 - Maurice Seevers Collegiate Professor and Chairman of Pharmacology, University of Michigan Medical School

1997 - 1999 Co-program Director of Cancer Pharmacology, University of Michigan Comprehensive Cancer Center


CONSULTING POSITIONS


1998 - 2001 Pharmaco Genesis, Ann Arbor, MI

1999 - 2002 DuPont Pharmaceuticals Company

2002 - Originus, Ann Arbor, MI

2003 - 2007 Pfizer Global Research and Development, Ann Arbor, MI

2004 - 2008 Vitae Pharmaceuticals

2009 - 2010 Agave Biosystems

2010 - Elan Pharmaceuticals

2010 - Cayman Chemical


SCIENTIFIC ACTIVITIES


1987 Co-founder of Chemical Research in Toxicology

1987 - 2004 Associate Editor of Chemical Research in Toxicology

2004 - Review Editor of Chemical Research in Toxicology

1998 - 2005 Field Editor for the Journal of Pharmacology and Experimental Therapeutics


Editorial Boards


1986 - 1991 Journal of Toxicology and Environmental Health

1989 - 2000 Fundamental and Applied Toxicology

1994 - Drug Metabolism and Disposition

2002 - 2006 British Journal of Pharmacology

2005 - Current Drug Metabolism

2008 Editor for 20th Anniversary Issue of Chemical Research in Toxicology

2010 Editor for Mechanisms of Metal Toxicity Issue of Chemical Research in Toxicology


Review articles on a regular basis for Analytical Biochemistry, Archives of Biochemistry and Biophysics, Biochemical Pharmacology, Biochemistry, Biochemistry International, Bioorganic & Medicinal Chemistry Letters, Cancer Research, Carcinogenesis, Cell Biology and Toxicology, Chemical Research in Toxicology, Chemico-Biological Interactions, Environmental Health Perspectives, Free Radical Biology and Medicine, Fundamental and Applied Toxicology, Journal of Biological Chemistry, Journal of Pharmacology and Experimental Therapeutics, Journal of Toxicology and Environmental Health, Molecular Pharmacology, Pharmacogenetics, Proceedings of the National Academy of Sciences of the United States of America, Trends in Pharmacological Sciences (TIPS), Toxicology and Applied Pharmacology, and Xenobiotica.


Study Sections


1984 NIH, Ad Hoc Member, Toxicology

1984 NIH Special Study Section, member

1986 NIH Special Study Section, member

1987 NIH Special Study Section, Chairman

1987 - 1991 NIH, Chemical Pathology Study Section, member

1991-present NIH Reviewers Reserve, member

1992 NIH Special Study Section, Chairman

1993 NIH Special Study Section, member

1995 NIH Special Study Section, member

1996 NIH Special Study Section, member

1999 NIH Special Study Section, member (3 times)

2002 CSR DIG IRG Study Section Boundary Team

2008 NIH Special Emphasis Panel (SEP) on Drug/Drug Interactions, Chair


OTHER PROFESSIONAL SERVICE ACTIVITIES


1977 - 1988 Ad hoc reviewer, Research Corporation

1980 - 1987 Ad hoc reviewer, American Cancer Society

1977, 1982, 1990, 1996 Special reviewer, National Science Foundation

1982 - 1985 Medical Advisory Board, Leukemia Research Foundation

1985 - 1987 Reviewer, Chicago Heart Association

1987, 1988, 1992 Reviewer, Outstanding Investigator Grant (NCI)

1988 Reviewer, American Chemical Society Petroleum Research Fund

1988 Reviewer, March of Dimes

1996 Grant Reviewer, The Wellcome Trust

1996 Reviewer, South Carolina Experimental Program to Stimulate Competitive Research (EPSCoR)

1998 Reviewer, United States-Israel Binational Science Foundation

1998 Consultant, Wayne State University Toxicology Center

1998 Consultant, Dept. of Pharmacology, Univ. of Pittsburgh Med. Sch.

1999 Reviewer of the Department of Pharmacology, Northwestern University

1999 External Reviewer, Dept. of Pharmacology, Univ. of Kansas Med. Sch.

1999 External Reviewer, Dept. of Pharmacology, Univ. of Toronto Med. Sch.

  1. External Reviewer, Dept. of Pharmacology, Univ. of Florida Coll. of Med.

2000, 2001 Consultant, Dept. of Pharmacology, Univ. of Louisville Medical School

  1. External Reviewer, Dept. of Pharmacology, Michigan State University

2004 External Reviewer, Dept. of Pharmacology, UMDNJ-Robert Wood

Johnson Medical School

2005 External Reviewer, Department of Pharmacology and Toxicology, University of Arizona


GRANT SUPPORT

Previous Grant Support


National Institutes of Health "Hemeprotein-catalyzed oxygenations of carcinogens"; 1974-1976 ($84,142)


Chicago and Illinois Heart Association "Mechanisms of hemeprotein-catalyzed oxygenations"; 1974-1976 ($21,918)


The Schweppe Foundation "Chemical carcinogenesis: Metabolic activation and detoxification of chemical carcinogens"; 1974-1977 ($30,000)


American Cancer Society, Illinois Division, Inc. "Role of aflatoxin receptor molecule in aflatoxin-induced carcinogenesis"; 1978-1979 ($21,162)

National Institutes of Health "Hemeprotein-catalyzed oxygenations of carcinogens"; 1978-1981 ($131,826)


NSF Biological Instrumentation Program "Purchase of EPR/ENDOR spectrometer system"; 1982-1983 ($179,825); co-investigator


National Institutes of Health "Hemeprotein-catalyzed oxygenations of carcinogens"; 1981-1984 ($158,191)


National Institutes of Health "Metabolism of pancreatic carcinogens"; 1981-1984 ($169,551); co-investigator


National Institutes of Health "Biologic mechanisms of renal cystic disease"; 1983-1986 ($325,554); co-investigator


National Institutes of Health "Biologic studies with liver peroxisome proliferators"; 1982-1987 ($588,521); co-investigator


National Institutes of Health "Metabolism of pancreatic carcinogens: Species differences"; 1986-1991 ($476,149); relinquished upon moving to Wayne State University; co-investigator


National Institutes of Health "Carcinogenesis Training Program"; 1986-1991 ($700,410); relinquished upon moving to Wayne State University; co-program director


National Institutes of Health "Hemeprotein-catalyzed oxygenations of carcinogens"; 1984-1988 ($296,176)


National Cancer Institute (R01-CA16954) "Hemeprotein-catalyzed oxygenations of carcinogens"; 03/01/88-02/28/93 (approximately $110,000 direct cost annually); MERIT AWARD


National Institutes of Health (T32 GM 08144) Pharmacological Sciences Training Grant. 07/01/87-06/30/92 (approximately $52,000 direct cost annually), Principal Investigator


National Cancer Institute (R01-CA16954-21) "Hemeprotein-catalyzed oxygenations of carcinogens"; 03/01/93-02/28/96 (approximately $135,000 direct cost annually); MERIT AWARD extension


National Institutes of Health "Interdepartmental Training in Pharmacological Sciences"; 07/01/93-06/30/98 (approximately $365,000 direct cost annually), Co-Director


National Cancer Institute (R01-CA16954-24S1) “Minority Supplement to hemeprotein-catalyzed oxygenations of carcinogens”; 09/01/98-08/31/00 (approximately $26,000 direct costs annually)


National Cancer Institute (R01-CA16954-24) “Hemeprotein-catalyzed oxygenations of carcinogens”; 04/01/96-03/31/01 (approximately $333,000 total costs annually)


National Institutes of Health (T32 GM07767-21) “Interdepartmental Training in Pharmacological Sciences”, 07/01/98-06/30/01 ($1,578,938 direct costs), Principal Investigator


National Institutes of Health (T32 GM07767-24) "Interdepartmental Training in Pharmacological Sciences", 07/01/01-06/30/06 ($647,000 direct costs first year), Principal Investigator


National Cancer Institute (R01-CA16954-31) “Hemeprotein-catalyzed oxygenations of carcinogens”, 04/01/01-08/31/07 (approximately $380,000 total costs annually)


National Institutes of Health (T32 GM07767-33) “Interdepartmental Training in Pharmacological Sciences,” 07/01/06-06/30/11 ($843,374 direct costs first year), Principal Investigator.


Current


National Cancer Institute (R01-CA16954-32) “Hemeprotein-catalyzed oxygenations of carcinogens”; 09/01/07-07/31/12 (approximately $410,000 total costs annually)


National Institutes of Health (T32 F001436) "Training Grant in the Urological Sciences, 07/01/04-06/30/09, training faculty.


Pending


National Institutes of Health (T32 GM07767-34) “Interdepartmental Training in Pharmacological Sciences,” 07/01/12-06/30/17 ($843,374 direct costs first year), Co-Principal Investigator.


RESEARCH INTERESTS


Structure and function of hemeproteins

Mechanisms of hemeprotein-catalyzed oxygenation reactions

Role of microsomal mixed function oxidases in drug toxicity and chemical carcinogenesis

Mechanisms of nitrosamine carcinogenesis

Relationships between structure and catalytic function of human P450s

Effects of genetic polymorphisms of human P450s on drug efficacy and toxicity in humans

Prediction of adverse drug effects and mechanisms of drug-drug interactions due to P450s


CERTIFICATION AND LICENSURE

None


MILITARY SERVICE

None


HONORS AND AWARDS


1960 - 1964 Wittenberg Honors Scholarship (Wittenberg University)

1965 - 1966 National Science Foundation Trainee (University of Michigan)

1966 - 1968 National Institutes of Health Predoctoral Fellow (University of Michigan)

1974 - 1977 Schweppe Foundation Research Fellow

1993 President’s Bonus Award for Extraordinary Service to the University (Wayne State University)

1998 Research featured on the cover of Chemical Research in Toxicology (April Issue)

2003 Research featured on the cover of the Journal of Pharmacology and Experimental Therapeutics (August Issue)

2004 Research featured on the cover of Drug Metabolism and Disposition (June Issue)

2004 Research featured on the cover of the Journal of Pharmacology and Experimental Therapeutics (December Issue)

2007 Distinguished Graduate Lecture, Department of Biochemistry, University of Michigan, Ann Arbor, MI

2010 Elected as a Fellow of the American Chemical Society

2011 League of Research Excellence, University of Michigan

2011 North American Scientific Achievement Award in Honor of Ronald Estabrook from the International Society for the Study of Xenobiotics (ISSX)

2011 Fourth Annual Theodore M. Brody Distinguished Lecturer, Michigan State University, Department of Pharmacology and Toxicology

Listed in Outstanding Young People, American Men and Women In Science, Who's Who in the Midwest, Who's Who of Emerging Leaders in America, Who's Who in American Education, Who's Who in Frontiers of Science and Technology, Who's Who in Science and Engineering,

Who's Who in Medicine and Healthcare, Who's Who in America and Who’s Who in the World


HONORARY SOCIETIES

1962 Kappa Mu Epsilon

1966 Phi Lamda Upsilon

1967 Phi Kappa Phi

1967 The Society of Sigma Xi

1973 New York Academy of Sciences


MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES


American Association for the Advancement of Science

American Association for Cancer Research

American Chemical Society

American Society for Biochemistry and Molecular Biology

American Society for Pharmacology and Experimental Therapeutics

1991 - 1997 Member of Finance Committee

1996 - 1997 Secretary-Treasurer elect

1997 - 1998 Secretary-Treasurer

2001 - 2002 President-Elect

2002 - 2003 President

2003 - 2004 Past President

2003 - 2006 Chair, Long Range Planning Committee

2005 - ASPET Representative to the Experimental Biology Board

Association for Medical School Pharmacology

1993 - 1995 Councilor

1997 - 1999 Councilor

Biophysical Society

British Pharmacological Society

International Society for the Study of Xenobiotics

The Oxygen Society

Society of Toxicology


TEACHING ACTIVITIES


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