Visiting Associate Professor, Ohio State University, joint appointment with the Mathematical Biosciences Institute & OSU Medical Center
Senior Research Scientist & Group Leader, Bioinformatics Institute (Biopolis), SingaporeAssociate Professor, Dept Genetics & Genomics, Boston Univ Sch Medicine (secondary appointments in: Biomedical Engineering Dept, and Bioinformatics & Systems Biology Program, Boston Univ)Associate Professor (tenured 1998), Laurentian University, Chem & Biochem Dept., 1997-2002; Assistant Professor, Laurentian University, Chem & Biochem Dept., 1994-1997.Term appointments: Assistant Professor at Lakehead Univ Chem Dept (1991-2), Univ Waterloo Chem Dept (1992-4; adjunct until 1998)
Memberships in Academic Institutes / CentersMember, Center for BioDynamics, Boston University, 2002-5Visiting Associate, California Institute of Technology, Oct00-Jun01 (Sabbatical)Visiting Scientist, Weizmann Institute of Science, Israel, Aug-Sep 2000 (Sabbatical)
Chemistry (Chemical Physics Program), Univ. of Alberta (Canada), 1986; Supervisor: Bruce L. ClarkeAgricultural Chemistry, Univ. of the Philippines, 1978 (Cum Laude).
York University, Chemistry Department (with H.O. Pritchard), 1990-91; Indiana Univ.-Purdue Univ. at Indianapolis (with R. Larter), 1988-90; University of Manitoba, Botany Department (with R. Gordon), 1986-87
HONORS & SERVICE
Program Committee Member, 25th International Symposium on Computer and Information Sciences (ISCIS2010), Sept 22-24, 2010, The Royal Society, London, U.K. (http://san.ee.ic.ac.uk/iscis2010/ )
Invited workshop leader and speaker, Mathematical Perspective on Cancer Immunology, University of Utah, May 5-7, 2008.
Member, Editorial Board, Philippine Science Letters ( http://www.philsciletters.org/)
Member, Advisory Committee, 10th International Conference in Molecular Systems Biology (ICMSB2008), Philippines, 25-28 Feb 2008. (Also, tutorial lecturer on ‘Extracting network models from pathways databases’)
Member, Program Committee, 6th International Conference in Bioinformatics (InCoB), Hong Kong- Hanoi -Nansha, 27-30 Aug 2007.
Tutorial lecturer at the ISMB2006 (Fortaleza, Brazil) on the topic ‘From Pathways Databases to Network Models’ (with A. Goryachev), 6 August 2006
Member, Proposal Review Panel for Molecular and Cellular Biosciences, National Science Foundation, USA (appointed for 3 years, from October 2004)
Invited to present a tutorial lecture on cell cycle modeling, Annual American Physical Society Meeting, Montreal, Canada, 21 March 2004.
Co-chair (with Jessie Au) of the workshop on Cell Growth, Proliferation and Death at the Mathematical Biosciences Institute (MBI), Ohio State University, 29 Sept- 3 Oct 2003, Columbus, OH, USA.
Co-chair (with C.D. Thron) of the session on ‘Nonlinear dynamics and the cell cycle' at the 3rd World Congress of Nonlinear Analysts in Catania, Italy, 19-26 July 2000.
Chairman of the session on 'Computational Dynamics in Natural and Artificial Systems' at the Second World Congress of Nonlinear Analysts in Athens, Greece, 10-17 July 1996.
Refereed for the following scientific journals:
Proc. Natl. Acad. Sci. USA Bioinformatics Journal of Theoretical Biology
Physical Biology Biophysical Journal J. Cell Science
Biophysical Chemistry J. Am. Chem. Soc. Journal of Physical Chemistry
Biophysical Chemistry Physical Review Letters Physical Review E
Chaos BMC Bioinformatics Bulletin of Mathematical Biology
Biomolecular Engineering BMC Systems Biology FEBS Letters
Mathematical Medicine and Biology PLoS ONE PLoS Computational Biology
Trends in Cell Biology
Reviewer of research grant proposals submitted to: National Science Foundation (USA), Natural Sciences & Engineering Research Council (Canada), Canadian Institutes of Health Research (CIHR), Wellcome Trust (UK), Italian Association for Cancer Research (AIRC), Ontario Research Fund (Canada)
1. B. D. Aguda & Avner Friedman, Models of Cellular Regulation, Oxford University Press (August 2008).
2. B.D. Aguda, G. Craciun, R. Cetin-Atalay, “Data Sources and Computational Approaches for Generating Models of Gene RegulatoryNetworks,” in Reviews in Computational Chemistry, Volume 21, p.381-411. (edited by Kenny B. Lipkowitz, Raima Larter, and Thomas R. Cundari) Wiley-VCH, John Wiley & Sons, Inc. (2005).
3. B. D. Aguda and H. M. Sauro, Computer Simulation of MAPK Signal Transduction, pp. 167-175 in Methods in Molecular Biology, vol 250: Protocols in MAPK Signaling (R. Seger, Ed.), Humana Press (2004).
4. B.D. Aguda, “Modeling the Cell Division Cycle,” in Lectures Notes in Mathematics, Vol. 1872 : Tutorials in Mathematical Biosciences III: Cell Cycle, Proliferation, and Cancer (Editor: A. Friedman, Ed.), Springer-Verlag GmbH, pp. 1-22 (2005).
5. B. D. Aguda, W. K. Yio, and F. Ng, “Control nodes linking the regulatory networks of the cell cycle and apoptosis,” Apoptosis, Cell Signaling and Human Diseases: Molecular Mechanisms, Volume 1 (R. Srivastava, Ed.) Humana Press, Inc. (2006).
6. B. D. Aguda, “Excitement and Opportunities in Systems Biology,” Selected Essays on Science and Technology for Securing a better Philippines,” Volume 1, Univ. of the Philippines Press, (2008).
7. B.D. Aguda & B.L. Clarke, "Bistability in Chemical Reaction Networks : Theory and Application to the Peroxidase-Oxidase Reaction", Journal of Chemical Physics 87 : 3461-3470 (1987).
8. R. Larter, C. Bush, T. Lonis & B.D. Aguda, "Multiple Steady States, Complex Oscillations and the Devil's Staircase in the Peroxidase-Oxidase Reaction", Journal of Chemical Physics 87 : 5765-5771 (1987).
9. R. Gordon & B.D. Aguda, “Diatom morphogenesis: natural fractal fabrication of a complex microstructure”. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Part 1/4: Cardiology and Imaging, New York: Institute of Electrical and Electronics Engineers 10: 273-274 (1988).
10. R. Larter, C. Steinmetz & B.D. Aguda, "Fast-Slow Variable Analysis of the Transition to Mixed-Mode Oscillations and Chaos in the Peroxidase Reaction", Journal of Chemical Physics 89 : 6506-6514 (1988).
11. B.D. Aguda & B.L. Clarke, "Dynamic Elements of Chaos in the Willamowski-Rossler Network", Journal of Chemical Physics 89 : 7428-7434 (1988).
12. B.D. Aguda, R. Larter & B.L. Clarke, "Dynamic Elements of Mixed-Mode Oscillations and Chaos in a Peroxidase-Oxidase Model Network", Journal of Chemical Physics 90 : 4168-4175 (1989).
13. B.D. Aguda & R. Larter, "A Bistable and Oscillatory Mechanism for the Peroxidase -Oxidase Reaction", React. Kinet. Catal. Lett. 42 : 339-342 (1990).
14. B.D. Aguda & R. Larter, "Sustained Oscillations and Bistability in a Detailed Mechanism of the Peroxidase-Oxidase Reaction", Journal of the American Chemical Society 112 : 2167-2174 (1990).
15. B.D. Aguda, L-L. Hofmann-Frisch & L.F. Olsen, "Experimental Evidence for the Coexistence of Oscillatory and Steady States in the Peroxidase-Oxidase Reaction", Journal of the American Chemical Society 112 : 6652-6656 (1990).
16. B.D. Aguda & R. Larter, "Periodic-chaotic Sequences in a Detailed Mechanism of the Peroxidase-Oxidase Reaction", Journal of the American Chemical Society 113 : 7913-7916 (1991).
17. B.D. Aguda & H.O. Pritchard, "Reversible and Irreversible Formulations of Unimolecular Reactions", Journal of Chemical Physics 96 : 5908-5914 (1992).
18. P.Q.E. Clothier, B.D. Aguda, A. Moise & H.O. Pritchard, "How do Diesel-Ignition Improvers Work?", Chemical Society Reviews 22 : 101-108 (1993).
19. J. Logan, J. Treurniet, A.D.O. Bawagan, S. Rizzetto, J.M. Braun & B.D. Aguda, "A Simple Apparatus for the Study of Experimental Fractal Structures in Gaseous Dielectric Breakdown", Canadian Journal of Chemistry 71 : 2079-2083 (1993).
20. B.D. Aguda, "Differential Flow-Induced Chemical Instability in a Model Enzyme Mechanism", Journal of Chemical Physics 99 : 5091-5096 (1993).
21. C. Steinmetz, R. Larter & B.D. Aguda, "Modeling a Biochemical Oscillator", Proc. Indiana Acad. Sci., 98 : 157-168 (1994).
22. S.N. Krylov, B.D. Aguda & M.L. Ljubimova, "Bistability and Reaction Thresholds in the Phenol-inhibited Peroxidase-catalyzed oxidation of Indole-3-acetic Acid", Biophysical Chemistry 53 : 213-218 (1995).
23. M.T.M. Koper and B.D. Aguda, "Experimental Demonstration of Delay and Memory Effects in the Bifurcations of Nickel Electrodissolution", Physical Review E 54 : 960-963 (1996).
24. B.D. Aguda, "Emergent Properties of Coupled Enzyme Reaction Systems. 1. Switching and Clustering Behaviour", Biophysical Chemistry 61 : 1-7 (1996).
25. B.D. Aguda, "Instabilities in Phosphorylation-Dephosphorylation Cascades and Cell cycle Checkpoints", Oncogene 18 : 2846-2851 (1999).
26. B.D. Aguda & Y. Tang, "The kinetic origins of the restriction point in the mammalian cell cycle", Cell Proliferation 32: 321-335 (1999).
27. B.D. Aguda, "A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system", Proc. Natl. Acad. Sci. USA 96 : 11352-11357 (1999).
28. B.D. Aguda, "Kick-starting the cell cycle: From growth-factor stimulation to initiation of DNA replication", Chaos 11: 269-276 (2001).
29. B.D. Aguda & C.K. Algar, “Structural analysis of the qualitative networks regulating the cell cycle and apoptosis”, Cell Cycle 2: 538-544 (2003).
30. G. Craciun, B.D. Aguda & A. Friedman, “A detailed mathematical analysis of a modular network coordinating the cell cycle and apoptosis,” Mathematical Biosciences and Engineering 2: 473-485 (2005).
31. K. B. Wee & B.D. Aguda, “Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death,” Biophys J. 91: 857-865 (2006).
32. Y. Wang, B.D. Aguda & A. Friedman, “A continuum mathematical model of endothelial layer maintenance and senescence,” Theoretical Biology and Medical Modelling, 4: 30 (10 August 2007).
33. B.D. Aguda & A. B. Goryachev (2007). “From Pathways Databases to Network Models of Switching Behavior,” PLoS Computational Biology, 3(9): e152
34. M. G. Hunter, N. Ismail, X. Zhang, B. D. Aguda, E. J. Lee, L. Yu, T. Xiao, J. Schafer, M.-L. T. Lee, T. Schmittgen, P. Nana-Sinkam, D. Jarjoura, C. B. Marsh (2008) “Detection of microRNA expression in human peripheral blood microvesicles” PLoS ONE 3(11):e3694. doi:10.1371/journal.pone.0003694
35. B.D. Aguda, Y. Kim, M. Piper-Hunter, A. Friedman & C. Marsh (2008), “MicroRNA regulation of a cancer network: Consequences of the feedback loops involving miR-17-92, E2F and Myc”, Proc Natl Acad Sci USA 105: 19678-19683 (published online before print December 9, 2008, doi:10.1073/pnas.0811166106.)
36. K. B. Wee, U. Surana & B.D. Aguda (2009) “Oscillations of the p53-Akt Network: Implications on Cell survival and death”. PLoS ONE 4(2): e4407.
37. V. A. Trabosh, K. A. Divito, B. Aguda, C. M. Simbulan-Rosenthal, D. S. Rosenthal (2009)“Sequestration of E12/E47 and suppression of p27KIP1 plays a role in Id2-induced
proliferation and tumorigenesis”, Carcinogenesis 30: 1252-1259.
38. Nam J, Aguda BD, Rath B, Agarwal S (2009) Biomechanical Thresholds Regulate Inflammation through the NF-B Pathway: Experiments and Modeling. PLoS ONE 4(4): e5262. doi:10.1371/journal.pone.0005262
39. R Visone, LZ Rassenti, A Veronese, C Taccioli, S Costinean, BD Aguda, S Volinia, Palatini, V Balatti, H Alder, TJ Kipps, CM Croce (2009) “Karyotype specific microRNA signature in Chronic Lymphocytic Leukemia”, Blood. 114: 3872-3879.
40. TS Elton, MM Martin, SE Sansom, BD Aguda, Down Syndrome and Human Chromosome 21-Derived microRNAs, Critical Reviews in Biochemicstry & Molecular Biology, submitted (2009).
INVITED TALKS, OTHER NON-REFEREED CONTRIBUTIONS (from 2000 only)
Neuro-Oncology Branch, National Cancer Institute/National Institutes of Health; Bethesda, Maryland, USA. 25 January 2010. “microRNA regulation of a cancer network” (invited talk)
Symposium of Bioinformatics & Systems Biology in Taiwan, 8-9 Oct 2009 (National Yang-Ming Univ, Taipei). “Combinatorial microRNA regulation of a cancer network” (invited talk)
Singapore Immunology Network (SigN), Biopolis, Singapore, 26 June 2009. “Biomechanical thresholds regulate inflammation through the NF-B pathway: Experiments and Modeling” (invited talk)
Inst Molecular & Cellular Biology (IMCB), Biopolis, Singapore, 29 June 2009. “MicroRNA regulation of the restriction point” (invited talk)
University of the Philippines, Diliman, Quezon City, 1-10 July 2000. “Cellular Regulatory Networks: molecular mechanisms, dynamics & control” (invited seminar series, 5 talks)
PAASE Annual Meeting, Ateneo de Manila Univ, 13 Jul 2009. “MicroRNAs as disease biomarkers” (invited talk).
Math Institutes Modern Mathematics Workshop, Salt Lake City, Utah, 8 Oct 2008. “Molecular interactions within the cell: Network, Scale, and Complexity” (invited talk)
Annual Meeting, Society for Mathematical Biology, July 30, 2008, Toronto, Canada. “Theoretical prediction of a microRNA-regulated ‘oncogenic zone’ between normal cell cycle and apoptosis”. (invited talk)
PAASE Annual Meeting, Washington, D.C., 23 May 2008. “MicroRNA regulation of the entry into the cell cycle, apoptosis, and oncogenesis” (invited talk).
University of Utah, May 5 & 7, 2008, USA. “The cancer immunoediting hypothesis: from biological hypotheses to qualitative network models”. (2 invited talks)
Amazing Biomolecular Computations, 8th Philippine Computing Science Congress, Manila, 24 Feb 2008 (invited talk)
Extracting Models from Networks and Pathways Databases. Tutorial talk at the International Conference in Molecular Systems Biology, Manila, 25 Feb 2008 (invited tutorial talk).
Analysis of Cancer Gene Networks in Cell Proliferation and Death, International Symposium on Information & Communications Technology for Health, Manila, 1 Mar 2008. (invited talk)
Ohio Collaborative Conference on Bioinformatics (OCCB), 9-11 July 2007, Oxford, Ohio, USA. “Mathematical modeling of PKCδ-mediated activation of caspase-3 during cell death”. Authors: J. Doolittle, B. Aguda & A. Doseff (contributed poster)
Boston University, Biomolecular Seminar Series, USA, 7 May 2007. “Modeling the Cell Cycle, Survival, and Death Regulatory Networks” (invited talk)
SomaLogic, Inc., Boulder, Colorado, USA, 2 May 2007. “Towards predicting protein signatures” (invited talk)
Ohio State University, Biomedical Engineering Dept, USA, 19 April 2007. “Modeling the Cell Cycle, Survival, and Death Regulatory Networks” (invited talk)
Stowers Institute for Medical Research, Kansas City, Missouri, USA, 13 March 2007. “Modeling Cancer Networks” (invited talk)
Center for Nonlinear Studies, Los Alamos National Lab, New Mexico, USA, 13 December 2006. “Oncogene and Tumor Suppressor Gene Networks” (invited talk)
Center for Integrative Cancer Biology, Ohio State Univ, 3 November 2006. “Oncogene and Tumor Suppressor Gene Networks” (invited talk)
Center for Integrative Cancer Biology, Ohio State Univ, 20 October 2006. “Using Pathways Databases to Extract Biological Network Models” (invited talk)
Dept Mathematical Sciences, Indiana Univ-Purdue Univ at Indianapolis, 6 October 2006. “Oncogene and Tumor Suppressor Gene Networks” (invited talk)
Joint SIAM-SMB Conference on the Life Sciences, Raleigh, North Carolina, USA, 2 August 2006. (co-author: K.B. Wee) “Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death,” (invited talk)
Mathematical Biosciences Institute, Ohio State Univ, May-December 2006. Journal Club talks on models of cell-fate regulation (18 talks total)
MITACS workshop on ‘Growth and Control of Tumours,” Banff, Alberta, Canada, 16-19 October 2005. “Analysis of Oncogene and Tumor Suppressor Gene Networks” (invited talk)
Dept Molecular Biology & Genetics, Bilkent University, Ankara, Turkey, 10 October 2005. “Analysis of Oncogene and Tumor Suppressor Gene Networks” (invited seminar)
3rd International Conference on Pathways, Networks, and Systems: Theory and Experiments, Rhodes, Greece, 2-7 October 2005. “Coupling between Oncogene and Tumor Suppressor Gene Networks: The case of Akt versus p53” (invited platform talk)
The Babraham Institute, University of Cambridge, UK, 13 December 2004. “Network instability, cell cycle checkpoints, and cancer” (invited talk)
Virginia Bioinformatics Institute, Blacksburg, Virginia, 28 Sept 2004. “Network instability, cell cycle checkpoints, and cancer” (invited talk)
Institute for Systems Biology, Seattle, Washington, 16 July 2004. “Network instability, cell cycle checkpoints, and cancer” (invited talk)
2004 SIAM conference on the Life Sciences, Portland, Oregon, 14 July 2004. “Control modules for cellular division, apoptosis, and differentiation” (contributed talk)
Dept of Mathematics, University of the Philippines, Quezon City, Metro Manila, Philippines, May 2004. “Network stability analysis, the Cell Cycle, and Apoptosis,” (talk presented to faculty members)
Bioinformatics Institute, Biopolis, Singapore, 11 May 2004. “Network instability, cell cycle checkpoints, and cancer” (invited talk)
Molecular & Quantitative Genetics Seminar Series, Boston Univ School of Medicine, 13 April 2004. “Network instabilities and Cell Cycle checkpoints” (invited talk)
American Physical Society Annual Meeting, Montreal, Canada, 21 March 2004. “Mathematical modeling of the Cell Cycle,” (invited tutorial lecture)
Workshop on Cell Growth, Proliferation and Death, Mathematical Biosciences Institute, Ohio State Univ, USA, 29 Sept-Oct 3, 2003. “The links and controls between the initiation of the Cell Cycle and Apoptosis” (invited talk)
Summer Course on Modeling Biological Systems, Dept Biology, Theoretical Biophysics, Humboldt University, Berlin, Germany, July 10-11, 2003. “Modeling the Cell Cycle and Apoptosis” (a series of 3 invited lectures)
Chem Dept, York University, Canada, 24 October 2002. "Chemical Kinetic Instabilities and the Control of the Biological Cell Division Cycle” (invited talk)
IBM T.J. Watson Research Center, Yorktown, NY, USA, 5 June 2002. "Cell cycle phase transitions, network instabilities and cell cycle checkpoints” (invited talk)
GlaxoSmithKline, Pennsylvania, USA, 21 May 2002. "Cell cycle phase transitions, network instabilities and cell cycle checkpoints” (invited talk)
Cell Cycle Meeting, Cold Spring Harbor Lab, USA, 15-19 May 2002. "Switching between the cell cycle and apoptosis”, (contributed poster)
Dept of Genetics & Genomics, Boston Univ School of Medicine, Boston, USA, 1 May 2002. "Network stability analysis and cell cycle checkpoints” (invited talk)
Dept of Biology, Univ of Waterloo, Waterloo, Ontario, Canada, 25 Feb 2002. “Cell cycle checkpoint models and pathway databases " (invited talk)
Department of Biomedical Informatics, Ohio State University, USA, 31 January 2002. "Mammalian cell cycle checkpoint models and pathway databases" (invited talk)
Pacific Symposium in Biocomputing 2002, Kauai, Hawaii, USA, 3-7 January 2002. "Stability of qualitative genetic and biochemical networks” (contributed poster)
Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, MD, USA, 13 December 2001. "Kick-starting the cell cycle" (invited talk)
Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, 6 December 2001. "Genome stability and the cell cycle" (invited talk)
University of Southern California (Program in Molecular and Computational Biology), USA, 30 November 2001. "Kinetic modeling of the G1-S transition in the mammalian cell cycle" (invited talk)
Chemical Biology Seminar Series, University of Illinois at Urbana-Champaign, USA, 25 October 2001. "Kinetics of cell cycle checkpoints" (invited talk)
Cell Cycle Meeting, Salk Institute, La Jolla, California, USA, 22-26 June 2001. "Network instabilities and the G1 & G2 cell cycle checkpoints"(submitted abstract chosen for oral presentation).
Keck Graduate Institute, Claremont, California, USA, 11 December 2000. "Of network instabilities and cell cycle checkpoints" (invited talk)
Cornell University (Computational Cancer Group), Ithaca, New York, USA, 27 September 2000. "Modeling mammalian cell cycle checkpoints" (invited talk)
Dept. of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 21 August 2000. "In search of the core mechanism of the restriction point in the mammalian cell cycle" (invited talk)
3rd World Congress of Nonlinear Analysts", Catania, Sicily, Italy, 20 July 2000. "The G2 Checkpoint in the Cell Cycle" (invited talk)
Mario Negri Research Institute, Milan, Italy, 17 July 2000. "Kinetics of the G2/M Checkpoint in the Mammalian Cell Cycle" (invited talk)
EPSRC Emergent Computing Workshop on ‘Computation in Cells’, University of Hertfordshire, United Kingdom, 17-18 April 2000. “How do cells ‘decide’ to replicate their DNA?” (invited talk)
California Institute of Technology (Control & Dynamical Systems Group), Pasadena, California, USA, 23 February 2000. “Mechanisms & Control of Cell Cycle Checkpoints” (invited talk)
Centre for Nonlinear Dynamics in Physiology & Medicine, McGill University, Canada, 3 February 2000. “Instabilites in cyclic enzyme cascades & cell cycle checkpoints” (invited talk)
TEACHING: COURSES TAUGHT (Summary)
Mechanisms & Models of Cellular Regulation. A new course developed for graduate students in Biomedical Engineering and Bioinformatics at Boston University. Course website: http://people.mbi.ohio-state.edu/baguda/AgudaLab/be700/index.html
Modeling the Cell Cycle and Apoptosis”, a series of 3 invited lectures presented at the Summer Course on Modeling Biological Systems, Dept Biology, Theoretical Biophysics, Humboldt University, Berlin, Germany, July 10-11, 2003.
Self-organization in nonequilibrium chemical reaction systems. A course developed for senior undergraduate and graduate students in Chemistry. First taught at the Univ of Waterloo (1993) and then at Laurentian University (1997).
At Lakehead Univ, Univ Waterloo, & Laurentian Univ : Quantum Chemistry, Statistical Thermodynamics, Spectroscopy, Physical Chemistry, General Chemistry
TEACHING: RESEARCH SUPERVISION (Summary)
Students, Postdocs, Visiting Scientists
National Univ Singapore : 1 PhD student (graduated)
Boston Univ : Supervised 1 visiting PhD scientist, 2 PhD Bioinformatics students, 5 rotating PhD students, 2 undergraduate thesis students.
Laurentian Univ, Canada : 3 postdocs, 5 visiting scientists, 1 graduate student, 15 undergraduate students
Grant Description & Role
The Center for Physics and Engineering of Microevolution in Cancer Metastasis (U54 Physical Sciences-Oncology NCI Proposal; M. Paulaitis, PI; Carlo Croce, co-PI); $16.8M for 5 yrs; Role: co-Investigator/co-Leader of a Modeling Project.
Center for Innovation in Integrated Science and Precision Medicine (OSU internal competition; C.B. Marsh & A. Pradhan, co-PIs); Role: co-Investigator.
Biomechanical Thresholds of Inflammation Mediated by NF-kappa B (R21, NIH); Jin Nam & B.D. Aguda (co-PIs). $412,500 for 2 yrs.
Grant Description & Role
Whitaker Foundation startup grant (Boston Univ, Dept Genetics & Genomics); $200,000.
Natural Sciences & Engineering Research Council (NSERC, Canada) Individual Research Grant: The Physico-chemical kinetics of the Cell Cycle. $152,000; Role: PI.
Natural Sciences & Engineering Research Council (NSERC, Canada) Individual Research Grant: Emergent Properties of Complex Reaction Networks. $119,070; Role: PI.
Natural Sciences & Engineering Research Council (NSERC, Canada) Individual Research Grant: Emergent Network Properties of Complex Reaction Mechanisms. $69,000; Role: PI.
Natural Sciences & Engineering Research Council (NSERC, Canada) Individual Research Grant: Mechanistic Origins of Chaos. $40,000; Role: PI.
Laurentian Univ Research Fund grants: 1994- Nonlinear Dynamic of Nonequilibrium
Chemical Reactions, $4000; 1995- Clustering in Coupled Bistable Chemical Cells, $4000; 1996- Kinetics of Nickel Electrodissolution, $4000; 1997- Complex oscillations and chaos in the nickel/sulfuric acid system, $3450; 1999- Kinetics of signal transduction through the MAP kinase cascade, $3200.
1996- Northern Training Opportunities Program (NORTOP), cell cycle, $2880; 1997- Human Resources Dev Canada, nickel electrodissolution, $ 2040.