Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine)




НазваниеHerald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine)
страница8/33
Дата13.09.2012
Размер0.72 Mb.
ТипДокументы
1   ...   4   5   6   7   8   9   10   11   ...   33

1086

© V.V. Bekezin, L.V. Kozlova, O.M. Kovalenko, S.D. Leonov, G.N. Feodorov, O.V. Peresetskaya, 2009


UDC 616-056.52-053.2/.6:577.195

Bekezin V.V., Kozlova L.V., Kovalenko O.M., Leonov S.D., Feodorov G.N., Peresetskaya O.V. Features of free radical oxidation in children and adolescents with obesity and metabolic syndrome // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 2(31). – Р. 50-54.

State Educational Establishment for Higher Professional Training “Smolensk State Medical Academy”. Россия, 214019, Smolensk, Krupskaya str., 28. Tel.: 8(4812) 550275, fax: 8(4812) 520151, e-mail: uusgma@sci.smolensk.ru  

Summary: 73 children 11-17 years old were examined: 35 with exogenous-constitutional obesity, 28 – with metabolic syndrome and 10 healthy subjects. Maximal disorder of oxidative status was registered due to the data of the induced chemoluminescence in children with metabolic syndrome and was manifested in a form of high intensity of processes of free radical oxidation (FRO) on the background of the decreased general plasma antioxidant activity. The revealed significant correlation associations between FRO parameters and parameters of lipid and carbohydrate metabolism confirm the important role of disorders of oxidative status in development and progress of metabolic syndrome in children and adolescents with obesity.

Key words: obesity, metabolic syndrome, children and adolescents, free radical oxidation, chemoluminescence.

References:

1. Балаболкин М.И., Клебанова Е.М. Роль окислительного стресса в патогенезе сосудистых осложнений диабета (лекция) // Проблемы эндокринологии. - 2000. - № 6. - С. 29-34.

2. Бобырева Л.Е. Свободнорадикальное окисление, антиоксиданты и диабетические ангиопатии // Проблемы эндокринологии. - 1996. - № 6. - С. 14-20.

3. Владимиров Ю.А. Электронный парамагнитный резонанс и хемилюминесценция – прямые методы исследования свободных радикалов и реакций, в которых они участвуют // Эфферентная терапия. - 1999. - № 4. - С. 18-27.

4. Емельянов В.В., Мещанинов В.Н. Показатели перекисного окисления липидов и антиоксидантной активности крови у больных сахарным диабетом с различным темпом старения // Госпитальный вестник. - № 1. - 2005. - С. 5-9.

5. Кисляк О.А. Артериальная гипертензия в подростковом возрасте.- М., 2007.- 288 с.

6. Климов А.Н., Шляхто Е.В. Атеросклероз. Проблемы патогенеза и терапии. – СПб., 2006. - 248 с.

7. Метаболический синдром / Под ред. академика РАМН Г.Е. Ройтберга. - М., 2007. - 224 с.

8. Скибицкая Л.И. Формирование липидной структуры клеточных мембран и клинические особенности конституционально-экзогенного ожирения у детей в различных регионах Сибири: Дис. … канд. мед. наук. - Красноярск, 2000. - 125 с.

9. Солдатов О.М. Антиоксиданты в коррекции проявлений автономной кардионейропатии у детей с сахарным диабетом / Балыкова Л.А., Масягина Е.Н., Гагарина О.В., Мухина Л.Ю. // Тезисы V Всероссийского Конгресса «Детская кардиология 2008» (Москва 6-7 июня 2008 г.). - М., 2008. - С. 232-234.

10. Школа по диагностике и лечению метаболического синдрома / Под ред. Оганова Р.Г., Мамедова М.Н. - М., 2007. - 64 с.

11. Cai H., Harrison D.G. Endothelial dysfunction in cardiovascular diseases. The role of oxidant stress Res // Circ. Res. – 2001.- Vol. 22(1). - P. 36-52.

12. Lundman P., Eriksson M.J. et al. Relation of hypertrigliceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation // Am. J. Cardiol. - 2003. - Vol. 91. - P. 1128-1131.

13. Mano T., Masuyama T. еt al. Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound // Am. Heart. J. - 1996. - Vol. 131. - P. 231-238.

Information about the author:

Bekezin Vladimir Vladimirovich – Doctor of Medicine, Assistant of the State Educational Establishment for Higher Professional Training “Smolensk State Medical Academy”. Russia, 214030, Smolensk, Marina Raskova str., 4, bd. 1, apt. 56.

1   ...   4   5   6   7   8   9   10   11   ...   33

Похожие:

Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconHerald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine)
«The Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian...
Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconHerald of the Mechnikov Saint-Petersburg State Medical Academy (profilactical and clinical medicine)
«Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian Federation»,...
Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconHerald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine
«Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian Federation»,...
Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconHerald of the Mechnikov Saint-Petersburg State Medical Academy (profilactical and clinical medicine)
«Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian Federation»,...
Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconSaint Petersburg State University

Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconSaint-Petersburg State University of Culture and Arts, Russia

Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconNational Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Clinical Practice: Quality requirements

Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconKaraganda state medical university Educational and clinical (training) center

Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconRussian Academy of Sciences The Institute of Russian History, St. Petersburg branch Trade Union Federation of St. Petersburg and Region of St. Petersburg
Российская Академия Наук Институт Российской истории. Санкт-Петербургский филиал Федерация Профсоюзов Санкт-Петербурга и Ленинградской...
Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine) iconThe University emblem symbolizes various systems of medicine and Para Medical systems. It also depicts the global character of preventive, Promotive and curative medicine. The motto “health for all” Reflects all the objectives of this medical university

Разместите кнопку на своём сайте:
Библиотека


База данных защищена авторским правом ©lib.znate.ru 2014
обратиться к администрации
Библиотека
Главная страница