Herald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine)




НазваниеHerald of the mechnikov saint-petersburg state medical academy (profilactical and clinical medicine)
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© N.V. Makharova, М.I. Voevoda , А.S. Golderova, R.V. Yakovlev, М.I. Tomskiy, 2009


UDC 616.13-004.6(57156)

Makharova N.V.1, Voevoda М.I.2, Golderova. А.S.1, Yakovlev R.V.1, Tomskiy М.I.1 Analysis of inflammation markers in native and alien men of Yakutia with the proved coronary atherosclerosis // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 2(31). – Р. 85-90.

1Yakut science center Russian Academy of Medical Science, Siberian Brunc, Russia, 677019, Yakutsk, Sergelyachskoe shosse, 4, tel./fax: (411-2) 32-19-81, e-mail: ysc@sakha.ru

2Institute of Internal Medicine, Russian Academy of Medical Science, Siberian Brunch, Novosibirsk, Russia, 630118, Novosibirsk, Boris Bogatkov str., 175/1, tel.: (383) 264-25-16, fax: (383) 264-25-16, voevoda@mail.ru

Summary: Levels of inflammation markers in men of Yakutia with the verified atherosclerosis of coronary arteries are studied. It is established, that at the verified coronary atherosclerosis the increased level of inflammation markers (IL-6, СRP, fibrinogen) is observed, and in aliens IL-6 level is higher unlike natives in whom authentic increase of thrombocytes’ level has been revealed. Authentic increase of TNF–α level, leukocytes and fibrinogen in patients with Аfter Miocardial infarction cardiosclerosis, increase of TNF–α level in patients with 2 type diabetes and CRP in patients with a chronic hepatitis is revealed.

Key words: atherosclerosis of coronary arteries, inflammation markers, native and alien inhabitants of Yakutia.

References:

1. Аргунов В.А. Популяционные особенности развития атеросклероза в условиях Крайнего Севера. Результаты сравнения первого (1965-1968 гг.) и второго (1985-1988 гг.) этапов эпидемиологических исследований / В.А. Аргунов В.А., В.П. Алексеев // Материалы Всесоюз. Рабочего совещания по эпидемиологии ИБС и атеросклероза. – Таллин, 1989. – С. 23-25.

2. Баргакан З.С. Метаболически-воспалительная концепция атеротромбоза и новые подходы к терапии больных / З.С. Баргакан, Г.И. Костюченко // Бюлл. СО РАМН. – 2006. – № 2 (120) – С. 132- 138.

3. Душкин М.И. Макрофаги и атеросклероз: патофизиологические и терапевтические аспекты / М.И. Душкин // Бюллетень СО РАМН. – 2006. – № 2 (120). – С. 47-55.

4. Лутай М.И. Атеросклероз: современный взгляд на патогенез / М.И. Лутай // Укр. кардиол. журн. – 2003. – № 6. – С. 3-11.

5. Никитин Ю.П. Новые фундаментальные и прикладные основы атерогенеза / Ю.П. Никитин // Бюллетень СО РАМН. – 2006. – № 2 (120). – С. 6-14.

6. Активность воспалительно-деструктивных изменений в процессе формирования нестабильной атеросклеротической бляшки / Ю.И. Рагино [и др.] // Кардиология. – 2007. – № 9. – С. 62-66.

7. Петрова И.Р. Клинические и генетические особенности гипертонической болезни в якутской популяции / И.Р. Петрова. – Якутск, 2005. – 104 с.

Information about the authors:

Makharova Natalya Vladimirovna - candidate of medical sciences Yakut science center Russian Academy of Medical Science, Siberian Brunch, work tel.: (8-4112) 32-19-81. home tel.: (8-4112) 47-63-51, e-mail: makharova@mail.ru

Voevoda Мikhail Ivanovich - doctor of medicine, head of the Institute of Internal Medicine, Russian Academy of Medical Science, Siberian Brunch, work tel.: (8-383) 264-25-16, e-mail: voevoda@iimed.ru

Golderova Аytalina Semyonovna - candidate of medical sciences Yakut science center Russian Academy of Medical Science, Siberian Brunch, work tel.: (8-4112) 32-19-81.

Yakovlev Roman Vasilyevich - candidate of medical sciences Yakut science center Russian Academy of Medical Science, Siberian Brunch, work tel.: (8-4112) 32-19-81.

Tomskiy Mikhail Innokentyevich - doctor of medicine, head of the Yakut science center Russian Academy of Medical Science, Siberian Brunch, work tel.: (8-4112) 32-19-81. ysc@sakha.ru

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