Hong Kong University of Science and Technology




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CURRICULUM VITAE


Donald Choy Chang, Ph.D.

张东才


ADDRESS:


Department of Biology

Hong Kong University of Science and Technology

Clear Water Bay, Kowloon,

Hong Kong, China


Tel : (852) 2358 7326

Fax : (852) 2358 1559

e-mail: bochang@ust.hk


CURRENT POSITION:


Professor of Biology, Hong Kong University of Science and Technology


EDUCATIONAL BACKGROUND:


1961   1965 National Taiwan University, Taipei, Taiwan

B.S. (Physics), June, 1965


1965   1970 Rice University, Houston, Texas, USA

M.A. (Physics), June, 1967

Ph.D. (Physics), May, 1970


RECORD OF APPOINTMENT:


1991 - pres Professor, Department of Biology, Hong Kong University of Science and Technology, Hong Kong.

1987 Adjunct Associate Professor, Dept of Cell Biology, Baylor College of Medicine

1985 Associate Professor (tenured), Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA.

1983 Faculty member, Neuroscience Program, Baylor College of Medicine.

1977 Assistant Professor, Department of Physiology, Baylor College of Medicine.

1974 Assistant Professor, Department of Pediatrics (Biophysics), Baylor College of Medicine, Houston, TX, USA.

1970 Research Associate, Physics Department, Rice University, and Biophysics program, Dept of Pediatrics, Baylor College of Medicine, Houston,TX, USA


PROFESSIONAL EXPERIENCE AND ACTIVITIES:


2002 Chairman, 2002 Conference of the Hong Kong Institution of Science “Science and Technology: Driver of Economic Growth”.

2001 Chairman, 2001 Conference of the Biophysical Society of Hong Kong “From Gonome to Cell Function”.

2000 Acting Head, Biology Department, Hong Kong University of Science and Technology, Hong Kong

1999 –2003 Vice President, The Hong Kong Institution of Science

1999 Chairman and organizer, Subgroup Meeting:Mechanisms of cell division as revealed by imaging studies”. The 39th Annual Meeting of the American Society for Cell Biology, Washington, DC, USA

1995 - present President, The Biophysical Society of Hong Kong

1994 - present Member of the Steering Committee, East Asian Symposium of Biophysics

1975 - 1995 Summer Investigator, Marine Biological Laboratory, Woods Hole, Massachusetts, USA.

1996 Visiting Scientist, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA, USA

1992 Chairman of the Plenary Session on "Recent Advances in Gene Transfer Technology", The 4th International Symposium of SCBA, Singapore.

1990 Conference Chairman and organizer, International Conference on Electroporation and Electrofusion. Woods Hole, MA, USA

1990 - 1992 Consultant, Bio-rad Laboratories, Richmond, California, USA

1989 Chairman and Organizer, Subgroup Meeting: “Electroporation and Electrofusion in Cell Biology and Molecular Biology. The 29th Annual Meeting of the American Society for Cell Biology, Houston, TX, USA.

1989 Organizer and Chairman, Workshop on Cell Fusion and Cell Poration by Electric Fields: Applications to Cell Biology and Molecular Biology. The 33rd Biophysical Society Annual Meeting, Cincinnati, Ohio, USA.

1989   1991 Member of Program Advisory Committee, Biotechnology Research Institute, Hong Kong University of Science and Technology.

1988 Chairman, Session on "Neurobiology", General Scientific Meeting of MBL, Woods Hole, MA, USA

1987 IPA Fellow, Neurobiology Laboratory, National Institutes of Health, USA.

1987 Chairman, Session on "Potassium Channels," The 31st Annual Meeting of the Biophysical Society, New Orleans, Louisiana, USA.

1986 Member of Editorial Board, Science and Technology Review (Beijing).

1986 Visiting Professor, Dept of Biological Science and Biotechnology, Tsinghua University, Beijing, China

1985 Chairman, Session on "Neurobiology and Behavior", General Scientific Meeting of MBL, Woods Hole, MA, USA

1985 Chairman, Session on "Sodium Channel", The 29th Annual Meeting of the Biophysical Society, Baltimore, MA, USA.

1981 Conference Chairman and organizer, International Conference on Structure and Function in Excitable Cells, Woods Hole, MA, USA

1981 Visiting Professor, Dept of Biology, Peking University, Beijing, China

1975 Coordinator, Electrophysiology Group of the Texas Medical Center, Houston, TX, USA

1975 Visiting Scientist, Laboratory of Neurobiology, National Institute of Mental Health, USA

1982 – Present Reviewer of grant proposals for the National Science Foundation (NSF) and National Institutes of Health (NIH) of USA, and for the Research Grant Council (RGC) of Hong Kong

1978 – Present Reviewer of manuscripts for the Biophsical Journal, Science, Current Biology, BioTechniques, Journal of Cellular Physiology, and Photochemistry and PhotoBiology


PROFESSIONAL AND HONORARY MEMBERSHIPS:


The American Society for Cell Biology

The American Association for the Advancement of Science

The Biophysical Society (USA)

The Biophysical Society of Hong Kong

Society of Chinese Bioscientists in America

Member of Corporation, Marine Biological Laboratory, Woods Hole, MA

Listed in American Men and Women of Science, Who's Who in Frontier of

Science and Technology, Who's Who in the World, and Who's Who in

Science and Engineering.


COMMUNITY SERVICES:


1999 – 2004 Member of the Senate, Hong Kong University of Science and Technology

1995 – 2004 President, The Biophysical Society of Hong Kong

2000 – 2003 Member of the University Court, Hong Kong University of Science and Technology, Hong Kong

2001 – 2003 Member of the University Administration Committee, Hong Kong University of Science and Technology

1999 – 2003 Vice President, The Hong Kong Institution of Science

1992 – 1994 Member of the Senate, Hong Kong University of Science and Technology

1988 – 1990 Secretary, Society of Chinese Bioscientists in America (SCBA), Houston Chapter, Texas, USA

1986 – 1990 Board Member, National Association of Chinese Americans (Newton, Massachusetts, USA).

1982 – 1990 Board Member, Education and Science Society, Inc. (New York).

1985 – 1986 President, National Association of Chinese Americans, Houston Chapter, Texas, USA.

1984 – 1985 President, Chinese in Neuroscience Club (North America).

1967 – 1968 Founding President, Chinese Student Association, Rice University, Houston, TX, USA


CURRENT RESEARCH INTERESTS:


1) Molecular mechanisms of cell division and programmed cell death.


  1. Studies of molecular signaling in living cells using optical methods; Laser microscopy and computer-enhanced imaging technology.


3) Calcium signaling and cell function.


4) Development of novel biophysical techniques for gene transfer and cell fusion.


PUBLICATIONS:


BOOKS:


Chang, D.C., Tasaki, I., Adelman, W.J., Jr., and Leuchtag, H.R. (Eds). 1983. Structure and Function in Excitable Cells, Plenum Publishing Co., New York. (499 pages).


Chang, D.C., Chassy, B.M., Saunders, J.A., and Sowers, A.E. (Eds). 1992. Guide to Electroporation and Electrofusion, Academic Press, San Diego. (581 pages).


PATENTS:


1. U.S. patent (No.4,822,470). "Methods of and Apparatus For Cell Poration and Cell Fusion Using Radio-Frequency Electrical Pulses." (Issued April 18, 1989).


2. U.S. patent (No.4,970,154). “Method For Inserting Foreign Genes Into Cells Using Pulsed Radio-Frequency Field.” (Issued Nov. 13, 1990).


3. U.S. patent (No.5,304,486). "Method and Apparatus for Cell Poration and Cell Fusion using Radio-Frequency Electrical Pulse." (Issued April 19, 1994).


  1. European patent (No.0386086). “Method for Cell Poration and Cell Fusion using Radio-frequency Electrical Pulses." (Issued May 29, 1996).


5. Japanese patent (Application No.509129). "Method and Apparatus for Cell Poration and Cell Fusion using Radio-Frequency Electrical Pulses." (Approved November 17, 1997).


6. U.S, patent (Application No. 09/551,380). Intra-molecular modification of GFP (green fluorescent protein) for detecting apoptosis and specific enzyme activity in living cells (pending).


7. U.S, patent (Application No. 09/866,447). “GFP-based methods for detecting apoptosis” (pending).


8. Chinese patent (Application No. 02120427.6). “GFP-based methods for detecting apoptosis” (pending).


REFEREED JOURNAL PAPERS AND BOOK CHAPTERS:


Hazlewood, C.F., Nichols, B.L., Chang, D.C., and Brown, B. 1971. On the state of water in developing muscle: A study of the major phase of ordered water in skeletal muscle and its relationship to sodium concentration. The Johns Hopkins Med. J. 128(3):171-131.


Chang, D.C., Hazlewood, C.F., Nichols, B.L., and Rorschach, H.E. 1972. Spin-echo studies on cellular water. Nature 235:170-171.


Hazlewood, C.F., Chang, D.C., Medina, D., Cleveland, G., and Nichols, B.L. 1972. Distinction between the preneoplastic and neoplastic state of murine mammary glands. Proc. Natl. Acad. Sci. USA 69:1478-1480.


Hazlewood, C.F., Chang, D.C., Rorschach, H.E., and Nichols, B.L. 1972. Cellular water and macromolecules. In: Reversibility of Cellular Injury Due to Inadequate Perfusion (T.I. Malinin, et al., Eds), pp. 22-38, Charles C. Thomas Publishers.


Chang, D.C. and Rorschach, H.E.1973. The spin diffusion coefficient of He3 in He3-He4 solutions. J. Low Temp. Phys. 10:245-266.


Chang, D.C., Rorschach, H.E., Nichols, B.L., and Hazlewood, C.F. 1973. Implications of diffusion coefficient measurements for the structure of cellular water. Annals N.Y. Acad. Sci. 204:434-443.


Chang, D.C., and Rorschach, H.E. 1973 The spin diffusion coefficient of He3 in He3-He4 solutions. In: Low Temperature Physics LT-l3, (K.D. Timmerhaus, W.J. O'Sullivan, and E.F. Hammel, Eds), 1:608-611, Plenum Publishing Co., New York.


Rorschach, H.E., Chang, D.C., Hazlewood, C.F., and Nichols, B.L. 1973. The diffusion of water in striated muscle. Annals N.Y. Acad. Sci. 204:444-452.


Vick, R.L., Hazlewood, C.F., Chang, D.C., Nichols, B.L., and Harvey, M.C. 1973. Sodium, potassium and water in cardiac tissues. Annals N.Y. Acad. Sci. 204:575-592.


Hazlewood, C.F., Chang, D.C., Nichols, B.L., and Woessner, D.E. 1974. NMR Transverse relaxation times of water protons in skeletal muscle. Biophys. J. 14:583-606.


Chang, D.C. and Hazlewood, C.F. 1975. Comments on PMR studies of tissue water. J. Mag. Res. 18:550-554.


Medina, D., Hazlewood, C.F., Cleveland, G.G., Chang, D.C., Spjut, H.J., and Moyers, R. 1975. Nuclear magnetic resonance studies on human breast dysplasias and neoplasms. J. Nat. Cancer Inst. 54:813-818.


Chang, D.C., Hazlewood, C.F., and Woessner, D.E. 1976. The spin-lattice relaxation times of water associated with early post-mortem changes in skeletal muscle. Biochim. Biophys. Acta 437:253-258.


Cleveland, G.G., Chang, D.C., Hazlewood, C.F., and Rorschach, H.E. 1976. NMR measurement on skeletal muscle: Anisotropy of the diffusion coefficient of the intracellular water. Biophys. J. 16:1043-1053.


Chang, D.C. 1977. A physical model of nerve axon: Ionic distribution, potential profile, and resting potential. Bull. Math. Biol. 39:1-22.


Beall, P.T., Medina, D., Chang, D.C., Seitz, P.K., and Hazlewood, C.F. 1977. Systemic effect of benign and malignant mammary tumors on the spin-lattice relaxation time of water protons in mouse serum. J. Nat. Cancer Inst. 59(5):1431 1433.


Udall, J.N., Alvarez, L.A., Chang, D.C., Soriano, H., Nichols, B.L., and Hazlewood, C.F. 1977. The effect of cholera enterotoxin on intestine tissue water as measured by nuclear magnetic resonance (NMR) spectroscopy. Physiol. Chem. & Physics 9:13-20.


Chang, D.C. and Woessner, D.E. 1977. "Bound water" in barnacle muscle as indicated in NMR studies. Science 198:1180-1181.


Beall, P.T., Chang, D.C., and Hazlewood, C.F. 1978. Structural changes in chromatin during the HeLa cell cycle: Effect on water NMR relaxation times. In: Biomolecular Structure and Function (P.R. Agris, Ed), pp. 233-237, Academic Press, New York.


Chang, D.C. and Woessner, D.E. 1978. Spin echo study of Na23 relaxation in skeletal muscle: Evidence of sodium ion binding inside a biological cell. J. Mag. Res. 30:185 191.


Udall, J.N., Alvarez, L.A., Chang, D.C., Hazlewood, C.F., and Nichols, B.L. 1978. The effects of cholera enterotoxin on intestinal tissue water as measured by NMR spectroscopy. Proc. of the 13th U.S. and Japan Conf. on Cholera, DHEW Publication No. (NIH) 78-1590:493-502.


Chang, D.C. 1979. A physical model of nerve axon - II: Action potential and excitation currents. Voltage-clamp studies of chemical driving forces of Na+ and K+ in squid giant axon. Physiol. Chem. & Physics 11:263-288.


Kasturi, S.R., Hazlewood, C.F., and Chang, D.C. 1980. Study of anisotropy in NMR relaxation times of water protons in skeletal muscle. Biophys. J. 30:369-382.


Beall, P.T., Asch, B.B., Chang, D.C., Medina, D., and Hazlewood, C.F. 1980. Distinction of normal, preneoplastic and neoplastic mouse mammary primary cell cultures by water NMR relaxation times. J. Nat. Cancer Inst. 64(2):335-338.


Chang, D.C. and Hazlewood, C.F. 1980. Nuclear magnetic resonance study of squid giant axon. Biochim. Biophys. Acta 630:131 136.


Misra, L.K., Smith, N.K.R., Chang, D.C., Sparks, R.L., Cameron, I.L., Beall, P.T., Harrist, R., Nichols, B.L., Fanguy, R.C., and Hazlewood, C.F. 1980. Intracellular concentration of elements in normal and dystrophic skeletal muscles of the chicken. J. Cellular Physiol. 103:193-200.


Michael, L., Seitz, P., Wood, J.M., Chang, D.C., Hazlewood, C.F., and Entman, M. 1980. Mitochondrial water in myocardial ischemia: Investigation with nuclear magnetic resonance. Science 208:1267-1269.


Chang, D.C., Misra, L.K., Beall, P.T., Fanguy, R.C., and Hazlewood, C.F. 1981. Nuclear magnetic resonance study of muscle water protons in muscular dystrophy of chickens. J. Cell Physiol. 107:139-145.


Seitz, P.K., Chang, D.C., Hazlewood, C.F., Rorschach, H.E. and Clegg, J.S. 1981. The self-diffusion of water in artemia cysts. Arch. Biochem. Biophys. 210:517-524.


Beall, P.T., Brinkley, B.R., Chang, D.C., and Hazlewood, C.F. 1982. Microtubule complexes correlated with growth rate and water proton relaxation times in human breast cancer cells. Cancer Res. 42:4124-4130.


Chang, D.C. 1983. A voltage-clamp study of the effects of colchicine on the squid giant axon. J. Cell Physiol. 115:260-264.


Chang, D.C. 1983. Dependence of cellular potential on ionic concentrations: Data supporting a modification of the constant field equation. Biophys. J. 43:149-156.


Chang, D.C. 1983. Ion-selectivity and gating properties of the conduction pathways in squid axon: The view of a membrane-cortex model. In: Structure and Function in Excitable Cells (D.C. Chang, et al., Eds), pp. 227-254, Plenum Publishing Co., New York.


Chang, D.C. 1985. Transport of Na+ inside the giant axon of squid. Cell Biophys. 7:107 114.


Chang, D.C. and Liu, J. 1985. A comparative study of the effects of tetrodotoxin and the removal of external Na+ on the resting potential: Evidence of separate pathways for the resting and excitable Na currents in squid axon. Cell Molec. Neurobiol. 5:311-320.


Chang, D.C. 1986. Axonal transport and the movement of 45Ca inside the giant axon of squid. Brain Res. 367:319-322.


Chang, D.C. and Tasaki, I. 1986. Ultrastructure of the squid axon membrane as revealed by freeze-fracture electron microscopy. Cell Molec. Neurobiol. 6:43-53.


Chang, D.C. 1986. Is the K permeability of the resting membrane controlled by the excitable K channel? Biophys J. 50:1095-1100.


Fong, C.N. and Chang, D.C. 1987. K+-selective microelectrode study of internally dialysed squid giant axons. Biophys J. 53:893-897.


Chang, D.C. 1988. Is the delayed rectifier the major pathway for resting K current? Biophys J. 54:971-972.


Chang, D.C., Hunt, J.R., and Gao, P.Q. 1989. Effects of pH on cell fusion induced by electric fields. Cell Biophys. 14:231-243.


Chang, D.C. 1989. Cell fusion and cell poration by pulsed radio-frequency electric fields. In: Electroporation and Electrofusion in Cell Biology. (E. Neumann, A.E. Sowers, and C.A. Jordan, Eds), Plenum Press Co., New York.


Chang, D.C. 1989. Cell poration and cell fusion using an oscillating electric field. Biophys. J. 56:641-652.


Chang, D.C. and Reese, T.S. 1990. Changes of membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys. J. 58:1-12.


Kasturi, S.R., Seitz, P.K., Chang, D.C. and Hazlewood, C.F. 1990. Intracellular water in Artemia cysts (brime shrimp): Investigation by deuterium and oxygen-17 nuclear magnetic resonance. Biophys. J. 58:483-491.


Zheng, Q. and Chang, D.C. 1990. Dynamic changes of microtubule and actin structures in CV-1 cells during electrofusion. Cell Motil. Cytoskel. 17:345-355.


Zheng, Q. and Chang, D.C. 1991. High-efficiency gene transfection by in situ electroporation of cultured cell. Biophys. Biochim. Acta 1088:104-110.


Chang, D.C., Gao, P.Q. and Maxwell, B.L. 1991. High efficiency gene transfection by electroporation using a radio-frequency electric field. Biophys. Biochim. Acta 1992:153-160.


Zheng, Q. and Chang, D.C. 1991. Reorganization of Cytoplasmic Structures During Cell Fusion. J. Cell Sci. 100:431-442.


Chang, D.C. 1992. Structure and dynamics of electric field-induced membrane pores as revealed by rapid-freezing electron microscopy. In: Guide to Electroporation and Electrofusion, ed. by Chang, D.C., Sowers, A.E., Chassy, B. and Saunders, J.A., Academic Press, San Diego. (pp.9-28).


Chang, D.C. 1992. Overview of Electroporation and Electrofusion. In: Guide to Electroporation and Electrofusion, ed. by Chang, D.C., Sowers, A.E., Chassy, B. and Saunders, J.A., Academic Press, San Diego. (pp.1-6).


Chang, D.C., Hunt, J., Zheng, Q. and Gao, P.Q. 1992. Electroporation and electrofusion using a pulsed radio-frequency electric field. In: Guide to Electroporation and Electrofusion, ed. by Chang, D.C., Sowers, A.E., Chassy, B. and Saunders, J.A., Academic Press, San Diego. (pp.303-326).


Zheng, Q. and Chang, D.C. 1992. Dynamics of cytoskeletal reorganization in CV-1 cells during electrofusion In: Guide to Electroporation and Electrofusion, ed. by Chang, D.C., Sowers, A.E., Chassy, B. and Saunders, J.A., Academic Press, San Diego. (pp.179-199).


Gallagher, S. and Chang, D.C. 1992. Novel applications of electroporation and electrofusion. In: Guide to Electroporation and Electrofusion, ed. by Chang, D.C., Sowers, A.E., Chassy, B. and Saunders, J.A., Academic Press, San Diego. (pp.411-425).


Chang, D.C. 1992. Design of protocols for electroporation and electrofusion: Selection of electrical parameters. In: Guide to Electroporation and Electrofusion, ed. by Chang, D.C., Sowers, A.E., Chassy, B. and Saunders, J.A., Academic Press, San Diego. (pp.429-456).


Chang, D.C., Leung, D.S.Y., Ehrlich, M. and Gao, P.Q. 1992. Rapid Loading of Molecules into Animal Cells using a Radio-Frequency Electric Field. Biological Bulletin 183:364-365.


Gao, P.Q., Sims, S.H., Chang, D.C. and Deisseroth, A.B. 1993. Interferon-gamma priming effects in the activation and deactivation of ISGF3 in K562 cells. J. Biol. Chem., 268 (17): 12380-12387.


Meng, C. and Chang, D.C. 1994. Study of calcium signalling in cell cleavage using confocal microscopy. Biol. Bull., 187:234-235.


Finch, R.A., Chang, D.C. and Chan, P.K. 1995. GTPS restores nucleophosmin (NPM) localization to nucleoli of GTP-depletred HeLa cells. Mol. Cell. Biochem. 146: 171-178.


Chang, D.C. and Meng, C. 1995. A localized elevation of cytosolic free calcium is associated with cytokinesis in zebrafish embryo. J. Cell Biol. 131:1539-1545.


Chang, D.C. 1996. Electroporation and electrofusion. In: The Encyclopedia of Molecular Biology and Molecular Medicine, ed. by R.A. Meyers, VCH Publishers, Weinheim, Germany. Vol. 2, pp 198-206.

Chang, D.C. 1997. Experimental strategies in efficient transfection of mammalian cells: Electroporation. In: Methods in Molecular Biology. Vol. 62: Recombinant Gene Expression Protocols, ed. by Rocky S. Tuan, Humana Press. pp 307-318.


Chang, D.C. 1997. Chapter 88: Electroporation and electrofusion, In: Cell Biology: A Laboratory Manual, ed. by D. Spector, R.Goldman and L. Leinwand, Cold Spring Harbor Laboratory Press, New York. pp. 88.1-88.11.


Metuzals, J., Chang, D., Hammar, K., and Reese ,T.S. 1997. Organization of the cortical endoplasmic reticulum in the squid giant axon. J Neurocytol 26(8):529-539.


Li, C.J., Heim, R., Lu, P., Pu, Y.M., Tsien, R.Y. and Chang, D.C. 1999. Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein technique. J Cell Sci. 112(10):1567-1577.


Li, C.J., Lu, P. and Chang, D.C. 1999. Using a GFP-labeling technique to study cell cycle-dependent distribution of calmodulin in living cells. Science in China, 42: 517-528.


Chang, D.C., Lu, P. and. Li, C.J. 1999. Dynamic redistribution of calmodulin in living cells during cell division: An in vivo study using a GFP-calmodulin fusion protein technique. Proceedings of the 1st Guangdong / Hong Kong Joint Biophysics Symposium, pp 9-12.


Pu, Y.M. and Chang, D.C. 1999. Study of Ca2+ signaling during the process of apoptosis. Proceedings of the 1st Guangdong / Hong Kong Joint Biophysics Symposium, pp 53-56.


Chang, D.C. and Lu, P. 2000. Multiple types of calcium signals are associated with cell division in zebrafish embryo. Microscopy Res. Tech., 49(2): 111-122.


Chang, D.C. 2000. Electroporation and electrofusion using an oscillating electric field. Electroporation, electrofusion and Electro-excitation: Principles, Techniques and applications, ed. H.M. Wang and T.D. Xie, Tianjin Science Press. pp.133-146


Chang, D.C. 2000. Structure and dynamics of electropores as revealed by rapid-freezing electron microscopy. Electroporation, electrofusion and Electro-excitation: Principles, Techniques and applications, ed. H.M. Wang and T.D. Xie, Tianjin Science Press. pp.85-94.


Pu, Y.M. and Chang, D.C. 2001. Cytosolic Ca2+ Signal is involved in regulating UV-induced apoptosis in HeLa cells. Biochem. Biophys. Res. Comm., 282(1):84-89.


Luo, K.Q., Yu, V.C., Pu Y.M. and Chang D.C. 2001. Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Biochem Biophys Res Comm. 283(5):1054-1060.


Gao, W.H., Pu Y.M., Luo, K.Q. and Chang D.C. 2001.Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. J. Cell Sci. 114:2855-2862.


Pu, Y.M., Luo, K.Q. and Chang, D.C. 2002. A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells. Biochem Biophys Res Comm 299:762-769


Luo, K.Q., Yu, V.C., Pu Y.M. and Chang D.C. 2003. Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNF-induced apoptosis. Biochem Biophys Res Comm. 304:217-222.


Xu, N.H., Luo, K.Q. and Chang, D.C. 2003. Ca2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint Biochem Biophys Res Comm. 306:737-745.


Luo, K.Q., Elsasser, S., Chang, D.C., Campbell, J.L. 2003. Regulation of the localization and stability of Cdc6 in living yeast cells. Biochem Biophys Res Comm. 306:851-859.


Chang, D.C, Xu, N.H. and Luo, K.Q. 2003. Degradation of cyclin B is required for the onset of anaphase in mammalian cells. J. Biol. Chem. 278:37865-37873.


Chang, D.C. 2004. Electroporation and electrofusion. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine. Ed. by R.A. Meyers, Wiley-VCH Publishers, Weinheim, Germany. Vol. 4, pp.135-157.


Chang, D.C, Zhou, L.Y. and Luo, K.Q. 2004. Using GFP and FRET technologies for studying signaling mechanisms of apoptosis in a single living cell. In: Biophotoncs-Optical Science & Engineering for 21st Century. Kluwer Academic/Plenum Publishers, New York (In press).


Luo, K.Q. and Chang D.C. 2004. The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region. Biochem Biophys Res Comm. 318:303-310.


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