Herald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine




НазваниеHerald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine
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1034

© T.E. Sadikova, V.A. Aleksandrova, 2009


UDC 616.5-002-053.2/.3:612.017.1

Sadikova T.E., Aleksandrova V.A. Clinical-immunological characteristics of children with topical dermatitis with different general IgE level // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 1 (30). – P. 33-36.

State Educational Establishment for Additional Professional Training «Saint-Petersburg Medical Academy for Post-Diploma Training of the Federal Agency for Public Health and Social Development of the Russian Federation», Russia, 191015, Kirochnaya str., 41, tel.: 272-52-06, fax: 273-00-39, e-mail: admin@maps.spb.ru

Summary: The article discusses clinical and immunology specific in children with atopic dermatitis with normal and elevated levels of the total IgE. We investigated 134 patients with atopic dermatitis (AD) aged 1-17 years. Patients have been divided in two groups: children with AD and elevated IgE (53 people), and children with AD and normal level of the IgE (81 people). A severe course of atopic dermatitis was recorded in children with AD and elevated IgE. Children with atopic dermatitis and normal level of the IgE more often had a continuously reccuring cource. Comparative analysis of blood lymphocytes in children with AD with normal and elevated levels of the total IgE showed opposite dynamics CD4 + and CD 16 + lymphocytes in different age groups. Children with AD and elevated IgE had increased absolute number of CD4 + in younger age group and decreased percentage CD4 + in the senior age group; decreased percentage CD 16 + in younger age group and increased percentage of CD 16 + in the senior age group compared with children with AD and normal IgE, that, probably, reflects participation of different subpopulations of that cells in regulation of IgE level in patients of different age. The efficacy of the complex therapy that included was higher in AD and elevated IgE.

Key words: atopic dermatitis, children, complex therapy, total IgE.

References:

1. Александрова В.А. Пищевая аллергия: учебное пособие для врачей. — СПб: СПбМАПО, 2001. — 18 с.

2. Согласительный документ Ассоциации детских аллергологов и иммунологов России «Современная стратегия терапии атопического дерматита: программа действия педиатра» // Ассоциация детских аллергологов и иммунологов России. — М., 2004.— 97с.

3. Иммунология: в 3-х томах / Пер.с англ.; Под ред. У.Пола. — Т.1. — М.: Мир, 1987–1988. — 476 с.

4. Dohil R.,Hassal E., Jevon G. et al. Gastritis and gastropathy in childhood // J.Pediatr. Gastrjenterol.Nutr.-1999.-Vol.29.-P.378-394.

5. Fulya Ilhan. Atopic dermatitis and V2 24+ Natural killers T-cells // SKINmed. - 2007. - Vol.6. - P. 218-220.

6. Tsuoshi Takahashi et al. V & alpha; 24+ natural killer T-cells are markedly decreased in atopic dermatitis patients // Human Immunology 2003. - Vol. 64. - P. 586-592.

7. Chiarelli K. et al. Natural killers cells function in atopic dermatitis // Acta Pediatr. Scand. - 1988. - Vol.77. - P. 275-278.

8. Mette C.et al. Cesarean section and Risk of severe children asthma: a population based Cohort study // The journal of Pediatrios. – 2008. – Vol. 153. - Р. 112-116.

1032

© T.V. Koltsova, 2009


UDC 618.14-005-089.881-053.6

Koltsova T.V. The experience of hysteroscopy application for adolescent girls with recurrent dysfunctional uterine bleeding // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 1 (30). – P. 36-40.

The department of children and adolescent gynecology of the Saint-Petersburg State Pediatric Medical Academy, Russia, 194100, Litovskaya str., 2, tel.:245-06-46, fax: 245-40-85, E-mail: spb@spma.ru

Summary: Research results of 21 adolescent girls with recurrent pubertal uterine bleeding are present in this article. To precise the endometrial condition hysteroscopy and endometrial biopsy were used. The obtained results have shown further tactic of hormonal treatment for this group of patients. The endometrial change revealed by using hysteroscopy for adolescent girls with recurrent uterine bleeding became an indication for treatment with low dosed contraceptives in cycle regimen for at least 6 months.

Key words: menstrual cycle, dysfunctional uterine bleeding, hysteroscopy, endometrium, low dosed contraceptives, gestagens.

References:

1. Вовк И.Б., Задорожная Т.Д., Петербургская В.Ф., Одобецкая В.И. Лечение тяжёлых форм пубертатных маточных кровотечений// Репродуктивное здоровье женщины. – 2003. – №1(13). – С.14-16.

2. Гоготадзе И.Н. Ювенильные кровотечения/Методическое пособие. – СПб., 2003. – С.11-19.

3. Гуркин Ю.А. Гинекология подростков. – СПб.: Фолиант, 2000. – С.208-211.

4. Дебольская А.И., Уварова Е.В., Веселова Н.М., Ежова Л.С. Сравнительная оценка методов диагностики при рецидивирующих маточных кровотечений пубертатного периода//Материалы V Всероссийского конгресса эндокринологов. – М., 2006. – 582 с.

5. Долженко И.С. Возможности использования дюфастона для регуляции менструального цикла у девушек с гипоталамическим синдромом периода полового созревания // Акушерство и гинекология. – 2004. – №1. – С.50-51.

6. Коколина В.Ф. Гинекологическая эндокринология детского и подросткового возраста. – М.: Медпрактика, 2005. – С.171-180.

Information about the author:

Koltsova Tatiana Vladimirovna – assistant of Children and adolescent Gynecological department of Saint-Petersburg pediatric medical academy, work tel.: 778-52-78, home tel.: 727-72-58, mobile phone 8-911-918-17-07, е-mail: koltsovy@mail.ru

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