Herald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine




НазваниеHerald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine
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© A.L. Kovalenko, T.N. Savateyeva, D.S. Sukhanov, A.Yu. Petrov, M.G. Romantsov, 2009


UDC 616.36:616.988:615.244:616-094.4

Kovalenko A.L., Savateyeva T.N., Sukhanov D.S., Petrov A.Yu., Romantsov M.G. Pharmacological activity of hepatoprotectors in cases of liver virus infections (experimental studies) // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 1 (30). – Р. 163-167.

1Scientific-Technological Pharmaceutical Firm “POLYSAN”, Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.: 8(812)110-82-25,112-13-79, е-mail: sales@polysan.ru, STPF “POLYSAN” www.polysan.ru

2Federal State Institution for Science «Institute of Toxicology» of the Federal Medical-Biological Agency of Russia, Russia, 192019, St.-Petersburg, Bekhterev str., tel./fax: 8(812)365-06-80

3State Educational Establishment of Higher Professional Training «Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian Federation», Russia, 195067, St.-Petersburg, К-67, Piskarevsky prospect, 47, tel. (812)543-96-09, fax: (812)140-15-24, e-mail: mechnik@gmail.com; www.mechnik.spb.ru

Summary:The article shows the positive influence of succinatecontaining solutions in the case of a liver damage by viruses, which characterized by the increase of a level of restored glutathione, the saving of concentration of SH-groups of proteins in liver tissues on the level of controled animals, which allows to achieve the saving of thioldisulfide status of hepatocytes. The antioxidant effect of medicine have been proven by study of catalase’s activity, its concentration, under an influence of succinatecontaining solutions, had increased, and pharmacological effect had been confirmed by decrease of the level of the lipid peroxidation (malondialdehyde) end products. Membrane-stabilazing effect of the succinatecontaining solutions is providing a decrease of the level of lipid hydroperoxides, at the same time metabolic effect is shown by decrease of endogenous intoxication with lipoperoxidation and cytolysis intensivety decrease at the same time. The acquired data has allow to take cytoflavin and remaxol as perspective hepatoprotectors with antioxidant activity for clinical use in the cases of acute and chronic virus infections of a liver.

Key words: liver damage by viruses, cytoflavin and remaxol - perspective hepatoprotectors with antioxidant activity

References:

1. Ивашкин В.Т. с соавт. Болезни печени и желчевыводящих путей. // Руководство для врачей. М., 2002.-С.222-231.

2. Коваленко А.Л. Фармакологическая активность оригинальных лекарственных препаратов на основе 1-дезокси-1(N-метиламино)-D-глюцитола //Автореф. Дисс. …д.б.н.-СПб.,-2005.-48с

3. Лазебник Л.Б., Звенигородская Л.А. Ишемические поражения печени //Хроническая ишемическая болезнь органов пищеварения._М.,-Анахархис.-2003.-С.72-78.

4. Оковитый С.В. Клиничеcкая фармакология антигипоксантов // Фарминдекс-практик. Информационный сборник для практических врачей. - М., – 2005. - № 6.- С. 30-39.

5. Петров А.Ю., Коваленко А.Л., Романцов М.Г. Антиоксидантная терапия как компонент лечения воспалительных процессов в печени // Вестник Санкт-Петербургской государственной медицинской академии им. И.И.Мечникова.-2004.-№4.-С.152-153

6. Подымова С.Д. Болезни печени. - М.: Медицина, 1998. - 544 с.

7. Покровский В.И., Онищенко Г.Г., Черкасский Б.А. Эволюция инфекционных болезней в России в 20 веке: Руководство для врачей. - М., 2003. - С. 236-248.

8. Сосина Т.Е., Подопригорова В.Г., Цыганкова Г.М. Влияние сукцината на процессы перекисного окисления липидов в динамике регенерации печени // Вестник Санкт-Петербургской государственной медицинской академии им. И.И. Мечникова. - 2004. - №3. - С. 95.

9. Шерлок Ш., Дули Дж. Заболевания печени и желчных путей. - М.-1999. - С. 213-218.

10. Alter M.J. Epidemiology of Hepatitis C // Hepathology. - 1997. - Vol. 26. - № 3. - Suppl. 1. - P. 62-65.

11. Tennant F. Hepatitis C, B, D and A: contrasting Features and liver function abnormalities in herion addicts // Journal of Addictive Diseases. - 2001. - Vol. 20. - № 1. - P. 9-17.

Information about the authors:

Kovalenko AlexsandrLeonidovith - Scientific-Technological Pharmaceutical Firm “POLYSAN”, Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.: 8(812)110-82-25,112-13-79, е-mail: sales@polysan.ru, STPF “POLYSAN” www.polysan.ru

Savateeva Tatiana Nikolaevna – MD, head of the laboratory of pharmacological toxicology of the Federal State Scientific Institution «INSTITUTE OF TOXICOLOGY», Federal medico-biological agency, office tel.:8(812) 567-91-63, office fax: 8(812) 365-06-80, home tel.: 8(812) 395-10-32, e-mail:drugs_safety@mail.ru

Sukhanov. Dmitrii Sergeevich - Candidate of Medical Sciences, senior consulting physician for scientific and clinical work Co Ltd “POLYSAN”, e-mail: d_suhanov@polysan.ru

Petrov Andrey Yurievich - PhD, head of scientific-technological laboratory of Scientific-technological pharmaceutical company «POLYSAN», office tel.: 8-812-710-82-25, mobile phone: 8-921-944-54-92, e-mail:adanol@ mail.ru

Romantsov Mikhail Grigorievich – Doctor of Medicine, Professor of the department of Infectious Diseases of SEEHPT «Saint-Petersburg State Medical Academy named after I.I.Mechnikov of Roszdrav». Тел.: 8-812-710-82-25. E-mail: RomantsovGCP@polysan.ru
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