Herald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine




НазваниеHerald of the Mechnikov Saint-Petersburg State Medical Academy profilactical and clinical medicine
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© D.K. Vasilyeva, L.G. Goryacheva, A.L. Mukomolova, M.Ya. Kotiv, 2009


UDC 616.36-002.2-053.2/.6:616.988

Vasilyeva D.K.1, Goryacheva L.G.2, Mukomolova A.L.1, Kotiv M.Ya.1 New aspects in the treatment of chronic hepatitis С оf children // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 1(30). – Р. 160-163.

State Educational Establishment of Higher Professional Training «Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian Federation», Russia, 195067, St.-Petersburg, К-67, Piskarevsky prospect, 47, tel. (812)543-96-09, fax: (812)140-15-24, e-mail: mechnik@gmail.com; www.mechnik.spb.ru

Summary: The therapy was conducted in 20 fallow cases: children 3-18 years old with chronic hepatitis C. Specific blood test with antiviral preparation has been conducted before the treatment and individual therapy schemes have been assigned according to tests' results. Early virological response of individual therapy of chronic hepatitis C was 65% of children and end of treatment response -75%. The frequency of side effects decreased 2-3 times in comparison with standards treatment.

Key words: viral hepatitis, chronic hepatitis C, children, antiviral treatment

References:

1. Волчек И.В. Индивидуальная терапия хронического гепатита С препаратами интерферона и Неовиром / И.В. Волчек, Т.В. Сологуб, М.А. Белопольская, Л. А. Белозерова, Т.Д. Григорьева и соавт. // «Terra Medica». – 2000. - №3. – С. 6-12.

2. Григорьева Т.Д. Состояние системы антиоксидантной защиты и ее значение в комплексе неспецифической резистентности организма у инъекционных наркопотребителей с HCV - инфекцией / Автореф. дисс. канд. – СПб, 2006. – 23 с.

3. Григорьева Т.Д. Способ индивидуального подбора лекарственных препаратов для лечения больных этиологически различными острыми и хроническими вирусными гепатитами / Т.В.Сологуб, Л.А. Белозерова, И.В. Волчек, Т.Д. Григорьева, Н.А. Семеняко // (Патент РФ N 2222011 от 20. 04. 2004).

4. Сологуб Т.В. Современные подходы к терапии хронического гепатита С / М.Г. Романцов, Ф.И. Ершов и др.// «Terra Medica». - 2006. - №3. - С.3-7.

5. Учайкин В.Ф. Вирусные гепатиты от А до ТТV у детей / Н. И. Нисевич, Т. В. Чередниченко. – М.: Новая волна, 2003 – 432 с.

6. Учайкин В.Ф. Вирусные гепатиты у детей: от прошлого к настоящему / С. Б. Чуелов // Детские инфекции. – 2006. – Т.5, №4. – С. 4-6.

7. Эсауленко Е.В. Эффективность нового отечественного интерферона альфа 2b в терапии хронического гепатита С: результаты открытого рандомизированного сравнительного исследования / Е. В. Эсауленко, О.О.Павлова, А.А.Го, И.В. Осе // Клинические перспективы гастроэнтерологии, гепатологии. - 2007. - №1. - С. 27-32.

8. Stefan Zeuzem. Использование пэгинтерферона альфа-2а (молекулярная масса 40 кД) и рибавирина при хроническом гепатите C, протекающем без повышения уровня аминотрансфераз в сыворотке крови / Moises Diago, Edward Gane, K. Rajender Reddy, Paul Pockros, Daniele Prati, Mitchell Shiffman, Patrizia Farci, Norman Gitlin, Christopher B. O’Brien, Francois Lamour, Pilar Lardelli // Клиническая гастроэнтерология и гепатология. - 2008. - Т.1, № 1. - С.3-7.

9. Berg T., Hoffmann R. M., Teuber G. et al. Efficacy of a shortterm ribavirin plus interferon alpha combination therapy followed by interferon alpha alone in previously untreated patients with chronic hepatitis C: randomized multicenter trial // Liver. – 2000. – Vol. 20, N 6. – P. 427–436.

10. Chemello L., Bonetti P., Cavalletto L. et al. Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. The TriVeneto Viral Hepatitis Group // Hepatology. – 1995. – Vol. 22, N 3. – P. 700–706.

11. Davis G.L., Balart L.A., Schiff E.R. et al. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial // N. Engl. J. Med. – 1989. – Vol. 321. – P. 1501–1506.

12. Dusheiko G., Main J., Thomas H. et al. Ribavirin treatment for patients with chronic hepatitis C: results of a placebocontrolled study // J. Hepatol. – 1996. – Vol. 25. – P. 591–598.

13. Poynard T., Marcellin P., Lee S.S. et al. Randomized trial of interferon alpha-2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha-2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group // Lancet. – 1998. – Vol. 352, N 9138. – P. 1426–1432.

Information about the authors:

Vasiliyeva D.K. Tel.: 8(812)234-34-16 (department for Viral Hepatitis and Liver Diseases), 8-904-601-61-24 (mobile phone). Е-mail: vassilieva.d@gmail.com
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