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A Ph.D. position (TV-L E13, 50%) is available at the Institute for Biochemistry I, Medical Faculty, University of Cologne. The central aim of this Fritz-Thyssen-Stiftung funded project is the characterization of the complex pathology and the identification of novel and disease related p97 binding partners particularly in protein aggregate myopathies.
Mutations of the human valosin containing protein gene (VCP, synonym: p97) on chromosom 9p13-p12 cause autosomal dominant IBMPFD, inclusion body myopathy (IBM) associated with Paget disease of the bone (P) and frontotemporal dementia (FD) or IBMPFD. Beyond the first description of a novel type of VCP-related frontotemporal dementia (Schroder et al., Annals of Neurology, 2005), we recently provided the first report on a novel form of VCP-related cardiomyopathy. We demonstrated that the IBMPFD striated muscle pathology is morphologically characterized by VCP- and ubiquitin-positive cytoplasmic and nuclear protein aggregates. The corroborative data on VCP-related IBMPFD currently indicates that the molecular pathogenesis of the disorder is related to an impairment of the ubiquitin proteasome protein degradation system (Hubbers et al., Brain, 2007). Our project strives to provide new insights in the complex molecular mechanisms leading to abnormal protein aggregation and progres!
sive muscle damage in IBMPFD and related forms of protein aggregate myopathies and cardiomyopathies.
Scope of this project is: i) The further biochemical and functional characterization of wild-type and mutant p97 protein. ii) The generation of mammalian cell lines expressing mutant p97 including the generation of a knock in model of the social amoeba Dictyostelium discoideum. Mouse embryonic stem cells heterozygote for a p97 mutation will be differentiated into neuronal cells and serve as a further cell culture model. iii) The determination of cellular activities like that of the ERAD system, proteasome, and autophagy employing these model systems. iv) Clinical phenotyping, neuropathological examination, and proteasomal analyses of a p97 knock in mouse model, which actually is generated, will be a major part of this study, too.
Highly motivated individuals with a diploma or equivalent degree in molecular biology, biochemistry or any other related area of modern biology are welcome to apply. Experience in molecular biology and biochemistry is desirable.
Bewerbungen von Frauen sind ausdruecklich erwuenscht. Bei gleicher Eignung, Befaehigung und fachlicher Leistung werden Frauen bevorzugt beruecksichtigt, sofern nicht in der Person eines Mitbewerbers liegende Gruende überwiegen.
Gleiches gilt für die Bewerbungen von Schwerbehinderten, die ausdruecklich erwuenscht sind.
Applications, together with CV and names and addresses of two references, should be sent in parallel to the following two addresses:
Prof. Dr. med. Rolf Schroeder
Institut für Neuropathologie
Dr. med. Christoph Clemen
Center for Biochemistry
University of Cologne
Tel: +49 221-478-6980
Fax: +49 221-478-6979
Being an international research competence centre, the Helmholtz Centre
for Environmental Research UFZ is investigating the interaction between
man and environment in used and disturbed landscapes. The centre
develops concepts and methods to assure a healthy environment for future
The Department of Community Ecology offers positions for
1 PhD position (m/f)
in the area of Plant Molecular Ecology
The candidate will work in a third party project founded by the German
Ministre for Science and Education (BMBF) in the frame of its BIOLOG
program. The project is embedded in the project SUBICON which follows
the natural succesion als well as land use changes in a former brown
coal mining area. The project specifically aims at the parallel analysis
of species richness and molecular genetic variation in grassland plants.
Both levels of biodiversity will be assessed in early successional in
brown coal sites and ancient natural grasslands. We test the hypothesis
that a correlation between genetic and species diversity is conditional
on long term stable habitat conditions. We will also apply a landscape
genetic approach to address the influence of landscape structure for
genetic and species diversity. Interdisciplinary cooperation with
external partners is another central part of the project because the
results will be also formatted and presented for local nature
The department of Community Ecology is an interdisciplinary group with
emphasis on biodiversity research. We focus on processes like evolution,
multitrophic interactions, ecosystem functioning under the impact of
various drivers like climate change, land use change or biological
invasions in disciplines from molecular ecology to population biology
and macroecology aiming at a scientific basis for understanding and
managing biodiversity. The Molecular Ecology group focuses on
conservation genetics, landscape genetics, genetics of invasive species
and the relationship between genetic variation and ecosystem functioning.
The UFZ offers well-structured additional qualification opportunity for
PhD students in the frame of its new Graduate School HIGRADE.
Requirements: Applicants should have a University Diploma or Master
Degree in Biology, with majors in Botany, Plant Ecology and/or
Population Genetics. They should be fluent in both German and English
and have experience in several of the topics population genetics,
community ecology, population biology, floristics, molecular biology.
The position will start 15.01.2008 and is for 2.5 years with possibility
for further 0.5 years. The place of work is Halle, Germany. Salary will
be according to the appropriate civil service level (TVoeD-O). Women are
explicitly encouraged to apply to increase their share in science and
research. Physically handicapped persons will be favored if they are
For further information please contact (see also www.ufz.de):
Dr. Walter Durka, Phone: +49 (0)345/558 5314, e-mail: firstname.lastname@example.org
Applications with curriculum vitae and certificates should be send till
30.10.2007 under the code digit 104/2007 and the position number to the
Personnel department of the Helmholtz-Centre of Environmental Research
P.O. box 500136, D-04318 Leipzig, Germany or by E-Mail to
positions are offered under www.ufz.de.
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