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Robert Patrick (Bob) Goldstein
University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-3280 USA
email bobg @ unc.edu
phone 919 843-8575, fax 919 962-1625
BS: Union College, Schenectady, New York, 1988, Biology
PhD: University of Texas at Austin, 1992, Zoology
1996-1999 Miller Institute Postdoctoral Research Fellow, University of California, Berkeley, Department of Molecular and Cell Biology, Laboratory of Dr. David Weisblat. Subject: Evolution of mesoderm specification gene functions and segmentation in spiralian embryos
1992-1996 Postdoctoral Fellow, MRC Laboratory of Molecular Biology, Cambridge, England. Laboratory of Dr. John White 1992-1993, independent 1993-1996. Subjects: Mitotic spindle orientation and embryonic axis specification in C. elegans, evolution of axis specification in nematodes
1988-1992 PhD student, University of Texas at Austin. Laboratory of Dr. Gary Freeman. Subject: Identification of a cell-cell interaction specifying endoderm using experimental embryology methods in C. elegans
1999-current Full Professor (2010-current), Associate Professor (2005-2010), Assistant Professor (1999-2005), UNC Chapel Hill Biology Department; Member, Lineberger Comprehensive Cancer Center
2007 Guggenheim Fellow
2007 Visiting Fellow, Clare Hall, Cambridge University (elected life member, 2008)
2000-2004 Pew Scholar
2000-2002 March of Dimes Basil O'Connor Scholar
1996-1998 Miller Institute Research Fellow, University of California, Berkeley
1996 Medical Research Council Postdoctoral Fellow, Cambridge, England
1995 Development Traveling Fellow
1994-1996 Human Frontiers Science Program Postdoctoral Fellow
1993-1994 American Cancer Society Postdoctoral Fellow
2012 Co-Organizer, Santa Cruz Developmental Biology Meeting
2011 External review team member, Duke University Developmental
and Stem Cell Biology Training Program
2011-current Associate Editor, Genetics
2011-current Editorial Board, PLoS One
2009 ASCB Meeting Program Committee
2007-current Editorial Board, Developmental Dynamics
2007-current Faculty of 1000, Morphogenesis and Cell Biology Section Member
2005-current Board of Reviewing Editors, Molecular Biology of the Cell
2004-current Editorial Board, BMC Developmental Biology
1999-current Editorial Board, Development
2006 NIH study section CHHD-C, ad hoc member
2005, 2006 NIH study section NCF, ad hoc member
2004, 2011 NIH study section DEV-1, ad hoc member
2004-current NSF Developmental Mechanisms Panel, three times
INVITED SEMINARS (special seminars are marked with notes in italics)
American Association for Cancer Research Annual Meeting, Orlando, Florida, March 2004
(Invited Chair, RNA Interference session)
ASCB Building The Cell session, scheduled for December 2012
Basel Worm Meeting, Switzerland, March 2011
BSDB meeting: Wnt Signalling in Development, Disease and Cell Biology, Aberdeen, Scotland, September 2005
Buck Institute, California, March 2009
C. elegans Conference, Co-Chair, Mitosis & Asymmetry in the Early Embryo Session, 13th Biennial International C. elegans Conference, Los Angeles, June 2001
C. elegans Development meeting Madison, Wisconsin, June 2006
(Keynote speaker on Polarity, Cell Fate and Morphogenesis)
Caltech, Division of Biology, May 2010
Cambridge University, Developmental Biology Seminar Series, October 2007
Carnegie Institution, Baltimore, Nov 2009
Cold Spring Harbor Laboratories Meeting on Germ Cells, Cold Spring Harbor, October 2000
Cold Spring Harbor Laboratory C. elegans course, August 2003
Cold Spring Harbor Laboratory Meeting on Evolution of Developmental Diversity, April 2002
College of William and Mary, October 2010
Columbia University, Department of Biological Sciences, April 2008
Developmental Biology Institute of Marseilles, France, Dec 2007
Duke University Developmental Biology Colloquium, April 2003
Duke University Developmental Biology Colloquium, Jan 2009
Duke University Evo-Devo Club, Oct 2008
Duke University Program in Genetics and Genomics, scheduled for April 2013
East Carolina University's Brody School of Medicine, Department of Cell Biol & Anatomy, April 2003
EMBO Workshop, Molecular Medicine of the Gut, Arolla, Switzerland, August 1999
Emory University, May 2005
Fourth International Tunicate Meeting, Villefranche-sur-Mer, France, June 2007
Gordon Conference, Developmental Physiology, Plymouth State College, Plymouth, NH, August 1998
Gordon Conference, Motile & Contractile Systems, New London, NH, August 2011
Gordon Conference, Developmental Biology, Italy, scheduled for June/July 2013
Gulbenkian Institute of Science Meeting on Cellular Differentiation, Lisbon, Portugal, October 2000
IGBMC, Strasbourg, France, March 2011
Institute for Research in Immunology and Cancer, University of Montreal, May 2008
Johns Hopkins Department of Cell Biology, September 2010
L'Institut Jacques Monod, Paris, Sept 2007
Max Planck CBG, Dresden, Germany, March 2011
MD Anderson Cancer Center, Program in Genes & Development, Blaffer Lecture, April 2004
Mount Sinai School of Medicine, NY, scheduled for April 2013
National Institutes of Health, NIDDK, Bethesda, MD, October 2004
North Carolina State University, Zoology Department, March 2000
NYU Developmental Genetics Symposium, December 2011
RIKEN CDB Symposium, Kobe, Japan, March 2009
Robert Wood Johnson Med School/UMDNJ, May 2006
Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Canada, October, 2000
Santa Cruz Developmental Biology Meeting, August 2004
Santa Cruz Developmental Biology Meeting, June 2010
Skirball Institute, New York, June 2008
(invited by the Developmental Genetics graduate students and postdocs)
Society for Developmental Biology Annual Meeting, Charlottesville, VA, June 1999
(Plenary Session on Development and Evolution)
Society for Developmental Biology Annual Meeting, Boulder, CO, June 2000
Society for Developmental Biology Annual Meeting, Philadelphia, PA, July 2008
Society for Developmental Biology, Southeast Regional Meeting, Athens, GA, June 2005
Symposium in Developmental Biology, University of Minnesota, September 2007
The Rockefeller University, March 2005
UConn Health Center, Department of Genetics & Developmental Biology, March 2005
University of Arizona, November 2009
University of Calgary, Department of Biochemistry & Molecular Biology, June 2006
University of California, Berkeley, Department of Molecular and Cell Biology, October 2001
University of California, Berkeley, Department of Molecular and Cell Biology, April 2010
University of California, Davis, April 2012
University of California, Irvine, Department of Developmental and Cell Biology, October 2001
University of California, Santa Barbara, May 2010
UCSF Biochemistry, May 2010
UCSF Developmental Biology Symposium, June 2011
(invited by the Developmental Biology graduate students and postdocs)
University of Chicago, May 2008
University of Maryland, scheduled for March 2013
University of Miami, May 2009
UMDNJ/Rutgers, May 2011
(invited by the Joint Molecular Biosciences graduate students)
University of Oregon, March 2007
University of Richmond, scheduled for November 2012
University of Texas Southwestern Medical Center, April 2008
University of Toronto, Department of Cell & Systems Biology, December 2006
University of Utah, June 2009
(invited by the Genetics graduate students)
University of Washington Friday Harbor Labs, Center for Cell Dynamics, July 2005
University of Washington, Biology Department, June 2006
(invited by the Developmental Biology graduate students)
University of Wisconsin, Madison, Anatomy Department, April 2004
Utrecht University, Netherlands, March 2011
Vanderbilt University Medical Center, Department of Cell and Developmental Biology, November 2003
Virginia Tech, April 2009
Wake Forest University, Biology Department, November 2003
Faculty Mentor for UNC's Carolina Covenant program for low-income student scholars 2006-2007, 2008-current
UNC Internal Selection Committee for Keck Award, 2004
UNC Internal Selection Committee for Pew & Searle Awards, 2002-2004
Biology Department Seminar Committee, 1999-current (Co-chair, 2003-current)
Biology Department Microscopy Committee, 2003-current
Biology Department Faculty Development Committee, 2005-current
Biology Department Library Committee, 2005-current
Biology Department MCDB Faculty Job Search Committee, 2005-2006
Biology Department Microscopy/Cell Biology Faculty Job Search Committee, 2003-2004
Biology Department Advising Committee, 2000-2004
Biology Department Faculty Secretary, 2000-2001
Biology Department MCDB Written Exam Committee, 2006
Biology Department Advisor to 1st year MCDB grad students, 2001-2005
BBSP admissions committee 2008-2009
Curriculum in Genetics and Molecular Biology Written Exam Committee, 2005-2007
Biology 801, Graduate Seminar in Biological Sciences
Fall 2009 and Fall 2011: “Great Experiments in Biology”
Biology 649, Graduate Seminar in Cell Biology
Fall 2001: “The Cytoskeleton and Development”
Fall 2003: “Early Development of C. elegans”
Fall 2005: “Cytoskeletal Dynamics in Development”
Biology 205, Cellular and Developmental Biology
1st half of course, each Spring (2000-current)
Biology 514, Evolution and Development
1st half of course, each Fall (2002-current)
Jean-Claude Labbé, 1999 - 2002; currently a tenured Associate Professor at the University of Montreal and Principal Investigator, Institute for Research in Immunology and Cancer
Daniel Marston, 2004 - 2008; currently a postdoc in Klaus Hahn's lab at UNC
Gideon Shemer, 2005 - 2009; currently a faculty member, UNC Chapel Hill Biology Department
Jennifer Tenlen, 2007 - 2012, currently an Assistant Professor in Biology at Seattle Pacific University
Jessica Sullivan-Brown, 2009 - current
Daniel Dickinson, 2011 - current
Rebecca Cheeks, PhD 2003, currently a yoga instructor in New York City
Jen-Yi Lee, PhD 2004, currently a postdoc in Richard Harland’s lab at The University of California at Berkeley
Nathaniel Dudley, PhD 2006, currently a postdoc in Joel Rothman’s lab at The University of California at Santa Barbara
Erin McCarthy Campbell, PhD 2007, currently a freelance science writer in Athens, Georgia, writes HighMag, contributor to The Node and EuroStemCell
Willow Gabriel, PhD 2007, currently a freelance scientific editor in California
Minna Roh-Johnson, PhD 2010, currently a Postdoc in John Condeelis' lab at Albert Einstein
Jessica Harrell, PhD 2010, currently the Director of the Academic and Career Excellence Program in the Office of Graduate Education at UNC Chapel Hill
Jacob Sawyer, PhD 2010, currently an Advanced Imaging Specialist with Nikon
Adam Werts, PhD 2011, currently a veterinary school student at NC State University
Chris Higgins, 2009-current
Jennifer Heppert, 2010-current
Sophie Tintori, 2012-current (co-advised with Jason Lieb)
Meaghan Rolland (5/00 – 1/02), currently a medical resident at The University of Alabama
Ahmad Amin (9/01 – 4/02, 5/03 – 5/04), currently an MD at UNC Chapel Hill
Sapna Patel (8/03 – 8/05), currently a Grad Student in a Physical Therapy doctoral program at UNC Chapel Hill
Thurston Lindberg (4/04 – 5/05), technician 5/05 to 8/05, currently a research technician at Duke University's Nicolas School for the Environment
Shefali Chudgar (1/06 – 6/06), currently a Grad Student in Health Policy and Administration at VCU in Richmond, VA
Trudy Li (6/06 – 6/08), currently in a Pre-Medical Basic Health Certificate Program at VCU in Richmond, VA
Charlene Mangi (5/07 – 12/07), currently a Teach for America teacher in California
Joe McClellan (8/07 – 5/10), currently a UNC Chapel Hill medical student
Patty Wang (5/10 – 6/10), currently a Wake Forest medical student
Stephanie Glass (8/09 – 5/11), currently a UNC Chapel Hill medical student
Susan Clark (1/11 – 5/12), currently a PhD student in Physics at Columbia University
Kim Bird (1/11 – 5/12), currently a PhD student at UNC Chapel Hill
Taylor Moquist (9/12 – current)
Mechanisms of C. elegans Gastrulation
National Institutes of Health R01 GM83071 (Goldstein)
6/1/08 – 5/31/12, NCE to 5/31/13
Total amount of award: $1,101,872 plus $100,000 ARRA equipment supplement
Cell Polarization in Response to Wnt Signaling in C. elegans
National Science Foundation IOS-0917726 (Goldstein)
7/1/09 – 6/30/13
Total amount of award: $600,000
A Novel System for Investigating Wnt-Dependent Cell Polarization
UNC UCRF Innovation Award (Goldstein)
Total amount of award: $84,000
Asymmetric Cell Division in the C. elegans embryo
National Institutes of Health R01 GM68966 (Goldstein)
5/1/03 - 4/30/08 plus 1 year no-cost extension
Total amount of award: $1,227,865
Characterization of a New Gene Required for RNA Interference
National Science Foundation IBN 0235654 (Goldstein)
4/15/03 – 3/31/06
Total amount of award: $390,000
Embryonic Development of a Tardigrade
National Science Foundation IBN-0235658 (Goldstein)
1/1/03 - 12/31/07 plus 1 year no-cost extension
Total amount of award: $328,206
Asymmetric Cell Division in C. elegans
Pew Scholars in the Biomedical Sciences (Goldstein)
7/1/00 - 6/30/05
Total amount of award: $240,000
The Dynamics and Genetics of Asymmetric Cell Division
March of Dimes Basil O'Connor Starter Scholar Award 5-FY99-730 (Goldstein)
2/1/00 - 1/31/02
Total amount of award: $100,000
High-Volume Confocal Imaging System. NIH/NCRR 1 S10 RR021055. July 2005-June 2006. Steven Crews PI, Mark Peifer and Bob Goldstein, co-PIs. $250,839 total and direct costs from the NIH plus $60,000 in University matching funds.
Member of UNC Chapel Hill NIH-funded training programs:
NIH Developmental Biology Training Program
NIH Cell and Molecular Biology Training Program
NIH Cancer Cell Biology Training Program
NIH Lineberger Cancer Center training Program
Roh-Johnson, M., Shemer, G., Higgins, C.D., McClellan, J.H., Werts, A.D., Tulu, U.S., Gao, L., Betzig, E., Kiehart, D.P., and B. Goldstein. (2012) Triggering a Cell Shape Change by Exploiting Pre-Existing Actomyosin Contractions. Science 335:1232-1235.
Gao, L., L. Shao, C.D. Higgins, J.S. Poulton, M. Peifer, M.W. Davidson, X. Wu, B. Goldstein, and E. Betzig (2012). Noninvasive Imaging of 3D Dynamics in Thickly Fluorescent Specimens Beyond the Diffraction Limit. Cell (in press).
Tse, Y.C., M. Werner, K.M. Longhini, J.-C. Labbé, B. Goldstein and M. Glotzer (2012). RhoA activation during polarization and cytokinesis of the early C. elegans embryo are differentially dependent on NOP-1 and CYK-4. Molecular Biology of the Cell (in press).
Sullivan-Brown, J. and B. Goldstein (2012). Neural tube closure: The curious case of shrinking junctions. Current Biology 22:R574-R576.
Edgar, L.G. and B. Goldstein (2012). Culture and Manipulation of Embryonic Cells, in Caenorhabditis elegans: Cell Biology and Physiology, eds. Joel H. Rothman and Andrew Singson. Methods in Cell Biology, 107:151-176.
Werts, A.D., M. Roh-Johnson and B. Goldstein (2011). Dynamic localization of C. elegans TPR-GoLoco proteins mediates mitotic spindle orientation by extrinsic signaling. Development 138:4411-4422.
Werts, A.D. and B. Goldstein (2011). How signaling between cells can orient a mitotic spindle. Seminars in Cell and Developmental Biology 22:842-9.
Sawyer, J.M., S. Glass, T. Li, G. Shemer, N.D. White, N.G. Starostina, E.T. Kipreos, C.D. Jones, and B. Goldstein (2011). Overcoming Redundancy: an RNAi Enhancer Screen for Morphogenesis Genes in C. elegans. Genetics 188:549-564.
Roh-Johnson, M., J. Sullivan-Brown and B. Goldstein (2011) Roles for Actin Dynamics in Cell Movements during Development. Chapter in Actin-Based Motility, ed. M.-F. Carlier, Springer-London.
Harrell, J.R. and B. Goldstein (2011). Internalization of multiple cells during C. elegans gastrulation depends on common cytoskeletal mechanisms but different cell polarity and cell fate regulators. Developmental Biology 350:1-12.
Goldstein, B. (2011). Primer: Visualizing with ImageJ. Make 27:116-121. (This is a magazine article that introduces ImageJ to non-scientists, encouraging them to write new ImageJ plugins that can benefit science).
Arata, Y., J.-Y. Lee, B. Goldstein and H. Sawa (2010) Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo. Development 137:3337-3345.
Higgins C.D. and B. Goldstein (2010) Asymmetric Cell Division: A New Way to Divide Unequally. Current Biology R1029-31.
Sawyer, J.M., J.R. Harrell, G. Shemer, J. Sullivan-Brown, M. Roh-Johnson and B. Goldstein (2010) Apical constriction: A cell shape change that can drive morphogenesis Developmental Biology 341:5-19.
Roh-Johnson, M. and B. Goldstein (2009). In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation. Journal of Cell Science 122:3983-3993.
Goldstein, B. and H. Hamada (2009) Shape Meets Polarity in Japan. Development 136: 2487-2492.
McCarthy Campbell, E.K., A.D. Werts and B. Goldstein (2009) A Cell Cycle Timer for Asymmetric Spindle Positioning. PLoS Biology 7(4):e88.
Marston, D.J., M. Roh, A. Mikels, R. Nusse, and B. Goldstein (2008) Wnt signaling during Caenorhabditis elegans embryonic development. Methods in Molecular Biology 469:103-111.
Goldstein, B. and I. G. Macara (2007) The PAR Proteins: Fundamental Players in Animal Cell Polarization. Developmental Cell 13:609-622.
Gabriel, WN, R McNuff, SK Patel, TR Gregory, WR Jeck, CD Jones and B Goldstein (2007) The Tardigrade Hypsibius dujardini, a New Model for Studying the Evolution of Development. Developmental Biology 312: 545-559.
Gabriel, W.N. and B. Goldstein (2007) Segmental Expression of Pax3/7 and Engrailed Homologs in Tardigrade Development. Development Genes and Evolution 217: 421-433.
Marston, D.J. and B. Goldstein (2006) Symmetry Breaking in C. elegans: Another Gift from the Sperm. Developmental Cell 11: 273-274.
Lee, J.-Y.*, D.J. Marston*, T. Walston, J. Hardin, A. Halberstadt and B. Goldstein (2006) Wnt/Frizzled Signaling Controls C. elegans Gastrulation by Activating Actomyosin Contractility. Current Biology 16: 1986-1997. (*equal contributors)
Marston, D.J. and B. Goldstein (2006) Actin-based forces driving embryonic morphogenesis in C. elegans. Current Opinion in Genetics and Development 16: 392-398.
Goldstein B.*, H. Takeshita*, K. Mizumoto and H. Sawa (2006) Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity. Developmental Cell 10: 391-396. (*equal contributors)
McCarthy, E.K. and B. Goldstein (2006) Asymmetric Spindle Positioning. Current Opinion in Cell Biology 18: 79-85.
Nance, J., J.-Y. Lee and B. Goldstein (2005) Gastrulation in C. elegans, WormBook, ed. The C. elegans Research Community.
McCarthy, E.K. and B. Goldstein (2005) Asymmetric Division: A Kinesin for Spindle Positioning. Current Biology 15: R591-593.
Dudley, N.R., A.Z. Amin and B. Goldstein (2005) Genes Required for RNA Interference, pp 55-68, chapter in RNA Interference Technology: From Basic Science to Drug Development, edited by K. Appasani (Cambridge University Press).
Dudley, N.R. and B. Goldstein (2005). RNA Interference in C. elegans. Chapter in RNA Silencing: Methods and Protocols, edited by G. Carmichael (Humana Press), Methods in Molecular Biology 309:29-38.
Labbé, J.-C., E. McCarthy and B. Goldstein (2004). The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. The Journal of Cell Biology 167: 245-256.
Cheeks, R.J., J.C. Canman, W.N. Gabriel, N. Meyer, S. Strome and B. Goldstein (2004). C. elegans PAR Proteins Function by Mobilizing and Stabilizing Asymmetrically Localized Protein Complexes. Current Biology 14: 851-862.
Goldstein, B. (2003). Asymmetric Division: AGS Proteins Position the Spindle. Current Biology 13: R879-R880.
Labbé, J.-C., P.S. Maddox, E.D. Salmon, and B. Goldstein (2003). PAR proteins regulate microtubule dynamics at the cell cortex in C. elegans. Current Biology 13: 707-714.
Lee, J.-Y. and B. Goldstein (2003). Mechanisms of cell positioning during C. elegans gastrulation. Development 130: 307-320.
Dudley, N.R. and B. Goldstein (2003). RNA interference: Silencing in the cytoplasm and nucleus. Curr Opin Mol Ther 5:113-117.
Dudley, N.R., J.-C. Labbé, and B. Goldstein (2002). Using RNA Interference to Identify Genes Required for RNA Interference. PNAS 99:4191-4196.
Labbé, J.-C. and B. Goldstein (2002). Embryonic Development: A New SPN on Cell Fate Specification. Current Biology 12:R396-R398.
Goldstein, B. and M. Blaxter (2002). Tardigrades. Current Biology 12: R475.
Goldstein, B. (2001). On the Evolution of Early Development in the Nematoda. Phil Trans Royal Society B 356: 1521-31.
Goldstein, B., M. Leviten and D. A. Weisblat (2001). Dorsal and Snail homologs in leech development. Development Genes and Evolution 211: 329-337.
Goldstein B. (2000). The Professional Debunker (review of the book Voodoo Science: the Road from Foolishness to Fraud, by Robert L. Park), Nature Cell Biology 2:E212.
Goldstein, B. (2000). Embryonic polarity: A role for microtubules. Current Biology 10:R820-R822.
Goldstein, B. (2000). When cells tell their neighbors which direction to divide. Developmental Dynamics 218:23-29.
Goldstein, B., L. Frisse and W. K. Thomas (1998). Embryonic axis specification in nematodes: evolution of the first step in development. Current Biology 8: 157-160.
Wittmann, C., O. Bossinger, B. Goldstein, M. Fleischmann, R. Kohler, K. Brunschwig, H. Tobler and F. Müller (1997). The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity. Development 124: 4193-4200.
Goldstein, B. and G. Freeman (1997). Axis specification in animal development. BioEssays 19: 105-116.
Goldstein, B. and S. N. Hird (1996). Specification of the anteroposterior axis in C. elegans. Development 122: 1467-1474.
Goldstein, B. (1995). Cell contacts orient some cell division axes in the early C. elegans embryo. The Journal of Cell Biology 129: 1071-1080.
Goldstein, B. (1995). An analysis of the response to gut induction in the C. elegans embryo. Development 121: 1227-1236.
Goldstein, B., S. N. Hird, and J. G.White (1993). Cell polarity in early C. elegans development. Development 1993 Supplement: 279-287.
Goldstein, B. (1993). Establishment of gut fate in the E lineage of C. elegans: the roles of lineage-dependent mechanisms and cell interactions. Development 118: 1267-1277.
Goldstein, B. (1992). Induction of gut in Caenorhabditis elegans embryos. Nature 357: 255-257.
|Business address: The University of Texas at Austin||Business address: The University of Texas at Austin|
|Business address: The University of Texas at Austin||Business address: The University of Texas at Austin|
|Business address: The University of Texas at Austin||Business address: The University of Texas at Austin|
|M. A. English Literature, September 1988 Herbert Lehman College, City University of New York M. A. Thesis: “The Philosopher as Poet: The Early Writings of Henry More” Thesis advisor: Angus Fletcher B. A||No âmbito do protocolo entre e Estado Português e a University of Texas at Austin|
|Research Agency: Texas Tech University, Lamar University, University of Houston, and U. S. Geological Survey||Predoctoral Research Assistant: Agricultural University of Athens, Department of Food Science and Technology, Athens, Greece. (1988-1991 & 1992-1993)|