Professor of Pharmacology & Toxicology




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OTHMAN A. AL-SHABANAH , Ph. D.

Professor of Pharmacology & Toxicology

FORMER CHAIRMAN

Department of Pharmacology

College of Pharmacy

King Saud University

P.O. Box 2457,

Riyadh 11451, Saudi Arabia

Tel. 966-1-467 7179

Fax. 966-1-467 7200

e-mail: SHABANAH@KSU.EDU.SA


Publications (Papers in Refereed Scientific Journals):


  1. Al-Shabanah, O. and Blankenship, J.

Toxicology of N1-Acetylspermidine and N8-Acetylspermidine in Mice.

Proc. West. Pharmacol. Soc. 29: 141-144 (1986).


2. Pame Marchant, Sasi Dredar, Victor Manneh, Othman Al-Shabanah, Harry Matthews, David Fries, and Jim Blankenship.

A selective inhibitor of N8-Acetylspermidine deacetylation in mice and Hela cells without effects on histone deacetylation.

Archieves of Biochemistry and Biophysics 273(1): 128-136, 1989.


  1. Othman Al-Shabanah, M.M. Al-Harbi, Naji Mohammad A. Al-Gharably, and Mohammnad W. Islam.

The Effect of maternal administration of Captopril on fetal development in rat.

Research Communication in Chemical Pathology and Pharmacology 73(2): 22-229 (1991).


  1. H.A. Al-Sawaf, M.M. Al-Harbi, O.A. Al-Shabanah, N. Al-Gharably, and M.W. Islam.

Effects of some antibiotics and immunosuppressive drug on peripheral blood lymphocyte superoxide dismutase activity.

Medical Science Research 20: 125-126 (1992).


  1. M.M. Al-Harbi, Naji M. Al-Gharably, Othman A. Al-Shabanah, Abdullah M. Al-Bekairi, Abdel-Moneim Osman, and Hassan N. Tawfik.

Prevention of doxorubicin-induced myocardial and haematological toxicities in rats by iron-chelator desferrioxamine.

Cancer Chemotherapy and Pharmacology 31: 200-204 (1992).


6. M.M. Al-Harbi, Othman A. Al-Shabanah , Naji M. Al-Gharably and M. W. Islam.

The effect of maternal administration of Enalapril, an angiotensin converting enzyme inhibitor on fetal development in rat.

Research Communication in Chemical Pathology and Pharmacology 77(3): 347-358 (1992).


7. O.A. Al-Shabanah, N.A. Al-Gharably, M.W. Islam, M.M. Al-Harbi,

Effect of Cathinone, an active constituent of khat (Catha edulis Forsk.) and amphetamine on experimental ulcer and gastric secretion.

Medical Science Research 20: 817-819 (1992).


8. Othman A. Al-Shabanah.

Inhibition of Adriamycin induced micronuclei by Desferioxamine in Swiss albino Mice.

Mutation Research 301: 107-111 (1993).


9. Abdel-Moneim M. Osman, Othman A. Al-Shabanah, Mohamed M. Al-Harbi, Naji M. Al-Gharably, Abdullah M. Al-Bekairi, Hassan N. Tawfik and Saif A. Aziz.

Effect of desferrioxamine on doxorubicin-induced cardio- and haemato- toxicity in normal mice.

Medical Science Research 21: 193-194 (1993).

10. Abdullah M. Al-Bekairi, Abdel-Moneim M. Osman, Mohamed A. Hafeez, Naji M. Al-Gharably, Othman A. Al-Shabanah, and Mohammed M. Al-Harbi.

Effect of desferrioxamine (DFO) on the hepatotoxicity of adriamycin in normal mice.

Drug Development Research 29: 56-62 (1993).


11. N.M. Al-Gharably, A.M. Osman, O.A. Al-Shabanah, A.M. Al-Bekairi and M.M. Al-Harbi.

Potentiation of doxorubicin cytotoxicity by the calcium channel blocker verapamil in Ehrlich ascites cells.

Journal of Chemotherapy 39: 410-415 (1993) ==


12. Othman A. Al.Shabanah, M.W. Islam, N.M. Al-Gharably and M.M. Al-Harbi.

Effect of Khatamine and their enantiomers on aspirin, indomethacin, phenylbutazone and reserpine induced gastric ulcers in rats.

Research Communications in Substances of Abuse 14(1): 81-94 (1993).


13. O.A. Al-Shabanah, A.M. Osman, M.M. Al-Harbi, N.M. Al-Gharably, and A.M. Al-Bekairi.

Enhancement of doxorubicin-induced cytotoxicity by hyperthermia in Ehrlich ascites cells.

Chemotherapy 40: 188-194 (1994).


14. Othman A. Al-Shabanah, N.M. Al-Gharably, M.W. Islam & M.M. Al-Harbi.

Gastric antiulcer and cytoprotective effects of Cathinone, A psychoactive alkaloid of khat (Catha Edulis Forsk.) and amaphetamie in rats.

Regulatory Peptides (Supplement 1) S297-S299 (21 February, 1994).


15. M.W. Islam, O.A. Al-Shabanah, M.M. Al-Harbi, N.M. Al-Gharably.

Evaluation of Teratogenic Potential of Khat (Catha Edulis Forsk.) in rats.

Drug and Chemical Toxicology 17(1): 51-68 (1994).


16. A.M. Osman, O.A. Al-Shabanah, M.M. Al-Harbi, A.M. Al-Bekairi, N.M. Al-Gharably and M.A. Soliman.

Protective effect of desferrioxamine against adriamycin-induced lethality and nephrotoxicity in mice.

Journal of biomedical sciences and therapeutics 10(70): 97-112 (1994).


17. Y.H. Mostafa, O.A. Al-Shabanah, M.T. Hassan, A.A. Khairaldin and H.A. Al-Sawaf.

Modulatory effectsof N-acetylcysteine and alpha tocopherol on brain glutathione and lipid peroxides in experimental diabetic and endotoxin stressed rats.

Saudi Pharmacetutical Journal 2(2): 64-69 (1994).


18. M.Waseemul Islam and Othman A. Al-Shabanah.

Contraceptive Effect of Castor Beans

Letter to the Editor, Saudi Pharmaceutical Journal 2(4): 201 (1994).


19. O.A. Al-Shabanah, O.T. Ginawi and S.A. Al-Bakheet.

Effect of morphine dependence on spontaneous and drug-induced locomotor activity in mice.

Regulatory Peptides (Supplement I) 54(1) 354, (November, 1994).


20. M.M. Al-Harbi, M.W. Islam, O.A. Al-Shabanah and N.M. Al-Gharably.

Effect of acute administration of fish oil (Omega-3 Marine Triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.

Food and Chemical Toxicology 33(7): 553-558 (Feb 1995).

  1. Mohammed M. Al-Harbi, Abdel Moneim M. Osman, Naji M. Al-Gharably, Abdullah M. Al-Bekairi, Othman A. al-Shabanah, Dorrya M. Sabah and M. Raza.

Effect of Desferrioxamine on Cisplatin-induced Nephrotoxicity in Normal rats.

Chemotherapy 41: 448-454 (1995).


22. Othman A. Al-Shabanah, Abdel-Moneim M. Osman, Mohammed M. Al-Harbi, Abdullah M. Al-Bekairi, Naji. M. Al-Gharably and Saif A. Aziz.

Diltiazem potentiation of doxorubicin cytotoxicity and cellular uptake in Ehrlich Ascites carcinoma cells.

Chemotherapy 41: 368-377 (1995).


23. Othman A. Al-Shabanah, Abdel-Moneim M. Osman, Mohamed M. Al-Harbi, Naji M. Al-Gharably, Abdullah M. Al-Bekairi and Mehmoud M. El-Merzabani.

Effect of hyperthermia on the action of methotrexsate against the growth of Ehrlich ascites carcinoma cells.

Medical Science Research 24(4): 275-277 (1996).


24. A.M.M. Osman, S.T. Al-Sedairy, I.M. Moran Verbeek, O.A. Al-Shabanah, M.M. Al-Harbi, N.M. Al-Gharably and A.M. Al-Bekairi.

Verapamil enhancement of the antitumor effect of cis-diammionedichloro-platinum (II) in mice bearing Ehrlich ascites carcinoma cells.

Medical Science Research 24(6): 429-431 (1996).


  1. O.A. Al-Shabanah, Y.H. Mostafa, M.T. Hassan, A.A. Khairaldin and H.A. Al-Sawaf.

Vitamin E protects agasinst bacterial endotoxin-induced increase of plasma corticosterone and brain glutamate in the rat.

Research Communications in Molecular Pathology and Pharmacology 92: (1) 95-105 (1996).


26. N.M. Al-Gharably, M.W. Islam, M.M. Al-Harbi and O.A. Al-Shabanah.

Cathionone [(R)(+)-Alpha-Aminopropiophenone]: A potent anti-gastric ulcer agent.

Research Communication in Alcohol and Substances of Abuse 17(3&4):165-184 (1996).


27. O.T. Ginawi, O.A. Al-Shabanah and A.I. Bakheet.

Increased Toxicity of Methamphetamine in Morphine-dependent Mice.

Gen. Pharmacology 28(5): 727-731 (1997).

28. M.M. Al-Harbi, H.A. Al-Sawaf, O.A. Al-Shabanah, N.M. Al-Gharably, and M.W. Islam.

Gentamycin and Cyclosporine increase total soluble thiols in the plasma and lymphocytes of rats and perturb erythrocyte fragility.

Medical Science Research 25:155-157 (March, 1997).


29. O.A. Al-Shabanah.

Effect of evening primrose oil on Gastric ulceration and secretion iduced by various ulcergogenic and necrotizing agents in rats.

Food and Chemical Toxicology 35: 769-775 (1977).


30. Othman A. Al-Shabanah.

The influence of selenium on adriamycin-induced cytological and biochemical changes in Swiss albino mice.

Pharmacology Reviews and Communications 9: 229-236 (1997).


31. Othman A. Al-Shabanah.

Influence of captopril on spermatogenic dysfunction, spermatocyte chromosomes and dominant lethality in Swiss albino mice.

Research Communications in Pharmacology &Toxicology 2(1&2):69-84 (1997).


32. Naji M. Al-Gharably, Osama A. Badary, Mahmud N. Nagi, Othman A. Al-Shabanah, Hussain A. Al-Sawaf, Ammar C.Al-Rikabi and Abdullah M. Al-Bekairi.

Protective effect of thymoquinone against carbon tetrachloride-induced hepatotoxicityh in mice.

Research Communication in Pharmacology & Toxicology 2(1&2): 41-50 (1997).


33. Osama A. Badary, Mahmud N. Nagi, Othman A. Al-Shabanah, Hussain A. Al-Sawaf, Mohammed O. Al-Sohaibani and Abdullah M.Al-Bekairi.

Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.

Canadian Journal of Physiology & Pharmacology 75(12): 1356-1361

(1997).


34. O.A. Al-Shabanah, M.A. Mansour, M.N. Nagi, H.A. Al-Sawaf & A.M. Al-Bekairi.

Does Captopril scavenge superoxide radical.

Medical Science Research 25(12): 841-843 (1997).


35. A.M. Al-Obaid, H.I. El-Subbagh, O.A. Al-Shabanah and M.A. Mahran.

Synthesis and biological evaluation of new cyclopentenob[b] thiophene derivatives as local anesthetic and antiarrhythmic agents.

DiePharmazie 53: 24-28 (1998).


36. Othman A. Al-Shabanah, Osama A. Badary, Mahmoud N. Nagi, Nagi M. Al-Gharably, Ammar C. Al-Rikabi and Abdullah M. Al-Bekairi.

Thymoquinone protect against doxorubicin-Induced cardiotoxicity without compromising its antitumor activity.

Journal of Experimental & Clinical Cancer Research 17(2): 193-198 (1998).


37. O.A. Al-Shabanah, O.T. Ginawi and A.I. Bakheet.

Some effects of sulpiride in morphine dependent mice.

Medical Science Research 26(2): 107-109 (1998).


38. H.A.El-kashef, M.A.Mansour, M.N. Nagi, Othman A. Al-Shabanah, H.A. Al-Sawaf and A.M. Al-Bekairi.

Effects of calcium ionophore-stimulated white blood cells and platelets on isolated rabbit pulmonary artery.

Medical Science Research 26:167-171(1998).


39. Othman A. Al-Shabanah

Effect of Magnesium sulphate on adriamycin- induced clastogenic and

biochemical changes in Swiss albino mice.

Chemotherapy 44:272-283(1998). ===


  1. H.A.El-kashef, O. Badary, M.M. El- Mazar, Othman A. Al-Shabanah, and A.M. Al-Bekairi.

Effects of Ehrilich Ascites Carcinoma Cells on the response on non- pregnant and pregnant uterine smooth muscles of mice to oxytocin and Acetylcholine.

Journal of Experimental and Clinical Cancer Research 17(3):1-4(1998).



  1. Othman Al-Shabanah, Mahmoud Mansour, Hassan El-Kashef and Abdullah Al-Bekairi.

Captopril Ameliorates myocardial and hematological toxicities induced by adriamycin.

Biochem. Mol. Biol. Intl. 45(2) 419-427 (1998).

  1. Osama A. Badary, Othman A. Al-Shabanah, Mahmoud N. Nagi, Abdullah .M. Al-Bekairi, and Mohamed M. El- Mazar.

Acute and Subchronic toxicity of thymoquinone in mice.

Drug Development Research 44:56-61(1998).

  1. Othman A. Al-Shabanah, Osama A. Badary, Nagi M. Al-Gharably, and Hussein A. Al-Sawaf.

Effects of L-Histidinol on the Antitumor Activity and Acute Cardiotoxicity of Doxorubicin in Mice.

Pharmacological Research 38(3): 225-230 (1998)


  1. Badary OA, Al-Shabanah OA, Al-Gharably NM, ElMazar MM.

Effect of cremophor EL on the pharmacokinetics, antitumor activity and

toxicity of doxorubicin in mice.

Anticancer Drugs 9(9):809-815 (Oct 1998)


  1. El-kashef H, Elmazar MM, Al-Shabanah OA, Al-Bekairi AM.

Effect of Adenosine on pulmonary circulation of rabbits

General Pharmacology 32(3):307-313 (Mar 1999).


46. Mahmoud A. Mansour, Hassan El-Kashef and Othman Al-Shabanah.

Effect of captopril on doxorubicin-induced nephrotoxicity in normal rats.

Pharmacological Research 39(3):233-237 (1999).


  1. O.A. Al-Shabanah and M.Raza

Effect of ulceration on rat gastric tissue polyamine contents in response to

Different procedures: inhibition of these effects by cimetidine.

Pharmacological Research 40(1):75-82 (1999)


48. Mahmoud N. Nagi, Khurshid Alam, Osama A.Badary, Othman A.

Al-Shabanah, Hussein A. Al-Sawaf and Abdullah M. Al-Bekairi.

Thymoquinone protective against carbon tetrachloride hepatotoxicity in

mice Via an antioxidant mechanism

Biochemistry and Molecular Biology International 47(1):153-159 (1999)


49. K. Alam, M. N. Nagi, , O. A.Badary, O. A. Al-Shabanah, A.C.Al-Rikabi,

and A. M. Al-Bekairi.

The protective action of Thymol against carbon tetrachloride

hepatotoxicity in Mice.

Pharmacological Research 40(2):159-163 (1999)


50. Othman A. Al-Shabanah, Khurshid Alam, Mahmoud N. Nagi, Ammar C.

Al-Rikabi, and Abdullah M. Al-Bekairi.

Protective effect of aminoguanidine, A nitric oxide synthase inhibitor,

against carbon tetrachloride induced hepatotoxicity in mice.

Life Sciences 66(3):265-270( 1999)


51. Osama A. Badary, Othman A. Al-Shabanah, Mahmoud N. Nagi, A.C.

Al- Rikabi, and Mohamed M. El- Mazar

Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice

by thymoquinone.

European Journal of cancer prevention 8:255-260 (1999)


52. Kamal E.H. ElTahir, Othman A. Gubara, Othman A. Al-Shabanah.

The Orphan Drug Riluzole: A Glimpse of Hope in the Treatment of

amyotrophic Lateral Sclerosis.

Saudi Pharmaceutical Journal 7(4): 228-233 (1999)


53. Raza M, AL-Shabanah O.A, Al-Bekairi A.M, N.M, Qureshi S.

Pathomorphological changes in mouse liver and kidney during prolonged

Valproate administration.

Int.J. Tissue React. XXI(3):27-34 (1999)


54. Abdulrahman M. Al-Obaid, Hussein I. El-Subbagh, Othman A. Al-

Shabanah, and Mohamed M. Elmazar.

Synthesis and Anticonvulsant Activity of Some I-Substited –2-

oxopyrrolidine Derivatives, II.

Med Chem Res 9 (9): 696-721 (1999)


55. Abdullah M. Al-Bekairi, Khurshid Alam, Mahmoud N. Nagi, Hussein A. Al-

Sawaf, Othman A. Al-Shabanah, and Ammar C. Al-Rikabi.

Coenzyme Q10 Ameliorates the hepatic toxcity induced by carbon tetrachloride

in Mice.

Research Communications in Pharmacology and Toxicology 4(3&4): 163-

170(1999)


56. Al-Shabanah OA, Mansour MA, Elmazar MM.

Enhanced generation of leukotriene B4 and superoxide radical from calcium

ionophore (A23187) stimulated human neutrophils after priming with

interferon-alpha.
Res.Commun. Mol. Pathol. Pharmacol. 106(1-2):115-28: (1999)


57. Adel M. Mostafa, Mohmoud N.Nagi, Othman A. Al-Shabanah and

Hassan A.El-Kashef .

Protective effect of Aminoguanidine against cardiovascular toxicity of

chronic doxorubicin treatment in rats.

Res.Commun. Mol. Pathol. Pharmacol. 106(3):193-202:1999


58. Othman A. Al-Shabanah, Hassan El-Kashef, Osama A. Badary, Abdullah

M. Al- Bekairi, and Mohamed M. El- Mazar

Effect of streptozotocin-induced hyperglycemia on intravenous

pharmacokinetics and acute cardiotoxicity of doxorubicin in rats.

Pharmacological Research 41(1):31-37(2000)


59. A.M. Mostafa, M.N. Nagi, O.A. Al Shabanah and H.A.El-Kashef

Effect of aminoguanidine and melatonin on the response of isolated urinary

bladder to acetylcholine in normal and diabetic rats.

Medical Science Research 28:33-37 (2000)


60. S.Qureshi, O.A. AL-Shabanah, A.M.Al-Bekairi, M.M. AL-Harbi,

N.M.AAl-Gharably and M. Raza.

Studies on the cytoxic, biochemical and Anti-carcinogenic potentials on

ninhydrin on Ehrlich Ascites Carcinoma cell-bearing swiss albino mice.

Investigational New Drugs 18 (3): 221-230 (2000)


61. O.A. AL-Shabanah, M. Raza, M.M. AL-Harbi, A.M.Al-Bekairi, N.M. Al-

Gharably, and S.Qureshi.

Effect of ninhydrin on the biochemical and histopathological changes

induced by ethanol in gastric mucosa of wistar rats.

Life Sciences 67:559-566 (2000)


62. O.A. AL-Shabanah, S.Qureshi, M.M. AL-Harbi A.M.Al-Bekairi, N.M. Al-

Gharably, and M. Raza.

Inhibition of gastric mucosal damage by methylglyoxal pretreatment in rats.

Food and chemical Toxicology 38:577-584 (2000)


63. Raza M., AL-Shabanah O. A., AL-Bekairi A.M., Qureshi S.

Pathomorphological changes in mouse liver and kidney during prolonged

valporate administration.

INT.J.TISSUE REACT. 22 (1) 15-22 (2000)


64. Muhammed Raza, Othman A. Al- Shabanah, Mohammed M. Al-Harbi,

Tarig M.H. El-Hadiyah, Shoeb Qureshi.

Antinociceptive activity of vigabatrin in mice.

Saudi Pharmaceutical Journal 8(4): 164-174 (October 2000)


65. M. Raza, O. A. Al- Shabanah, T.M.H. El-Hadiyah and S. Qureshi.

Thermoregulatory and In-vivo Anti-inflammatory effects of Vigabatrin in rat

and mice.

Scientia Pharmazeutica (Sci.Pharm) 68: 379-388(2000)


66. El.khatib A S, Moustafa A M, Abdel-ziz A H, Al-Shabanah O A, El-Kashef

H A.

Effect of aminoguanidine and desferriaxamine on some vascular and

biochemical change with sreptozocin-induced hyperglycemia in rats.

Pharmacological Research 43(3):233-240 (2001)


67. Kamal E.H. ElTahir and Othman A. Al-Shabanah

Malaria: With Special Stress on Plasmodium Falciparum Resistance to

Chloroquine and its Reversal.

Saudi Pharmaceutical Journal 9(3-4): 136-151 (October 2001)


68. S.Qureshi, O.A. AL-Shabanah, M.M. AL-Harbi, A.M.Al-Bekairi, M. Raza.

Boric acid enhances in vivo Ehrlich ascites carcinoma cell proliferation in

Swiss albino mice.

Toxicology 165: 1-11(2001)


69. Muhammed Raza, Othman A. Al- Shabanah, Tarig M.H. El-Hadiyah,

Abdullah M.Al-Bekairi, Shoeb Qureshi.

Antinociceptive activity of vigabatrin in mice after prolonged treatment:

Possible development of tolerance.

Scientia Pharmazeutica (Sci. Pharm) 69: 203-210 (2001)


70. Aiman S. El-Khatib, Adel M. Moustafa, Abdel-Aziz H. Abdel-Aziz,

Othman A. Al-Shabanah and Hassan A. El-Kashef.

Ginkgo Biloba Extract (EGb 761) Modulates Bleomycin-induced acute lung

injury in rats.

Tumori, 87: 417-422, 2001


71. Khurshid Alam, Manmoud N. Nagi, Othman A. Al-Shabanah, and

Abdullah M. Al-Bekairi.

Beneficial effect of nitric oxide synthase inhibitor on hepatotoxicity induced

by allyl alcohol.

Journal of Biochemical and Molecular Toxicology 15(6): 317-321 (2001)

72. Muhammed Raza, Othman A. Al- Shabanah, O.Y.Mohmmed and Tarig

M.H. El-Hadiyah.

Vigabatrin: Effect on central responses, functional Integrity and

pshcophysical performance in experimental models of stress and Anxiety.

Pharmacology Reviews and Communication, 11(4):275-284(2001)


73. Mansour MA, Ginawi OT, El-Hadiyah T, El-khatib AS, Al-Shabanah OA,

Al-Sawaf HA.

Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-

Induced hepatotoxicity in mice: evidence for antioxidant effects of

thymoquinone.

Res Commun Mol Pathol Pharmacol. 110(3-4): 239-251(2001)


74. Ali M. Gado, Mahmoud N. Nagi and Othman A. Al-Shabanah

Protective effect of thymoquinone and aminoguanidine a gainst paraquat

induced Cardiotoxicity: Possible role of nitric oxide synthase.

Mansoura J. Forensic Med. Clin. Toxicol 9 (1): 53-67(2001)


75. Al-Majed AA, Daba MII, Asiri YA, Al-Shabanah OA, Mostafa AA. and

Hassan A. El-kashef.

Thymoquinone-induced relaxation of guinea-pig isolated trachea.

Res Commun Mol Pathol Pharmacol 110(5-6):333-345(2001)


76. M.Khatab, Othman A. Al-Shabanah and H. El-Kashef

Comparative study of the contractile activity evoked by ATP and

diadenosine tetraphosphate in isolated rat urinary bladder.

Pharmacological Research 45(2):93-99 (2002)


77. O.A. AL-Shabanah, M.M. AL-Harbi, A.M.Al-Bekairi, M. Raza and

S.Qureshi.

A study of boric acid pretreatment on the protection of gastric mucosa

against toxic damage in wistar albino rats.

Arab Journal of Pharmaceutical Sciences 2(1): 11-26(2002)


78. Othman A. Al- Shabanah and Muhammed Raza

Vigabatrin Induced Hypothermia and Antipyrexia: Involvement of GABAA

Receptors

Pharmacology Review and Communications, 12: 25-37(2002)


79. Raza M, Al-Shabanah O A, El-hadiyah TM, Al-Majed AA

Effect of prolonged vigabatrin treatment on hematological and biochemical

parameters in plasma, liver and kidney of Swiss albino mice.

Scientia Pharmaceutica 70:135-145 (2002)


80. M. Mansour, T. El-Hadiayah, O.Ginawi, A. Mostafa, A. Al-Majed and

O. Al-Shabanah.

The Beneficial Interaction between Enalapril and Danazol in normal Rat.

Scientia Pharmaceutica 70:165-175 (2002)


81. Abdulhakeem A. Al-Majed , Adel M. Mostafa , Ammar C. Al-Rikabi,

Othman A. Al-Shabanah

Protective effects of oral Arabic gum administration on gentamicin- induced

nephrotoxicity in rats.

Pharmacological Research 64(5):445-451 (2002)


82. Mahmoud A. Mansour, Adel M. Mostafa, Mahmoud N. Nagi, Mahmoud M.

Khattab, Othman A. Al-Shabanah

Protective effect of aminoguanidine against nephrotoxicity induced by

cisplatin in normal rats.

Comparative Biochemistry and Physiology 132 (2):123-128 (2002)


83. Mohamed H. Daba, Abdek-Aziz H. Abdel-Aziz, Adel M. Moustafa,

Abdulhakeem Al-Majed, Othman A. Al-Shabanah and Hassan A. El-Kashef.

Effect of L-Carnitine and Ginko biloba Extract (Egb 761) in experimental

bleomycin- induced lung fibrosis.

Pharmcological Research 45:(6)461-467(2002)


84. Mahmoud A. Mansour, Fahad I. Al-Jenoobi, Saleh A. Al-Suwayeh,

Abdulhakeem A.Al-Majed and Othman A. Al-Shabanah

Formation of leukotrienes from calcium Ionophore-A23187 Stimulated

rabbit, rat and mice white blood cells.

Scientia Pharmaceutica 70:233-243 (2002)


85. Adel. Mustafa, Ali.M. Gado, O.A. Al-Shabanah and A.M. Al-Bekairi

Protective effect of aminoguanidine against paraquat-induced oxidative

stress in the lung of mice.

Comparative Biochemistry and Physiology 132:391-397 (2002)


86. Mahmoud M. Khattab, Adel M. Moustafa, Othman A. Al-Shabanah and

Aiman S. El-khatib

Involvement of nitric oxide in carbon tetrachloride-induced acute

hepatotoxicity in mice.

Research Communication in Pharmacology and Toxicology 7(1&2)53-

64(2002)


87. Mahmoud N. Nage, Mahmoud A. Mansour, Othman A. Al-Shabanah and

Hassan A. El-kashef

Melatonin Inhibits the contractile effect of Vanadate in the isolated

pulmonary arterial rings of rats: possible role of hydrogen peroxide.

J Biochem Molecular Toxicology 16: 273-278 (2002)


88. Abdulhakeem A.Al-Majed, Ali M. Gado, Othman A. Al-Shabanah and

Mahmoud A. Mansour

Alpha-Lipoic acid ameliorates myocardial roxicity induced by doxorubicin.

Pharmacological Research 46(6): 499-503(2002)


89. Adel RA Abd-Allah, Abdulhakeem A. Al-Majed, Adel M. Mostafa,

Othman A. Al-Shabanah, Ayman Gamal El Din and Mahmoud N. Nagi.

Protective Effect of Arabic Gum Against cardiotoxicity induced by

doxorubicin in mice: A possible mechanism of protection.

J Biochem Molecular Toxicology 16(5): 254-259 (2002)


90. Mahmoud A. Mansour and Othman A. Al-Shabanah

Enhanced generation of Leukotriene B4 from calcium ionophore-stimulated

rat peritoneal inflammatory cells: a possible clinical relevance.

Current Drug Targets- Inflammation & Allergy 2:47-52 (2003)

91. M. Raza, M. Ahmed, A. Gado, O.A. Al-Shabanah

A comparison of hepatoprotective activities of aminoguanidine and N-

acetylcysteine in rat against the toxic damage induced by azathioprine.

Comparative Biochemistry and Physiology Part C 134:451-456 (2003)


92. Al-Majed AA, Abd-Allah AR, Al-Rikabi AC, Al-Shabanah OA, Mostafa

AM.

Effect of oral administration of Arabic gum on cisplatin induced

nephrotoxicity in rat.

J Biochem Mol Toxicol. 17(3): 146-153 (2003)


93. Raza M, Al-Shabanah OA.

Effect of vigabatrin on contractile response to arachidon acid and

prostaglandis in smooth muscle preparation and platelet aggregation in

experimental laboratory animals.

Pharmacol Res. 47(6):477-483(2003)


94. Mahmoud A. Mansour, Othman A. Al-Shabanah and Hassan A. El-

khashef.

L-Arginine Ameliorates kindeny function and urinary bladder sensitivity in

Experimentally- induced renal dysfunction in rats.

Journal of Biochemistry and Molecular Biology 36(4):373-378(2003)


95. A.A. Al-Majed , M. Khattab, M. Raza, O. A. Al-Shabanah and A.M.

Mostafa

Potentiation of diclofenac-induced anti-inflammatory response by

aminoguanidine in

carrageenan-induced acute inflammation in rats: The role of nitric oxide.

Inflamation Research 52 (9): 378-382 (2003)


96. Gamal el-din AM, Mostafa AM, Al-Shabanah OA, Al-Bekairi AM, Nagi

MN.

Protective effect of Arabic gum against acetaminophen-induced

hepatotoxicity in mice.

Pharmacological Research 48(6):631-635 (2003)


97. Mahmoud A. Mansour, Aymen Gamal , Mahmoud Nagi, Othman Al-

Shabanah, and Abdullah Al-Bekairi .

Nomega-nitro-L-arginine Methylester Ameliorates Myocardial Toxicity

Induced by Doxorubicin.

Journal of Biochemistry and Molecular biology. 36(6):593-596(2003)


98. Adel RA Abd-Allah, Ali M. Gado, Abdulhakem A. Al-Majed, Abdulaziz A.

Al-Yehia and Othman.A. Al-Shabanah.

Protective effect of taurine against cyclophosphamide -induced urinary

bladder toxicity in Rats.

Clin Exp Pharmacol Physiol 31:167-172 (March 2004)


99. Mobasher Ahmad, O.A. Al-Shabanah

A comparative study on the in vitro hepatic metabolism of retinoic acid

using different species.

Scientia Pharmaceutica (Sci.Pharm) 72:265-274 (2004)


100. Mahmoud Khattab, Mobasher Ahmad, Othman A. Al-Shabanah and

Muhammad Raza

Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite

levels in the Nitric oxide deficient hypertensive rats

Receptors and Channels. 10:147-157 (2004)


101. Mahmoud Khattab, Tarig M. El-Hadiyah, Othman A. Al-Shabanah and

Muhammad Raza.

Modification by L-Name of codeine induced analgesia: Possible role of

Nitric Oxide

Receptors and Channels. 10:139-145(2004)


102. Adel R. A. Abd-Allah, Abdulhakeem A. Al-Majed, Abdel, Abdulaziz Al-

yaha, Soliman I. Fouda and Othman A. Al-Shabanah.

L- Carnitine halts apoptosis and myelsuppression induced by carboplatin in

rat bone marrow cell culture.

Archives of Toxicology. 79:406-413 (2005)


103. Abdulhakeem A. Al-Majed, Abdulaziz A. Al-Yahya, A.M.Al-Bekairi,

O.A.Al-Shabanah and S. Qureshi

Genetic and biochemical effects of Ginko biloba on somatic and germ cells

of mice

Saudi Pharmaceutical Journal 13(4):149-158 (2005)


104. Mahmoud M. Khattab, Adel Mostafa and Othman A. Al-Shabanah.

Effect of captopril on cardiac and renal damage, and metabolic alterations

in the nitric oxide-deficient hypertensive rat.

Kidney Blood Pressure Research 28:243-250 (August 2005)


105. Abdulrahman M. Al-Obaid, Hassan A. Frag, Ashraf A. Khalil, Othman A.

Al-Shabanah, Sami G. Abdel Hamide, Hassan A. El-kashef, Hassan

S.Ahmed, Ahmed M.Al-Affifi, Elrasheed A. Gadkariem, Hussen I. El-

Subbagh.

Synthesis and investigation of novel shelf-stable, brain-specific chemical

delivery system.

Saudi Pharmaceutical Journal 14(1) 1-15 (January 2006)


106. Abdulhakeem A. Al-Majed, Mohamed M. Sayed-Ahmed, Abdulaziz A.

Al-Yahya, Abdulaziz M. Aleisa, Salim S. Al-Rejaie, Othman A.Al-

Shabanah

Propionyl-L-carnitine prevents the progression of cisplatin-induced

cardiomyopathy in a carnitine-depleted rat model.

Pharmacological Research 53:278-286(2006)


107. Amr Darwish Mariee and Othman Al-Shabanah

Protective ability and binding affinity of captopril towards serum albumin

in an in vitro glycation model of diabetes mellitus.

Journal of Pharmaceutical and Biomedical Analysis 41: 571-575 (2006)


108. Abdulhakeem A. Al-Majed, Abdulaziz A. Al-Yahya, A.M.Al-Bekairi,

O.A.Al-Shabanah and S. Qureshi

Reproductive, cytological and biochemical toxicity of Yohimbe in male

swiss albino mice

Asian Journal of Andrology 80: 1-8 (2006)


109. Omer T. Ginawi, Othman A. Al-Shabanah, Abdulrahman M. Al-

Matroudi and Tarig M.H. El-Hadiyah

Effect of valproic acid on food intake and nociception in morphine-

dependent mice

Saudi Pharmaceutical Journal 14(3,4): 149-154 July-October (2006)


110. Abdulhakeem A. Al-Majed, Abdulaziz A. Al-Yahya, A.M.Al-Bekairi,

O.A.Al-Shabanah and S. Qureshi

Studies on the cytological and biochemical effects of valerian in somatic

and germ cells of Swiss albino mice

Food and chemical toxicology 44: 1830-1837 (2006)


111. Abdulaziz A. Al-Yahya, Abdulhakeem A. Al-Majed, A.M.Al-Bekairi,

O.A. Al-Shabanah and S. Qureshi

Studies on the reproductive, cytological and biochemical toxicity of Ginkgo

Biloba in Swiss albino mice.

Journal of EthanoPharmacology 107:222-228 (2006)


PUBLICATION (Abstracts):


1. Blankenship, J. and Al-Shabanah, O.

Toxicology of N1-Acetylspermidine and N8-Acetylspermidine in Mice.

Fed. Pro.42. Abstract, No. 7625 (1982).


2. Al-Shabanah, O. and A Blankenship, J.

Increases in Polyamine Levels in Mousse Spleen during Hematopoiesis

Induced by Phenylhydrazine.

Fed. Proc. 72. Abstract No: 7362 (1988).


3. O.A. Al-Shabanah, N.M. Al-Gharably, M.W. Islam and M.M. Al-Harbi.

Gastric Antiulcer and Cytoprotective Effects of Cathinone,A Psycoactive

Alkaloid of khat and Amphetamine in Rats.

International Narcotics Research Conference, July 10-15, Skovde, Sweden*.


4. Othman A. Al-Shabanah

Teaching of Clinical Pharmacy in the College of Pharmacy, King Saud

University, Riyadh, Saudi Arabia.

Expert Meeting on the Role of Clinical Pharmacology in Medical and

Pharmacy Curricula. November 19-21, 1993, Ismailia, Egypt.*


5. O.A. Al-Shabanah, O.T. Ginawi and S.A. Al-Bakheet.

Effect of Morphine Dependence on Spontaneous and Drug-induced

Locomotor activity in mice.

I nternational Narcotics Research Conference (INRC). July 16-21, 1994,

North Falmouth,

MA, USA.*


6. Othman A. Al-Shabanah

Continuing Pharmaceutical Education in Saudi Arabia. National symposium

“Continuing Medical Education is it necessary or luxury? Proceedings, King

Fahad

Hospital, Buraidah, Saudi Arabia. 8/8/1416 H (30/12/1995 AD).


7. Othman A. Al-Shabanah ,Osama A. Badary, , H.A. El-Kashef,Abdullah .M.

Al-Bekairi, and Mohamed M. El- Mazar.

Pharmacokinetics and acute Cardiotoxicity of doxorubicin after intravenous

administration to rats with streptozotocin- induced diabetes mellitus.

Experimental Biology 98, Abstracts Part I, Abstract NO:2384, San Francisco,

California,USA, April 18-22, 1998 , Published in: the FASEB Journal 12(4):

March 17,1998


8. O. A. Al-Shabanah, O.T. Ginawi and S.A.Bakheet.

Some central effects of Apomorphine in morphine dependent mice.

Archives of Pharmacology, Suppl 1 Vol 358(1):95 (1998).

Munchen, Germany 3-8/4/1419 H (26-31/7/1998 AD)


9. Othman A. Al-Shabanah and Mahmoud A Mansour

Enhanced Generation of Leukotriene B4 and Superoxide Radical From

Human Polymorphnuclear after Priming with Interferone-Alpha.

Experimental Biology 99, Abstracts Part I, Abstract NO: 153.23,

Washington, DC., USA, April 17-21, 1999 , Published in: the FASEB Journal

13(4): March 12,1999


10. O.A. Al-Shabanah and M.Raza

Simultaneous determination of differential polyamines and their mono-

Acetylated derivatives in gastric tissue by HPLC with post-column

derivatization

AAPS annual meeting, New Orleans, LA. November 14-18,1999, Abstact

No: 4015


11. O. A. AL-Shabanah, K.S.O. AL-Khanbashi, M.N.Nagi

Aminoguanidine, a nitric oxide synthase inhibitor, protects against acute doxorubicin myocardial toxicity in mice

VII Word Conference on Clinical Pharmacology and Therapeutics,

Florence, Italy, July

15-20, 2000, Abstact No: 890


12. Othman A. Al-Shabanah and Hussen Al-Swaf.

Developing of the Mechanism of Application of the Study Plan for the

Master Programs in the Department of Pharmacology.

The Graduate Study Symposium in the Saudi University. Abstract book,

King Abdulaziz University, Jeddah , Saudi Arabia, 16-18/4/2001


13. O. Al-Shabanah, T. El-Hadiyah and M. Mansour

Effects of volatile oil constituents of Nigella Sativa against carbon tetrachloride-

induced hepatotoxicity in mice: Evidence of antioxidant effects of ip

administration of thymoquinone.

Abstracts of the IX th International Congress of Toxicology,

Brisbane,Australia 8-12/7/2001

Toxicology 164(1-3):1-266 (2001)


14. Othman A. Al-Shabanah and Muhammad Raza.

Estimation of histamine and endogenous polyamines in gastric tissue extracts by

HPLC using post-column derivatization: assessment of gastric ulcer recovery status.

AAPS PharmSci Supplement 3(3) 2001 (NA)


15. Othman A. Al-Shabanah

Continuing pharmaceutical education in Saudi Arabia: Past and present “ Saudi

pharmaceutical society experience”

Abstracts of The 3rd KFMMC International Pharmacy Conference: Future

Trends.

Dhahran, Saudi Arabia 15-17/10/2002


16. Othman A. Al-Shabanah

Priorities of Health Research in the kingdom of Saudi Arabia.

Abstract submitted to:Consultative Meeting on Priorities of Health Research.

Health Ministers Council for GCC States and Global Forum for Health

Research.

Abu-Dhabi 20-21/9/2003 (23-24/7/1424 H)

17. Othman A. Al-Shabanah, Omar T. Ginawi. Abdulrahman I. Al-Matroudi


Increased toxicity of valproic acid and vigabatrin in morphine dependent

mice.

Abstracts of the X th International Congress of Toxicology, Tampere, Finland

11-15/7/2004

The premier International journal in Toxicology 197(3):182 (June 15,2004)


18. Othman A. Al-Shabanah,

Status of Saudi Pharmaceutical Publication: Present and Future: Abstract

submitted to the Second Regional Conference on Medical Journal in the

WHO Eastern Mediterranean Region 10-12/10/ 2004.


19. Abdulaziz A. Alyaha , Abdulhakeem A. Al-Majed, Othman A. Al-

Shabanah ,

Effect of Ginkgo biloba on reproductive function in male swiss albino mice.

Experimental Biology 2005, Abstract NO: LB337, San Diego, CA , USA,

March 31- April 2005


20. Abdulaziz A. Alyaha , Abdulhakeem A. Al-Majed, Othman A. Al-

Shabanah ,

Studies on the cytological and biochemical effects of Valerian in somatic

and germ cells of swiss albino mice.

Experimental Biology 2005, Abstract NO: LB316,San Diego, CA , USA,

March 31- April 5 (NA)


21. Othman A. Al-Shabanah, A.A. Al-Majed Abdulaziz A.A. Alyaha ,

A.M.Al-Bekairi and S.Qureshi.

Studies on the genetic, reproductive and biochemical toxicity of yohimbine

in swiss albino mice.

Toxicology letters 158 supplement S101 (2005): Abstract of the 42nd

Congress of the European societies of toxicology. Eurotox 2005 Cracow,

Poland September 11th- 14th 2005.


22. Othman A. Al-Shabanah, A.M.Al-Bekairi, A.A. Al-Majed Abdulaziz A.A.

Alyaha ,and S.Qureshi.

Studies on the genetic and biochemical effects of Ginko Biloba in somatic

and germ cells of swiss albino mice.

Toxicology letters 158 supplement S102 (2005): Abstract of the 42nd

Congress of the European societies of toxicology. Eurotox 2005 Cracow,

Poland September 11th- 14th 2005.


23. Othman A. Al-Shabanah, Abdulhakeem A. Al-Majed, Abdulaziz A. Al-

Yahya, Abdulaziz M. Aleisa , Salem Al-Regay and Mohamed M. Sayed-

Ahmed.

Propionyl-L-carnitine prevents The Progression of Cisplatin-Induced

Cardiomyopathy in a Carnitine-Depleted Rat Model.

Experimental Biology 2006, San Francisco, CA , April 1-5

The FASEB Journal 20 (4): A 234 (2006), Abstract NO: 164.23 (NA)


24. Al-Shabanah Othman, Al-majed A, Al-Yahya A, Aleisa A.Al-Regay S,

Sayed-Ahmed M

Propionyl- L- carnitine prevent the progression of cisplatin- induced

cardiomyopathy in Carnitine –depleted rat model.

XV th Word Congress of Pharmacology, Beijing, China, July 2-7, 2006

Acta Phamaclogica Sinica, Supplement 1: 1-489 (July 2006)


25. A.M.Aleisa, M. Sayed-Ahmed, F.Al-Omar, A. Al-Yahya, O. Al-Shabanah,

S. Al-Rejaie, A. Al-Majed.

Carnitine esters prevents oxidative stress damage and energy depletion

following transient forebrain ischemia in rat hippocampus.

Neuroscience 2006, Atlanta, Georgia, USA. October 15, 2006





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