This is a list of Bachelor courses in English from the study programme (Medical) Biology at the Radboud University Nijmegen for the study year 2012-2013




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НазваниеThis is a list of Bachelor courses in English from the study programme (Medical) Biology at the Radboud University Nijmegen for the study year 2012-2013
Дата17.10.2012
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This is a list of Bachelor courses in English from the study programme (Medical) Biology at the Radboud University Nijmegen for the study year 2012-2013.

The programme is not yet confirmed, but we don’t expect major changes.


NWI-BB017C Biochemistry and molecular biology II

Coordinator: Dr. H. Pluk, h.pluk@ncmls.ru.nl

6 ec, September 3 –November 9, on Mondays and Tuesdays


Subjects

  • DNA structure, replication, recombination and repair

  • Regulation of transcription in prokaryotes and eukaryotes

  • Process of transcription in eukaryotes

  • Cell autonomous control of the cell cycle

  • Cancer


Literature

  • Lodish et al.: Molecular Cell Biology, 6th edition (Freeman and Company, New York, 2007), ISBN: 9781429203142, costs: € 70

  • Hand-outs and more additional information through Blackboard


Additional

Students are going to take part in the Journal Club. Enrollment in the JC happens through KISS or trough the teacher.


NWI-BB043B Genome analysis of plants

Coordinator: Dr. J. Peters, jl.peters@science.ru.nl

6 ec, September 3 –November 9, on Mondays and Tuesdays


Subjects

  • General structure of the genome: the chromosomes

  • General structure of the gene

  • Recombination: why and how

  • Localization of genes in the genome; genetic maps

  • Induction and identification of mutations

  • Forward genetics: how to identify the gene responsible for a mutant fenotype

  • Reverse genetics: how to mutagenize a specific sequence with the goal to analyse the function of that sequence

  • How to identify (all) genes that are part of a certain process

  • The development of gene families and the consequences for functional diversification


Literature

All necessary information will be distributed through Blackboard


NWI-BB081B Cognitive Neuroimaging
Coordinator: Dr. C.F.A. Döller, c.doeller@donders.ru.nl
6 ec, February 4 – April 12, on Thursdays and Fridays      



Subjects

  • General anatomical and functional organisation of the brain;

  • Types of neuronal signals, the way they are generated, and how they can be measured by neuroimaging techniques;

  • Synchronized brain activity (neuronal oscillations), how it can be analysed, and its relation to cognitive functions;

  • Connectivity between brain regions, how this can be investigated, the difference between the different types of connectivity, and their use and limitations for cognitive research;

  • Presenting and assessment of scientific work.


 Literature
All literature information will be distributed during the lectures and through Blackboard

 


NWI-BB039C Neurodevelopment

Coordinator: Dr. S. Kolk, s.kolk@ncmls.ru.nl

6 ec, September 3 – November 9 , on Thursdays and Fridays


Subjects

  • the basic mechanisms of Developmental Biology;

  • the embryological development of the nervous system, especially the brain;

  • the various research approaches and strategies used by developmental biologists, and how to summarize, introduce and discuss these issues in a report;

  • the critical reading and analysis of an original research paper, and how to give an oral presentation or write a research proposal.


Aims

  • rank the obtained information in order of importance;

  • make a synthesis of the offered learning matters;

  • study in an integrated way the information dealing with various disciplines (experimental, morphological, cellu­lar and molecular aspect);

  • analyse a developmental physiological process and describe it at a scientific and academic level, taking into account the obtained knowledge of the various disciplines mentioned. In the response lectures, the lecture material is being discussed interactively.



Literature

Development of the Nervous System (with CDROM) by Thomas A. Reh & William A. Harris & Dan H. Sanes| Elsevier Science Publishing Co Inc | 2 | November 2005| English- Hardcover| App. 80 Euro

ISBN13: 9780126186215


Suggested but not obligatory:

Developmental Biology- Revised Edition by Scott F. Gilbert | Sinauer Associates Inc | april 2010| English- Hardcover| App. 110 Euro

ISBN13: 9780878935642

NWI-MOL078 Nanobiotechnology

Coordinator: Prof. Dr. R. Brock, r.brock@ncmls.ru.nl

6 ec, November 12 – February 1, Mondays and Tuesdays


Subjects

  • An introduction to nanobiotechnology and areas of application

  • Chemistry for nanobiotechnology, focussing on various conjugation strategies for biomolecules

  • Nanotechnology-based fluorescent probes and their applications in cell biology

  • The various available techniques for high-resolution microscopy

  • Microfluidics and single-molecule techniques

  • Micro- and nanostructures in cell biology and single molecule enzymology

  • The synthesis and application of nanoparticles in drug delivery and as nanoreactors

  • Medical devices


Literature

  • This course is fully based on handouts by the faculty, covering the contents of the lectures. For an introduction, the students may readtexts “Nanomedicine: Nanotechnology for Health” en “European Technology Platform on NanoMedicine” which can be down-loaded via http://cordis.europa.eu/nanotechnology/ nanomedicine.htm



NWI-BB051B Applied Bioinformatics

Coordinator: Dr. C. van Gelder, c.vangelder@ncmls.ru.nl

6 ec, November 12 – February 1, on Mondays and Tuesdays

Subjects

  • Database searching (sequence and structures databases)

  • Homology, similarity searches (BLAST)

  • The amino acids, their physical and chemical properties and the relation between these properties and the structure and function of a protein.

  • Sequence alignment

  • Prediction of secondary structure of a protein sequence

  • Applying all theory learned to two biomedically oriented research projects.

 Literature
All course material will be distributed during the course through the course website and through Blackboard.


NWI-BB064B Functional Genomics

Coordinator: Dr. G.J. Veenstra, g.veenstra@ncmls.ru.nl

6 ec, November 12 – February 1, on Thursdays and Fridays


Subjects

  • Molecular structure of genes and chromosomes

  • Epigenetic marking of the genome

  • Experimental annotation of genomic information (genomewide location analysis)

  • ‘High throughput’ nucleic acid analysis (DNA chips, solid phase amplification and sequencing)

  • Experimental approaches in model organisms exploiting genomic information

  • Bioinformatic methods for analyzing and visualizing genomic data


Literature

  • Lodish et al.: Molecular Cell Biology, 6th edition (Freeman and Company, New York, 2008)

  • Review articles



NWI-MB021B Geographical Information Systems

Coordinator: Prof.dr. A.M.J. Ragas, a.ragas@science.ru.nl

6 ec, November 12 – February 1, on Thursdays and Fridays


Subjects

  • What is GIS?

  • Spatial data modeling

  • Raster and vector structures

  • Remote sensing

  • Clearinghouses with geographical data

  • Querying spatial data

  • Transformation and reclassification of spatial data

  • Data processing (overlay, interpolation, buffering, etc)

  • Making maps


Literature

An introduction to Geographical Information Systems" by I. Heywood, S., Cornelius and S. Carver and published by Pearson Education (Prentice Hall; ISBN 0-13-129317-6). All other information will be available through Blackboard and Content-e.


NWI-BB032B Biotechnology of plants

Coordinator: Prof.dr. C. Mariani, c.mariani@science.ru.nl

6 ec, February 4 – April 12, Mondays and Tuesdays


Subjects

  • Methods and tools for plant genetic transformation

  • Agrobacterium and T-DNA transfer

  • Presentation of genetic modified plants

  • The major traits introduced in GM-plants:

Engineering of herbicide resistance for the battle against weeds

Engineering of insect resistance using Bt

Resistance against plant diseases

Improvement of crop quality

Male sterility for the production of hybrid crops

  • Social aspects in relation to the use of genetic modified plants and their introduction in the environment

  • Practical work:

Techniques for plant transformation

Molecular techniques for identifying transformed plants

  • Distribution of pollen as carrier of transgene characteristics


Literature

  • Adrian Slater, Nigel Scott and Mark Fowler: Plant Biotechnology, The genetic manipulation of plants. Second edition.Oxford University Press, ISBN 019 9254680



NWI-MOL055 Molecular basis of Disease

Coordinator: Prof. Dr. R. Brock, r.brock@ncmls.ru.nl

6 ec, February 4 – April 12, Mondays and Tuesdays


Subjects

  • The detection of genetic disorders

  • Sexual disorders

  • X-linked mental retardation

  • DNA repair and hereditary cancer

  • Usher Syndrome

  • Hereditary eye diseases

  • Microarray technology

  • An introduction to immunology

  • Immuneregulation

  • Cell adhesion and migration

  • Membrane organisation and the analysis of membrane organisation using microscopy

  • Defects in oxidative phosphorylation in mitochondrial metabolic disorders

  • Diagnostics of metabolic diseases

  • Analytical techniques for the detection of metabolic diseases


Literature

  • This course is fully based on handouts by the faculty, covering the contents of the lectures as well as background on the individual topics were needed. For the latter review articles are made available.


Work forms

  • 18 hrs lectures

  • 10 hrs responding lectures

  • 16 hrs practicum and computer practicum

  • self study

  • end grade: 50% written exam, 25% written essay, 25% oral presentation



NWI-BB047C Human Embryology and Developmental Biology

Coordinator: Dr. S. Kolk, s.kolk@ncmls.ru.nl

6 ec, February 4 – April 12, on Thursdays and Fridays


Subjects

The development of a fertilized ovum to a multicellular organism is a remarkable triumph of the evolution. During the embryonic development one cell will divide to millions of cells that together will form complex organ systems. In the last century, the descriptive embryology has given us an overview of the formational changes that an organism needs to go through from its existence till its adulthood. In this century, the human embryology encounters an exciting new era as molecular underpinnings of developmental processes are getting more and more clear.

This course initially deals with normal human development. The lectures will discuss the early embryonic development, the fetus-mother relationship and the molecular-physiological mechanisms that drive the development of an embryo. The organogenesis will be studied by assignments in which microscopical slides and illustrations are central. In the teratological part of the course disorders are discussed that can appear during embryonic and fetal development. The demonstrations will be held in the Pathological Museum of the UMC St Radboud, where specimens of human embryos can be studied that have a certain form of misdevelopment. This course is mainly exploratory in terms of biological and clinical data that are interesting for students that follow medical oriented biological courses during the specialization part of the curriculum.


Literature

  • Obligatory:

Human Embryology And Developmental Biology (with student consult online access), 4th Revised edition by Bruce M. Carlson & Bruce Carlson | Elsevier Health Sciences Division | August 2009| English- Hardcover

ISBN: 978-0-323-05385-3

  • Suggested but not obligatory:

  Larsen's Human Embryology (with student consult online access), 4th Revised edition by Gary C. Schoenwolf & Steven B Bleyl & Philip R. Brauer | Elsevier Health Sciences  | June 2011| English- Hardcover

Developmental Biology- Revised Edition by Scott F. Gilbert | Sinauer Associates Inc | april 2010| English- Hardcover

ISBN13:  9780878935642


NWI-BB027B Ecological Microbiology

Coordinator: Dr. H. Op den Camp, h.opdencamp@science.ru.nl

6 ec, February 4 – April 12, on Thursdays and Fridays


Aims

  • Understanding the elemental cycles (C, N, S, Fe), the biogeochemical processes within these cycles and the microbes responsible. In addition, insight into the relevant physical/chemical processes (gradients, diffusion, chemical reactions). Understanding the impact of human activities on the natural cycles.

  • Learning key types of energy metabolism of microorganisms (e.g. denitrification, photosynthesis, methanogenesis, fermentation, ammonium and methane oxidation, and many others).

  • Overview of the biodiversity of prokaryotes and learning the evolutionary relations between ecological relevant species including the current theories and concepts concerning microbial evolution.

  • Being able to quantitatively describe growth of microorganisms (using formulas)

  • Profound understanding of molecular ecology in theory and practice. Key words: PCR, fluorescence in situ hybridization, BLAST, phylogeny, genomics.

  • Insight into the importance of isotopes in microbial ecology. Key words: delta13C, natural carbon fractionation, biomarkers and labeling.

  • Learning the geochemical history of the planet earth ("the past is the key to the future").

  • Experience in designing own experiments and writing scientific reports of the results.

  • First insight into the history of this field of research and the current major questions. 


Literature

  • Brock – Biology of microorganisms, 11th edition or higher, Prentice Hall, (price €90)

  • Laboratory coat and safety glassess (for exchange students this will be provided)

  • Syllabus


Work forms

  • 16 hrs computer practicum

  • 8 hrs excursion

  • 56 hrs lectures

  • 16 hrs individual supervising

  • 300 hrs practicum

  • 20 hrs self study

  • written examination 30%, praktikum 30% and the other assignments 30%.


NWI-BB063B Neuroscience

Coordinator: Dr. D. Schubert, d.schubert@donders.ru.nl

6 ec, September 3 – November 9, on Mondays and Tuesdays


Subjects:

1. Structural and functional organization of the brain

• Structural & functional organization of the cortex

• Theory and application of large scale functional recording & neuroimaging techniques

• Single neuron classification: Morphology, biochemistry and electrophysiology

• Cortical neuronal communication and plasticity

• Application on specific research questions

2. Computational neuroscience

• Hodgkin-Huxley model for action potentials

• Dynamics of macroscopic neural networks

3. Clinical Neuroscience: from basics to current research

• Depression

• Brain & addiction

• Alzheimer's Disease

• Movement disorders: Parkinson's Disease and Dystonia


Literature

Electronic syllabus (pdf), lecture powerpoints and review original/articles. Students should already have basic knowledge of basics in neurobiology (neuron theory, synaptic signal transmission, basic anatomy of the brain).


Work forms

  • 10 uur computerpracticum

  • 6 uur excursie / labdemos

  • 29 uur hoorcollege

  • 8 uur presentatie door studenten

  • 12 uur responsie-college

  • 4 uur werkcollege

  • 26 uur zelfstudie

  • end grade: 75% written exam, 25% oral presentation

NWI-MOL054 Toxicology

Coordinator: Dr. J.B. Koenderink, j.koenderink@ncmls.ru.nl

6 ec, February 4 – April 12, on Thursdays and Fridays


Subjects

  • Toxicokinetics: Absorption, distribution and excretion of toxic compounds.

  • Biotransformation: Chemical modification by organisms of (toxic) compound.

  • Risk assessment: Determination of risk related to a recognized threat (hazard).

  • Organ toxicity: kidney, liver, lung, neuro, and immune –toxicology.

  • Industrial toxicology and chemical carcinogenesis.

  • Clinical toxicology and party drugs.

  • Developmental toxicology / teratogenesis.

  • Molecular mechanisms in toxicology.



Literature

  • John A. Timbrell, Principles of Biochemical Toxicology. Fourth edition, 2009. Informa health care, ISBN 978-08493-7302-2


Work forms

  • 15 hrs computer practicum

  • 12 hrs lectures

  • 20 hrs project work

  • 10 hrs responding lectures

  • 10 hrs work group

  • 78 hrs self study

  • Written examination and report. The exam provides 70% of the final mark and must be at least 5.0.


NWI-BB034B Neurobiology

Coordinator: Dr. W.J.J.M. Scheenen, W.Scheenen@science.ru.nl

6 ec, April 15 – July 5, on Mondays and Tuesdays


Subjects

  • The role of the central and the peripheral nervous system and the neuroendocrine system in regulating body functions and behaviour

  • Molecular and cellular mechanisms of hippocampus-mediated learning and memory

  • The role of neuropeptides in the integration of central and perifere functions

  • Detailed analysis of the working of the hypothalame circadian clock in the suprachiasmatic nucleus


Literature

CD containing the PowerPoint presentations of the lectures, extensive Speaker's Notes, a self-study tutorial on "Mechanisms of Cell Signaling" and  a tutorial on the use of the Allan Brain Atlas


Work forms

  • 45 hrs lecture

  • 15 hrs problem session

  • 80 hrs individual study period

  • written examination 80% and a written examination about the computer directed tutorial 20%


NWI-MOL053 Farmacochemistry

Coordinator: Prof. dr. F.G.M Russel, f.russel@pharmtox.umcn.nl

6 ec, April 15 – July 5, on Mondays and Tuesdays


Subjects

  • drug development process – role of pharmacochemistry/medicinal chemistry

  • receptor pharmacology

  • dose-response relationships

  • pharmacokinetics

  • absorption, distribution, biotransformation and excretion

  • pharmacogenetics

  • molecular design strategies

  • (quantitative) structure-activity relationships

  • computer-assisted drug design

  • combinatorial chemistry

  • antibiotics and cytostatics


Literature

  • Gareth Thomas, Medicinal Chemistry. An Introduction, 2nd edition, Wiley 2007, ISBN 978-0-470-02598-7

  • Course guide, will be sold during the course


Work forms

  • 20 hrs computer practicum

  • 18 hrs lectures

  • 30 hrs project work

  • 5 hrs responding lectures

  • 4 hrs work group

  • 80 hrs self study

  • written examination 75% and oral presentations in trio (25%) about a new medicine.



NWI-BB019B Immunology

Coordinator: dr. Johan van der Vlag, j.vandervlag@nier.umcn.nl

6 ec, November 12 – February 2, on Mondays and Tuesdays


Subjects


  • Cells and tissues from the immune system

  • Antigene recognition through antibodies

  • Major histocompatibility complex

  • Antigene recognition through T cells

  • Cellular immunity

  • Humoral immunity

  • Infections and defense

  • Immunodeficienties, AIDS

  • Autoimmunity and tolerance

  • Transplantation and immunosuppression

  • Immunological techniques



Literature


  • Book to be determined

  • Syllabus "Immunology" for the Biosciences (blokcommission Immunology; coordinator Dr. J. van der Vlag).

  • For practicum a white laboratory jacket is obligatory.  



Work forms


  • 20 hr computer practicum

  • 12 hr lecture

  • 9 hr practicum

  • 12 hr responding lecture

  • 104 hr self study



All Master courses of the Master Biology/Master Environmental Sciences and the Master Medical biology are in English. For course names and descriptions see the following website: http://www.ru.nl/english/education/prospectuses/


For more information: c.mooren@science.ru.nl


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