Cell and Molecular Biology Program: Ph. D.; D. O./Ph. D.; M. S. (thesis only) Page 2




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UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

GRADUATE SCHOOL OF BIOMEDICAL SCIENCES

STRATFORD DIVISION


COURSE CATALOG


Table of Contents:


Cell and Molecular Biology Program: Ph.D.; D.O./Ph.D.; M.S. (thesis only) Page 2

Master of Biomedical Sciences Program: M.S. (thesis); M.B.S. (non-thesis); D.O./M.S. (thesis) Page 7

Certificate in the Biomedical Sciences Program: Certificate Page 7

Master of Science in Molecular Pathology and Immunology Program: M.S. (thesis) Page 16

UMDNJ-School of Osteopathic Medicine: First Year D.O. Courses Page 19

UMDNJ-School of Public Health: Master of Public Health Page 21

Rutgers-Camden: Master of Science in Biology Program Page 22

Rutgers-Camden: Master of Science in Chemistry Program Page 28


Please note that Certificate students are NOT allowed to take any School of Osteopathic Medicine courses.


Please note that Non-matriculated students are NOT allowed to take any School of Osteopathic Medicine courses, School of Public Health courses or any Rutgers-Camden courses.


"This catalog is informational only and does not constitute a contract between UMDNJ and any student. It may be changed by UMDNJ without prior notice to students. Any rules, regulations, policies, procedures or other representations made herein may be interpreted and applied by UMDNJ to promote fairness and academic excellence, based on the circumstances of each individual situation.


This catalog represents a program of the current curricula, educational plans, offerings and requirements of the UMDNJ-Graduate School of Biomedical Sciences. The School reserves the right to change any provisions, offerings, tuition, fees, or requirements at any time within the student's period of study at UMDNJ.

In addition, UMDNJ may at any time eliminate, modify or change the location of any School, Institute, Center, Program, Department, course or academic activity."

Cell and Molecular Biology Program: Ph.D.; D.O./Ph.D. (thesis only)

Course Descriptions


MBIO 5020U GRADUATE BIOCHEMISTRY FALL 4 Credits CORE COURSE

COURSE DIRECTORS: DR. SERGEI BORUKHOV

PREREQ: NO. MASTERS STUDENTS BY PERMISSION ONLY

T,TH 3:00-5:00 PM SC-145

REQUIRED TEXT: Lehninger Principles of Biochemistry, 5th Edition

ISBN-10: 0-7167-7108-X

D.L. Nelson and M.M. Cox

W.H. Freeman and Company Publishing, 2009.

This is a problems-oriented biochemistry course that requires substantial student participation in class. The course covers the major areas of biochemistry including - DNA, RNA, protein, carbohydrate and lipid structure and biosynthesis; enzyme kinetics; carbohydrate, lipid and nucleotide metabolism; DNA replication, repair and recombination. Class-time consists of an engaging dialog on learning objectives and problems in various aspects of biochemistry. Previous exposure to biochemistry is helpful but not required. Students are required to come to class prepared to address the learning objectives and discuss the problems relevant to each section of the course.


MBIO 5021U MOLECULAR BIOLOGY OF THE CELL SPRING 4 Credits CORE COURSE

COURSE DIRECTOR: DR. MICHAEL HENRY

PREREQ: NO. MASTERS STUDENTS BY PERMISSION ONLY

T,TH 3:00-5:00 PM SC-145

REQUIRED TEXT: Molecular Biology of the Cell, 5th Edition

ISBN: 978-0- 8153-4105-5

B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter.

Garland Publishing, 2007.

This course is the cornerstone of the graduate curriculum and is taken in the Spring semester of the student’s first year of graduate study. There are four sections to this course: I. Introduction to the cell. This section includes evolutionary aspects of the cell, a study of small molecules, energy metabolism and biosynthesis, macromolecular structure and function. II. Molecular genetics, including protein function, genetic mechanisms, recombinant DNA technology, the cell nucleus, and the control of gene expression. III. Internal organization of the cell, including membrane structure, transport mechanisms, cell signaling, cell division and the mechanisms controlling the phases of the cell-cycle. IV. Cells in their social context, including cell junctions, cell adhesion, germ cells and fertilization, cellular mechanisms of development, differentiation and tissue formation, the immune system and cancer.


MBIO 5001U ETHICS IN SCIENCE, RESEARCH AND SCHOLARSHIP SPRING 2 Credits SKILL COURSE

COURSE DIRECTOR: DR. KATRINA COOPER

F 10:00 AM - 12:00 PM SC-145

REQUIRED TEXT: Scientific Integrity Text and Cases in Responsible Conduct of Research, 3rd Edition

ISBN: 1-55581-318-6

F. L. Macrina

ASM Press, 2005.

Major advances in biotechnology and biomedical knowledge, the limited funding available for biomedical research as well as the restructuring of traditional academic institutions has shaped the contemporary biomedical research environment. Ethical and legal concerns centering on scientific misconduct, including plagiarism, grant writing and data handling as well as the use of animals, human subjects and biohazards will be addressed in both lecture format and through various workshops. Upon completion of this course students are expected to be able to 1) examine attitudes toward ethical problems in biomedical research and education, and 2) have the ability through an awareness of the technical and ethical aspects of decision making, to critically reflect on current ethical issues in biomedicine. Assigned readings relevant to these issues will be made prior to the class meeting. This course requires substantial student participation in class. It is a letter-graded course.


MBIO 5045U EXPERIMENTAL DESIGN FALL 2 CREDITS SKILL COURSE

COURSE DIRECTOR: DR. ERIC MOSS

PREREQ: NO but THESIS STUDENTS ONLY

M 2:00-4:00 PM SC-330

REQUIRED TEXT: Experimental Design for Biologists

David J. Glass

CSHL Press, 2007

ISBN: 978-087969735-8

This course covers generally how experiments are designed in biomedical sciences. The focus is on how research questions are posed, including the reasoning behind hypotheses, controls, repetition, and models. Discussions will revolve around simple thought-experiments and real-life biomedical research. The goal of the course is to help students to read biomedical research literature critically, participate constructively in peer review, and to better approach research problems. A small amount of elementary statistics will be discussed. The course will consist of short advance reading assignments followed by in-class discussion of each topic. Short presentations (“vignettes”) at the end of each class will illuminate particular relevant ideas. Doctoral and Thesis Masters students only.


MBIO 5065U SCIENTIFIC WRITING FALL 2 CREDITS SKILL COURSE

COURSE DIRECTORS: DRS. MULLER-WEEKS AND FISCHER

PREREQ: NO but DOCTORAL STUDENTS ONLY

W 2:00-4:00 PM SC-145

REQUIRED TEXT: How to Write and Publish a Scientific Paper, 7th Edition

Robert A. Day and Barbara Gastel

Greenwood Press, 2011

ISBN (hardcover): 978-0-313-39195-8

ISBN (paperback): 978-0-313-39197-2

ISBN (e-book): 978-0-313-39196-5

This course presents fundamentals of clear scientific writing in the context of a selected research theme (i.e., the immune system, cancer mechanisms, etc). Students will develop and apply writing skills and thought processes necessary for a successful career in biomedical sciences. Topics include components of a manuscript, hypothesis formulation, utilization of scientific databases and elements of a research proposal. Students will complete several short written assignments during the semester as well as a research proposal, oral presentation and proposal critique. Upon completion of this course students will have acquired practical experience in all forms of scientific communication.


MBIO 5055U CRITICAL READINGS IN CELL & MOLECULAR BIOLOGY SPRING 2 Credits SKILL COURSE

COURSE DIRECTOR: DR. DMITRY TEMIAKOV

PREREQ: NO. DOCTORAL STUDENTS ONLY

M 2:00-4:00 PM SC-145

This course is designed to give students experience in speaking in front of an audience of scientific peers as well as scientific writing. Given the objective of realistic speaking, each student will give at least one formal seminar to the members of the department. Formal didactic sessions will include an introduction to seminar preparation and student presentations in journal club format. Student presentations will be based upon scientific papers selected by the student based on topics provided by the faculty. Each semester’s seminars will focus upon a different area of research depending on the professor who is teaching the course.


MBIO 5140U CELL CULTURE AND STEM CELLS SPRING 2 Credits FOCUS COURSE

COURSE DIRECTORS: DRS. DIMITRI PESTOV AND HRISTO HOUBAVIY

PREREQ: NO. MASTERS STUDENTS BY PERMISSION ONLY

W 10:00 AM-12:00 PM SC-145

RECOMMENDED TEXT: Essentials of Stem Cell Biology, 2nd Edition

Lanza, R., et.al.

Academic Press, 2009

ISBN: 978-0-12-374729-7

RECOMMENDED TEXT: Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, 6th Edition

R. Ian Freshney

Wiley-Blackwell, 2010

ISBN: 978-0-470-52812-9

This course focuses on both the fundamentals and practical aspects of mammalian cell culture and transgenic technologies. Particular emphasis is given to the biology of stem cells and their emerging therapeutic applications. The major goal of the course is to give the students a deep understanding of the principles of cell culture and help them to creatively approach complex problems at the forefront of the modern cell biological research.


MBIO 5023U GRADUATE GENETICS FALL 2 Credits FOCUS COURSE

COURSE DIRECTOR: DR. RONALD ELLIS

PREREQ: NO. MASTERS STUDENTS BY PERMISSION ONLY

M 10:00 AM-12:00 PM SC-145

RECOMMENDED TEXT: Introduction to Genetic Analysis, 10th Edition or earlier

ISBN: 978-1-4292-2943-2

AJF Griffiths, SR Wessler, SB Carroll, and J Doebley

W.H. Freeman and Company Publishing, 2010.

This course covers advanced topics in genetic analysis and genetic methods. Our focus will be on the techniques and logic common to all research subjects, from viruses to humans. Previous exposure to Genetics is helpful but not required. Students must attend lectures, read the textbook, solve problems and read papers before each class.


MBIO 5560U PRACTICAL BIOINFORMATICS SPRING 2 Credits FOCUS COURSE

COURSE DIRECTOR: DR. ERIC MOSS

PREREQ- GRADUATE BIOCHEMISTRY OR GRADUATE GENETICS

F 2:00-4:00 PM UDP, Room 2300

REQUIRED TEXT: Bioinformatics for Dummies

ISBN: 0-7645-1696-5

J.-M. Claverie and C. Notredame

Wiley, New York, 2003

Students learn basic computer- and web-based molecular biology methods, including DNA sequence analysis, protein sequence analysis, BLAST searches, use of genome databases, protein structure viewing, and electronic literature searches. 


MBIO 5024U MOLECULAR ONCOLOGY SPRING 3 Credits FOCUS COURSE

COURSE DIRECTOR: DR. RANDY STRICH

PREREQ: NO. MASTERS STUDENTS BY PERMISSION ONLY

M 5:00-8:00 PM SC-145

REQUIRED TEXT: The Biology of Cancer

ISBN: 9780815340768
ISBN-10: 0815340761


Robert Weinberg

Garland Science, 2006

This course aims to give the student a comprehensive the principals of cancer genetics. The course is divided into 3 sections. The first covers cell cycle control of cancer (oncogenes, tumor suppressors, apoptosis). The second, the roles that signal transduction, epigenetics, and genomic stability play in developing cancer. The third covers the immune system and cancer, angiogenesis, metastasis, stem cells and mouse models. Finally, bio-markers and the rationale behind cancer treatments will be presented.


MBIO 520 A-D U LABORATORY ROTATION A-D/Ph.D. FALL/SPRING 1 Credit REQUIRED COURSE

COURSE DIRECTOR: GSBS FACULTY

PREREQ: PERMISSION BY FACULTY/INVESTIGATOR

Laboratory rotations are essential components of a student’s education in both the Cell Biology and Molecular Biology tracks. These experiences introduce students to specific areas of cell and molecular biology; expose students to specialized techniques, and familiarize students with specific projects in the program in anticipation of choosing a research advisor. Students will be evaluated on their attendance, motivation and interest within the lab as well as their attendance and participation at lab meetings. Students are responsible for learning new techniques, asking questions and working semi-independently by the end of each lab rotation. Students are encouraged to select their laboratory rotations so as to acquire diverse research experiences. Three laboratory rotations must be completed prior to the selection of a thesis advisor. During the first two weeks of the fall semester, the student will provide the Program Coordinator with the names of two faculty members, who have agreed to sponsor the student for lab rotation in the Fall. Each lab rotation will consist of 7 weeks with two in the fall and one in the spring semester; if a fourth is necessary, it can be completed within the spring semester. Hence, by the middle or end of the spring semester, the student will know which lab they will do their research in for their thesis. 


MBIO 5511U RESEARCH IN CELL AND MOLECULAR BIOLOGY FALL/SPRING 5 Credits REQUIRED COURSE

COURSE DIRECTOR: DOCTORAL STUDENT’S MENTOR

Each course will be directed by a doctoral student’s Mentor who is a member of the Cell or Molecular Biology Department and its content will reflect his/her research interests. The goal is to have the student gain experience in a research laboratory and gain insight into the creative research process.


MBIO 5600U WORK IN PROGRESS/Ph.D. FALL/SPRING 1 Credit REQUIRED COURSE

COURSE DIRECTOR: DOCTORAL STUDENT’S MENTOR

This course is for students who are official Ph.D. candidates, i.e. they have passed the Ph.D. Qualifying Exam. In either the Fall or Spring semester, both an oral seminar presentation of the student’s research progress within the Department Seminar Series (MBIO 5050) and the Semi-Annual Thesis Progress Report are required. The Semi-Annual Thesis Progress Report includes a one-page update of research progress. It is the student’s responsibility to inform their Thesis Advisory Committee (TAC) AND the Program Coordinator by email when their seminar is scheduled. In the other semester within an academic year, only the Semi-Annual Thesis Progress Report, which includes a one-page update of research progress is required, given to the student’s Mentor for commenting then passed to the TAC for approval. The Thesis Advisory Committee is responsible for grading this Satisfactory/Unsatisfactory course.

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