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Particle nature of radiation – the Photoelectric effect, Compton effect. Motion of a charged particle in and electric and magnetic field, magnetic and electrostatic focusing, Hall effect, The origin of quantum theory – Planck’s hypothesis, the wave nature of matter – wave – particle duality, matter waves (de Broglie hypothesis).

Basics Postulates of quantum mechanics – the wave function – it physical interpretation, the Schrodinger equation.

The electromagnetic spectrum- sources of light, emission and absorption spectra, Brief introduction to spectroscopy (optical, magnetic resonance). Principles, Instrumentation and Biological Applications of Computational Tomography (CT), Magnetic resonance Imaging (MRI); and Positron Emission Tomography (PET)


UNIT – V

BIO PHYSICAL PROPERTIES OF BIOMATERIALS

Volumetric properties of gases, exhibiting non ideal behavior in biological systems; Osmotic pressure in an Ideal Gas and Liquid; Osmotic Fragility of Red Blood Cells; transport through Membrane-solute Transport, Artificial Kidney.

Methods of determination of Surface Tension and specific gravity of Bio-fluids, Viscosity, Specific and Intrinsic Viscosities and their determination by Ostwald’s Method Bio-fluids, fluid dynamics-Philology of fluids, specific and intrinsic viscosities and their determination. Ideal and Non –Ideal Solution –Molar Properties.


EXAMINATION: One question from each unit with internal choice


TEXT BOOKS:



  1. Molecular Biophysics by RB Setlow and EC Pollard,Addition Weley, Publishing Company, Inc.,1964.

  2. Bio Physical Chemistry by A.G.Marshall, Wiley & Sons , New York.

  3. Intermediate Physics for Medicine and Biology by Russel K. Hebby.

  4. Introduction to Biophysics, Tyszynski J.A, Kurzynki.M, First Edition, (2003), CRC Press, Florida.

  5. Physical Biology of the Cell, by Phillips, Rob/Kondney, Jane, ISBN-10: 0815341636 Publisher Routledge.

  6. Essentials of Biophysics, 1 st Edition, Narayanan. K , (2005), New age publishers, New Delhi.



REFERENCE BOOKS:



  1. Modern Physics by D Holiday, R Resnik & KS Krane Fifth edition, John Wiley & Sons Inc. (2002).

  2. Modern Physics by Concepts of Modern Physics by A. Beiser, Sixth edition. Tata Mc Graw Hill .

  3. Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond Puglisi, Joseph D. (EDT) 9781402058998 09781402058998.

  4. Applied Biophysics - Tom A. Waigh. Ohn Wiley , Sons Inc.,(2007), ISBN: 047001718X.

  5. Physical Biology of the Cell by Rob Phillips, Jané Kondev , Julie Theriot Garland Science; 1 edition (2008).

  6. Molecular and Cellular Biophysics by Jackson, Meyer B. ISBN-10: 0521624703 Publisher Cambridge Univ Press.

  7. Chemical Biophysics: Quantitative Analysis of Cellular Systems, by Beard

Beard, Daniel A./ Qian, Hong ISBN-10: 0521870704 Publisher Cambridge Univ. Press.

  1. Biophysics, 4 th Edition, Glaser .R, (2001), Springer, New York..

  2. Jackson. M.B , Molecular & Cellular Biophysics, First edition, (2006) , Cambridge University Press.

  3. Understanding of Enzymes, Fourth edition, Trevor Palmer, (2003), Cambridge University Press, New York.

  4. Creighton,T.E., Proteins Structure and molecular properties, 2 nd edition, 1993, W H freeman publishers, Madison avenue, New York.



CHEMISTRY

(INORGANIC, PHYSICAL & ANALYTICAL)



Subject code : BTT.1.104

Sessional : 30

Periods / Week : 3

Examination : 70

Nature of Examination : Theory

Exam Duration : 3 Hrs



PART-A: INORGANIC CHEMISTRY

UNIT-I

PERIODICITY: Periodic properties: Ionization energy, Electron affinity, electro negativity, Atomic size. S.P and d-Block Elements: Oxides, halides and hydrides of alkali and alkaline earth metals, B, Al, Si, N, P and S- general characteristics; Properties of 3d- elements (Color, Geometry and Magnetic Properties).

Role of various Metal ions in Biological Systems: Na, K, Fe, Mg, Mn, Mo, Co, Se.


UNIT-II

Chemical Bonding: Properties of Ionic and Covalent molecules, VSEPR theory and shape of molecules, Valence Bond theory approaches for diatomic molecules.

Molecular Orbital Theory: Approaches for diatomic molecules (H2, H2-Li2, Be2, N2, O2, NO, CO, N-).

Hybridization and Shapes of molecules: sp, sp2, sp3, sp3d, sp3d2, sp3d3.

Structure parameters: Bond length, Bond angle, Bond energy.

Hydrogen bonding, Vanderwaals interactions, Lattice energy (Born-Haber Cycle)

Coordination complexes: Crystal field theory.


PART-B: PHYSICAL CHEMISTRY

UNIT-III

Thermodynamics: First law, reversible and irreversible processes, internal energy, enthalpy, Kirchoff’s equation, heat of reaction, Hess law, heat of formation, Second law, entropy, free energy and work function, Gibbs-Helmoltz equation, Clasious-Clapeyron equation, free energy change, Troutons rule, Third law of thermodynamics, Bio-energetics-ATP, c-AMP

Chemical Equilibria: Equilibrium constants (Kc, Kp and Kx) for homogeneous reactions, hydrolysis of salts.


UNIT-IV

Colligative properties: Aoult’s law, elevation of boiling point, depression of freeging point, osmotic pressure.

Electrochemistry: Conductance, Kohlraush law, Half Cell potentials, emf, Nernst equation, galvanic cells.

Kinetics of chemical reactions: Rate constant, order of reaction, molecularity, activation energy, zero, first and second order kinetics. Catalysis and elementary enzyme reactions.


PART-C: ANALYTICAL CHEMISTRY


UNIT-V

Fundamentals of volumetric Analysis- Methods of expressing concentration, primary and secondary standards, Titrations: Acid- Base and Protein Titrations, Buffer and pH solutions-their applications in chemical analysis.

Qualitative and semi-micro analysis-Reactions involved in the separation and identification of anions & cat ions. Solubility product, common ion effect.


Examination: One question from each unit with internal choice.


TEXT BOOKS:

  1. Anew concise Inorganic chemistry, 3rd Edn-J.D.Lee, ELBS. London.

  2. Physical chemistry- 3rd Edn. P.W.Atkins,Oxford University Press.

  3. University General Chemistry- C.N.R.Rao, MacMillan India.

  4. Essentials of Bio-organic Chemistry by R. W. Hanson ISBN 071313500X

  5. A Text Book of Engineering Chemistry by Balaram Pani, Galgotia Publications, New Delhi (2004).

  6. Advanced Engineering Chemistry by Senapati and Mohanty, Laxmi Publications, New Delhi ((2002)).



REFERENCE BOOKS:

  1. Elements of Physical chemistry-2nd Edn- Samuel Glasstone and David Lewsis;

MacMillan & Co. London.

  1. Priciples of Chemistry-Paul Ander andAnthony J.Sonnessa, Collier-MacMillan

Ltd., London.

  1. Physical chemistry with Applications to Biological Systems, 2nd Edn-Raymond Chng, McMillan Publishing Company, New York.

  2. Principles Of Physical Chemistry (2008), by Puri Br, Sharma Lr, Madan S Pathania, Vishal Publishing Co

  3. Housecroft, C. E. and Sharpe, A. G. “Inorganic Chemistry, Pearson/Prentice Hall”, (2005) (2nd Edition).

  4. KS Kaim, W. and Schwederski, B. Bioinorganic chemistry: inorganic elements in the chemistry of life : an introduction and guide (Wiley, (1994).

  5. Que, L., Jr. ed. Physical Methods in Bioinorganic Chemistry (Univ. Sci. Books;

Mill Valley, CA, (2000).

8 Shriver, D. F.; Atkins, P. and Langford, C Inorganic Chemistry (3rd edition) -

9. WW Wilkins, P. C.; Wilkins, R. G. Inorganic Chemistry in Biology Oxford

University Press: 1997.

  1. A text book of Engineering Chemistry by S.S. Dara, S.Chand & Co, New Delhi (2004).

  2. Engineering Chemistry by J C Kuriacose and J. Rajaram, Tata McGraw-Hill Co, New Delhi (2004).



BIOORGANIC CHEMISTRY



Subject code : BTT.1.105

Sessional : 30

Periods / Week : 3

Examination : 70

Nature of Examination : Theory

Exam Duration : 3 Hrs



UNIT – I : INTRODUCTION TO BIO-ORGANIC CHEMISTRY

History of organic and Bioorganic Chemistry; Uniqueness of Carbon atom and general characteristics of organic compounds; Nomenclature of organic compounds; structure, Isomerism, Hybridization and Functional Groups of Organic Compounds;

Types of Organic reactions; Nucleophilic & Electrophilic Addition, Substitution and Elimination reactions; Properties of Carbonyl, Acid, Ester, Hydroxyl and Amine Functional Groups;

UNIT – II: STRUCTURE REACTIVITY CORRELATIONS OF BIO-ORGANIC MOLECULES

Structure Activity Relation-Acids and bases; Electronic and Steric Effects; Stereo Isomers, Tautomers and Conformer; Concepts of Aromaticity; Basic Organic Reactions – Elementary reatment of SN1, SN2, E1 and E2 reactions; rules and effects of Organic reaction –Hoffman Rule, Saytzeff Rule and Markonikoff Rule, Functional Group Effect, Orientation Effect, Kharash Effect; Name Reactions –Diels –Alder Reaction; Aldol Condensation, Hoffman Degradation; Classification of Bio MOLECULES, Structural and Functional Bio Polymers.


UNIT – III: STRUCTURAL & FUNCTIONAL BIO POLYMERS – PROTEINS & NUCLEIC ACIDS

Classification, Structure, Stereochemistry and Reactivity of Carbohydrates & Lipids; Study of glucose, fructose, maltose, glycogen, dextrin, cellulose and starch; Study of Lipids –Fatty Acids, Glycerol, Oils, Sterols and Prostaglandins; Role of Carbohydrates and Lipids as a source of Energy and Health; Classification, Structure, Stereochemistry and reactivity of Building Blocks of proteins and Nucleic Acids (Amino Acids, Purines, Pyrimidines, Nucleosides and Nucleotides); Study of Proteins as Functional and structural bio polymers, Role of Proteins as Enzymes, Hormones and Carrier Molecules; Study of Nucleic Acids (DNA and RNA) as Functional Bio polymers.


UNIT – IV: CHEMISTRY OF BIO PRODUCTS

Isolation, Separation, Purification and characterization techniques of some bio products derived from Natural sources of living things; Chemistry of Alkaloids – Ephedrine, Atropine, papaverine and Quinine; Chemistry of Alkloids –Derivatives of Purine and Xanthine Bases–Caffeine Theophylline, Theobromine and Uric Acid; Chemistry of Flavonoids, Teroebidusm Carotenoids, Vitamins and their role in Human health.


UNIT – V: CHEMISTRY OF STEROIDS

Classification and Nomenclature of Steroids; Isolation and Qualitative Analysis of Steroids; Anabolic Agents and Progenstational agents-Androgens and Estrogens; Structure and functions of Cholesterol, Stigma sterol and some Bile Acids; Steroids of Pharmaceutical Significance (Steroidal Saponins); Bio-transformation of steroids; steroids of pharmaceutical Significance (Steroidal Saponins); Bio-transformation of steroids; Tools used for Structure determination of Bio Products


EXAMINATION: One question from each unit with internal choice.

TEXT BOOKS:

  1. Bioorganic Chemistry: A Chemical Approach to Enzyme Action

Series: Springer Advanced Texts in Chemistry Dugas, Hermann, (1996).

  1. Organic Chemistry Vol. – 2, I.L. Finar Pearson Education Asia Pvt. Ltd.

  2. Advanced Organic Chemistry –Reactions, Mechanisms and Structure, 4th Edn, (2003), by Jeery March, john – Wiley and Sons Inc, NY.

  3. Bioorganic Chemistry: A Chemical Approach to Enzyme Action (Springer Advanced Texts in Chemistry) by Hermann Dugas, Springer; 3rd edition ((1999)).



REFERENCE BOOKS:

  1. Chemistry of Natural Products. (Vol. I) by O.P. Agarwal Krishna Prakashan Media (P) Ltd.

  2. Stereochemistry of Organic compounds, (2003), by Ernest L.Eliel, Samuel H. Wilen and Lewis N Mander, John Wiley & Sons INC., NY.

  3. Lehinger Principles of Biochemistry 3rd Edn, (2002) by Michael C Mix, PAUL Farber and Keith I king Harper Collins college publishers, NY.

  4. Highlights in bioorganic chemistry: methods and applications by Carsten Schmuck; Helma Wennemers; (2004) Weinheim : Wiley-VCH.

  5. Modern tendencies in organic and bioorganic chemistry: today and tomorrow by Abdulakh K Mikitaev; Mikhail Kh Ligidov; Gennadiĭ Efremovich Zaikov;Publisher: New York : Nova Science Publishers, (2008).

  6. Bioorganic chemistry and chemical biology by H Waldmann; Petra Janning

Publisher: Weinheim : Wiley-VCH ; Chichester : John Wiley, (2004).

  1. Bioorganic chemistry : highlights and new aspectsby Ulf Diederichsen; et al

Publisher: Weinheim ; New York : Wiley-VCH,(1999).

  1. Recent research developments in organic & bioorganic chemistry, vol. 5 ((2002))

By S G Pandalai; Publisher: Transworld Research Network, (2002).

9. Kinghorn, A.D.; Falk, H.; Kobayashi, J., Series Editors. Progress in the Chemistry of Organic Natural Products (Fortschritte de Chemie organischer Naturstoffe), vol. 89; Springer-Verlag: (2008).


­­­­­ INTRODUCTION TO ANATOMY AND PHYSIOLOGY OF HUMANS



Subject code : BTT.1.106

Sessional : 30

Periods / Week : 3

Examination : 70

Nature of Examination : Theory

Exam Duration : 3 Hrs



UNIT -I: INTRODUCTION TO ANATOMICAL TERMS AND ENDOCRINE GLANDS

Elementary Knowledge on Various parts of Human Body, systems and organs; Basic Anatomy and Types of Endocrine glands; Physiology of Endocrine glands and their hormones. General Introduction of Hormonal secretions and Action.


UNIT - II: ANATOMY OF SKELETAL, MUSCULAR, NERVOUS, DIGESTIVE & EXCRETORY SYSTEMS

General Structure and Composition of Bones and Types of Joints.

Structure of Muscles and Muscle Cells, Limbs and their functions.

General structure of Nervous system and nerve cells and their functions. Brain, spinal chord, peripheral and autonomous nervous systems.

General Structure and Functions of Digestive System, Stomach, Intestines, Liver, gall bladder and Pancreas.

General Structure, Various parts and Functions of Excretory System, Kidney and Urinary

Bladder.

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