School of Biomedical, Biomolecular and Chemical Sciences




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School of Biomedical, Biomolecular and Chemical Sciences




Unit Outline




Molecular and Structural Biochemistry


BIOC3371



Semester: 1



Campus: Crawley



Unit Coordinator: A/Prof. Paul Attwood (Theory)

Dr. Robert Tuckey (Laboratory)



This outline is the currently available version for this unit. Detailed Information on unit content and assessment may undergo modification before the time of delivery of the unit. For the most up to date information students must consult material supplied to enrolled students by the unit co-ordinator.


All material reproduced herein has been copied in accordance with and pursuant to a statutory licence administered by Copyright Agency Limited (CAL), granted to the University of Western Australia pursuant to Part VB of the Copyright Act 1968 (Cth).


Copying of this material by students, except for fair dealing purposes under the Copyright Act, is prohibited. For the purposes of this fair dealing exception, students should be aware that the rule allowing copying, for fair dealing purposes, of 10% of the work, or one chapter/article, applies to the original work from which the excerpt in this course material was taken, and not to the course material itself


© The University of Western Australia 2001




Broad Learning Outcomes


Outcomes

Assessment Activity

Students will be able to recall and integrate key knowledge and concepts about:

  • DNA structure, replication and genomic packaging



  • Transcriptional processes including control of gene expression, post-transcriptional processing and translation.



  • Posttranslational processing of proteins, including folding and structural modification.

  • Relationships between enzyme function and structure.




  • Proteomics



  • Methods of protein structure determination



  • Bioinformatics related to protein structure and function.



Theory Exam (possibly tutorial journal assignment)


Theory Exam, Lab notebook (possibly Lab report and/or possibly tutorial journal assignment)


Theory Exam (possibly tutorial journal assignment)


Theory Exam, Assignment,

Lab notebook (possibly Lab report and/or possibly tutorial journal assignment)


Theory Exam (possibly tutorial journal assignment)


Theory Exam (possibly tutorial journal assignment)


Theory Exam

Students will acquire skills in:

  • Biochemical calculations



Quizzes, Theory Exam



Advisable Prior Study


Prerequisites are: Biochemistry of the Cell 201 (BIOC2201); Biochemical Regulation of Cell Function 202 (BIOCC2202); TEE Applicable Maths OR MATH1050 Calculus C AND STAT1123 Statistics B. Strongly recommended: Molecular Biology 225 (SCIE2225); a level 2 Chemistry unit.


Contact Details


Unit web site (may include Web CT URL): http://Webct.uwa.edu.au/

Name of Unit coordinator: A/Prof. Paul Attwood

e-mail: pattwood@cyllene.uwa.edu.au

Phone: PVA - 6488 3329

Fax: 6488 1149

Consultation hours: By appointment


Unit Structure Summary


Lectures

Three 1-hour lectures per week


Tutorials

Biochemical Calculations/Journal Club Assignments approx 1 hour per week.


Topics


For details of times and venues of all teaching sessions please consult the university timetable at http://www.timetable.uwa.edu.au/


Lecture Topics

1

Course structure and logistics

2

Genome content

3

The hidden genome?

4

Packaging of genomes

5

The perfect copy – DNA replication

6

Maintenance of the genetic material –the road to immortality

7

Motifs and DNA binding proteins

8

Split genes - post-transcriptional processing

9

Transcriptional regulation of gene expression

during liver development

10

Ribosomes - machines for peptide formation Peptide chain initiation, elongation and termination

11

The first and second genetic code and the Wobble Hypothesis

12

Cleaving, sequencing and modifying DNA

13

The transcriptional complex

14

Transcription factors

15

Promoters, enhancers and response elements

16

Molecular biological approaches to the

isolation of transcription factors

Lecture Topics continued

17

Proteins - function reflected by structure

18

Proteins - understanding function with motifs & domains

19

Proteins - structural modifications

20

Protein folding

21

Structure and function of enzymes I

22

Structure and function of enzymes II

23

Macromolecular Structure Determination - X-ray/NMR

24

Protein Chemistry I - ligand binding analysis

25

Protein Chemistry II - chemical labelling,

protein digestion and sequencing

26

Cytochromes P450, structure and mechanism

27

Cyt P450scc structure-function studies

28

Proteomics - Where proteins meet Genomics

29

Proteomics - Technologies behind the revolution

30

Proteomics - Finding function in a complex world

31

Proteomics - Using proteomics to investigate the

impact of plant stress on respiration

32

Domains - the building blocks of protein structure

33

Protein structure databases

34

Predicting protein structure


References, Resources and Reading Materials


Recommended Text

Garrett, R.H. & Grisham, C.M. Biochemistry 3rd Edition. In much of the lecture material references are made to journal articles which can, in most cases, be accessed through the UWA Library Cygnet system or through the NCBI website (http://www.ncbi.nlm.nih.gov/)


Journal club articles will be available for collection on a fortnightly basis.


A course outline, lecture timetable and journal club timetable will be supplied to all students.


Biochemical calculation quizzes will be available for collection on a regular basis throughout the semester.


Unit Web Site

All enrolled students have access to the unit WebCT site (http://webct.uwa.edu.au). This site will be used for notices, posting of supplementary course materials, email and discussion. It is strongly recommended that you log onto this site on a daily basis. The website should be used for all remote communication to the unit co-ordinator. Students are encouraged to pose questions about course content on the discussion forum of the site so that all class members can view and contribute to the discussion.


Assessment Details


Assessed Work

% Mark

Timing

Mid-semester theory exam

25

after Easter break

End of semester theory exam

55

exam period in June

Quantitative biochemistry quizzes

10

throughout semester

Journal club assignment

10

once during semester


Plagiarism

The University of Western Australia takes very seriously the matter of academic misconduct by students and has policies in place that define misconduct (including plagiarism) and the penalties that apply. The consequences for misconduct can be severe, including exclusion from the university.

All students are expected to make themselves aware of the definitions and policies relating to academic misconduct, found at the websites below, and with any additional requirements or stipulations that may be provided by individual unit co-ordinators.

http://www.secretariat.uwa.edu.au/__data/page/20839/StuMiscondInfo.rtf

http://www.teachingandlearning.uwa.edu.au/tl/academic_conduct


When you obtain authority to log in to the unit website, you will se an online module on academic conduct which you are strongly advised to complete in your own time.






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