NB: If it is unclear whether or not a change to an existing module should be proposed on this form, the Chair or Secretary of the Undergraduate Studies Committee/Sub-Faculty or Graduate Studies Committee should be consulted. In order to reduce printing costs please




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Module proposal


UNIVERSITY OF WARWICK


Proposal Form for New or Revised Modules (MA1- version 3)


For consideration by the Undergraduate Studies Committee/Sub-Faculty or Graduate Studies Committee only.


NB: 1. If it is unclear whether or not a change to an existing module should be proposed on this form, the Chair or Secretary of the Undergraduate Studies Committee/Sub-Faculty or Graduate Studies Committee should be consulted.


2. In order to reduce printing costs please delete the text provided as guidance in the body of the form before submission to the Faculty Secretariat. However, all sections must be completed to the satisfaction of the Faculty Undergraduate/Graduate Studies Committee.


1. Title of Module:

CH269 Introduction to Biological and Medicinal Chemistry


2. New or Revised Module:

New module? [ X]

Revised module? [ ]


Level: D (Doctorate) [ ]

M (Masters) [ ]

H (Honours) [X ]

I (Intermediate) [ ]

C (Certificate) [ ]


If this new module replaces an existing approved module specify the code and title of the module to be discontinued and date on which change will occur:

Replaces CH2A3 Introduction to Biological Chemistry and CH2A2 Introduction to Medicinal Chemistry, October 2009


If this is a proposal for a revised module, specify which sections have been amended, and give an outline rationale for the changes:






3. Date of Introduction of new module or revised version of existing module:

October 2009


4. Department Responsible for Teaching:

Chemistry


If the module is taught by more than one department please indicate this (for matrix purposes):



Department

%

Department

%


Name of Module Leader:

Prof Tim Bugg


If the module leader is not a member of Warwick staff and has not previously been appointed as a module leader/tutor, please include a C.V with this form.


5. Availability/Location of module within courses:

List the degree courses on which this module is available, indicating the year of study, whether the module is core or an option and the credit weighting in each case. Include any part-time or 2+2 degrees on which this module is available.



Degree

Title










Year of

Core

Optional

Option list

CATS*

Code













study




core?

A,B or C




F100

Chemistry BSc

2

Core







7.5

F101

Chemistry BSc with Intercalated year

2

Core







7.5

F102

General Chemistry BSc

2

Core







7.5

F105

Chemistry MChem

2

Core







7.5

F106

Chemistry MChem with Professional Experience

2

Core







7.5

F107

Chemistry MChem with Intercalated Year

2

Core







7.5

F108

Chemistry MChem with Industrial Training

2

Core







7.5

F121

Chemistry with Medicinal Chemistry BSc

2

Core







7.5

F122

Chemistry with Medicinal Chemistry BSc with Intercalated Year

2

Core







7.5

F125

Chemistry with Medicinal Chemistry MChem

2

Core







7.5

F126

Chemistry with Medicinal Chemistry MChem with Professional Experience

2

Core







7.5

F127

Chemistry with Medicinal Chemistry MChem with Intercalated Year

2

Core







7.5

F128

Chemistry with Medicinal Chemistry MChem with Industrial Training

2

Core







7.5

F1N1

Chemistry with Management BSc

2







A

7.5

F1N2

Chemistry with Management BSc with Intercalated Year

2







A

7.5

BF91

Biomedical Chemistry BSc

2

Core







7.5

B9F1

Biomedical Chemistry BSc with Intercalated Year

2

Core







7.5

FC11

Chemical Biology MChem

2

Core







7.5

F1C1

Chemical Biology MChem with Intercalated Year

2

Core







7.5




Visiting Students













7.5


*Credit should be in one of the following tariffs:


6, 12, 18, 24, 48 credits; or

7.5, 15, 30, 45, 60 credits; or

(for postgraduate courses only) 10, 20, 30, 40, 50,60 credits


6. Consultation with other Departments:


It is important that any departments affected by the introduction of this module are consulted before the module is considered by the relevant Faculty committee.


Which other departments will be affected by the introduction/revision of this module (i.e. other departments offering the module as an option in their degree courses, including joint degree courses involving the department proposing the module)? Please give details of any consultations undertaken and indicate whether the other departments have approved the proposal.


Not applicable


7. Context:

Describe the relationship to any other modules with which the new module has a close connection and any prerequisite relationships.

This module follows on from new introductory biological chemistry material in the revised 1st year Chemistry course, and leads on to biological chemistry modules CH3D2 and CH3D3 in Year 3.


Pre-requisites

CH161

Post-requisites

CH3B5

CH3D3


8. Module Aims:

These should identify the module’s broad educational purposes. Indicate how the module will contribute to the achievement of the aims of the degree courses on which it is available.

This is a core module for all Chemistry students, introducing the principles of biological chemistry, which is an important facet of a modern Chemistry degree, and is an active topic of research in the Chemistry Department at Warwick. The module covers three major topics in biological chemistry: carbohydrate chemistry; enzymes & enzyme catalysis; and an introduction to medicinal chemistry & drug discovery. The module is particularly relevant to BSc Biomedical Chemistry and MChem Chemical Biology joint degree students, and BSc/MChem Chemistry with Medicinal Chemistry students. This module is a prerequisite for the subsequent optional modules CH3D2 Enzymes and Natural product biosynthesis and CH408 Advanced Medicinal Chemistry.


A-level biology is not an essential prerequisite for the module, but students who do not have this qualification will find they have met little of the material before. Many of the concepts in this module build on concepts assimilated in the core module for all students Organic Chemistry II (Mech and Sterochemistry part). Consequently this module should ideally be delivered after this one.




9. Learning Outcomes:

Successful completion of the module leads to the learning outcomes. The learning outcomes identify the knowledge, skills and attributes developed by the module. Learning Outcomes should be presented in the following format using the table below:

By the end of the module students should be able to...


Learning Outcomes should include reference to subject knowledge and understanding, key skills, cognitive skills and subject-specific practical and professional skills and be clearly relevant to fulfilling the educational aims. Learning Outcomes should be measurable by the assessment methods for the module. Indicate how the module will contribute to the achievement of degree course learning objectives.


(a) Subject knowledge and understanding

The knowledge and understanding that a student will be expected to have upon completion, such as : ‘a theoretical knowledge of the principles and methods of archaeology’ or ‘a knowledge of the major types of chemical reaction and the main characteristics associated with them.’

(b) Key Skills

Communication (written, verbal, graphical...)

Numeracy

Use of information technology (e.g. WP, www, databases, spreadsheets, specialist packages)

Ability to learn

Others (e.g. teamwork)


(c) Cognitive Skills

For example: ability in critical analysis; the ability to formulate and test concepts and hypotheses.


(d) Subject-Specific/Professional Skills

For example: laboratory skills; scientific support writing; research skills and methods.

LEARNING OUTCOMES

(By the end of the module the student should be able to....)


Which teaching and learning methods enable students to achieve this learning outcome?

Which assessment methods will measure the achievement of this learning outcome?

Understand and explain the structures, reactivity and synthesis of monosaccharides, disaccharides, and polysaccharides; answer problem-based questions on these topics


Lectures, workshops, tutorials and directed reading

Examination

Understand and explain the molecular basis for enzyme catalysis, enzyme structure, and Michaelis-Menten enzyme kinetics; answer problem-based questions on these topics

Lectures, workshops, tutorials and directed reading

Examination

Understand the principles and practices of introductory medicinal chemistry, examples of drug action through enzyme inhibition and receptor binding; assess structure-activity data and answer problem-based questions on these topics

Lectures, workshops, tutorials and directed reading

Examination

10. Syllabus:

Give an outline of the syllabus for the module.

Carbohydrates. Cellular energy and glucose; the structure of D-glucose, anomers and the anomeric effect; the structures and functions of monosaccharides; the glycosidic bond; oligosaccharides – structures and functions of disaccharides and polysaccharides; biosynthesis of oligosaccharides (5 lectures)


Proteins & Enzymes. Protein structure, information flow from DNA to RNA to proteins; Enzyme catalysis, transition state theory, Michaelis-Menten kinetics, selected examples of enzyme catalytic mechanisms; use of enzymes for biocatalysis, resolution of enantiomers (5 lectures)


Introduction to Medicinal Chemistry. Introduction to drug discovery process; enzyme inhibition, examples of enzyme inhibitors; receptors, introduction, structure/function of receptors; selected examples of receptor agonists/antagonists (5 lectures)


11. Illustrative Bibliography:

List the core texts only. The illustrative bibliography should provide an indication of the focus and level of the reading required by this module, rather than the full range (this should not be more than half a page):


“Organic Chemistry”, J. Clayden, N. Greeves, S. Warren & P. Wothers, OUP, 2001 (core text for all Organic Chemistry modules)


“Introduction to Enzyme and Coenzyme Chemistry”, T.D.H. Bugg, 2nd edition, Blackwells Science, 2004


“An Introduction to Medicinal Chemistry”, G.L. Patrick, 3rd edition, OUP, 2005


“Biochemistry”, L. Stryer, 5th edition, W.H. Freeman and Company, New York, 2001


12. Teaching:

Give the number of each type of teaching event per week and the length of each session in hours.



Lectures

3 x 1 hr per week, 15 hrs in total

Workshops

1 x 1 hr workshop, 2 x 1 hr tutorials over whole module







Total contact hours

18 hrs

Module duration (weeks, if applicable)

5 weeks

Self Study & Revision

57 hrs



13. Assessment Methods:


Type of assessment

Length

% weighting

Examination

1.5 hrs

100%



14. Resources:

Are any resources required for this module which are not already available from the Department’s own baseline resources (e.g. staff costs, accommodation, equipment, minor works, library costs, audio visual and computing facilities, vacation study requirements)? Is the module likely to require high usage of centrally timetabled teaching rooms or specific slots (e.g. for a module on a part time postgraduate course)?


Any additional requirements should be discussed with the appropriate Officer (see list below) before submitting the proposal.


List any additional requirements and indicate the outcome of any discussions.


Signature of Module Leader:


­­ Date


Signature of Chair of Department:


Date


Assessment Details (information required by the Exams Office)


This form should be completed only for modules to be assessed by an exam organised by the Exams Office


The form does not have to be submitted for approval but should be sent to Andrea Humber in the Exams Office. If this information is not provided the module cannot be set up on the Student Record System and students will therefore be unable to register for the module and exam. If you have any queries about this form please contact Andrea Humber in the Examination Office (ext 74160)


Module Title

CH2xx Introduction to Biological and Medicinal Chemistry

Department

Chemistry

Module Leader

Prof TDH Bugg

Name of Examiner





Indicate all available methods of assessment in the table below

% Examined

% Assessed by other methods

Length of examination paper

100%




1.5hrs











Examination Details

Will this module be examined together with any other module (sectioned paper)? If so please give details.

Yes it will be examined along with CH248 Organic Synthesis (3hr paper in total)




Is the module to be examined by 1 paper [ x ]

or 2 papers [ ]

When will the exam take place (e.g. Jan, April, Summer)? . Summer . . . . . . .


Is reading time required? Yes [ ] No [ x ]


Give any special exam timetable arrangements





Stationery Requirements

No. of Answer Books

2

Graph Paper

Should be available, if necessary

Calculator

Students may be required to use a calculator for certain questions


List any other special stationery requirements (e.g. Data books, tables etc):





Type of Paper

Seen: Yes [ ] No [ x ]

Open Book : Yes [ ] No [ x ]

Restricted: Yes [ ] No [ x ]

Where restricted please provide list of texts permitted here:











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