Room A1 07: 15 – 8: 25 Chairs: David G. Norris, ismrm president & Isabel Berry, M. D., Ph. D., Esmrmb president




НазваниеRoom A1 07: 15 – 8: 25 Chairs: David G. Norris, ismrm president & Isabel Berry, M. D., Ph. D., Esmrmb president
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Monday AM

OPENING SESSION

Room A1 07:15 – 8:25 Chairs: David G. Norris, ISMRM President & Isabel Berry, M.D., Ph.D., ESMRMB President

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7:15 Welcome and Awards Presentations

2010 LAUTERBUR LECTURE

Room A1 08:25 – 9:05 Chair: David G. Norris, ISMRM President

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8:25 Lauterbur Lecture: MRI Over the Next Decade: Quo Vadis?

William G. Bradley, M.D., Ph.D.

University of California, San Diego, CA, USA

Clinical Needs & Technological Solutions: Alzheimer's & Dementia

A1 09:05-10:15 Organizers & Moderators: Stefan Sunaert and Mark A. van Buchem

09:05 1. Clinical Needs for Dementia and AD: Revising the Criteria

Bruno Dubois1

1Hôpital La Salpêtrière, Paris, France

New diagnostic criteria for Alzheimer disease have been recently proposed that are centered around a clinical core of early and significant episodic memory impairment. They stipulate that in addition there must also be at least one or more abnormal biomarkers amongst structural neuroimaging with MRI, molecular neuroimaging with PET and CSF analysis of amyloid β/tau proteins. The timeliness of these criteria is underscored by the myriad of drugs currently under development that are directed at altering the disease pathogenesis, particularly at the production and clearance of amyloid β as well as at the hyperphosphorylation state of tau.

09:25 2. Imaging Solutions I: Structural and Functional Imaging

Wiesje M. van der Flier1

1Lieden University, Leiden, Netherlands

MRI has an increasingly large role in the clinical work-up of dementia. In the new research criteria, atrophy of the medial temporal lobe is mentioned as one of the diagnostic criteria for AD, but norm values are still awaited. Mixed disease (i.e. combination with vascular disease) remains a challenge, as there are no diagnostic guidelines available. MRI measures hold promise as markers of disease progression and can potentially be used as outcome measures in trials. The heterogeneity of AD is increasingly acknowledged. MRI may prove valuable to describe endophenotypes of AD, both in terms of structural and functional brain changes

09:50 3. Imaging Solutions II: Molecular Imaging

Louise van der Weerd1

1Leiden University Medical Centre, Leiden, Netherlands

The development of molecular imaging techniques for in vivo assessment of beta-amyloid accumulation in the ageing brain is an important and active area of research in AD. Numerous ligands have been developed with affinity for beta-amyloid, based on beta-amyloid peptide, monoclonal antibody fragments, or small peptides, which were functionalized with iron oxide particles or gadolium chelates. Alternatively, amyloid plaques have been labeled with small molecules containing a 19F atom and visualized using 19F MRI. Up to now, the only compounds that are in use for clinical imaging are nuclear medicine–based amyloid labeling tracers.

CLINICAL INTENSIVE COURSE
(Admission limited to Clinical Intensive Course registrants only)
Shoulder & Elbow Imaging: Case-Based Teaching


K1 08:15-10:15 Organizer & Moderator: Juerg Hodler

08:15 Elbow: Case-based
Russell C. Fritz, M.D.

09:15 Shoulder: Case-based
Lynne S. Steinbach, M.D.

10:15 Adjournment


CLINICAL INTENSIVE COURSE
Women’s Imaging: Case-Based Teaching


K1 11:00 -13:00 Moderators: Talissa Altes, Elmar Max Merkle, and Bachir Taouli

EDUCATIONAL OBJECTIVES
Upon completion of this course participants should be able to:

  • Describe the impact of functional MR methods in body imaging;

  • Apply new body MR techniques in their practice;

  • Use multiparametric MRI for improved diagnosis of abdominal diseases; and

  • Design new female pelvic and prostate MR protocols tailored to new therapeutic methods, introduce these methods and compare them to more conventional approaches.

11:00 Benign Breast Lesions
Elizabeth A. Morris, M.D.


11:30 Breast MRI: Easy and Difficult Cases
Bonnie N. Joe, M.D., Ph.D.


12:00 Benign Diseases of the Uterus
Andrea G. Rockall, M.R.C.P., F.R.C.R.


12:30 Ovarian Masses
Evis Sala, M.D., Ph.D., F.R.C.R.


13:00 Adjournment


CLINICAL INTENSIVE COURSE
SWI Metalheads: Imaging Brain Iron


K2 11:00 -13:00 Organizers & Moderators: Stefan Sunaert and Mark A. Van Buchem

EDUCATIONAL OBJECTIVES
Upon completion of this course participants should be able to:

  • Describe methods and underlying principles for obtaining and analyzing susceptibility weighted images;

  • Explain current thinking regarding iron metabolism and deposition within the brain; and

  • Describe several diseases of iron deposition within the brain and the application of susceptibility weighted imaging to diagnosis and study of these processes.

11:00 SWI Basics, Applications and Pitfalls
Jürgen R. Reichenbach, Ph.D.


11:40 Pathophysiology of Brain Iron
John F. Schenck, M.D., Ph.D.


12:20 Diseases of Iron Deposition
Mark A. Van Buchem, M.D., Ph.D.


13:00 Adjournment


MRI of Neural Plasticity

Room A1 11:00-13:00 Moderators: Jeffrey Joseph Neil and John G. Sled

11:00 Introduction
Jeffrey Joseph Neil


11:12 4. Training Induced Volume Changes Seen by Structural MRI Correlate with Neuronal Process Remodelling

Jason Philip Lerch1, Adelaide P. Yiu2, Alonso Martinez-Cabal2, Tanyar Pekar2, Veronique D. Bohbot3, Paul Frankland2, R Mark Henkelman1, Sheena A. Josselyn2, John G. Sled1

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada; 3Douglas, Department of Psychiatry, McGill University, Montreal, Quebec, Canada

We correlated training induced volume changes seen by high-resolution mouse MRI with four cellular markers to test whether (1) alterations in neuron numbers/sizes; (2) alterations in astrocyte numbers/sizes; (3) increased neurogenesis/survival of new neurons; or (4) remodelling of neuronal processes best explain the MRI results. We detected a significant positive correlation between GAP-43 and structure volume, but found no correlation between MR volume and any other cellular measure. We can thus conclude that, among the hypotheses tested, the largest explanatory factor for learning induced MRI detectable volume changes is the remodelling of neuronal processes.

11:24 5. Do Congenitally Blind People Have a Stria of Gennari? First in Vivo Insights on a Subcortical Level

Robert Trampel1, Derek Veit Ott1, Robert Turner1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

The primary visual cortex V1 is characterized by an easily identifiable anatomical landmark: the heavily myelinated stria of Gennari. Using T1, T2, T2* or phase contrast, high resolution MRI studies can routinely identify the stria of Gennari in vivo. However, the development and function of the Gennari stripe is unclear. MRI at 7 Tesla with isotropic 0.5 mm voxels was used to scan the occipital brain of sighted and congenitally blind subjects. The stria of Gennari was reliably detected in both sighted and blind subjects, showing that this anatomical feature is not a developmental result of visual input, and it does not degenerate in the absence of visual input.

11:36 6. Cerebral Myelin Content Correlation with Mathematical Abilities in Young Children

Richard Davis Holmes1, Silvia Mazabel2, Burkhard Maedler3, Christian Denk, Linda Siegel4, Christian Beaulieu5, Alex MacKay6

1UBC MRI Research Centre, University of British Columbia, Vancouver, British Columbia, Canada; 2Department of Educational and Counselling Psychology, and Special Education, University of British Columbia; 3Philips Medical Systems; 4Department of Educational and Counselling Psychology and Special Education, University of British Columbia; 5Department of Biomedical Engineering, University of Alberta; 6Department of Physics and Astronomy, University of British Columbia

Structural imaging applied to children with wide ranging mathematical abilities has the potential to elucidate the question of what neural circuits underly computation based tasks. The present investigation analyzed the myelin water fraction images of 20 children in a standard space to deduce correlations between myelin content and math abilities. Subjects wrote a calculation-based test and an applied problem-based test. The results implicated occipital/parietal white matter, the right anterior limb of the internal capsule and the left external capsule with positive correlations of 0.61,0.65 and 0.60, respectively.


11:48 7. Structural Brain Plasticity Visualized with Diffusion MRI Following a Learning and Memory Task

Tamar Blumenfeld-Katzir1, Ofer Pasternak2, Yaniv Assaf1

1Neurobiology Department, Tel-Aviv University, Tel-Aviv, Israel; 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

We utilized DTI to follow up on micro-structural changes that occur following a spatial memory task. We scanned rats before and after water maze task and compared their MRI scans using voxel-based statistics. Significant changes in the various DTI parameters were found in a multitude of brain regions including the limbic system and white matter systems. The changes in the DTI indices were found to correlate with immuno-reactivity staining of myelin, synapses and astrocytes. Using these observations, we conclude that DTI can be used as an in-vivo probe of structural plasticity both in gray matter and white matter.

12:00 8. Hard-Wired or Soft-Wired ? Evidence for the Structural Plasticity of White Matter Networks Following Anterior Temporal Lobectomy

Mahinda Yogarajah1, Niels Focke2, Silvia Bonelli1, Pam Thompson1, Christian Vollmar1, Andrew McEvoy3, Mark Symms1, Matthias Koepp1, John Duncan1

1MRI Unit, National Society for Epilepsy, Chalfont St Peter, Bucks, United Kingdom; 2University of Goettingen, Germany; 3University College London Hospital, United Kingdom

Epilepsy is the most chronic, common neurological condition. Many patients with temporal lobe epilepsy undergo anterior temporal lobe resection, but up to 40% of patients are at risk of language decline after surgery. We carried out a longitudinal study using diffusion tensor imaging to assess the structural reorganisation of white matter after surgery. In patients undergoing surgery in the language dominant hemisphere, there is an increase in FA in white matter connecting fronto-temporal regions. The location of these increases and their correlation with language function suggest they may represent the structural plasticity of language networks after surgery.

12:12 9. Diffusion MRI of Short-Term Spatial Memory Related Brain Plasticity

Ido Tavor1, Yaniv Sagi1, Shir Hofstetter1, Efrat Sasson1, Yaniv Assaf1

1Neurobiology, Tel Aviv university, Tel Aviv, Israel

Neuroimaging studies of brain plasticity reveal long-term learning related structural changes in several brain regions. Animal studies revealed that short term micro-structural changes can be observed with diffusion MRI. Here, we study the diffusion MRI changes in a short term spatial memory task in humans. Subjects underwent two MRI scans separated by two hours of a learning session. We found that DTI parameters had changed in several brain regions, including the hippocampus, entorhinal cortex, amygdala and insula. The main result of this work is that DTI can follow on learning-induced micro-structural tissue changes, already 2 hours following the training episode.

12:24 10. A Demonstration of Neural Plasticity in Resting Brain Network

Kuang-Chi Tung1, Jinsoo Uh1, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

We hypothesized that an important feature of the evoked activity, the plasticity of the neural response, may also be present in the resting condition and may provide critical information for understanding the nature and significance of the resting state brain activity. Using motor cortex as a model, we demonstrated for the first time that the resting brain activity can be altered after repetitive stimulation of the associated brain networks. This method may provide a new approach to study brain plasticity in humans and may find applications in studies of aging and neurodegenerative diseases.

12:36 11. Unilateral Infraorbital Denervation Leads to Plasticity in the Rat Whisker Barrel Cortex.

Xin Yu1, Stephen J. Dodd1, Seungsoo Chung1, John Isaac1, Judith R. Walters1, Alan P. Koretsky1

1NINDS, NIH, Bethesda, MD, United States

Interhemispheric plasticity may play a critical role during functional restoration following central/peripheral nervous system injuries in humans. Previously, the interhemispheric plasticity in the rat somatosensory cortex (S1) following forepaw unilateral denervation has been studied in order to develop rodent models of plasticity detected in humans by fMRI. Here, the effects of unilateral infraorbital denervation (IO) to rat whisker responses were studied. Large ipsilateral fMRI activation was detected after IO. In addition, BOLD signals in the contralateral barrel cortex were significantly increased. This indicates that the unilateral IO caused plasticity of the whisker-barrel cortex ascending pathways and increased interhemispheric interactions.

12:48 12. fcMRI Plasticity Following Rat Median Nerve Injury and Repair at 9.4T

Rupeng Li1, Patrick Hettinger2, Younghoon Cho1, Christopher P. Pawela1, Maida Parkins2, Seth Jones2, Ji-Geng Yan2, Andrzej Jesmanowicz1, Anthony Hudetz3, Hani Matloub2, James Hyde1

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 3Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States

Plasicity happening to the resting state connectivity map following rat peripheral nerve injury and repair was shown using 9.4T. Unique patterns of plasticity could help monitoring the neuro-network function when functional test in not available.

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