1966 B. S. in Microbiology, Ohio State University




Название1966 B. S. in Microbiology, Ohio State University
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RICHARD H. BALTZ


6438 North Olney Street

Indianapolis, IN 46220




Personal:


Date of Birth: September 23, 1944

Place of Birth: Johnson County, Indiana

Marital Status: Married, 5 children


Education:


1966 B.S. in Microbiology, Ohio State University,

Columbus, OH


1970 M.S. in Microbiology, University of Illinois,

Champaign-Urbana, IL


1971 Ph.D. in Microbiology (Biochemistry Minor),

University of Illinois, Champaign-Urbana, IL


Academic Activities and Employment:


2009-present Chief Scientific Officer, CognoGen Biotechnology Consulting, Indianapolis, IN


2004- 2009 Scientific Fellow, Cubist Pharmaceuticals, Lexington, MA. Retired September 30, 2009


2001- 2004 Executive Director of Discovery Research, Cubist Pharmaceuticals, Lexington, MA


1998- 2001 Chief Scientific Officer, CognoGen Biotechnology Consulting, Indianapolis, IN; Resident Consultant, Dow AgroSciences, Indianapolis, IN



1997- 1998 Visiting Research Advisor, Natural Products Discovery Division, Dow AgroSciences, Indianapolis, IN


1992-1998 Research Advisor, Infectious Diseases Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN.

Retired, November, 1998.

1990-1992 Research Advisor, Natural Products Research Division,

Lilly Research Laboratories


1989-1990 Research Advisor, Molecular and Cell Biology Division,

Lilly Research Laboratories


1983-1988 Senior Research Scientist, Molecular and Cell Biology

Division, Lilly Research Laboratories


1981-1990 Group Leader, Department of Molecular Genetics,

Molecular and Cell Biology Division, Lilly Research

Laboratories


1979-1982 Research Scientist, Biochemical Development Division and

Molecular and Cell Biology Division, Lilly Research

Laboratories


1974-1978 Senior Microbiologist, Biochemical Development

Division, Eli Lilly and Company


1973 Visiting Assistant Professor, Department of Microbiology,

University of Illinois, Urbana, IL


1971-1974 Postdoctoral research associate, Department of

Microbiology, University of Illinois, Urbana, IL


1969-1971 United States Public Health Service Trainee, Department

of Microbiology, University of Illinois, Urbana, IL


1968-1969 Teaching Assistant and Research Assistant, Department

of Microbiology, University of Illinois, Urbana, IL


1966-1968 Associate Microbiologist, Antibiotic Fermentation

Development Department, Eli Lilly and Company, Indianapolis, IN


Honors and Awards:


Charles Porter Award, Society for Industrial Microbiology - 2008

David Gottlieb Memorial Award, University of Illinois - 2007

Fellow, Society for Industrial Microbiology – 1999

Industrial Scientific Achievement Award, ASM Indiana Branch - 1997

Kitasato Medal, Kitasato Institute - 1985

MDS Panlabs Award, Society for Industrial Microbiology – 1999

Phi Kappa Phi - 1971


Professional Societies:


American Association for the Advancement of Science

American Society for Microbiology

Society for Industrial Microbiology and Biotechnology


Editorial Boards:


Antimicrobial Agents and Chemotherapy (1981-1987)

Applied and Environmental Microbiology (1981-1987)

Applied Microbiology and Biotechnology (1985-1987)

Biotechnology Letters (1996-2000)

Biotechnology Techniques (1996-2000)

Journal of Industrial Microbiology and Biotechnology

Senior Editor (1999-2004)

Ad Hoc Special Topics Editor (2006)

Senior Editor, Reviews (2008-present)

Microbiology (1999-2002)


Ad Hoc Editor:

Antimicrobial Agents and Chemotherapy

Antonie van Leeuwenhoek Journal of Microbiology

Applied and Environmental Microbiology

BMC Genomics

Chemistry and Biology

ChemBioChem

Current Microbiology

FEMS Microbiology Letters

Infection and Immunity

Journal of Antibiotics

Journal of Applied Microbiology

Journal of Bacteriology

Journal of Biological Chemistry

Microbiology and Molecular Biology Reviews

Molecular Microbiology

Nature Chemical Biology

Nature Biotechnology

Nature Reviews Microbiology

Proc Nat Acad Sci USA

Trends in Molecular Medicine

Society Offices, Working Groups and Advisory Boards:

Delegate for Joint US/USSR Seminar on Genetics of Actinomycetes, Yalta, 1980

Delegate for First Soviet-American Symposium on Antibiotics and

Chemotherapy, Moscow, 1988

Member Advisory Board for the International Commission of Genetics of

Industrial Microorganisms, GIM-IC (1983-present)

Secretary General, GIM-IC (1983-1994)

Vice-President, GIM-IC (1994-2002)

Member International Committee on Economic and Applied Microbiology,

ICEAM (1988-present)

Working Group on Gram Positive Bacteria, Recombinant DNA Advisory

Committee of the National Institutes of Health (1985-1986)

International Advisory Board for the 10th International Symposium on Biology

of Actinomycetes, Beijing, China (May 27-30, 1997)

Program Committee for the Fifth International Conference on the Biotechnology of Microbial Products (BMP): Novel Pharmacological and Agrobiological Activites, Williamsburg, VA (April 27-30, 1997)

Scientific Committee for the 11th International Symposium on the Biology of Actinomycetes, Crete (October 24-28, 1999)

Scientific Committee for the 12th International Symposium on the Biology of Actinomycetes, Vancouver, B.C. (August 5-9, 2001)

Scientific Committee for the 13th International Symposium on the Biology of Actinomycetes, Melbourne, Australia (Dec. 1-5, 2003)

International Advisory Board, 10th International Symposium on the Genetics of Industrial Microorganisms, Prague, Czech Republic (2006)

Board of Directors, Society for Industrial Microbiology (1999- 2002)

President Elect, Society for Industrial Microbiology (2003-2004)

President, Society for Industrial Microbiology (2004-2005)

Past President, Society for Industrial Microbiology (2005-2006)


Scientific Advisory Boards and Consultantships


Scientific Advisory Boards

Harvard/Broad Institute, Actinomycete Genome Sequencing (2008-2009)

SynBERC (2011)

TerraGen Discovery, Inc., (1998-2001)

U. of Illinois/Northwestern U. Natural Products Discovery (2011)


Consultantships

Biotica (2007; 2009-2010)

Cubist Pharmaceuticals (1997- 2001; 2009-present)

Dow AgroSciences (1998-2001; 2009-present)

Eli Lilly and Company (2007)

Integrated Genomics (1999- 2001)

Marion College Board of Visitors (2008)

Revaax Pharmaceuticals (2000- 2001)

Schering Plough Research Institute (1998- 2001)

TerraGen Discovery, Inc. (1999- 2000)

Third Rock Ventures (2010-present)

TMO Renewables LTD (2010)

Research Grants


Phase I SBIR Grant to genetically modify daptomycin. $150,000 (2001)

Phase I SBIR Grant to genetically modify A54145. $180,000 (2002)

Phase II SBIR Grant to genetically modify daptomycin. $900,000 (2003)


Current Scientific Interests:


Application of bacterial genomics to discovery of novel secondary metabolites from actinomycetes

Application of molecular genetics to discover novel secondary metabolites by combinatorial biosynthesis

Application of traditional mutagenesis and molecular genetics to improve secondary metabolite yields

Isolation of rare actinomycetes that produce novel secondary metabolites


Postdoctoral Students:


Dr. Donald R. Hahn (1988-1990)

Dr. Thomas J. Hosted (1992-1996)


Other Scientists Mentored:


Dr. Eugene Seno 1974-1979

Anna Radue 1974-1976

Karen Cox 1979-1981

Patty Matsushima 1979-1997

Jill Stonesifer 1978-1984

Karen Cox 1978-1981

Patricia Solenberg 1988-1997

Margaret McHenney 1985-1996

Dr. Paul Skatrud -1985-1991

Dr. Jim Miller – 1982-1991

Dr. Clegg Waldron – 1996-2001

Dr. Vivian Miao – 2000-2005

Dr. Steve Wrigley – 2001-2004

Dr. Paul Brian - 2000- 2008

Dr. Dylan Alexander – 2002- 2009

Dr. Kien Nguyen – 2002- 2009


PUBLICATIONS


  1. F. M. Huber, R. H. Baltz and P. G. Caltrider (1968). Formation of desacetylcephalosporin C in cephalosporin C fermentation. Appl. Microbiol. 16:1011-1014.




  1. F. M. Huber, P. A. Barnhill and R. H. Baltz (1971). Purification and partial characterization of a proteolytic enzyme from Cephalosporium acremonium (Corda). Mycopath. Mycol. Appl. 44:149-157.




  1. R. H. Baltz (1971). Infectious DNA of bacteriophage T4. J. Mol. Biol. 62:425-437.




  1. R. H. Baltz and J. W. Drake (1972). Bacteriophage T4 transformation: an assay for mutations induced in vitro. Virology 49:462-474.




  1. R. H. Baltz (1976). Biological properties of an improved transformation assay for native and denatured T4 DNA. Virology 70:52-64.




  1. R. H. Baltz, P. M. Bingham and J. W. Drake (1976). Heat mutagenesis in bacteriophage T4: the transition pathway. Proc. Nat. Acad. Sci. USA. 73:1269-1273.




  1. P. M. Bingham, R. H. Baltz, L. S. Ripley and J. W. Drake (1976). Heat mutagenesis in bacteriophage T4: the transversion pathway. Proc. Nat. Acad. Sci. USA. 73:4159-4163.




  1. J. W. Drake and R. H. Baltz (1976). The biochemistry of mutagenesis. Ann. Rev. Biochem. 45:11-37.




  1. R. H. Baltz (1978). Genetic recombination in Streptomyces fradiae by protoplast fusion and cell regeneration. J. Gen. Microbiol. 107:93-102.




  1. S. W. Queener and R. H. Baltz (1979). Genetics of industrial microorganisms. Ann. Reports Fermentation Processes 3:5-45.




  1. R. H. Baltz (1980). Genetic recombination by protoplast fusion in Streptomyces. Dev. Ind. Microbiol. 21:43-54.




  1. R. H. Baltz and P. Matsushima (1980). Application of protoplast fusion, site directed mutagenesis and gene amplification to antibiotic yield improvement in Streptomyces. Proceedings of the Joint US/USSR Seminar on the Genetics of Actinomycetes. U.S. Dept. of Commerce, Nat. Tech. Inform. Serv. p. 124-143.




  1. R. H. Baltz, E. T. Seno, J. Stonesifer, P. Matsushima and G. M. Wild (1981). Genetics and biochemistry of tylosin production by Streptomyces fradiae. In D. Schlessinger (ed.), Microbiology-1981. American Society for Microbiology, Washington, D.C., p. 371-375.




  1. R. H. Baltz and E. T. Seno (1981). Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin. Antimicrob. Agents Chemother. 20:214-225.




  1. E. T. Seno and R. H. Baltz (1981). Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations. Antimicrob. Agents Chemother. 20:370-377.




  1. R. H. Baltz and P. Matsushima (1981). Protoplast fusion in Streptomyces: conditions for efficient genetic recombination and cell regeneration. J. Gen. Microbiol. 127:137-146.




  1. R. H. Baltz (1982). Genetics and biochemistry of tylosin production: a model for genetic engineering in antibiotic-producing Streptomyces. Basic Life Sci 19:431-444.




  1. E. T. Seno and R. H. Baltz (1982). S-adenosyl-L-methionine: macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants which produce different levels of the macrolide antibiotic tylosin. Antimicrob. Agents Chemother. 21:758-763.




  1. N. D. Jones, M. O. Chaney, H. A. Kirst, G. M. Wild, R. H. Baltz, R. L. Hamill and J. W. Paschal (1982). Novel fermentation products from Streptomyces fradiae: X-ray crystal structure of 5-O-mycarosyltylactone and proof of the absolute configuration of tylosin. J. Antibiotics 35:420-425.




  1. R. H. Baltz, E. T. Seno, J. Stonesifer, P. Matsushima and G. M. Wild (1982). Genetics and biochemistry of tylosin production. In H. Umezawa et al. (ed.), Trends in Antibiotics Research - Genetics, Biosyntheses, Actions and New Substances. Japan Antibiotics Research Association, Tokyo, pp. 65-72.




  1. H. A. Kirst, G. M. Wild, R. H. Baltz, R. L. Hamill, J. L. Ott, F. T. Counter and E. E. Ose (1982). Structure-activity studies among 16-membered macrolide antibiotics related to tylosin. J. Antibiotics 35:1675-1682.




  1. R. H. Baltz, E. T. Seno, J. Stonesifer and G. Wild (1983). Biosynthesis of the macrolide antibiotic tylosin: a preferred pathway from tylactone to tylosin. J. Antibiotics 36:131-141.




  1. H. A. Kirst, G. M. Wild, R. H. Baltz, R. L. Hamill, J. W. Paschal and D. E. Dorman (1983). Elucidation of structure of novel macrolide antibiotics produced by mutant strains of Streptomyces fradiae. J. Antibiotics 36:376-382.




  1. R. H. Baltz and P. Matsushima (1983). Advances in protoplast fusion and transformation in Streptomyces. Experientia Suppl. 46:143-148.




  1. K. L. Cox and R. H. Baltz (1984). Restriction of bacteriophage plaque formation in Streptomyces spp. J. Bacteriol.
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