1. Lindenbaum, J., Tse-Eng, D., Butler, V. P. and




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Original articles


1. Lindenbaum, J., Tse-Eng, D., Butler, V.P. and Rund, D.G. Urinary excretion of reduced metabolites of digoxin. Am. J. Med., 71:67-74, 1981.


2. Lindenbaum, J., Rund, D. G., Butler, V.P., Tse-Eng, D. and Saha, J.R. Inactivation of digoxin by the gut flora: Reversal by antibiotic therapy. N. Engl, J. Med., 305:789-794, 1981.


3. Butler, V.P., Tse-Eng, D., Lindenbaum, J., Kalman, S.M., Preibisz, J.J., Rund, D.G. and Wissel, P.S. the development and application of a radioimmunoassay for dihydrodigoxin, a digoxin metabolite. J. Pharmacol. Ther., 221:123-131, 1982.


4. Rund, D.G., Lindenbaum, J., Dobkin, J. F., Butler, V. P. and Saha, J.R. Decreased digoxin cardioinactive-reduced metabolites after administration as an encapsulated liquid concentrate. Clin. Pharmacol. Exp. Ther., 34:738-743, 1983.


5. Rund, D.G., Dobkin, C. and Bank, A. Regulated expression of amplified human beta-globin genes. Blood 70:733-739, 1987.


6. Bank, A., Donovan-Peluso, M., Lerner, N. and Rund, D. Human globin gene expression after gene transfer. Blood Cells 13:269- 275, 1987.


7. Rund, D., Kornhendler, N., Shalev, O., Oppenheim, A. The origin of sickle cell alleles in Israel. Human Genetics, 85:521-524, 1990.


8. Oppenheim, A., Rund, D., Yaari, A., Miller, B.A., Kazazian, H.H. Jr., Nathan, D.G., and Rachmilewitz, E.A. Intrinsic capacity for high fetal hemoglobin production in a Druze patient with o- thalassemia intermedia is due to an unlinked genetic determinant. Human Genetics, 86:175-180, 1990.


9. Rund, D., Filon, D., Granat, M., Hemo, Y., Cohen, T., Oppenheim, A., Rachmilewitz, E.A. Prenatal diagnosis of thalassemia: Identification of mutations in conjunction with gene amplification in vitro. Harefuah (in Hebrew), J. Israel Med. Assoc., 120:57-60, 1991.


10. Rund, D., Cohen, T., Filon, D., Dowling, C.E., Warren, T., Barak, I., Rachmilewitz, E.A., Kazazian, H.H. Jr., Oppenheim, A. Evolution of a genetic disease in an ethnic isolate: -thalassemia in the Jews of Kurdistan. Proc. Natl. Acad. Sci. USA., 88:310-314, 1991.


11. Rund, D., Filon, D., Strauss, N., Rachmilewitz, E.A., Oppenheim, A. Mean corpuscular volume (MCV) of heterozygotes varies with severity of the mutation. Blood, 79:238-243, 1992.


12. Rund, D., Filon, D., Warren, T.C., Dowling, C.E., Kazazian, H.H. Jr., Rachmilewitz, E.A. and Oppenheim, A. Molecular analysis of -thalassemia in Israeli ethnic groups and its application to prenatal diagnosis. Hematology Reviews and Communications, 6:117-124, 1992.


13. Rund, D., Dowling, C., Rachmilewitz, E.A., Kazazian, H.H. Jr., Oppenheim, A. Novel mutations in the -globin polyadenylylation signal reveal extended transcripts and new RNA polyadenylylation sites. Proc. Natl. Acad. Sci. USA., 89:4324-4328, 1992.


14. Rund, D., Abramov, A., Oppenheim, A., Filon, D. Silent carrier -thalassemia due to a severe mutation in the -globin gene. Eur. J. Ped., 152:574-576, 1993.


15. Oppenheim, A., Jury, C.L., Rund, D., Vuilliamy, T.J., Luzzatto, L. G6PD Mediterranean accounts for the high prevalence of G6PD in Kurdish Jews. Human Genetics, 91:293-294, 1993.


16. Oppenheim, A., Oron, V., Filon, D., Fearson, C.C., Kazazian, H.H. Jr., Rund, D. Sporadic alleles, including a novel mutation, characterize -thalassemia in Ashkenazi Jews. Human Mutation, 2:155-157, 1993.


17. Filon, D., Oron,V., Krichevski S., Shaag, A., Warren, T.C., Goldfarb, A., Shneor, Y., Koren, A., Aker, M., Abramov, A., Rachmilewitz, E.A., Rund, D., Kazazian, H.H. Jr., and Oppenheim, A. Diversity of -globin mutations in Israeli ethnic groups reflects recent historic events. Am. J. Hum. Genet, 54: 836-843, 1994.


18. Oron, V., Filon, D., Oppenheim, A. and Rund, D. Severe thalassemia intermedia caused by interaction of homozygosity for -globin triplication with heterozygosity for o-thalassemia. Br. J. Haematology, 86: 377-379, 1994.


19. Rund, D., Rachmilewitz, E.A. Thalassemia 1995: Older patients, new therapies. Blood Reviews, 9: 25-32, 1995.


20. Filon, D., Oron, V., Shawa, R., Elborno, E., Najjar, K., Tulchinsky, T., Rachmilewitz, E.A., Rund, D., Oppenheim, A. Spectrum of -thalassemia mutations in the Gaza area. Human Mutation, 5:351-353, 1995.


21. Rund, D., Rachmilewitz, E.A. Advances in the pathophysiology and treatment of thalassemia. Critical Reviews in Hematology-Oncology, 20:237-254, 1995.


22. Gillis, S., Dann E.J., Rund, D. Selective discharge of patients with acute myeloid leukemia during chemotherapy-induced neutropenia. Am. J. Hematol, 51:26-31, 1995.


23. Filon, D., Oron, V., Schneor, Y., Rund, D., Oppenheim, A. A new frameshift mutation in codon 10 of the -globin gene discovered during prenatal diagnosis. Human Mutation, 6:278-279, 1995.


24. Oppenheim, A., Filon, D., Faerman, M., Oron, V., Smith, P., Rund, D. The evolution of -thalassemia since early human history. Cellular Pharmacology, 3:195-198, 1996.


25. Ben-Yehuda, D., Krichevsky, S., Caspi, O., Rund, D., Polliack, A., Abeliovitch, Zelig, O., Paltiel, O., Or, R., Peretz, T., Ben-Neriah, S., Yehuda, O., Rachmilewitz, E. p53 mutations and microsatellite instability in therapy-related leukemia suggests mutator phenotype. Blood, 88:4296-4303, 1996.


26. Oron-Karni, V., Filon, D., Rund, D., Oppenheim, A. A novel mechanism generating short deletions/insertions following slippage is suggested by a mutation in the human 2-globin gene. Human Molecular Genetics, 6:881-885, 1997.


27. Fridlender, Z., Rund, D. Multidrug resistance (MDR1): its significance in hematological malignancies and its role in normal tissues and blood cells. Harefuah (in Hebrew) 133:64-70, 1997.


28. Rund, D, Schaap, T., Gillis, S. Intensive plasmapheresis for thrombotic thrombocytopenic purpura: long term outcome. J. Clinical Apheresis, 12:194-195, 1997.


29. Rund, D., Oron-Karni, O., Filon, D., Goldfarb, A., Rachmilewitz, E., Oppenheim, A. Genetic analysis of -thalassemia intermedia in Israel: Diversity of mechanism and unpredictability of phenotype. Am. J. Hematol, 54:16-23, 1997.


30. Rund, D., Dagan, M. Dalyot, N., Kimchi-Sarfaty, C., Schoenlein, P., Gottesman, MM, Oppenheim, A. SV40 pseudovirions efficiently transduce human hematopoietic cells with multidrug resistance (MDR1) gene. Human Gene Therapy, 9:649-657, 1998.


31. Rund, D., Fibach, E., Goldfarb, A., Friedberg, A., Rachmilewitz, E.

Heme arginate therapy for -thalassemia: in vitro and in vivo effects. Acta Hematologica, 100:82-84, 1998.


32. Oron-Karni, V., Filon, D., Oppenheim, A., Rund, D. Rapid detection of the common Mediterranean -globin deletions/rearrangements using PCR. Am J. Hematol, 58:306-310, 1998.


33. Steiner, H., Polliack, A., Kimchi-Sarfaty, C., Libster, D., Fibach, E., Rund, D. Differences in rhodamine 123 efflux in B type chronic lymphatic leukemia suggest possible gender and stage variations in drug resistance gene activity. Annals Hematol, 76:189-194, 1998.


34. Rund, D., Azar, I., Shperling, O. A mutation in the promoter of the multidrug resistance gene (MDR1) in human hematological malignancies may contribute to the pathogenesis of resistant disease. Adv. Exp. Med. Biol.;457:71-5, 1999.


35. Dalyot-Hermann, N., Rund, D., Oppenheim, A. Expression of -globin in primary erythroid progenitors of -thalassemia patients using an SV40-based gene delivery system. J. Hematotherapy, 8:593-599, 2000.


36. Rund, D., Rachmilewitz, E. A. New trends in the treatment of -thalassemia. Crit. Rev. Hematol. Oncol. 33:105-118, 2000.


37. Oron-Karni, V., Filon, D., Shifrin, Y., Fried, E., Pogrebijsky, G., Oppenheim, A., Rund, D. Diversity of -globin mutations and clinical presentation of -thalassemia in Israel. Am J. Hematol. 65: 196-203, 2000.


38. Rund, D., Rachmilewitz, E.A. Pathophysiology of - and -thalassemia; treatment implications. Sem. Hematol., 38:343-349, 2001.

39. Mahmoud Abd El-latif, M., Filon, D., Rund, D., Oppenheim, A., Kanaan, M. The -globin mutation IVS1-6 accounts for half of the thalassemia chromosomes in the Palestinian population of the mountain region. Hemoglobin, 26:33-40, 2002.


40. Kimchi-Sarfaty, C., Ben-Nun-Shaul, O., Rund, D., Pastan, I., Oppenheim, A., Gottesman, M.M. In vitro packaged SV40 pseudovirions as highly efficient vectors for gene transfer. Hum. Gene Ther., 13:299-310, 2002.

41. Durst, R., Rund, D., Schurr, D., 1, Eliav, O., Ben-Yehuda, D., Shpizen, S., Ben-Avi, L., Schaap, T., Pelz, F., Leiterdorf, E. One year's experience with an LDL apheresis system. Isr. Med. Assoc. Journal, 4:677-680, 2002.


42. Altarescu, G., Rudensky, B., Abrahamov, A., Goldfarb, A., Rund, D., Goldfarb, A. Zimran, A., Elstein, D. Plasma chitotriosidase activity in patients with -thalassemia. Am. J. Hematol. 71:7- 10, 2002.


  1. Mittleman, M., Zeidman, A., Kanter, P., Katz, O., Oster, H., Rund, D., Neumann, D. Erythropoietin has an anti-myeloma effect: a hypothesis based on a clinical observation supported by animal studies. Eur J. Haematol, 72:155-65, 2004.




  1. Rund, D. and Ben-Yehuda, D. Therapy-related leukemia and myelodysplasia: Evolving concepts of pathogenesis and treatment. Hematology, 9:179-187, 2004.




  1. Rund, D., Filon, D., Jackson, N., Asher, N., Oron-Karni, V., Sacha, T., Czekalska, S., Oppenheim, A. An unexpectedly high frequency of heterozygosity for -thalassemia in Ashkenazi Jews. Blood Cells, Molecules and Diseases, 33:1-3, 2004.




  1. Gross, M., Ben-Yaacov, A., Rund, D., Elidan, J. Role of open incisional biopsy in parotid tumors. Acta Otolaryngol. 124:758-60, 2004.


47. Rund, D. and Rachmilewitz, E.A. Update on Thalassemia. New Engl J Med., 353:1135-46, 2005.


48. Rund D., Krichevsky, S., Bar-Cohen, S., Goldschmidt, N., Kedmi, M., Malik, E., Shafran-Tikva, S., Ben-Neriah, S., Ben-Yehuda, D. Therapy-related leukemia: Clinical characteristics and analysis of new molecular risk factors in 96 adult patients. Leukemia, 19:1919-28, 2005.


49. Gofrit, O., Rund, D., Podeh, D. Thrombocytosis accompanying urinary tract infection suggests obstruction or abscess. Am. J. Emerg. Med. 24:118-121, 2006.


50. Rahav, G., Volach, V., Shapira, M., Rund, D. Rachmilewitz, E., Goldfarb, A. Severe infections in thalassemic patients: prevalence and predisposing factors. Br. J. Haematol. 133:667-674, 2006.


51. Malik, E., Bar Cohen, S., Sahar, D., Dann, E.J., Rund, D. The frequencies of NAD(P)H quinone oxidoreductase (NQO1) variant allele in Israeli ethnic groups and the relationship of NQO1*2 to adult acute myeloid leukemia in Israeli patients.
Haematologica. 91:956-9, 2006.


52. Breitbar, O., Bishara-Shieban, J., Glickstein, H., Kott-Gutkowski, M., Pace, U., Rund, D., Stein, W. D. An ELISA-based procedure for assaying proteins in digests of human leukocytes and cell lines, using specifically selected peptides and appropriate antibodies. Proteome Sci. Jun 21;4:14, 2006.


53. Gofrit, O.N., Shapiro, A., Rund, D., Landau, E.H., Katz, R., Shenfeld, O.Z., Pode D. Postoperative thrombocytosis as a marker for complications after urologic

surgery. Scand J Urol Nephrol. 40:161-5, 2006.


54. Lalazar, G., Rund, D., Shouval, D. Screening, prevention and treatment of viral hepatitis B Reactivation in patients with haematological malignancies. Br J Haematol. 136: 699-712, 2007.


55. Rund, D. Multidrug Resistance in Lymphoma: is it time for clinical trials? Leuk Lymphoma, 48:643-4, 2007.


56. Kedmi, M., Maayan, S. Bar Cohen, S., Hauzi, M., Rund, D. MDR1 and CYP3A4 polymorphisms are associated with HIV seropositivity in Israeli patients but do not influence the course of HIV disease. AIDS Patient Care and STDs 21:653-8, 2007.


57. Elazary, A.S., Wolf, D.G., Amir, G., Avni, B., Rund, D., Ben-Yehuda, D., Sviri, S. Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. J Clin Virol 40:156-9, Epub, Aug 17, 2007.


58. Rund, D. Hyperforin modulation of drug resistance: Saint or sinner? Leuk Lymphoma 48:1470-1, 2007.


59. Rund, D. FLT3 tandem duplication in low risk MDS: clinical and basic science relevance. Leuk Lymphoma, 48:2302-3, 2007.
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