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Summary of Linkage Infrastructure Applications for Funding to Commence in 2006


Queensland


The University of Queensland

LE0668507 A/Prof BJ Carroll; Dr DJ Maclean; Dr PR Ebert; Prof M Trau; Prof MP Jennings; Dr PR Young; Prof RJ

Henry; A/Prof LS Lee

Approved Real time PCR and nanoparticle diagnostic facilities for high throughput quantitative analysis of

Project Title genomic structure and gene expression

2006 : $260,000

Primary RFCD 2702 GENETICS


Partner Organisation(s)

The University of Queensland

Southern Cross University

Administering Institution The University of Queensland

Project Summary

Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic

need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically diverse

genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, pioneered by

The University of Queensland (UQ) and Southern Cross University (SCU) using ARC funding in 1996, is now the technology

of choice for much of this research. This project will provide high throughput equipment for real time PCR, and will develop

complementary high throughput "nanoparticle" DNA genotyping technologies, with applications to medicine and agriculture.


LE0668543 A/Prof MJ Garson; Dr SE Bottle; Prof MJ Gidley; Prof PN Shaw; Dr JJ De Voss; Dr JT Blanchfield; Prof I

Toth

Approved A high resolution, high throughput chromatographic system for separation and characterisation of

Project Title complex samples

2006 : $280,000

Primary RFCD 2504 ANALYTICAL CHEMISTRY


Partner Organisation(s)

The University of Queensland

Queensland University of Technology

Administering Institution The University of Queensland

Project Summary

Purchase of this equipment will support innovative and collaborative research addressing three of the National Research

Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's

bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority

goals of breakthrough science and frontier technologies. The research into trace components in food products, and on fruit fly

chemistry, relates to National Research priority four 'Safeguarding Australia', with a priority goal of protecting Australia from

invasive diseases and pests. Nutraceutical research addresses the goal of 'Promoting and maintaining good health'.


LE0668521 A/Prof IR Gentle; Prof GM Lu; Prof M Trau; Prof J Drennan; Prof AK Whittaker; A/Prof JL Martin; A/Prof RL

Frost; Dr JT Kloprogge; Dr CL Brown

Approved Small Angle Scattering Facility for the Materials and Biological Sciences

Project Title

2006 : $300,000

Primary RFCD 2501 PHYSICAL CHEMISTRY (INCL. STRUCTURAL)


Partner Organisation(s)

The University of Queensland

Queensland University of Technology

Griffith University

Administering Institution The University of Queensland

Project Summary

There are many benefits to the community from the application of modern technology for materials and protein

characterisation, particularly one that is as broadly applicable as small angle scattering. For example, it can directly aid in the

development of new materials for energy storage and generation, biomaterials for improved health and the process of design

of drugs for many types of disease. This facility will benefit a large number of researchers and significantly enhance the

outcomes of recent investments in high quality pure and applied research.


LE0668241 Prof TJ Gonda; Dr BG Gabrielli; Dr SM Grimmond; Dr SC Barry; Prof PF Bartlett; Dr JP Whitehead; Prof M

Crossley; Dr RW Johnstone; A/Prof EA Musgrove

Approved A Facility for High Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression

Project Title Cloning

2006 : $824,610

Primary RFCD 2701 BIOCHEMISTRY AND CELL BIOLOGY


Partner Organisation(s)

The University of Queensland

The University of Adelaide

The University of Sydney

Peter MacCallum Cancer Institute

Garvan Institute of Medical Research

Administering Institution The University of Queensland

Project Summary

The proposed facility will represent world leading technology in functional genomics and provide Australian scientists with

unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental

knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems

such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which

new therapies may be developed. This endeavour will contribute to national research priorities in both the health and

scientific/technological development arenas.


LE0668073 Prof JA Hay; A/Prof RA Fotheringham; A/Prof DJ Carter; Ms KM Kilner; Ms AH Horn; Prof BH Bennett; Prof

PR Eggert; Mr JF Arnold; Prof EA Webby; Mr RH Coleman; Prof GR Worby; A/Prof W Ommundsen; Ms

DM Bird; Prof DJ Haskell; Dr CM Taylor; Dr P Mead

Approved AustLit   humanities research infrastructure development through knowledge based dataset

Project Title building, augmentation of key research elements and ICT developments.

2006 : $544,000

Primary RFCD 4202 LITERATURE STUDIES


Partner Organisation(s)

The University of Queensland

The University of New South Wales

Monash University

The University of Sydney

The Flinders University of South Australia

The University of Western Australia

Deakin University

James Cook University

University of Tasmania

Administering Institution The University of Queensland

Project Summary

The AustLit development and augmentation program 2006 2008 will enable researchers to gain a greater understanding of

the breadth and scope of Australia's conversation with the world through its literature by providing new datasets and

enhanced access to the pre eminent resource to our literary culture. AustLit aims to deliver authoritative information and

analysable data about all Australian writers and their writing and in 2006 will develop specialist datasets relating to Aboriginal

and Torres Strait Islander writers; multicultural writers; and regional and colonial writing from Tasmania and Qld. ICT

developments will provide other collaborative groups with an opportunity to use a highly successful middleware platform for

new KM projects.


LE0668526 A/Prof RJ Lewis; Dr JD Hooper; Dr DL Pountney; Prof JF Hancock; Prof RJ Capon; Prof Dr MJ Waters;

Prof R Minchin; Dr BA Reynolds; Prof P Timms; Dr SE Bottle; Prof JA Clements; Prof NW Johnson

Approved Biomolecular discovery and analysis facility

Project Title

2006 : $542,000

Primary RFCD 2701 BIOCHEMISTRY AND CELL BIOLOGY


Partner Organisation(s)

The University of Queensland

Queensland University of Technology

Griffith University

Administering Institution The University of Queensland

Project Summary

This facility will provide Australian researchers with unrivalled access to advanced cell visualisation and analysis tools, which

until very recently were only available to the pharmaceutical industry and large US and European institutions. The facility will

allow new approaches to identifying novel natural products and understanding cell signalling pathways. Knowledge of these

pathways and the identification of molecules that can affect them are keys to understanding normal cellular physiology and

identifying drug like molecules able to inhibit malfunctioning pathways found in different disease such as cancer. The facility

will accellerate drug discovery and basic research in cell biology and underpin National Research Priorities.


LE0668382 A/Prof JL Martin; A/Prof IR Gentle; A/Prof CJ Kepert; Dr P Turner; Dr JM Guss


Approved e Research Infrastructure for the Molecular and Materials Structure Sciences

Project Title

2006 : $1000,000

Primary RFCD 2701 BIOCHEMISTRY AND CELL BIOLOGY


Partner Organisation(s)

The University of Queensland

The University of Sydney

Administering Institution The University of Queensland

Project Summary

Understanding molecular and materials structure in atomic detail is vital to a knowledge based economy and a healthy

society. The development of smart materials, nanotechnological devices, hydrogen storage materials, molecular switches,

magnets and sensors, for example, depends on knowledge of three dimensional atomic structure. Cures for illnesses such

as SARS, AIDS and Alzheimer's disease and understanding the aging process depends on knowledge of biomolecular

structure. The deployment and development of automation enhanced remote access to structural instruments through the

web will greatly enhance Australian structure based research, and make this science accessible to the public.


LE0668445 Prof BA Pailthorpe; Dr RA Gingold; Prof DA Abramson; A/Prof IM Atkinson; Prof S Crozier; Prof MA Ragan;

Prof ML Heron; Dr A Khan; Dr PV Ridd; Dr NS Bordes; A/Prof MA Knackstedt; Prof RA Lewis

Approved Data Grid Storage Infrastructure for e Research

Project Title

2006 : $800,000

Primary RFCD 2916 COMPUTER HARDWARE


Partner Organisation(s)

The University of Queensland

The Australian National University

Monash University

James Cook University

OTHER   QPSF Ltd

Administering Institution The University of Queensland

Project Summary

Vast increases in computing power and the arrival of new scientific instruments are contributing to the so called data deluge

of the 21st century. Archiving these data is essential to research. While the underlying computing and network requirements

are well resourced, data storage capacity has been relatively neglected in Australia. A continuing problem in Australian

research communities is the absence of coordinated digital storage resources. In many cases computational and

experimental data are stored on ad hoc resources, such as local university servers, PC disc drives, CDs, or DVDs, and are

not generally accessible. The central goal of this proposal is to provide a long term, integrated scientific data storage capacity

for Australia.


LE0668246 Dr LJ Richards; Dr GJ Goodhill; Prof PF Bartlett; Prof PA Koopman; Prof BJ Wainwright; Prof MT Smith;

Prof A Mackay Sim; Prof T Kilpatrick

Approved Advanced Cell Labelling and Imaging Facility

Project Title

2006 : $400,000

Primary RFCD 3207 NEUROSCIENCES


Partner Organisation(s)

The University of Queensland

Griffith University

The University of Melbourne

Administering Institution The University of Queensland

Project Summary

Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important

frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide

solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and

ageing related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as

to better understand the genetic regulation of normal cellular processes.

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