Stephen (Steve) Brandt, M. D. Lab




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НазваниеStephen (Steve) Brandt, M. D. Lab
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ROTATION GUIDE

Cell and Developmental Biology

2008-2009




Timothy Blackwell, M.D.                            Lab: B-1307 MCN Tel #: 3-1773

Professor, Medicine                                              Office: T-1217 MCN Tel #: 3-4761

– Allergy/Pulmonary/Critical Care timothy.blackwell@vanderbilt.edu

Cell and Developmental Biology, Cancer Biology     


Research Interest:  Transcriptional regulation of mediators of:  1) lung inflammation and injury, 2) lung repair and fibrosis, and 3) lung carcinogenesis.  We are interested in how manipulating key signaling pathways, particularly NF-kB can alter the pathobiology of these processes.


Rotation ProjectsPotential projects for new students include studying models of lung injury, remodeling, and host defense using genetically modified mice and cell culture systems.  Other potential projects involve models of lung carcinogenesis and metastasis.  





Stephen (Steve) Brandt, M.D. Lab:  540-542 PRB Tel #: 6-1808

Professor, Medicine, Office: 540B PRB Tel #: 6-1809

Cell and Developmental Biology, stephen.brandt@vanderbilt.edu

and Cancer Biology

 
Research Interests:  Regulation of gene expression in normal and leukemic hematopoiesis.


Rotation Projects: Our laboratory is interested in the function of transcription factors, particularly those of the basic helix-loop-helix (bHLH) family, in erythroid and monocytic differentiation and blood vessel formation.  Rotation projects will employ a combination of molecular biology techniques (especially as related to transcription) and mammalian cell culture (e.g. of hematopoietic or endothelial cells). Current interests include the actions of the bHLH transcription factor TAL1 (or SCL) in mouse monocyte/macrophage differentiation and the functions in transcriptional regulation and erythroid differentiation of two recently discovered components of TAL1-containing complexes, the ring finger protein Ring1B and single-stranded DNA-binding protein SSBP2. Students interested in rotations are encouraged to phone or e-mail for more details





Vivien A. Casagrande, Ph.D. Lab: T-2304 MCN Tel #: 2-2694

Professor, Cell and Developmental Biology, Office: T-2302 MCN  Tel #: 3-4538

Psychology, vivien.casagrande@vanderbilt.edu

Ophthalmology & Visual Sciences 


Research Interest: Our laboratory is interested in the functional significance and structural correlates of proposed parallel visual information channels in primates. 

http://www.psy.vanderbilt.edu/faculty/Casagrande/Casagrandelab/index.htm


Casagrande continued

Rotation Projects:  Students who rotate in this laboratory will be trained in a variety of techniques used to examine the function and structure of the visual system using anesthetized and awake behaving primates. Specific projects for this year include: 1) Comparison of the morphologies of axons from two main inputs to a higher visual cortical area to determine if signature profiles of a driver axon can be established. This project uses a variety of tools including surgery, electrophysiology, optical imaging, immunocytochemistry and confocal microscopy to compare the morphologies of specific types of axon in relationship to physiology. 2) Determine under what conditions auditory input influences visual responses in the visual thalamus of awake, behaving monkeys. This project uses electrophysiological recording to examine firing of individual cells while the monkey performs different tasks while auditory and visual stimuli are presented. 3) Examine the responses of pulvinar neurons to complex visual stimuli in anesthetized primates to determine if these responses are similar to responses seen in cortical target neurons. This project uses electrophysiological tools and analysis. 4) Determine the role of feedback from higher cortical visual areas to lower visual areas by pharmacologically manipulating the feedback pathway and examining for changes in response properties in a lower visual cortical area. This project uses as combination of optical imaging, recording and pharmacological manipulations. 5) Explore the role of synchrony as a mechanism for coding visual features using multielectrode recording. This project using a hundred electrode array to record from multiple single visual cortical cells simultaneously in an anesthetized primate All of these rotation projects involve collaborative interactions with other laboratories especially the laboratories of Dr. Jeffrey Schall (Psychology), Dr. A.B. Bonds (Electrical Engineering and Computer Science) and Dr. Mark Wallace (Department of Hearing and Speech Sciences).  





Jin Chen, M.D., Ph.D.  Lab: A4323 MCN  Tel #: 3-3820

Associate Professor, Medicine, Office: A4323MCN  Tel #: 3-3819

Cell and Developmental Biology, jin.chen@mcmail.vanderbilt.edu

 and Cancer Biology


Research Interest: Eph receptor tyrosine kinase, blood vessel formation, cancer metastasis
http://medschool.mc.vanderbilt.edu/facultydata/php_files/part_dept/show_part.php?id3=747
 
Rotation Projects: Our goal is to understand the molecular mechanisms that regulate angiogenesis in an effort to identify new targets for therapeutic intervention in cancer and cardiovascular diseases.  Rotation projects are aimed at providing an introduction to molecular and cell biology while contributing to our goal of understanding the role of Eph RTK in angiogenesis and tumor metastasis.  Projects are expected to evolve from open discussion. Examples of rotation project include, but not limited to, generation of Eph receptor mutants, siRNA knock down of signaling molecules in the Eph receptor pathway, imaging of tumor-induced endothelial cell migration, and analysis of tumor sections from transgenic/knock out mice.




Chin Chiang, Ph.D.  Lab: 4114 MRB III Tel #: 3-4916

Associate Professor Office: 4110 MRB III Tel #: 3-4922

Cell and Developmental Biology chin.chiang@vanderbilt.edu


Research Interest: Sonic hedgehog signaling in development and disease

Rotation Projects: Sonic hedgehog (Shh) is a secreted signaling molecule that specifies cell fates by instructing cells to either proliferate or differentiate in a context-dependent manner. Therefore, it is not surprising that dysregulation of the Shh signal, either at the level of Shh secretion, movement or reception, has been linked to various birth defects and cancers. Over the past several years, we have generated a number of mouse mutants serving as paradigms for human diseases. Additionally, we have also generated several transgenic mouse lines that enable us to generate tissue-specific deletion of Shh pathway activity. Rotation projects will include the utilization of these tools to understand the cellular and molecular mechanisms of Shh signaling in brain development and disease.





Robert J. Coffey, M.D. Lab: 4148 MRB III Tel #: 3-6230

Professor, Medicine, Office: 4140MRBIII Tel #: 3-6228

Cell and Developmental Biology robert.coffey@vanderbilt.edu

                                                                                                                                   
Research Interest: The Coffey lab seeks a comprehensive understanding of the role of EGF receptor (EGFR) and its ligands in normal epithelial cell growth as well as how these functions are altered in cancer.

https://medschool.mc.vanderbilt.edu/facultydata/php_files/show_faculty.php?id3=749

Rotation Projects: The EGFR has critical functions in regulating developmental processes as well as normal cell function in the adult. EGFR function is often misregulated in cancer, and this misregulation can help to drive carcinogenesis. Our lab is interested in the normal and aberrant cancerous functions of EGFR through studying the ligands that bind and activate it. We focus on the trafficking and processing of three of these ligands TGF- amphiregulin and HB-EGF. TGF- amphiregulin and HB-EGF each have unique characteristics that lead to different downstream signaling events. We are interested in understanding the diverse molecular consequences of these various ligands in regulating growth and differentiation of polarized epithelial cells. We are also interested in other pathways, such as the Wnt pathway, that intersect with EGFR signaling, addressing their roles in cancer using cell culture models, mouse models and in the human cancers directly. Potential rotation projects include:

1) Validating proteomic data that has identified a novel class of basolaterally targeted exocytic vesicles that contain TGF as a cargo and Naked2, a putative negative regulator of Wnt signaling, as a coat;

2) Analyzing a tumor suppressor role for Naked2 using recently generated conditional knockout and transgenic mice;

3) Helping to establish a lentiviral expression system for both primary intestinal cells and established intestinal cell lines to overexpress and knockdown expression of specific genes;

4) Helping to characterize molecular changes that occur in Ménétrier’s disease, a premalignant overgrowth state of the stomach that is highly sensitive to EGFR blockade.





Mark P. deCaestecker, M.D., Ph.D. Lab: C-3111 MCN Tel #: 2-3081

Assistant Professor of Medicine, Office: C3126 MCN Tel #: 3-2844

Cell and Developmental Biology mark.de.caestecker@vanderbilt.edu

and Cancer Biology

 

Research Interest:   Stem cell differentiation in kidney development, malignancy and tissue injury repair, and BMP/TGF- signaling in vascular remodeling.    

          

Rotation Projects: Our laboratory is interested in the mechanisms regulating kidney development. Over the last few years we have focused on the role of CITED1, 2 and 4, a family of transcriptional co-activators that appear to be involved in regulating fate and/or migration of epithelial progenitor cells within the developing kidney. Our studies have involved analysis of all three mouse mutant lines, lineage tracing of CITED1 expressing cells using BAC transgenic mice and evaluation of the cellular functions of CITED1 using cell culture and biochemical approaches. In addition, based on our preliminary evaluation of CITED1 knockout mice, we have begun to evaluate the role of placental function in regulating the development of the renal medulla. These studies are likely to have implications for in patients with intrauterine growth retardation, as there is evidence that this is associated with the onset of hypertension.


The specific focus of an IGP rotation projects will be to extend findings from recent cell culture studies in our lab. The first project is based on the observation that CITED1 expression regulates cell adhesion by modifying lamelapodia formation, and will involve the use of siRNA knockdown and rescue strategies, and cell adhesion signaling studies to evaluate the mechanisms by which CITED1 regulates this response. The second project is based on the observation that BMP signaling regulates the expression of TGF- activated SMAD2/3 phosphatase activity. These studies will involve biochemical modification of phosphatase activity and expression in order to define its impact on BMP and TGF dependent cross talk in pulmonary vascular cells





Daniela Drummond-Barbosa, Ph.D. Lab: 4124 MRB III Tel #: 6-3616

Assistant Professor Office: 4120B MRBIII Tel #: 6-3620

Cell and Developmental Biology daniela.drummond-barbosa@vanderbilt.edu

Research interest: Stem cells, insulin, and the dietary control of oogenesis in Drosophila


Rotation projects: How does diet control stem cells and their descendents in the Drosophila ovary? We have shown that nutritional inputs can control the number of cells produced in the Drosophila ovary. This process is mediated in part by neural insulin-like peptides that directly control the rate of germline stem cell division and the growth of oocytes. We are taking several approaches to identify other signals controlling stem cell activity and ovarian function in response to diet. Our goal is to dissect the molecular mechanism of action of these signals and understand how they are integrated in the ovary. Rotation projects include: the study of the potential role of fat-derived molecules in the dietary control of oogenesis; the functional analysis of additional signaling molecules; participation in a screen for factors controlling stem cells.




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