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![]() ![]() ![]() ![]() ![]() ![]() MARKS DISTRIBUTION (ACCORDING TO AUTONOMY) FOR ALL THEORY COURSES: -
2) End semester (final examination) of all theory courses Total: 100 marks 3) Total of on semester + end semester evaluation is of : 200 marks 4) To pass a theory course student should obtain Minimum: - 40 marks in on semester evaluation. : - 35 marks in end semester evaluation. Total: - 80 marks out of 200. Criterion for passing and failing the theory course: -
Distribution FOR ALL PRACTICAL (LABORATORY) COURSES: -I) On semester evaluation of all practical (laboratory) courses would be of total: 120 marks.
II) End semester evaluation (final lab exam + oral or viva test) Total: 80 marks III) Total of on semester evaluation final lab examination + end semester evaluation is of : 200 marks IV) To pass a lab course student should obtain Minimum: - 48 marks in on semester evaluation. 28 marks in end semester evaluation. Total- 80 marks out of -200 Criterion for passing and failing the lab course is just like theory course. Distribution CALCULATION OF SEMESTER GRADE POINT AVERAGE: -Semester grade point average (SGPA) is the weighted average of the grade for the subjects registered in a Semester and is computed as follows: ![]() ![]() ![]() Cumulative Grade Point Average (CGPA) is the weighted average of the grades of the subjects for the registered in the semester. N. C. COLLEGE OF ENGINEERING, ISRANASCHEME OF STUDIES AND EXAMINATION B.Tech. -BIOTECHNOLOGY 4th Year (Semester–VII) 2011-12
*Departmental Elective: NanoBiotechnology (NC-BT-415) OR Biosensor (NC-BT-417) 7th Semester B. Tech (Bio-Technology) BIOINFORMATICS NC-BT-401 L T End Semester Examination: 100 Marks 3 1 On Semester Examination: 100 Marks Note: - 1. There are NINE questions in a set of question-paper. All questions carry equal marks.
the whole syllabus. Attempt ONE question from each of the other four Units UNIT I 1. Information Theory And Biology: Entropy and information- Shannon's formula-divergence from equiprobability and independence, elementary ideas about Mark off Chains and Ergodic process, redundancy concepts - applications to DNA and protein sequences. 2. Databases: a.) Sequence Databases: the nucleotide and protein sequence databases: introduction, primary and secondary databases, the database, the gene bank flat file, its content. Submission to NCBI database. b) Structure Databases: Introduction to structures, PDB (Protein Data Bank) Molecular Modeling database at NCBI, structure file formats, visualizing structural information, database structure viewers, cn3D, Rasmol. UNIT – II
Information retrieval from biological database, retrieving database entries, the retrieve server, integrated information retrieval, The Entrez system, Integrated information axis: the query/server, sequence database beyond NCBI, medical databases. 4. Phylogenetic Analysis: Elements of phylogenetic models, phylogenetic data analysis: alignment, substitution model building, tree building and tree evaluation, building the data model (alignment), determining the substitution model, tree-building methods, searching for trees, rooting trees, evaluation trees and data, phylogenic software (PHYLIP), phylogenetics on the web, some simple practical considerations. UNIT III 5. Sequence Alignment And Database Searches: Various formats of sequences, the modular nature of proteins, optional alignment methods, substitution scores and gap penalties, statistical significance of alignment, database similarity searching, FASTA, BLAST- BLASTX, BLAST P, BLAST N against different databases, low-complexity regions, repetitive elements, practical aspects of multiple sequence alignment, progressive alignment methods, motifs and patterns. CLUSTALW, CLUSTALX. tree building exercises using NCBI databases. UNIT –IV6. Genome Bioinformatics: Genome sequencing, raw genome sequence data, expressed sequence tags, polymorphism, comparative genomics, genome annotation, Genomics and research: pharmaceutical and agricultural, RH maps, synteny & conserved domains. 7. Informatics And Automation in Genome Mapping: Finding LTRS, prediction of promoter regions, genes sequence and codes, fundamentals of bio molecular, prediction of protein secondary and tertiary structures, Related software. References:
7th Semester B. Tech (Bio-Technology) STEM CELL IN HEALTH CARE NC-BT-403 L T End Semester Examination: 100 Marks 3 0 On Semester Examination: 100 Marks Note: - 1. There are NINE questions in a set of question-paper. All questions carry equal marks. 2. Attempt five questions in all. FIRST question is compulsory which covers the whole syllabus. Attempt ONE question from each of the other four Units UNIT – I 1. Cell Diversification in Early Animal Embryo: Process of fertilization & stages of development in Eukaryotes, pluripotency & formation of three germ layers, cellular mechanism relating to these developments. UNIT –II 2. Stem cell differentiation: The process of stem cell differentiation leading to the formation of epidermal cells, Skeletal muscles. Transformation of stem cell into gametes/ fertilization entity. UNIT-III 3. Hemopoietic Stem Cells: Classification and manifestation of Hemopoietic stem cell disorders, plastic hemopoietic stem cell disorders, myelo dysplastic, myelo proliferative disorders, complications involved in gene therapy, blood transfusion & marrow transplantations, preservation & clinical use of blood, hemapheresis & Apheresis procedures, xenoplantation. UNIT-IV
Stem cells & their unique properties, Embryonic stem cells, Adult stem cells, induced pluripotent stem cells, epidermal stem cells & their applications hepatic stem cells & their role in liver regeneration, stem cell treatments, ethical issues of stem cell research.
Potential of stem cell therapy for various diseases, eg. AIDS/HIV, Alzhemier’s disease, Anaemia, Anti-ageing, Multiple sclerosis, Parkinson disease, Rheumatoid Arthritis. References:
7th Semester B. Tech (Bio-Technology) ESSENTIALS OF VIROLOGY NC-BT-405L T End Semester Examination: 100 Marks 3 0 On Semester Examination: 100 Marks Note: - 1. There are NINE questions in a set of question-paper. All questions carry equal marks. 2. Attempt five questions in all. FIRST question is compulsory which covers the whole syllabus. Attempt ONE question from each of the other four Units UNIT-I
Overview of viruses, Virulent Bacteriophage & T4, Temperate Bacteriophage, lambda Bacteriophage. RNA Bacteriophages; Icosohedral single stranded DNA Bacteriophages, Filamentous single stranded DNA Bacteriophages- T7, Mu: Double Stranded transposable DNA Bacteriophage. Life Cycle of Bacteriophages and their use in genetic analysis. UNIT-II
Plant viruses-Geminivirus, TMV, caulimovirus, RNA viruses, Animal viruses -Positive strand RNA virus- Poliovirus and Coronavirus. Negative strand RNA Viruses- Rabies & Influenza. Double stranded RNA Viruses- Reoviruses. Double stranded DNA Viruses-Herpesvirus, Pox Virus and Adenovirus. Viruses with reverse transcriptase- Retroviruses and Hepadnaviruses. UNIT-III 3. Viral Genetics: Viral Replication & Multiplication ,Growth & Quantification: The virus host, Quantification of virus. Virus replication: General features of viral replication, virus multiplication- attachment and penetration, production of viral nucleic acid and protein, the Baltimore classification scheme & DNA Viruses, positive & negative stranded DNA viruses, Reverse transcription, viral protein. UNIT-IV 4. Applications of Virology: Viruses and transgenic plants and animals. Overview of Tumor Viruses. Viral Vaccines: Conventional Vaccines. New Generation Vaccines including DNA Vaccines with examples Interferon’s-Production and mode of action, Antiviral drugs. References:
7th Semester B. Tech (Bio-Technology) INTELLECTUAL PROPERTY RIGHTS IN BIOTECHNOLOGY NC-BT-407L T End Semester Examination: 100 Marks 3 0 On Semester Examination: 100 Marks Note: - 1. There are NINE questions in a set of question-paper. All questions carry equal marks. 2. Attempt five questions in all. FIRST question is compulsory which covers the whole syllabus. Attempt ONE question from each of the other four Units UNIT-I Intellectual Property Rights : Scope and Meaning of Intellectual Property & Intellectual Property Rights, Rational, advantages, disadvantages of intellectual property protection. Role of Intellectual Property Protection in fostering research & economic development. IPR issues relevant for India, authorities and their functions, consequences and options of reinforced IPP (Intellectual Property Protection) for developing countries, Management of intellectual property. UNIT-II Patents and procedure for filing applications: Patentable and non-patentable subjects matters, reasons for inclusion and exclusion. Novelty, public domain and other requirements for patenting. Procedure for filing a patent application. Rights, responsibilities and obligation of patent holder. Protection of patent and fighting piracy. UNIT-III Patenting a biological material: Patenting of living organisms, higher plants and animals, transgenic, organisms, patenting of genes and isolated DNA sequences, Protection of plant varities in UPOV, Suei generies system, plant variety protection and farmer rights Authorities of India. Conservation and use of genetic resources. UNIT-IV Other categories of Intellectual Property Protections: Other categories of Intellectual Property Protection including copyrights, designs, trade secrets, trademarks, geographical appellations. International conventions, treaties, GATT, TRIP’s and WIPO (World Intellectual Property Organisation). References: 1. Biotechnology by John E. Smith, Cambridge University Press, 2004. 2. Biotechnology: An Introduction by Susan R. Barman. 3. Elements of Biotechnology by P.K.Gupta, rastogi Publications, 2003 4. A Textbook on Biotechnology by H.D.Kumar, East West Press Pvt. Ltd. 5. Modern Concepts of Biotechnology by H.D.Kumar, Vikas Publishing House Pvt. Ltd., 1998. 7th Semester B. Tech (Bio-Technology) BIOINFORMATICS LABORATORYNC-BT-411 P On Semester Examination: 120 Marks 3 End Semester Examination: 80 Marks List of Experiments: 1. Computer basics 2. Searching biological database for relevant information 3 Restriction mapping 4. Sequence (FASTA & BLAST) searches. 5. usage of CLUSTAL W & CLUSTAL X 6 Evolutionary studies/ Phylogenic analysis. 7 Identification of genes in genomes. 8. Protein databank retrieval and visualization.
. References:
ELECTIVE-I 7th Semester B. Tech (Biotechnology) NANOBIOTECHNOLOGY NC-BT-415 L T End Semester Examination: 100 Marks 3 0 On Semester Examination: 100 Marks Note: - 1. There are NINE questions in a set of question-paper. All questions carry equal marks. 2. Attempt five questions in all. FIRST question is compulsory which covers the whole syllabus. Attempt ONE question from each of the other four Units UNIT-I 1. Bionanotechnology – An Overview: What can engineers learn from biology? From biotechnology to Bionanotechnology, Bionanomachines in action. Molecular recognition: How molecular recognition underlies cellular communication, material transfer into and within cells, and biotransformations. Information: How information is stored in the cell and how it isread? UNIT-II 2. Biomolecular Design and Biotechnology: Molecular Modeling and Biomolecular structure determination. Structural Principles of Bionanotechnology: Natural Bionano-machinery, Hierarchical strategy, raw materials, Protein folding, self assembly and self- organization, molecular recognition and flexibility. UNIT-III 3. Functional Principles of Bionanotechnology: Information driven Nano assembly, Energetics, chemical transformation, regulation, Biomolecular motors, Biomolecular sensing, self replication and machine - phase Bionanotechnology UNIT-IV 4. Applications of Bionanotechnology : Basic capabilities, DNA computers, hybrid materials, artificial life and biosensors. Nano Medicine & Drug Delivery, References:
& Technology Series. Springer. ELECTIVE-I 7th Semester B. Tech (Bio-Technology) BIOSENSORS NC-BT-417 L T End Semester Examination: 100 Marks 3 0 On Semester Examination: 100 Marks Note: - 1. There are NINE questions in a set of question-paper. All questions carry equal marks. 2. Attempt five questions in all. FIRST question is compulsory which covers the whole syllabus. Attempt ONE question from each of the other four Units UNIT – I1. Introduction: History of Biosensors, types of biosensors, chemical biosensors & commercial biosensors, advantages & future use of biosensors. 2. Cell based biosensors using microelectrode: Measurement of cellular activity, planar array for cultured cell systems, impedance techniques, 3. Biosensors for determination of metabolites: Glucose determination, Ethanol determination, Determination of glycerol & triglycerides. UNIT – II
Reporter genes, containment sensing components, arsenic sensing biosensors, methods for using whole cell biosensors, advantages.
Immunoassays, Atomic Force Microscopy, interaction between biomolecules, cantilever-based sensors, FABS. UNIT – III
Introduction, Antibody-Antigen binding forces, Polymer Films, Ligand Immobilization, Mass transfer.
Extrinsic & intrinsic sesors, coating based sensors, New sesing schemes- Microbent sensors, SERS sensors, SPR sensors & applications. UNIT – IV
Sciences, Applications. 9. Applications of Biosensors: Applications in food industry- Biacore System, Assay Development, Application in Environmental monitoring. References:
B.Tech (Bio- Tech.) 7th Semester, Syllabus 2011-12 |