Скачать 114.28 Kb.

SEMESTER I
CORE COURSE – I BIOLOGICAL SYSTEMS UNITI Biology of Cells: Prokaryotic and Eukaryotic cells  E. coli and Yeast; Cell organelles and their functions, Differences and similarities in plant and animal cells, Principles of Membrane organization, Membrane proteins, Cell transport, Cell division  mitosis, meiosis cell cycle; Enzymes classification, structure, Mechanism of action. UNITII Cell Energetics and respiration: Energy  life's driving force; energy capture – photosynthesis; role of ATP in energy cycle  Glycolysis, TCA cycle, Oxidative phosphorylation; Fats and protein as alternate energy sources, Key biomolecules  lipids, polysaccharides, proteins, nucleic acids. UNITIII Chromosome structure in Prokaryotes and Eukaryotes, Structures of DNA  Watson and Crick model, Different conformations, Replication; RNA secondary structure; Central dogma of molecular biologyTranscription, Post – transcriptional modifications, codon and anticodon concepts, Translation and Post–translational modifications; MutationTypes, Molecular mechanism DNA repair mechanism Gene regulation operon concept  lac, trp. UNIT IV Basics of recombinant DNA technology  Introduction to cloning, gene selection, restriction enzymesa brief account; cloning vectors – plasmid, phage vectors, cosmids, shuttle vectors; DNA transformation; methods of clone selection and screening. Hybridization techniquesSouthernNorthernWestern blots analysis and their applications. UNITV DNA sequencing MaxamGilbert, Sanger methods, automated DNA sequencing. PCR, RFLP and RAPD techniques, biochips and DNA finger printing, Applications of recombinant DNA technology  commercial aspects of recombinant proteins. Text Books :
Reference Books :
SEMESTER I
CORE COURSE – II PROGRAMMING IN C Unit I Computer Introduction: Overview and functions of a computer System. Input and output devices. Storage devices: Hard Disk, Diskette, Magnetic Tape, CDROM, DVD, Main Board: Chips, Ports, Expansion Slots. Memory: Register, buffer, RAM / ROM, Types of Computer on usage and capability. Unit II Types of Software – operating systems, application program – tools, packages , Networks – LAN, WAN, MAN – Routers, Hubs. Concepts of flowchart, algorithm – Programming Techniques. Unit III ‘C’ programming: Data types, operators and expressions, Hierarchy of operators Declaring Variable and constants, Control statements including decision (if, ifelse), loops (while, dowhile, for), branching (switch, break, continue), Iterative statements, Functions – Simple, recursive functions, library functions – arguments. Unit IV Arrays – one dimension, two dimension, string and numeric, Pointers, array of pointers, Pointer to pointer, File Operations in C – read, write, append – Sequential and random files. Opening and closing of files for data. Unit V Structures, unions, storage classes, dynamic memory allocation, macros and preprocessor directives, command line arguments. Reference Books:
SEMESTER I
CORE COURSE – III C Programming – Lab 1. C Basic Input / Output Functions 2. Arrays Concepts 3. Example for Structure 4. Sample program for Pointers 5. Illustration of Conditional Statements 6. Explaining Looping Statements 7. Functions – recursive, library functions 8. Dynamic memory Allocation 9. Data Structure operations like stacks and queues 10. File Operations including read, write and appending records SEMESTER I
CORE COURSE – IV BIOSTATISTICAL AND MATHEMATICAL TECHNIQUES UNIT I BIOSTATISTICS – Introduction – Applications, Collection of Data: Sampling techniques, Graphical and diagrammatic representation. CENTRAL TENDENCY – Arithmetic Mean, Geometric Mean, Harmonic Mean, Median, Mode DISPERSION – Importance, range, Mean Deviation, Variance, Standard Deviation UNIT II CORRELATION – types & measures, Karl Pearson, Scatter Diagram, Rank Correlation, Correlation for bivariate frequency distribution, REGRESSION  types, measures, Testing of hypothesis, ANOVA – One way, Two way, STUDENT ‘t’ tests for mean and difference of mean, CHI SQUARE distribution: independent of attributes, goodness of fit. UNIT III PROBABILITY – Basic Laws: Events, Sample Space, Addition Rule, multiplication Rule, Random Variable, Probability Distribution, NORMAL Distribution, BINOMIAL Distribution, Poisson distribution, Introduction to Hidden Markov model UNIT IV CALCULUS – Basics, Differentiation of algebraic functions, Trigonometric functions, Integrations – simple problems, properties of definite integrals , Uses of table of Integrals, Numerical differentiations – Euler’s method, RK second order method, Numerical integration: Trapezoidal and Simpson 1/3 rule. UNIT V MATRIX – Types, Inverse, Algebra, Simultaneous Equations, Determinant, Eigen Values , Rank of a matrix. VECTORS – Operations, Scalar, Vector Product, Vector Calculus, Scalar Triple Product, Divergence, Curl of Vector. Reference Books:
SEMESTER I
CORE BASED ELECTIVE COURSE – I BIOPHYSICS AND STEREOCHEMISTRY UNITI Parameters to describe a structure: bond angle, bond length and bond strength. Levels of structure description: primary, secondary, tertiary and quarternary structures. Forces deciding the molecular structures: inter and intramolecular forces – hydrogen bonding, hydrophobic interactions and water structure, ionic interactions, disulphide bonds. UNITII Forces driving the molecular structures: Conformation, potential energy calculations, potential well, LJ curve, time scales and energy criteria, conformational principles, conformational space. Types of movements: vibrational, rotational, torsion angles; Conformational analysis, calculation of surface areas, Volumes and radius of biomolecules. UNITIII Nucleic acids  structural characteristics of nucleic acids – geometry of glycosidic bond, rotational isomers, sugar puckering; forces stabilizing the structures  base pairing, base stacking. Tertiary structure of nucleic acids; chemical bonds in biomolecules – hydrogen bond, peptide bond, phosphate bond. UNITIV Stereochemistry: Principles  Chirality, Symmetry in organic compounds, Molecular isomerism, polypeptide chain geometries  Ramachandran plot, observed values for rotation angles, prediction of protein structure. UNITV Application of sterochemical principles: Conformation of open chain compounds, chiral compounds, Macromolecular stereochemistry, Determination of relative and absolute configuration. Reference Books
SEMESTER II
