Curriculum vitae




НазваниеCurriculum vitae
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CURRICULUM VITAE



Name: Ralph R. Weichselbaum


Business Address: The University of Chicago Medical Center

5758 S. Maryland Avenue, MC-9006

Chicago, IL 60637-1470


Education/Degrees:


1967 B.S. University of Wisconsin, Madison, WI

1971 M.D. University of Illinois, Chicago, IL


Postdoctoral Training:

Internship and Residencies:


1971-1972 Medical Intern, Highland-Alameda County Hospital,

Oakland, CA


1972-1975 Resident in Radiation Therapy, Harvard Medical School, Joint Center

for Radiation Therapy, Boston, MA 02115


Research Fellowships:


1970-1971 Research Fellow, Department of Surgical Oncology

University of Illinois, Chicago, IL


1973-1975 Research Fellow, Harvard School of Public Health Laboratory of

Radiobiology, Boston, MA 02115


Licensure and Board Certification:


American Board of Radiology, (Therapeutic Radiology)

Massachusetts: 34518; California: G-25314;

Illinois: 036-069-955


Academic Appointments:


1975-1976 Instructor in Radiation Therapy

Harvard Medical School, Boston, MA


1977-1980 Assistant Professor in Radiation Therapy, Harvard Medical School, Boston, MA


1979-1982 Research Member, Harvard, MIT, Division Health Sciences, Boston, MA


1980-1984 Associate Professor, Department of Radiation Therapy, Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA


1983-1984 Associate Professor, Department of Cancer Biology, Harvard School of Public Health, Boston, MA


1984-present Professor and Chairman, Department of Radiation and Cellular Oncology,

University of Chicago, Division of the Biological Sciences and Pritzker School of Medicine, Chicago, IL 60637

Head, Michael Reese/University of Chicago,

Center for Radiation Therapy

Director, Chicago Tumor Institute


1985-present Senior Biologist, Argonne National Laboratories, Argonne, IL


1990-2000 Harold H. Hines, Jr., Professor and Chairman, University of Chicago


2000-present Director, Center for Molecular Oncology, University of Chicago


2001-present Daniel K. Ludwig Professorship, University of Chicago


2006 – 2011 Professor of Surgery, University of Chicago (Joint Appointment)


2006-present Co-Director, Ludwig Center for Metastasis Research, University of Chicago


Hospital Appointments:


1976-1984 Radiotherapist, New England Deaconess Hospital, Boston, MA

1976-1984 Associate Radiotherapist, Children’s Hospital, Medical Center, Boston, MA

Boston Hospital for Women, Beth Israel Hospital, Boston MA


1977-1984 Associate Director, Head and Neck Clinic, Dana Farber Cancer Institute, Boston, MA


1977-1984 Head, Radiotherapy Division, Peter Bent Brigham Hospital, Dana Farber Cancer Institute, Boston, MA


1984- Director, Radiation Oncology, University of Chicago Hospitals and Clinics, Chicago, IL


1984- Director, Radiation Oncology, Michael Reese Hospital and Medical Center, Chicago, IL


1987-2009 Director, LaGrange Treatment Pavilion, LaGrange Memorial Hospital, LaGrange, IL


1993- Lecturer and Chief, Radiation Oncology, University of Illinois Hospital, Chicago, IL


Awards and Honors:


1975 American Radium Society, Resident Research Award


1987 Lee Lecture, University of Minnesota


1989 Clifford Allen Lecture, University of Oregon


1991 MacLaren Lecture, Hamilton Regional Cancer Centre, Ontario


1994 Evan and Marion Helfaer Lectureship, Medical College of Wisconsin


1995 Roentgen Centennial Lecturer, University of Zurich


1995 Honorary Member, Swiss Society of Radiology


1996 Ruvelson Lecturer, University of Minnesota


1997 Keynote Lecturer, International Conference of Environmental Mutagenesis, Toulouse, France


1997 Member, Institute of Medicine, National Academy of Sciences


1998 Glenn Sheline Lecturer, University of California, San Francisco


1998 Keynote Lecturer Inauguration Ceremony of the Cancer Center

Karolinska Institutet and 70th Anniversary of the

King Gustaf’s V Jubilee, Stockholm, Sweden


1998 Lecturer, L Academie des Sciences de institut de France, Paris, France


1998 John B. Little Lecture Award, Harvard University


1999 Keynote Lecturer, American Radium Society Annual meeting, Hawaii


  1. Lecturer, Nobel Symposium, Stockholm, Sweden




  1. Keynote Lecturer, Third International Symposium on Anti-Angiogenic Agents, Irving, Texas


2002 Lecturer, Herman D. Suit Science Festivity Days, Boston, MA


2004 Copeland Lecturer, The University of Texas M.D. Anderson Cancer Center, Houston, Texas


2004 Simon Kramer Lectureship, Thomas Jefferson University, Philadelphia, PA


2006 Lecturer and Chair, “Radiation Targeted Gene Therapy: Laboratory

and Clinical Studies” A Symposium in Honor of Samuel Hellman, M.D., University of Chicago, Oct. 31 2006.


2009 The Highest Cited Radiation Oncologist of the Past Decade. (K. Choi et al, Int. J. Radiation Oncology Biol. Phys. 74:172-178, 2009).


2010 Lecturer, Annual Tolmach Symposium, Washington University, St. Louis, MO. October 2010.


2011 Keynote Speaker, Thermal Society, Portland OR April 2011


Invited Lectures


2001 Lecturer, Gordon Research Conference, Ventura, California


2004 Lecturer, AACR Special Conference in Cancer Research, Radiation Biology and Cancer: From Molecular Response to the Clinic, Dana Point, CA


2006 Invited Speaker, “Genetic Therapy Approaches with Radiation Therapy Inducible Transcription Units”, Sidney Kimmel Cancer Center Conference, San Diego, CA, Feb 27-Mar 1, 2006.


2006 Invited Speaker, “Applications of Viral Gene Therapy in Combination with Radiation Therapy”, 4th International Chicago Symposium on Malignancies of the Chest and Head & Neck, The Sheraton Chicago Hotel, Chicago, IL, Oct 26-28, 2006.


2007 Invited Speaker, “Targeting the Vascular Endothelium with Radio Inducible Gene Therapy”, The Two-Way Bridge Between the Laboratory and the Clinic: A Symposium in Honor of Zvi Fuks, MD, Memorial Sloan-Kettering Cancer Center, New York, NY, May 21, 2007.


2007 Invited Speaker, “Gene Therapy Targeted by Radiotherapy”, Oncology Grand Rounds, Lombardi Comprehensive Cancer Center, Washington, DC, Dec 7, 2007.


2008 Invited Speaker, “Novel Gene Therapy for Pancreatic Cancer”, Innovations in the Multidisciplinary Treatment of Pancreatic Cancer, The University of Chicago Center for GI Oncology, Sept. 19, 2008.


2008 Invited Speaker, Chicago Multidisciplinary Symposium in Thoracic Oncology, Chicago, IL, November 13-15, 2008.


2009 Invited Speaker, Meet-the Expert Sessions, “Control of Gene Therapy by Ionizing Radiation: Basic Principles to Clinical Trials”. AACR Annual Meeting, Denver, CO, April 2009.


2009 Invited Speaker, ASTRO’s 51st Annual Meeting, “Oligometastasis in Bone and Soft Tissue:  The Biology of Single Fraction Radiation”. ASTRO’s 51st Annual Meeting, Chicago, IL. November 2009.


2011 Invited Speaker, 102nd AACR Annual Meeting, “Systems Biology at the Clinic”, Orlando, FL., April 2-6, 2011.


Memberships, Offices and Committee

Assignments in Professional Societies:


1972 New England Roentgen Ray Society

1973 New England Society for Radiation Oncology

1976 American Society of Therapeutic Radiology

1977 American College of Radiology

1978 Radiation Research Society

1979 American Society for Clinical Oncology

1981 Study Section, American Cancer Society, Boston

1982 Committee on Cancer Management, American College of Radiology

1983 Study Section, American Cancer Society, New York (National)

1983 American Association for Advancement in Science

1983 ASTR Committee on Biology and Physics

1983 American Association for Cancer Research

1983 American Society for Head and Neck Surgery

1984 Extramural Advisory Committee, M.D. Anderson Hospital, Houston, TX

1984 Society of Academic Radiation Oncology Chairmen

1985 ASTRO Committee on Academic Radiation Oncology

1985 Executive Committee, University of Chicago Cancer Center

1985 Study Section, National Institutes of Health, Experimental Therapeutics "B"

1985-87 Inter Society Council for Radiation Oncology

1986-87 Committee on Radiotherapy Research and Development, American College of Radiology

1986-88 Award Identification Committee, Radiation Research Society

1987-89 Upper Aerodigestive Tract Committee Working Group, National Cancer Institute

1987 External Advisory Committee, Department of Radiation Oncology, University of Arizona

1987-88 Co-Chairman, Cancer Committee, University of Chicago

1988 Chairman, Pathology Review Committee, University of Chicago

1988 External Advisory Committee Department of Radiation Therapy, University of Michigan

1988 Chairman, Cancer Task Force, Michael Reese Hospital

1989-93 Board of Scientific Counselors, Division of Cancer Treatment, National Cancer Institute

1989 Organizing Committee, 15th LH Gray Conference, Canterbury, England

1989 American Society of Microbiology

1990 External Advisory Committee, Commonwealth of Virginia, Cancer Center

1990 Oncology Council of the Medical Staff, Michael Reese Hospital and Medical Center

1990 External Advisory Committee, Department of Radiation Therapy, University of Massachusetts

1990 Chairman, NCI Workshop on Mechanisms of Radioresistance

1990 Organizer, Fannie May Symposium, "The Cell Cycle from Yeast to Beast " University of Chicago

1991 Organizing Committee, "Neoplastic Transformation Human Cell Systems in vitro Mechanisms of Carcinogenesis", Georgetown University

1991 Consultant, Onco Med Incorporated

1991 External Advisory Committee, University of Illinois Chicago

1991 General Motors Award Committee, Kettering Prize

1991 Co-Course Director, Concomitant Chemoradiotherapy for Solid Tumors, University of Chicago

1992 Comprehensive Cancer Center External Scientific Advisory Committee, Duke University

1992 The Board of Chancellors, American College of Radiation Oncology

1993 Vice-Chairman, Kettering Committee General Motors Award

1993 Radiation Research Society - Strategic Planning Committee

1993 Committee to Evaluate the Relationship between Argonne National Laboratory and The University of Chicago

1993 External Review Committee, University of Arizona

1993 Site Selection Committee, Radiation Research

1993 Program Committee, Radiation Research

1993 Founding Scientist - Gen Vec

1993-95 Board of Directors, American College Radiation Oncology

1994-95 Rosenthal Awards Committee AACR


1994 Organizer, University of Chicago Symposium in honor of Samuel Hellman, M.D., The Therapeutic Promise of Molecular Oncology

1994 Committee on Cancer Biology, The University of Chicago

1995 Co-Chairman, Cancer Advisory Committee - GEN-VEC

1995 Onkoservices Scientific Advisory Board Member

1995 Organizing Committee, A Workshop on "Neoplastic Transformation in Human Cell Systems in Culture: Mechanisms of Carcinogenesis" The University of Chicago and Georgetown University

1995 Symposium Director, "Concomitant Chemoradiotherapy for Solid Tumors", The University of Chicago

1995 International Editorial Board, Cancer Gene Therapy

1995 External Advisor, Comprehensive Cancer Center, University of Alabama, Birmingham

1995 Fourth International Congress on Gene Therapy Committee

1995 Prostate Cancer Executive Committee/Steering Committee, The University of Chicago

1996 Clinical Cancer Research Committee (AACR)

1996-97 American Radium Society

1996 AACR Clowes Memorial Award Committee/American Association for Cancer Research

1997 National Advisory Board, Wendy Will Case Cancer Fund, Inc.

1997 External Advisor, Gene Therapy Program, M.D. Anderson Hospital, Houston TX

1997 NIH Conference on Herpes Vectors for Gene Therapy

Founding Scientist ROMCOR & Consulting Scientist NeurVir

1997 External Advisory Committee, University of Wisconsin Cancer Center

1998 Founding Scientist Convengence Therapeutics (Sold to ILEX)

1998 Scientific Advisory Board, NeuroVir, Inc.

NIH Conference, AMolecular Biology of Mutational Biomarkers for Human Exposure to Ionizing Radiation, Bethesda, MD

1998 Member, Institute of Medicine, National Academy of Sciences

1999 ASTRO Cancer and Radiation Biology Committee

2000 External Advisory Committee, Columbia University Cancer Center, New York, New York

2000 Medical Advisory Board, iMetricus

2000 Scientific Advisory Board, PrevOnc

2000 Member of Lung Cancer Committee, American College of Surgeons

2000 The Committee on Intellectual Properties, University of Chicago

2002-05 American Society of Gene Therapy

2002 Committee on Molecular Medicine, University of Chicago

2004 External Scientific Advisory Committee, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC

2004 Co-Chair, Medical Review Committee, University of Chicago

2004-5 Co-Chair, Department of Medicine Search Committee, University of Chicago

2004 Radiation Research Society, Councilor – Medicine

2005 Association of American Physicians

2006 Co-Director, Ludwig Center for Metastasis Research, University of Chicago

2010 Cardiology Review Committee, University of Chicago

2011-2014 Member, National Cancer Policy Forum (NCPF), Institute of Medicine (IOM)


Editorial Services


1988 Editorial Board, Radiation Research


1988 Editorial Board, International Journal Radiation Oncology, Biology, and Physics


1990-91 Editorial Board, Yearbook of Oncology


    1. Editorial Board, Radiotherapy and Oncology, (ESTRO), Journal of the European Society for Therapeutic Radiology and Oncology, The Netherlands


1992 Editorial Board, Cancer Research


1992-93 Advisory Editor, Radiation Oncology Investigations


1993 Editorial Academy - The International Journal of Oncology


1995-98 Editor, International Journal of Radiation Oncology, Biology, Physics


1996-97 Editor, Encyclopedia of Cancer


1997-99 Editorial Board, Cancer Research (AACR)


2001 Editorial Board, Cancer Biology and Therapy


2008 Editorial Board, Journal of Oncology, Hindawi Publishing Corporation



PATENTS























Disclosure Number

Patent Title

Patent Status

Lineage

Country

Patent App Number

Filing Date

Patent Number

Issue Date

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized PCT

Australia

91702/91

12/19/1991

657111

6/20/1995

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized PCT

Australia

48509/93

9/8/1993

686112

5/21/1998

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Austria

92903431.2AT

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Austria

93921410.2AT

9/8/1993

E 295 889

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Belgium

92903431.2BE

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Belgium

93921410.2BE

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Allowed

Nationalized PCT

Canada

2,098,849

12/19/1991

 

 

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Pending

Nationalized PCT

Canada

2,144,406

9/8/1993

 

 

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Denmark

92903431.2DK

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Denmark

93921410.2DK

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

France

92903431.2FR

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

France

93921410.2FR

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Germany

92903431.2DE

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Germany

93921410.2DE

9/8/1993

69333815.6

5/18/2005

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Greece

3054313

9/8/1993

20050402281

5/18/2005

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Ireland

93921410.2IE

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Italy

92903431.2IT

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Italy

93921410.2IT

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized PCT

Japan

503403/92

12/19/1991

3337214

8/9/2002

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Pending

Nationalized PCT

Japan

508137/94

9/8/1993

 

 

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Lichtenstein

92903431.2LI

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Luxembourg

93921410.2LU

9/8/1993

662137

5/18/2005

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Monaco

93921410.2MC

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Netherlands

92903431.2NL

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Netherlands

93921410.2NL

9/8/1993

662137

5/18/2005

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Portugal

93921410.2PO

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Spain

92903431.2ES

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Spain

93921410.2ES

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Sweden

92903431.2SE

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Sweden

93921410.2SE

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

Switzerland

92903431.2CH

12/19/1991

563278

3/8/2000

328

Gene Transcription and Ioninzing Radiation - Methods and Compositions

Issued

Nationalized EPO

Switzerland

93921410.2CH

9/8/1993

662137

5/18/2005

328

Control of Gene Expression by Ionizing Radiation

Issued

Nationalized EPO

United Kingdom

92903431.2GB

12/19/1991

563278

3/8/2000
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