Curriculum vitae jan-Åke Gustafsson




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in vivo. Proc. Natl. Acad. Sci. USA, 92, 4437-4441, 1995.

223. A. Wyss, J.-Å. Gustafsson and M. Warner: Cytochromes P450 of the 2D subfamily in rat brain. Mol. Pharmacol., 47, 1148-1155, 1995.

224. H. Tanaka, Y. Makino, K. Dahlman-Wright, J.-Å. Gustafsson, K. Okamuto, and I. Makino: Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations. Mol. Pharmacol., 48, 938-945, 1995.

225. H. Hellmold, J. G. Lamb, A. Wyss, J.-Å. Gustafsson and M. Warner: Developmental and endocrine regulation of P450 isoforms in rat breast. Mol. Pharmacol. 48, 630-638, 1995.

226. P. Coumailleau, L. Poellinger, J.-Å. Gustafsson and M. L. Whitelaw: Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. J. Biol.Chem. 270, 25291-25300, 1995.

227. T. Härd, H.J. Barnes, C. Larsson, J.-Å. Gustafsson and J. Lund: Solution structure of a mammalian PCB-binding protein in complex with a PCB. Nature Struct. Biol.2, 983-989, 1995.

238. J.-Q. Chen, A. Ström, J.-Å. Gustafsson and E.T. Morgan: suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: Comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter seqences are involved in the suppressive response to interleukins 1 and 6. Mol. Pharmacol. 47, 940-947, 1995.

229. J. McGuire, P. Coumailleau, M.L. Whitelaw, J.-Å. Gustafsson and L. Poellinger: The basic helix-loop-helix/PAS factor Sim is associated with hsp90. J. Biol. Chem. 270, 31353-31357, 1995.

230. P. Tollet, O. Lahuna, R. Ahlgren, A. Mode, and J.-Å. Gustafsson: CCAAT/enhancer-binding protein--dependent transactivation of CYP2C12 in rat hepatocytes. Mol. Endocrinol., 9, 1771-1781, 1995.

231. H. Tanaka, Y. Makino, K. Dahlman-Wright, J.-Å. Gustafsson, K. Okamoto, and I. Makino: Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations. Mol. Pharmacol. 48, 938-945, 1995.

232. H. J. Barnes, L. Nordlund-Möller, M. Nord, O. Andersson, J.-Å. Gustafsson, J. Lund and M. Gillner: Structural basis for calcium binding by uteroglobins. J. Mol. Biol. 256, 392-404, 1996.

233. G.G.J.M. Kuiper, E. Enmark, M. Pelto-Huikko, S. Nilsson, and J.-Å. Gustafsson: Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc.Natl.Acad.Sci. USA 93, 5925-5930, 1996.

234. E. Hedlund, A. Wyss, T. Kainu, M. Backlund, C. Köhler, M. Pelto-Huikko, J.-Å. Gustafsson and M. Warner: Cytochrome P4502D4 in the brain: Specific neuronal regulation by clozapine and toluene. Mol.Pharmacol. 50, 342-350, 1996.

235. J.C. Rowlands, I.J. McEwan and J.-Å. Gustafsson: Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbn receptor nuclear translocator protein: Direct interactions with basal transcription factors. Mol.Pharm. 50, 538-548, 1996.

236. U. Lind, J. Carlstedt-Duke, J.-Å. Gustafsson and A.P.H. Wright: Identification of single amino acid substitutions of cys-736 that affect the steroid-binding affinity and specificity of the glucocorticoid receptor using phenotypic screening in yeast. Mol. Endocrinol. 10, 1358-1370, 1996.

237. E. Enmark and J.-Å. Gustafsson: Orphan nuclear receptor - The first eight years. Mol. Endocrinol. 10, 1293-1307, 1996.

238. J.C. Corton, C. Bocos, E.S. Moreno, A. Merritt, D.S. Marsman, P.J. Sausen, R.C. Cattley and J.Å. Gustafsson: Rat 17-hydroxysteroid dehydrogenase type IV is a novel peroxisome proliferator-inducible gene. Mol. Pharmacol., 50, 1157-1166, 1996.

239. G.G.J.M. Kuiper, B. Carlsson, K. Grandien, E. Enmark, J. Häggblad, S. Nilsson and J.-Å. Gustafsson: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors  and . Endocrinology., 138, 863-870, 1997.

240. G. Spyrou, E. Enmark, A. Miranda-Vizuete, and J.-Å. Gustafsson: Cloning and expression of a novel mammalian thioredoxin. J. Biol. Chem., 272, 2936-2941, 1997.

241. T. Almlöf, J.-Å. Gustafsson, and A.P.H. Wright: Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor. Mol. Cell Biol., 17, 934-945, 1997.

242. H. Wakui, A.P.H. Wright, J.-Å. Gustafsson, and J. Zilliacus: Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 protein. J. Biol. Chem. 272, 8153-8156, 1997.

243. M. Byers, G.G.J.M. Kuiper, J.-Å. Gustafsson, and O.-K. Park-Sarge: Estrogen receptor- mRNA expression in rat ovary: Down-regulation by gonadotropins. Mol. Endocrinol. 11, 172-182, 1997.

244. I. McEwan, A.P.H. Wright and J.-Å. Gustafsson: Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactions. BioEssays, 19, 153-160, 1997.

245. A. Henriksson, T. Almlöf, J. Ford, I.J. McEwan, J.-Å. Gustafsson and A.P.H. Wright: Role of the Ada Adaptor Complex in Gene Activation by the Glucocorticoid Receptor. Mol. Cell Biol. 3065-3073, 1997.

246. J.C. Rowlands and J.-Å. Gustafsson: Aryl hydrocarbon receptor-mediated signal transduction. Critical Rev. Toxicol., 27, 109-134, 1997.

247. J.-Å. Gustafsson: Estrogen receptor - Getting in on the action? Nature Medicine, 3, 493-494, 1997.

248. K. Pettersson, K. Grandien, G. G. J. M. Kuiper and J.-Å. Gustafsson: Mouse estrogen receptor  forms estrogen response element binding heterodimers with estrogen receptor . Mol. Endocrinol. 11, 1486-1496, 1997.

249. K. Paech, P. Webb, G. G.J.M. Kuiper, S. Nilsson, J.-Å. Gustafsson, P. J.Kushner, and T. S. Scanlan: Differential transactivation properties of the estrogen receptor isotypes (, ): Estrogen-like effects with antiestrogens and antiestrogen effects with estrogen. Science, 277, 1508-1510, 1997.

250. J. F. Couse, J. Lindzey, K. Grandien, J.-Å. Gustafsson and K.S. Korach: Tissue distribution and quantitative analysis of estrogen receptor- (ER) and estrogen receptor- (ER) mRNA in the wild-type and ER-knockout mouse. Endocrinology., 138, 4613-4621, 1997.

251. A.M. Brzozowski, A.C.W. Pike, Z. Dauter, R.E. Hubbard, T. Bonn, O. Engström, L. Öhman, G.L. Greene, J.-Å. Gustafsson and M. Carlquist: Insights into the molecular basis of agonism and antagonism in the oestrogen receptor as revealed by complexes with 17-oestradiol and raloxifene. Nature, 389, 753-758, 1997.

252. J. Arts, G.G.J.M. Kuiper, J.M.M.F. Janssen, J.-Å. Gustafsson, C.W.G.M. Löwik, H.A.P. Pols and J.P.T.M. van Leeuwen: Differential expression of estrogen receptor  and  mRNA during human osteoblast differentiation. Endocrinology, 138, 5067-5070, 1997.

253. K. Hecht, J. Carlstedt-Duke, P. Stierna, J.-Å. Gustafsson, M. Brönnegård and A.-C. Wikström: Evidence that the -isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor. J. Biol. Chem., 272, 26659-26664, 1997.

254. J. Lechner, T. Welte, J.K. Tomasi, P. Bruno, C. Cairns, J.-Å. Gustafsson and W. Doppler: Promoter dependent synergy between glucocorticoid receptor and Stat5 in the activation of -casein gene transcription. J. Biol. Chem. 272, 20954-20960, 1997.

255. B. van der Burg, J. Lidén, S. Okret, F. Delaunay, S. Wissink, P.S. van der Saag, J.-Å. Gustafsson: Nuclear Factor-Kappa-B Repression in Antiflammation and Immunosuppression by Glucocorticoids. Trends Endocrinol. Metab.., 8, 152-157, 1997.

256. H. Hellmold, T. Rylander, M. Magnusson, R.J. Edwards, E. Reihnér, M. Warner and J.-Å. Gustafsson: Use of samples from reduction mammaplasties for characterization of the P450 profile in human breast tissue. J. Clin. Endo. Metab. 83, 886-895, 1998.

257. F.F. Wiebel, J.-Å. Gustafsson: Heterodimeric interaction between RXR and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation. Mol. Cell. Biol., 17, 3977-3986, 1997.

258. I. McEwan and J.-Å. Gustafsson: Interaction of the human androgen receptor transactivation function and TFIID. Proc.Natl.Acad.Sci. USA., 94, 8485-8490, 1997.

259. J. Ford, I.J. McEwan, A.P.H. Wright and J.-Å. Gustafsson: Involvement of the TFIID protein complex in gene activation by the N-terminal transactivation domain of the glucocorticoid receptor in vitro. Mol.Endocrinol., 11, 1467-1475, 1997.

260. F. Delaunay, A. Khan, A. Cintra, B. Davani, Z.-C. Ling, A. Andersson, C.-G. Östenson, J.-Å. Gustafsson, S. Efendic, and S. Okret: Pancreatic -cells are important targets for the diabetogenic effects of glucocorticoids. J. Clin. Invest. 100, 2094-2098, 1997.

261. O. Lahuna, L. Fernandez, H. Karlsson, D. Maiter, F.P. Lemaigre, G. G. Rousseau, J.-Å. Gustafsson and A. Mode: Expression of hepatocyte nuclear factor-6 in rat liver is sex-dependent and regulated by growth hormone. Proc.Natl.Acad.Sci., USA, 94, 12309-12313, 1997.

262. G.S. Prins, M. Marmer, C. Woodham, W. Chang, G. Kuiper, J.-Å. Gustafsson, L. Birch: Estrogen receptor beta mRNA ontogeny in the rat prostate and effects of neonatal estrogen exposure on the expression pattern. Endocrinology 139, 874-883, 1998.

263. A. Miranda-Vizuete, A. E. Damdimopoulos, J.-Å. Gustafsson and G. Spyrou: Cloning, expression and characterization of a novel Escherichia coli thioredoxin. J.Biol.Chem., 30841-30847, 1997.

264. J. Lidén, F. Delaunay, I. Rafter, J.-Å. Gustafsson, and S. Okret: A new function for the C-terminal zinc finger of the glucocorticoid receptor. J. Biol. Chem., 272, 21467-21472, 1997.

265. Y. Yang, W.J. Griffiths, J. Sjövall, J.-Å. Gustafsson and J. Rafter: Liquid chromatography-mass spectrometry with collision-induced dissociation of conjugated metabolites of benzo[a]pyrene. J. Am. Soc. Mass. Spectrom., 8, 50-61, 1997.

266. E. Enmark, M. Pelto-Huikko, K. Grandien, S. Lagercrantz, J. Lagercrantz, G. Fried, M. Nordenskjöld and J.-Å. Gustafsson: Human estrogen receptor  -gene structure, chromosomal localization and expression pattern. J. Clin. Endocrinol. Metab., 82, 4258-4265, 1997.

267. H. Hellmold, M. Magnusson, M. Pelto-Huikko, J.-Å. Gustafsson and M. Warner: Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal rat breast. Mol. Pharmacol., 53, 475-482, 1998.

268. H. Nebb Sorensen, E. Treuter and J.-Å. Gustafsson: Regulation of peroxisome proliferator-activated receptors (PPARs). Vitamins and Hormones, 54, 121-166, 1998.

269. E. Treuter, T. Albrektsen, L. Johansson, J. Leers, and J.-Å. Gustafsson: A regulatory role for RIP140 in nuclear receptor activation. Mol. Endocrinol., 12, 864-881, 1998.

270. G.G.J.M. Kuiper, J.G. Lemmen, B. Carlsson, J.C. Corton, S.H. Safe, P. T. van der Saag, B. van der Burg, and J.-Å. Gustafsson: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor . Endocrinology, 139, 4252-4263, 1998.

271. G.G.J.M. Kuiper, P.J. Shughrue, M. Pelto-Huikko, I. Merchenthaler and J.-Å. Gustafsson: The estrogen receptor  subtype: A novel mediator of estrogen action in neuroendocrine systems. Frontiers in Neuroendocrinol, 19, 253-286, 1998.

272. C. Buggs, P. Tollet, H.-F. Zhao, N. Nasrin, A. Mode, J.-Å. Gustafsson, and M. Alexander-Bridges: IRE-ABP, an SRY-like protein, inhibits C/EBP-stimulated expression of the sex-specific cytochrome P450 2C12 gene. Mol. Endocrinol.., 12, 1294-1309, 1998.

273. J.-Å. Gustafsson: Raloxifene: Magic bullet for heart and bone? Nature Medicine, 4, 152, 1998.

274. S. Nilsson, G. Kuiper and J.-Å. Gustafsson: ER: a novel estrogen receptor offers the potential for new drug development. Trends in Endocrinol. and Metabolism, 9, 387-395, 1998.

275. G.S. Prins, M. Marmer, C. Woodham, W. Chang, G. Kuiper, J.-Å. Gustafsson, L. Birch: Estrogen receptor beta mRNA ontogeny in the rat prostate and effects of neonatal estrogen exposure on the expression pattern. Endocrinology, 139, 874-883, 1998.

276. H. Hellmold, T. Rylander, M. Magnusson, R.J. Edwards, E. Reihnér, M. Warner and J.-Å. Gustafsson: Use of samples from reduction mammaplasties for characterization of the P450 profile in human breast tissue. J. Clin. Endo. Metab., 83, 886-895, 1998.

277. E. Hedlund, J.-Å. Gustafsson and M. Warner: Cytochrome P450 in the brain: 2B or not 2B. TIPS, 19, 82-85, 1998.

278. T. Barkhem, B. Carlsson, Y. Nilsson, E. Enmark, J.-Å. Gustafsson and S. Nilsson: Differential response of estrogen receptor  and estrogen receptor  to partial estrogen agonists/antagonists. Mol. Pharmacol., 54, 105-112, 1998.

279. L. Fernández, A. Flores-Morales, O. Lahuna, D. Sliva, G. Norstedt, L.-A. Haldosén, A. Mode and J.-Å. Gustafsson: Desensitization of the growth hormone induced JAK2/STAT 5 signaling pathway requires protein synthesis and phospholipase C. Endocrinology, 139, 1815-1824, 1998.

280. J.-Å. Gustafsson: Therapeutic potential of selective estrogen receptor modulators. Current Opinion in Chemical Biology, 2, 508-511, 1998.

281. T. Almlöf, A. E. Wallberg, J.-Å. Gustafsson and A. P. H. Wright: Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor 1-core activation domain and target factors. Biochemistry, 37, 9586-9594, 1998.

282. J.C. Corton, L.Q. Fan, S. Brown, C. Bocos, R.C. Cattley, A. Mode, and J.-Å. Gustafsson: Down-regulation of cytochrome P450 2C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals. Mol. Pharmacol., 54, 463-473, 1998.

283. G.G.J.M. Kuiper, M. Carlquist, and J.-Å. Gustafsson: Estrogen is a male and female hormone. Science & Medicine, 5, 36-45, 1998.

284. A.Dumont, S.P. Hehner, M.L. Schimtz, J.-Å. Gustafsson, J. Lidén, S. Okret, P. T. van der Saag, S. Wissink, B. van der Burg, P. Herrlich, G. Haegeman, K. de Bosscher and W. Fiers: Cross-talk between steroids and NF-B: what language? TIBS, 233-235, 1998.

285. J. Leers, E. Treuter and J.-Å. Gustafsson: Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2. Mol. Cell. Biol. 18, 6001-6013, 1998.

286. J. H. Krege, J. B. Hodgin, J. F. Couse, E. Enmark, M. Warner, J. F. Mahler, M. Sar, K. S. Korach, J.-Å. Gustafsson, and O. Smithies: Generation and reproductive phenotypes of mice lacking estrogen receptor . Proc.Natl.Acad.Sci. USA, 95, 15677-15682, 1998.

287. Johansson, J. S. Thomsen, A. E. Damdimopoulos, G. Spyrou, J.-Å. Gustafsson, and E. Treuter: The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ER and ER. J. Biol. Chem., 247, 345-353, 1999.

288. T.J. Pircher, H. Petersen, J.-Å. Gustafsson, and L.-A. Haldosén: Extracellular signal regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a. Mol. Endocrinol., 13, 555-565, 1999.

289. A.M.M. van Pelt, D. G. de Rooij, B. van der Burg, P. T. van der Saag, J.-Å. Gustafsson, and G.G.J.M. Kuiper: Ontogeny of estrogen receptor- expression in rat testis. Endocrinology, 140, 478-483, 1999.

290. J.R. Pedrajas, E. Kosmidou, A. Miranda-Vizuete, J.-Å. Gustafsson, A.P.H. Wright, and G. Spyrou: Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. J. Biol. Chem., 274, 6366-6373, 1999.

291. E. Treuter, L. Johansson, J.S. Thomsen, A. Wärnmark, J. Leers, M. Pelto-Huikko, M. Sjöberg, A.P.H. Wright, G. Spyrou, and J.-Å. Gustafsson: Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intemediary factor (TIF) 2 for binding to nuclear receptors. J. Biol. Chem., 274, 6667-6677, 1999.

292. D. Feltkamp, F.F. Wiebel, S. Alberti, and J.-Å. Gustafsson: Identification of a novel DNA binding site for nuclear orphan receptor OR1. J. Biol. Chem., 274, 10421-10429, 1999.

293. U. Lind, P. Greenidge, J.-Å. Gustafsson, A.P.H. Wright, and J. Carlstedt-Duke: Valine 571 functions as a regional organizer in programming the glucocorticoid receptor for differential binding of glucocorticoids and mineralocorticoids. J. Biol. Chem., 274, 18515-18523, 1999.

294. J.G. Lemmen, J.L.M. Broekhof, G.G.J.M. Kuiper, J.-Å. Gustafsson, P.T, van der Saag, and B. van der Burg: Expression of estrogen receptor alpha and beta during mouse embryogenesis. Mechanisms Development, 81, 163-167, 1999.

295. R. Schultz, W. Yan, J. Toppari, A. Völkl, J.-Å. Gustafsson, and M. Pelto-Huikko: Expression of peroxisome proliferator-activated receptor  messenger ribonucleic acid and protein in human and rat testis. Endocrinology, 140, 2968-2975, 1999.

296. F.F. Wiebel, K.R. Steffensen, E. Treuter, D. Feltkamp, and J.-Å. Gustafsson: Ligand-independent coregulator recruitment by the triply activatable OR1/Retinoid X receptor- nuclear receptor heterodimer. Mol. Endocrinol., 13, 1105-1118, 1999.

297. S. Mäkelä, H. Savolainen, E. Aavik, M. Myllärniemi, L. Strauss, E. Taskinen, J.-Å. Gustafsson, and P. Häyry: Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors  and . Proc. Natl. Acad. Sci. USA, 96, 7077-7082, 1999.

298. J.-Å. Gustafsson: Seeking ligands for lonely orphan receptors. Science, 284, 1285-1286, 1999.

299. H.M. Guardiola-Diaz, S. Rehnmark, N.Usuda, T. Albrektsen, D. Feltkamp, J-Å. Gustafsson, and S.E.H. Alexson: Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. J. Biol. Chem., 274, 23368-23377, 1999.

300. J.-M. Vanacker, K. Pettersson, J.-Å. Gustafsson and V. Laudet: Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) , but not by ER. EMBO J. 18, 4270-4279, 1999.

301. A. E. Wallberg, K. E. Neely, J.-Å. Gustafsson, J.L. Workman, A.P.H. Wright, and P.A. Grant: Histone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid receptor activation domain. Mol. Cell. Biol., 19, 5952-5959, 1999.

302. A.C.W. Pike, A.M. Brzozowski, R.E. Hubbard, T. Bonn, A.-G. Thorsell, O. Engström, J. Ljunggren, J.-Å. Gustafsson and M. Carlquist: Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J., 18, 4608-4618, 1999.

303. P. Webb, P. Nguyen, C. Valentine, G. N. Lopez, G.R. Kwok, E. McInerney, B.S. Katzenellenbogen, E. Enmark, J.-Å. Gustafsson, S. Nilsson, and P.J. Kushner: The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol. Endocrinol., 13, 1672-1685, 1999.

304. S. Ogawa, J. Chan, A.E. Chester, J.-Å. Gustafsson, K.S. Korach, and D.W. Pfaff: Survival of reproductive behaviors in estrogen receptor  gene-deficient (ERKO) male and female mice. Proc.Natl.Acad.Sci.USA, 96, 12887-12892, 1999.

305. L.D. Croce, S. Okret, S. Kersten, J.-Å. Gustafsson, M. Parker, W. Wahli and M. Beato: Steroid and nuclear receptors. EMBO J., 18, 6201-6210, 1999.

306. S.H Windahl, O. Vidal, G. Andersson, J.-Å. Gustafsson, and C. Ohlsson: Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ER -/- mice. J. Clin. Invest., 104, 895-901, 1999.

307. J. An, R.C. J Ribeiro, P. Webb, J.-Å. Gustafsson, P.J. Kushner, J.D. Baxter, and D.C. Leitman: Estradiol repression of tumor necrosis factor- transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc.Natl.Acad.Sci. USA, 96, 15161-15166, 1999.

308. R.H. Karas, J. B. Hodgin, M. Kwoun, J.H. Krege, M. Aronovitz, W. Mackey, J.-Å. Gustafsson, K.S. Korach, O. Smithies, and M.E. Mendelsohn. Estrogen inhibits the vascular injury response in estrogen receptor  -deficient female mice. Proc.Natl. Acad.Sci.USA, 96, 15133-15136, 1999.

309. S. Saji, E. V. Jensen, S. Nilsson, T. Rylander, M. Warner, and J.-Å. Gustafsson: Estrogen receptors  and  in the rodent mammary gland. Proc.Natl.Acad.Sci. USA, 97, 337-342, 2000.

310. B. Saville, M. Wormke, F. Wang, T. Nguyen, E. Enmark, G. Kuiper, J.-Å. Gustafsson, and S. Safe: Ligand-, cell-, and estrogen receptor subtype (/)-dependent activation at GC-rich (Sp1) promoter elements. J. Biol. Chem. 275, 5379-5387, 2000.

311. F. Caira, P. Antonson, M. Pelto-Huikko, E. Treuter, and J.-Å. Gustafsson: Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275, 5308-5317, 2000.

312. L. Johansson, A. Båvner, J.S. Thomsen, M. Färnegårdh, J.-Å. Gustafsson, and E. Treuter: The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors. Mol. Cell. Biol. 20, 1124-1133, 2000.

313. C. Patrone, G. Pollio, E. Vegeto, E. Enmark, I. de Curtis, J.-Å. Gustafsson and A. Maggi: Estradiol induces differential neuronal phenotypes by activating estrogen receptor  or . Endocrinol., 141, 1839-1845, 2000.

314. A. E. Wallberg, K. E. Neely, A. H. Hassan, J.-Å. Gustafsson, J. L. Workman and A.P.H. Wright: Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor 1 activation domain. Mol. Cell. Biol. 20, 2004-2013, 2000.

315. O. Vidal, M. K. Lindberg, K. Hollberg, D. J. Baylink, G. Andersson, D. B. Lubahn, S. Mohan, J.-Å. Gustafsson, and C. Ohlsson: Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc.Natl.Acad.Sci. USA, 97, 5474-5479, 2000.

316. K.A. Risan Tobin, H. Hermansen Steineger, S. Alberti, Ö. Spydevold, J. Auwerx, J.-Å. Gustafsson, and H. I. Nebb: Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-. Mol. Endo., 14, 741-752, 2000.

317. Z. Weihua, S. Saji, S. Mäkinen, G. Cheng, E. V. Jensen, M. Warner and J.-Å. Gustafsson: Estrogen receptor (ER) , a modulator of ER in the uterus. Proc.Natl.Acad.Sci. USA, 97, 5936-5941, 2000.

318. A. Wärnmark, J.-Å. Gustafsson, and A.P.H. Wright: Architectural principles for the structure and function of the glucocorticoid receptor 1 core activation domain. J. Biol. Chem. 275, 15014-15018, 2000.

319. E. Enmark and J.-Å. Gustafsson: Nematode genome sequence dramatically extends the nuclear receptor superfamily. TIPS, 21, 85-87, 2000.

320. J. R. Pedrajas, A. Miranda-Vizuete, N. Javanmardy, J.-Å. Gustafsson, and G. Spyrou: Mitochondria of Saccharomyces cerevisiae contan one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J. Biol. Chem. 275, 16296-16301, 2000.

321. F. Delaunay, K. Pettersson, M. Tujague, and J.-Å. Gustafsson: Functional differences between the amino-terminal domains of estrogen receptors  and . Mol. Pharmacol., 58, 584-590, 2000.

322. C. S. Rosenfeld, P. S. Cooke, T. H. Welsh, Jr., G. Simmer, M. G. Hufford, J.-Å. Gustafsson, R. A. Hess and D. B. Lubahn: The differential fate of mesonephric tubular-derived efferent ductules in estrogen receptor- knockout versus wild-type female mice. Endocrinology, 141, 3792-3798, 2000.

323. C. Palmieri, S. Saji, J.-Å. Gustafsson, R C. Coombes: False negatives in oestrogen-receptor assay. The Lancet, 356, 944, 2000.

324. M. K. Österlund, J.-Å. Gustafsson, E. Keller and Y. L. Hurd: Estrogen receptor  (ER) messenger ribonucleic acid (mRNA) expression within the human forebrain: Distinct distribution pattern to ER mRNA. J. Clin. Endocrin. & Metabol., 85, 3840-3846, 2000.

325. K. Pettersson, F. Dalaunay, and J.-Å. Gustafsson: Estrogen receptor  acts as a dominant regulator of estrogen signaling. Oncogene, 19, 4970-4978, 2000.

326. K. Mikitani, T. Sugasaki, T. Shimada, M. Kobayashi, and J.-Å. Gustafsson: The chitinase gene of the silkworm, Bombyx mori, contains a novel Tc-like transposable element. J. Biol. Chem., 275, 37725-37732, 2000.

327. C. M. Sadek, S. Jalaguier, E P. Feeney, M. Aitola, A. E. Damdimopoulos, M. Pelto-Huikko, J.-Å. Gustafsson. Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mechanisms of Development 97, 13-26, 2000.

328. C. Widén, J. Zilliacus, J.-Å. Gustafsson, and A.-C. Wikström. Glucocorticoid receptor interaction with 14-3-3 and raf-1, a proposed mechanism for cross-talk of two signal transduction pathways. J. Biol. Chem., 275, 39296-39301, 2000.

329. A. Ström, N. Arai, J. Leers, and J.-Å. Gustafsson. The Hairy and Enhancer of Split homologue-1 (HES-1) mediates the proliferative effect of 17-estradiol on breast cancer cell lines. Oncogene, 19, 5951-5953, 2000.

330. H. Zhang, J. S. Thomsen, L. Johansson, J.-Å. Gustafsson, and E. Treuter. DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors. J. Biol. Chem., 275, 39855-39859, 2000.

331. S. Ogawa, A.E. Chester, S. Curtis Hewitt, V. R. Walker, J.-Å. Gustafsson, O. Smithies, K.S. Korach, and D. W. Pfaff. Abolition of male sexual behaviors in mice lacking estrogen receptors  and  (ERKO). Proc.Natl.Acad.Sci. USA, 97, 14737-14741, 2000.

332. Y. Yang, W. J. Griffiths, M. Nordling, J. Nygren, L. Möller, J. Bergman, E. Liepinsh, G. Otting, J.-Å. Gustafsson, J. Rafter, and J. Sjövall. Ring opening of benzo[a]pyrene in the germ-free rat is a novel pathway for formation of potentially genotoxic metabolites. Biochemistry, 39, 15585-15591, 2000.

333. J. L. Temple, H. N. Fugger, X. Li, S. J. Shetty, J.-Å. Gustafsson & E. R. Rissman: Estrogen receptor  regulates sexually dimorphic neural responses to estradiol. Endocrinol., 142, 510-513, 2001.

334. L. Wang, S. Andersson, M. Warner, and J.-Å. Gustafsson: Morphological abnormalities in the brains of estrogen receptor  knockout mice. Proc.Natl.Acad.Sci. USA, 98, 2792-2796, 2001.

335. M. E. Quaedackers, C. E. van den Brink, S. Wissink, R.H.M.M. Schreurs, J.-Å. Gustafsson, P. T. van der Saag, and B. van der Burg: 4-hydroxytamoxifen trans-represses nuclear factor-B activity in human osteoblastic U2-OS cells through estrogen receptor (ER), and not through ER. Endocrinol. 142, 1156-1166, 2001.

336. S. Alberti, G. Schuster, P. Parini, D. Feltkamp, U. Diczfalusy, M. Rudling, B. Angelin, I. Björkhem, S. Pettersson, and J.-Å. Gustafsson: Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXR-deficient mice. J. Clin. Invest., 107, 565-573, 2001.

337. K. Pettersson and J.-Å. Gustafsson: Role of estrogen receptor beta in estrogen action. Annu. Rev. Physiol., 63, 165-92, 2001.

338. J. Zilliacus, E. Holter, H. Wakui, H. Tazawa, E. Treuter and J.-Å. Gustafsson: Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. Mol. Endocrinol., 15, 501-511, 2001.

339. W. Doppler, M. Windegger, C. Soratroi, J. Tomasi, J. Lechner, S. Rusconi, A.C.B. Cato, T. Almlöf, J. Lidén, S. Okret, J.-Å. Gustafsson, H. Richard-Foy, D. B. Starr, H. Klocker, D. Edwards, and S. Geymayer: Expression level-dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5. Mol. Cell. Biol., 21, 3266-3279, 2001.

340. M. Elholm, I. Dam, C. Jörgensen, A.-M. Krogsdam, D. Holst, I. Kratchmarova, M. Göttlicher, J.-Å. Gustafsson, R. Berge, T. Flatmark, J. Knudsen, S. Mandrup and K. Kristiansen: Acyl-CoA esters antagonize the effects of ligands on peroxisome proliferator-activated receptor  conformation, DNA binding, and interaction with co-factors. J. Biol. Cell., 276, 21410-21416, 2001.

341. P. Roger, M. E. Sahla, S. Mäkelä, J.-Å. Gustafsson, P. Baldet, and H. Rochefort: Decreased expression of estrogen receptor protein in proliferative preinvasive mammary tumors. Cancer Res., 61, 2537-2541, 2001.

342. A. C. W. Pike, A. M. Brzozowski, J. Walton, R. E. Hubbard, A.-G. Thorsell, Y.-L. Li, J.-Å. Gustafsson, and M. Carlquist: Structural insights into the mode of action of a pure antiestrogen. Structure, 9, 145-153, 2001.

343. Z. Weihua, S. Mäkelä, L. C. Andersson, S. Salmi, S. Saji, J. I. Webster, E. V. Jensen, S. Nilsson, M. Warner, and J.-Å. Gustafsson: A role for estrogen receptor  in the regulation of growth of the ventral prostate. Proc.Natl.Acad.Sci. USA, 98, 6330-6335, 2001.

344. K. Rose, A. Allan, S. Gauldie, G. Stapleton, L. Dobbie, K. Dott, C. Martin, L. Wang, E. Hedlund, J. R. Seckl, J.-Å. Gustafsson, and R. Lathe: Neurosteroid hydroxylase CYP7B vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. J. Biol. Chem., 276, 23937-23944, 2001.

345. S. Saji, H. Sakaguchi, S. Andersson, M. Warner, and J.-Å. Gustafsson: Quantitative analysis of estrogen receptor proteins in rat mammary gland. Endocrinol. 142, 3177-3186, 2001.

346. A. Wärnmark, T. Almlöf, J. Leers, J.-Å. Gustafsson, and E. Treuter: Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptor ER and ER. J. Biol. Chem., 276, 23397-23404, 2001.

347. L. G. Horvath, S. M.. Henshall, C.-S. Lee, D. R. Head, D. I. Quinn, S. Makela, W. Delprado, D. Golovsky, P. C. Brenner, G. O’Neill, R. Kooner, P. D. Stricker, J. J. Grygiel, J.-Å. Gustafsson, and R. L. Sutherland: Frequent loss of estrogen receptor- expression in prostate cancer. Cancer Res., 61, 5331-5335, 2001.

348. A. Miranda-Vizuete, J. Ljung, A. E. Damdimopoulos, J.-Å. Gustafsson, R. Oko, M. Pelto-Huikko, and G. Spyrou: Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. J. Biol. Chem., 276, 31567-31574, 2001.

349. S.H. Windahl, K. Hollberg, O. Vidal, J.-Å. Gustafsson, C. Ohlsson, and G. Andersson: Female estrogen receptor  -/- mice are partially protected against age-related trabecular bone loss. J. Bone and Mineral Res., 16, 2001.

350. R. H. Karas, H. Schulten, G. Pare, M. J. Aronvitz, C. Ohlsson, J.-Å. Gustafsson, M. E. Mendelsohn: Effects of estrogen on the vascular injury response in estrogen receptor ,  (double) knockout mice. Circ Res.,89, 534-539, 2001.

351. S. Nilsson, S. Mäkelä, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.-Å. Gustafsson: Mechanism of estrogen action. Phys. Rev. 81, 1535-1565, 2001.

352. E. Enmark and J.-Å. Gustafsson: Comparing nuclear receptors in worms, flies and humans. Trends Pharmacol. Sci., 22, 611-615, 2001.

353. M. Hedengran Faulds, K. Pettersson, J.-Å. Gustafsson and L.-A. Haldosén: Cross-talk between ERs and signal transducer and activator of transcription 5 is E2 dependent and involves two functionally separate mechanisms. Mol. Endocrinol. 15, 1929-1940, 2001.

354. E. V. Jensen, G. Cheng, C. Palmieri, S. Saji, S. Mäkelä, S. van Noorden, T. Wahlström, M. Warner, R. C. Coombes, and J.-Å. Gustafsson: Estrogen receptors and proliferation markers in primary and recurrent breast cancer. Proc.Natl.Acad.Sci. USA, 98, 15197-15202, 2001.

355. A. Wärnmark, A. Wikström, A. P. H. Wright, J.-Å. Gustafsson, and T. Härd: The N-terminal regions of estrogen receptor  and  are unstructured in vitro and show different TBP binding properties. J. Biol. Chem. 276, 45939-45944, 2001.

356. Y. Zhu, Z. Bian, P. Lu, R. H. Karas, L. Bao, D. Cox, J. Hodgin, P. W. Shaul, P. Thorén, O. Smithies, J.-Å. Gustafsson, M. E. Mendelsohn: Abnormal vascular function and hypertension in mice deficient in estrogen receptor . Science, 295, 505-508, 2002.

357. P. Ciana, E. Vegeto, M. Beato, P. Chambon, J.-Å. Gustafsson, M. Parker, W. Wahli and A. Maggi: Looking at nuclear receptor from the heights of Erice. Workshop on nuclear receptor structure and function. EMBO reports., 31, 125-129, 2002.

358. E. Holter, N. Kotaja, S. Mäkelä, L. Strauss, S. Kietz, O. A. Jänne, J.-Å. Gustafsson, J. J. Palvimo, and E. Treuter: Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1. Mol. Endocrinol., 16, 515-528, 2002.

359. C. Palmieri, G. J. Cheng, S. Saji, M. Zelada-Hedman, A. Wärri, Z. Weihua, S. Van Noorden, T. Wahlstrom, R. C. Coombes, M. Warner, and J.-Å. Gustafsson: Estrogen receptor beta in breast cancer. Endocrine-Related Cancer, 9, 1-13, 2002.

360. E.F. Rissman, A. L. Heck, J. E. Leonard, M. A. Shupnik, and J.-Å. Gustafsson: Disruption of estrogen receptor  gene impairs spatial learning in female mice. Proc.Natl.Acad.Sci. USA, 99, 3996-4001, 2002.

361. K. A. Risan Tobin, S. M. Ulven, G. U. Schuster, H. Hermansen Steineger, S. M. Andresen, J.-Å. Gustafsson, and H. I. Nebb: Liver X receptors as insuling-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem., 277, 10691-10697, 2002.

362. M. K. Lindberg, S. Movérare, S. Skrtic, S. Alatalo, J. Halleen, S. Mohan, J.-Å. Gustafsson, and C. Ohlsson: Two different pathways for the maintenance of trabecular bone in adult male mice. J. Bone Mineral Res, 17, 555-562, 2002.

363. T. Barkhem, L.-A. Haldosen, J.-Å. Gustafsson and S. Nilsson: pS2 gene expression in HepG2 cells: Complex regulation through crosstalk between the estrogen receptor alpha, an estrogen-responsive element, and the activator protein 1 response element. Mol. Pharmacol., 61, 1273-1283, 2002.

364. S. H. Windahl, G. Andersson, and J.-Å. Gustafsson: Elucidation of estrogen receptor function in bone with the use of mouse models. TEM, 13, 195-200, 2002.

365. A. Wärnmark, E. Treuter, J.-Å. Gustafsson, R. E. Hubbard, A. M. Brzozowski, and A. C. W. Pike: Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor . J. Biol. Chem., 277, 21862-21868, 2002.

366. A. Båvner, L. Johansson, G. Toresson, J.-Å. Gustafsson, E. Treuter: A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. EMBO reports, 5, 478-484, 2002.

367. L. Wang, S. Andersson, M. Warner and J.-Å. Gustafsson: Estrogen actions in the brain. Science STKE, 138, 2002. http://stke.sciencemag.org/cgi/content/full/sigtrans;2002/138/pe29

368. T. M. Stulnig, U. Opperman, K. R. Steffensen, G. U. Schuster and J.-Å. Gustafsson: Liver X receptor downregulates 11-hydroxysteroid dehydrogenase type 1 expression and activity. Diabetes, 51, 2426-2433, 2002.

369. H. Helander, J.-Å. Gustafsson, and A. Mode: Possible involvement of truncated signal transducer and activator of transcription-5 in the GH pattern-dependent regulation of CYP2C12 gene expression in rat liver. Mol. Endocrinol., 16, 1598-1611, 2002.

370. P. Müller, S. Kietz, J.-Å. Gustafsson and A. Ström: The anti-estrogenic effect of all-trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression. J. Biol. Chem., 277, 28376-28379, 2002.

371. G. U. Schuster, P. Parini, L. Wang, S. Alberti, K. R. Steffensen, G. K. Hansson, B. Angelin, J.-Å. Gustafsson: Accumulation of foam cells in liver X receptor-deficient mice. Circulation, 106, 1147-1153, 2002.

372. S. Saji, Y. Omoto, C. Shimizu, M. Warner, Y. Hayashi, S.-I. Horiguchi, T. Watanabe, S.-I. Hayashi, J.-Å. Gustafsson and M. Toi: Expression of estrogen receptor (ER) cx protein in ER -positive breast cancer: specific correlation with progesterone receptor. Cancer Res. 62, 4849-4853, 2002.

373. S. Nilsson and J.-Å. Gustafsson: Biological role of estrogen and estrogen receptors. Critical Rev. Biochem. Mol. Biol., 37, 1-28, 2002.

374. L. Wang, G. U. Schuster, K. Hultenby, Q. Zhang, S. Andersson, and J.-Å. Gustafsson: Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration. Proc.Natl.Acad.Sci. USA, 99, 13878-13883, 2002.

375. Z. Weihua, R. Lathe, M. Warner, and J.-Å. Gustafsson: An endocrine pathway in the prostate, ER, AR, 5-androstane-3, 17-diol, and CYP7B1, regulates prostate growth. Proc.Natl.Acad.Sci. USA, 99, 13589-13594, 2002.

376. A. D. Schreihofer, D. F. Rowe, E. F. Rissman, E. M. Scordalakes, J.-Å. Gustafsson, and M. A. Shupnik: Estrogen receptor  (ER), but not ER, modulates estrogen stimulation of the ER-truncated variant, TERP-1, Endocrinol., 143, 4196-4202, 2002.

377. T. M. Stulnig, K.R. Steffensen, H. Gao, M. Reimers, K. Dahlman-Wright, G. U. Schuster, and J.-Å. Gustafsson: Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol. Pharmacol., 62, 1299-1305, 2002.

378. C. Förster, S. Mäkelä, A. Wärri, S. Kietz, D. Becker, K. Hultenby, M. Warner, and J.-Å. Gustafsson: Involvement of estrogen receptor in terminal differentiation of mammary gland epithelium. Proc. Natl. Acad. Sci. USA, 99, 15578-15583, 2002.

379. T. Barkhem, L.-A. Haldosén, J.-Å. Gustafsson, and S. Nilsson: Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor- depends on the coactivator subtype, the type of estrogen response element, and the promoter context. Mol. Endocrinol. 11, 2571-2581, 2002.

380. L. Johansson Borgius, K. R. Steffensen, J.-Å. Gustafsson, E. Treuter: Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP. J. Biol. Chem., 277, 49761-49766, 2002.

381. M.K. Lindberg, S. Movérare, A.-L. Eriksson, S. Skrtic, H. Gao, K. Dahlman-Wright, J.-Å Gustafsson, and C. Ohlsson: Identification of estrogen-regulated genes of potential importance for the regulation of trabecular bone mineral density. J. Bone & Min. Res., 17, 2183-2195, 2002.

382. L. Wang, S. Andersson, M. Warner, and J.-Å. Gustafsson: Estrogen receptor (ER) knockout mice reveal a role for ER in migration of corticol neurons in the developing brain. Proc. Natl. Acad. Sci. USA, 100, 703-708, 2003.

383. S. Ogawa, J. Chan, J.-Å. Gustafsson, K. S. Korach, and D. W. Pfaff: Estrogen increases locomotor activity in mice through estrogen receptor : Specificity for the type of activity. Endocrinol. 144, 230-239, 2003.

384. P. M. Cunnea, A. Miranda-Vizuete, G. Bertoli, T. Simmen, A. E. Damdimopoulos, S. Hermann, S. Leinonen, M. Pelto-Huikko, J.-Å. Gustafsson, R. Sitia, and G. Spyrou: Erdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J. Biol. Chem. 278, 1059-1066, 2003.

  1. L. K. Juvet, S.M. Andresen, G.U. Schuster, K.T Dalen, K.A.R. Tobin, K. Hollung, F. Haugen, S. Jacinto, S.M. Ulven, K. Bamberg, J.-Å. Gustafsson, and H. I. Nebb: On the role of liver X receptor in lipid accumulation in adipocytes. Mol. Endocrinol. 17, 172-182, 2003.

  2. M. K. Lindberg, S. Movérare, S. Skrtic, H. Gao, K. Dahlman-Wright, J.-Å. Gustafsson, and C. Ohlsson: Estrogen receptor (ER)-reduces ER-regulated gene transcription, supporting a “ying yang” relationship between ER and ER in mice. Mol. Endocrinol. 17, 203-208, 2003.

  3. G.J. Shim, L. Wang, S. Andersson, N. Nagy, L. Levente Kis, Q. Zhang, S. Mäkelä, M. Warner and J.-Å. Gustafsson: Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Proc. Natl. Acad. Sci. USA., 100, 6694-6699, 2003.

  4. C. M. Sadek, A. Jiménez, A. E. Damdimopoulos, T. Kieselbach, M. Nord, J.-Å. Gustafsson, G. Spyrou, E.C. Davis, R. Oko, F. A. van der Hoorn, and A. Miranda-Vizuete: Characterization of human thioredoxin-like 2. J. Biol. Chem. 278, 13133-13142, 2003.

  5. E. Choleris, J.-Å. Gustafsson, K. S. Korach, L. J. Muglia, D. W. Pfaff, S. Ogawa: An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor- and - knockout mice. Proc. Natl. Acad. Sci USA, 100, 6192-6197, 2003.

  6. H. Tazawa, W. Osman, Y. Shoji, E. Treuter, J.-Å. Gustafsson, and J. Zilliacus: Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. Mol Cell Biol, 23, 4187-4198, 2003.

  7. B. Kauppi, C. Jakob, M. Färnegårdh, J. Yang, H. Ahola, M. Alarcon, K. Calles, O. Engström, J. Harlan, S. Muchmore, A.-K. Ramqvist, S. Thorell, L. Öhman, J. Greer, J.-Å. Gustafsson, J. Carlstedt-Duke, and M. Carlquist: RU-486 induces a transcon-formation that leads to active antagonism. J. Biol. Chem., 278, 22748-22754, 2003.

  8. Xu, Q. Pan-Hammarström, A. Försti, K. Hemminki, L. Hammarström, D. Labuda, J.-Å. Gustafsson, and K. Dahlman-Wright: Human estrogen receptor  548 is not a common variant in three distinct populations. Endocrinol. 144, 3541-3546, 2003.

  9. J.-Å. Gustafsson: What pharmacologists can learn from recent advances in estrogen signaling. Trends Pharmacol. Sci., 2003.

  10. M. Otsuki, H. Gao, K. Dahlman-Wright, C. Ohlsson, N. Eguchi, Y. Urade and J.-Å. Gustafsson: Specific regulation of lipocalin-type prostaglandin D synthase in mouse heart by estrogen receptor . Mol. Endocrinol., 17, 1844-1855, 2003.

  11. J. Garey, A. Goodwillie, J. Frohlich, M. Morgan, J.-Å. Gustafsson, O. Smithies, K.S. Korach, S. Ogawa, and D.W. Pfaff: Genetic contributions to generalized arousal of brain and behavior. Proc. Natl. Acad. Sci USA, 100, 11019-11022, 2003.

  12. M. Färnegårdh, T. Bonn, S. Sun, J. Ljunggren, H. Ahola, A. Wilhelmsson, J.-Å. Gustafsson, and M. Carlquist: The three-dimensional structure of the liver X receptor  reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J. Biol. Chem., 278, 38821-38828, 2003.

  13. A. Wärnmark, E. Treuter, A. P. H. Wright, and J.-Å. Gustafsson: Activation functions 1 and 2 of nuclear receptors: Molecular strategies for transcriptional activation. Mol. Endocrinol., 17, 1901-1909, 2003.

  14. C Patrone, T. N. Cassel, K. Pettersson, Y.-S. Piao, G. Cheng, P. Ciana, A. Maggi, M. Warner, J.-Å. Gustafsson, and M. Nord: Regulation of postnatal lung development and homeostasis by estrogen receptor . Mol. Cell. Biol., 23, 8542-8552, 2003.

  15. S. Movérare, K. Venken, A.-L. Eriksson, N. Andersson, S. Skrtic, J. Wergedal, S. Mohan, P. Salmon, R. Bouillon, J.-Å. Gustafsson, D. Vanderschueren, and C. Ohlsson: Differential effects on bone of estrogen receptor  and androgen receptor activation in orchidectomized adult male mice. Proc. Natl. Acad. Sci. USA, 100, 13573-13578, 2003.

  16. E. Mandelin, H. Lassus, M. Seppälä, A. Leminen, J.-Å. Gustafsson, G. Cheng, R. Bützow, and Riitta Koistinen: Glycodelin in ovarian serous carcinoma: Association with differentiation and survival. Cancer Res., 63, 6258-6264, 2003.

  17. K. T. Dalen, S. M. Ulven, K. Bamberg, J.-Å. Gustafsson, and H. I. Nebb: Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor . J. Biol. Chem., 278, 48283-48291, 2003.

  18. S. Movérare, J. Dahllund, N. Andersson, U. Islander, H. Carlsten, J.-Å. Gustafsson, s. Nilsson, and C. Ohlsson: Estren is a selective estrogen receptor modulator with transcriptional activity. Mol. Pharmacol., 64, 1428-1433, 2003.

  19. J. S. Thomsen, S. Kietz, A. Strom, and J.-Å. Gustafsson: HES-1, a novel target gene for the aryl hydrocarbon receptor. Mol. Pharmacol., 65, 165-171, 2004.

  20. M. Nilsson, S. Naessén, I. Dahlman, A. Lindén Hirschberg, J.-Å. Gustafsson and K. Dahlman-Wright: Association of estrogen receptor  gene polymorphisms with bulimic disease in women. Mol. Psychiatry, 9, 28-34, 2004.

  21. K. Steffensen and J.-Å. Gustafsson: Putative metabolic effects of the liver X receptor (LXR). Diabetes, 53, S36-S42, 2004.

  22. A. Ström, J. Hartman, J.S. Foster, S. Kietz, J. Wimalasena, and J.-Å. Gustafsson: Estrogen receptor  inhibits 17-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc. Natl. Acad. Sci. USA, 101, 1566-1571, 2004.

  23. G.-J. Shim, L. Levente Kis, M. Warner, and J.-Å. Gustafsson. Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene. Proc. Natl. Acad. Sci. USA, 101, 1720-1724, 2004.

  24. M. Hedengran Faulds, H. Olsen, L. A. Helguero, J.-Å. Gustafsson, and L.-A. Haldosén: Estrogen receptor functional activity changes during differentiation of mammary epithelial cells. Mol. Endocrinol., 18, 412-421, 2004.

  25. S. Sanyal, J. Matthews, D. Bouton, H.-J. Kim, H.-S. Choi, E. Treuter, and J.-Å. Gustafsson: Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor . Mol. Endocrinol. 18, 312-325, 2004.

  26. G. Cheng, Z. Weihua, M. Warner, and J.-Å. Gustafsson: Estrogen receptors ER and ER in proliferation in the rodent mammary gland. Proc. Natl. Acad. Sci. USA, 101, 3739-3746, 2004.

  27. M. Tujague, J. S. Thomsen, K. Mizuki, C. M. Sadek, and J.-Å. Gustafsson: The focal adhesion protein vinexin  regulates the phosphorylation and activity of estrogen receptor . J. Biol. Chem., 279, 9255-9263, 2004.

  28. A. Chagin, M. K. Lindberg, N. Andersson, S. Moverare, J.-Å. Gustafsson, L. Sävendahl, and C. Ohlsson: Estrogen receptor- inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice. J. Bone Miner. Res., 19, 72-77, 2004.

  29. N. Heldring, M. Nilsson, B. Buehrer, E. Treuter, and J.-Å. Gustafsson: Identification of tamoxifen-induced coregulator interaction surfaces within the ligand-binding domain of estrogen receptors. Mol. Cell Biol., 24, 3445-3459, 2004.

  30. J. B. Seo, H. M. Moon, W. S. Kim, Y. S. Lee, H. W. Jeong, E. J. Yoo, J. Ham, H. Kang, M.-G. Park, K. R. Steffensen, T. M. Stulnig, J.-Å. Gustafsson, S. D. Park, and J. B. Kim: Activated liver X receptors stimulated adipcyte differentiation through induction of peroxisome proliferator-activated receptor expression. Mol. Cell Biol., 24, 3430-3444, 2004.

  31. C. Palmieri, E. W.-F. Lam, J. Mansi, C. MacDonald, S. Shousha, P. Madden, Y. Omoto, A. Sunters, M. Warner, J.-Å. Gustafsson and R.C. Coombes: The expression of ERcx in human breast cancer and the relationship to endocrine therapy and survival. Clin. Cancer Res., 10, 2421-2428, 2004.

  32. O. Imamov, A. Morani, G.-J. Shim, Y. Omoto, C. Thulin-Andersson, M. Warner, and J.-Å. Gustafsson: Estrogen receptor regulates epithelial cellular differentiation in the mouse ventral prostate. Proc. Natl. Acad. Sci. USA., 101, 9375-9380, 2004.

  33. M. Polanczyk, S. Yellayi, A. Zamora, S. Subramanian, M. Tovey, A. A. Vandenbark, H. Offner, J. F. Zachary, P. D. Fillmore, E. P. Blankenhorn, J.-Å. Gustafsson, and C. Teuscher: Estrogen receptor-1 (Esr1) and –2 (Esr22) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Am. J. Pathology, 164, 1915-1923, 2004.

  34. A. Jiménez, Z. Wie, V. Y. Rawe, M. Pelto-Huikko, C. J. Flickinger, P. Sutovsky, J.-Å. Gustafsson, R. Oko, and A. Miranda-Vizuete: Spermatocyte/spermatid-specific thioredoxin-3, a novel golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. J. Biol. Chem., 279, 34971-34982, 2004.

  35. G.-J. Shim, M. Warner, H.-J. Kim, S. Andersson, L. Liu, J. Ekman, O. Imamov, M. E. Jones, E. R. Simpson, and J.-Å. Gustafsson: Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjögren’s syndrome. Proc. Natl. Acad. Sci. USA., 101, 12628-12633, 2004.

  36. A. E. Damdimopoulos, A. Miranda-Vizuete, E. Treuter, J.-Å. Gustafsson and G. Spyrou: An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling. J. Biol. Chem., 279, 28721-38729, 2004.

  37. M. Esslimani-Sahla, J. Simony-Lafontaine, A. Kramar, R. Lavaill, C. Mollevi, M. Warner, J.-Å. Gustafsson, and H. Rochefort: Estrogen receptor  (ER) level but not its ERcx variant helps to predict tamoxifen resistance in breast cancer. Clin. Cancer Res., 10, 5769-5776, 2004.

  38. C. Förster, S. Kietz, K. Hultenby, M. Warner, and J.-Å. Gustafsson: Characterization of the ER -/- mouse heart. Proc. Natl. Acad. Sci. USA., 101, 14234-14239, 2004.

  39. A. E. Kudwa, J.-Å. Gustafsson, and E. F. Rissman: Estrogen receptor  modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area. Endocrinol., 145, 4500-4506, 2004.

  40. H. Gronemeyer, J.-Å. Gustafsson, and V. Laudet: Principles for modulation of the nuclear receptor superfamily. Nature Reviews Drug Discovery, 3, 950-964, 2004.

  41. J. C. Corton, U. Apte, S. P. Andersson, P. Limaye, L. Yoon, J. Latendresse, C. Dunn, J. I. Everitt, K. A. Voss, C. Swanson, C. Kimbrough, J. S. Wong, S. S. Gill, R. A. S. Chandraratna, M.-K. Kwak, T. W. Kensler, T. M. Stulnig, K. R. Steffensen, J.-Å. Gustafsson and H. M. Mehendale: Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. J. Biol. Chem., 44, 46204-46212, 2004.

  42. G. M. Leong, S. Moverare, J. Brce, N. Doyle, K. Sjögren, K. Dahlman-Wright, J.-Å. Gustafsson, K.K.Y. Ho, C. Ohlsson and K.-C. Leung: Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and –3 in vivo and in vitro. Endocrinology, 145, 5525-5531, 2004.

  43. S. P. Anderson, C. Dunn, A. Laughter, L. Yoon, C. Swanson, T. M. Stulnig, K. R. Steffensen, R. A. S. Chandraratna, J.-Å. Gustafsson, and J. C. Corton: Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor , retinoid X receptor, and liver X receptor in mouse liver. Mol. Pharmacol., 66, 1440-1452, 2004.

  44. J. Harman, P. Müller, J. S. Foster, J. Wimalasena, J.-Å. Gustafsson, and A. Ström: HES-1 inhibits 17-estradiol and heregulin-1-mediated upregulation of E2F-1. Oncogene, 23, 8826-8833, 2004.

  45. R. K. Vadlamudi, S. Balasenthil, R. R. Broaddus, J.-Å. Gustafsson and R. Kumar: Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. J. Clinic. Endocrinol. Metabol., 89, 6130-6138, 2004.



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