Curriculum vitae jan-Åke Gustafsson




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НазваниеCurriculum vitae jan-Åke Gustafsson
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in vitro to a cloned DNA fragment that mediates a delayed secondary response to glucocorticoids in vivo. Proc. Natl. Acad. Sci. USA 87, 2564-2568, 1990.

156. M. Rebuffe-Scrive, M. Brönnegård, A. Nilsson, J. Eldh, J.-Å. Gustafsson, and P. Björntorp: Steroid hormone receptors in human adipose tissue. J.Clin.Endocrinol. Metab. 71, 1215-1219, 1990.

157. J. Zilliacus, K. Dahlman-Wright, A. Wright, J.-Å. Gustafsson, and J. Carlstedt-Duke: DNA binding specificity of mutant glucocorticoid receptor DNA-binding domains. J. Biol. Chem., 266, 3101-3106, 1991.

158. C. Cairns, J.-Å. Gustafsson, and J. Carlstedt-Duke: Identification of protein contact sites within the glucocorticoid/progestin response element. Mol. Endocrinol., 5, 598-604, 1991.

159. M. Alksnis, T. Barkhem, P.-E. Strömstedt, H. Ahola, E. Kutoh, J.-Å. Gustafsson, L. Poellinger and S. Nilsson: High level expression of functional full length and truncated glucocorticoid receptor in chinese hamster ovary cells. J. Biol. Chem., 266, 10078-10085, 1991.

160. H. Tanaka, Y. Dong, Q. Li, S. Okret and J.-Å. Gustafsson: Identification and characterization of a cis-acting element that interferes with glucocorticoid-inducible activation of the mouse mammary tumor virus promoter. Proc.Natl.Acad.Sci. USA, 88, 5393-5397, 1991.

161. P. Tollet, C. Legraverend, J.-Å. Gustafsson, and A. Mode: A role for protein kinases in the growth hormone regulation of cytochrome P4502C12 and insulin-like growth factor-I messenger RNA expression in primary adult rat hepatocytes. Mol. Endocrinol., 5, 1351-1358, 1991.

162. J. Hapgood, S. Cuthill, P. Söderkvist, A. Wilhelmsson, I. Pongratz, R.H. Tukey, E. F. Johnson, J.-Å. Gustafsson, and L. Poellinger: Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor. Mol. Cell. Biol., 11, 4314-4323, 1991.

163. A.P.H. Wright and J.-Å. Gustafsson: Mechanism of synergistic transcriptional transactivation by the human glucocorticoid receptor. Proc. Natl. Acad. Sci. USA, 88, 8283-8287, 1991.

164. G. C.-K. Chan, P. Hess, T. Meenakshi, J. Carlstedt-Duke, J.-Å. Gustafsson and F. Payvar: Delayed secondary glucocorticoid response elements. J. Biol.Chem. 266, 22634-22644, 1991.

165. H. Eguchi, S. Westin, A. Ström, J.-Å. Gustafsson, and P.G. Zaphiropoulos: Gene structure and expression of the rat cytochrome P450IIC13, a polymorphic, male-specific cytochrome in the P450IIC subfamily. Biochemistry, 30, 10844-10849, 1991.

166. P.-E. Strömstedt, L. Poellinger, J.-Å. Gustafsson, and J. Carlstedt-Duke: The Glucocorticoid Receptor Binds to a Sequence Overlapping the TATA Box of the Human Osteocalcin Promoter: a Potential Mechanism for Negative Regulation. Mol. Cell. Biol, 11, 3379-3383, 1991.

167. A.P.H. Wright, I.J. McEwan, K. Dahlman-Wright, and J.-Å. Gustafsson: High level expression of the major transactivation domain of the human glucocorticoid receptor in yeast cells inhibits endogenous gene expression and cell growth. Mol. Endocrinology.,5, 1366-1372, 1991.

168. K. Dahlman-Wright, A. Wright, J.-Å. Gustafsson, and Jan Carlstedt-Duke: Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids. J. Biol. Chem., 5, 3107-3112, 1991.

169. L. Poellinger, M. Göttlicher and J.-Å. Gustafsson: The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands. TIPS. 13, 241-245, 1992.

170. S.H. Kaufmann, W.W. Wright, S. Okret, A.-C. Wikström, J.-Å. Gustafsson, N.L. Shaper, and J.H. Shaper: Evidence that rodent epididymal sperm contain the Mr 94,000 glucocorticoid receptor but lack the Mr 90,000 heat shock protein. Endocrinology, 130, 3074-3084, 1992.

171. M. Göttlicher, E. Widmark, Q. Li, and J.-Å. Gustafsson: Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc.Natl.Acad.Sci. USA, 89, 4653-4657, 1992.

172. A.P.H. Wright and J.-Å. Gustafsson: Glucocorticoid-specific gene activation by the intact human glucocorticoid receptor expressed in yeast. J.Biol.Chem., 267, 11191-11195, 1992.

173. M. Rudling, G. Norstedt, H. Olivecrona, E. Reihnér, J.-Å. Gustafsson and B. Angelin: Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc.Natl.Acad.Sci. USA, 89, 6983-6987, 1992.

174. K. Dahlman-Wright, A.P. Wright, and J.-Å. Gustafsson: Determinants of high affinity DNA-binding by the glucocorticoid receptor: Evaluation of receptor domains outside the DNA-binding domain. Biochemistry, 31, 9040-9044, 1992.

175. J. Zilliacus, A.P.H. Wright, U. Norinder, J.-Å. Gustafsson and J. Carlstedt-Duke: Determinants for DNA-binding site recognition by the glucocorticoid receptor. J.of Biol.Chem., 267, 24941-24947, 1992.

176. S. Werner, M. Thorén, J.-Å. Gustafsson, and M. Brönnegård: Glucocorticoid receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical disorders. J. Endocrinol. Metab., 75, 1005-1009, 1992.

177. C. Legraverend, A. Mode, T. Wells, I. Robinson, and J.-Å. Gustafsson: Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J., 6, 711-718, 1992.

178. C. Legraverend, A. Mode, S. Westin, A. Ström, H. Eguchi, P.G. Zaphiropoulos, and J.-Å. Gustafsson: Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol. Endocrinol., 6, 259-266, 1992.

179. C.D. Banner, A. Goos-Nilsson, J. Sjövall, J.-Å. Gustafsson, and J. Rafter: A Method for Characterization of Endogenous Ligands to Orphan Receptors Belonging to the Steroid Hormone Receptor Superfamily - Isolation of Progesterone from Pregnancy Plasma Using Progesterone Receptor Ligand-Binding Domain. Anal. Biochem., 200, 163-170, 1992.

180. H. Berglund, H. Kovács, K. Dahlman-Wright, J.-Å. Gustafsson, and T. Härd: Backbone dynamics of the glucocorticoid receptor DNA-binding domain. Biochemistry, 31, 12001-12011, 1992.

181. H. Baumann, K. Paulsen, H. Kovács, H. Berglund, A.P.H. Wright, J.-Å. Gustafsson, and T. Härd: Refined solution structure of the glucocorticoid receptor DNA-binding domain. Biochemistry, 32, 13463-13471, 1993.

182. I.J. McEwan, A.P.H. Wright, K. Dahlman-Wright, J. Carlstedt-Duke, and J.-Å. Gustafsson: Direct interaction of the 1 transactivation domain of the human glucocorticoid receptor with the basal transcriptional machinery. Mol. Cell. Biol., 13, 399-407, 1993.

183. K.L. Gearing, J.-Å. Gustafsson and S. Okret: Heterogeneity in the polyglutamine tract of the glucocorticoid receptor from different rat strains. Nucleic Acids Res., 21, 2014, 1993.

184. K. L. Gearing, M. Göttlicher, M. Teboul, E. Widmark, and J.-Å. Gustafsson: Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc. Natl. Acad. Sci. USA, 90, 1440-1444, 1993.

185. M. Whitelaw, I. Pongratz, A. Wilhelmsson, J.-Å. Gustafsson, and L. Poellinger: Ligand-dependent recruitment of the arnt coregulator determines DNA recognition by the dioxin receptor. Mol. Cell. Biol., 13, 2504-2514, 1993.

186. A. Cintra, V. Solfrini, B. Bunnemann, S. Okret, F. Bortolotti, J.-Å. Gustafsson, and K. Fuxe: Prenatal development of glucocorticoid receptor gene expression and immunoreactivity in the rat brain and pituitary gland: A combined in situ hybridization and immunocytochemical analysis. Neuroendocrinology, 57, 1133-1147, 1993.

187. T. Lundbäck, C. Cairns, J.-Å. Gustafsson, J. Carlstedt-Duke, and T. Härd: Thermodynamics of the glucocorticoid receptor-DNA interaction: Binding of wild-type GR DBD to different response elements. Biochemistry, 32, 5074-5082, 1993.

188. M. Gillner, J. Bergman, C. Cambillau, M. Alexandersson, B. Fernström, and J.-Å. Gustafsson: Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Mol. Pharmacol., 44, 336-345, 1993.

189. M. L. Whitelaw, M. Göttlicher, J.-Å. Gustafsson and L. Poellinger: Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor. EMBO J., 12, 4169-4179, 1993.

190. C.D. Banner, M. Göttlicher, E. Widmark, J. Sjövall, J.J. Rafter, and J.-Å. Gustafsson: A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptor from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma. J. Lipid Res., 34, 1583-1591, 1993.

191. H. Tanaka, Y. Dong, J. McGuire, S. Okret, L. Poellinger, I. Makino and J.-Å. Gustafsson: The glucocorticoid receptor and a putative repressor protein coordinately modulate glucocorticoid responsiveness of the mouse mammary tumor virus promoter in the rat hepatoma cell line M1.19. J. Biol. Chem., 268, 1993.

192. S. Westin, A. Mode, M. Murray, R. Chen, and J.-Å. Gustafsson: Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes. Mol. Pharmacol., 44, 997-1002, 1993.

193. M. Strömstedt, M. Warner, C. D. Banner, P.C. Macdonald, and J.-Å. Gustafsson: Role of brain cytochrome P450 in regulation of the level of anesthetic steroids in the brain. Mol. Pharmacol., 44, 1077-1083, 1993.

194. T. Härd and J.-Å. Gustafsson: Structure and function of the DNA-binding domain of the glucocorticoid receptor and other members of the nuclear receptor supergene family. Accounts of Chem. Res., 26, 644-650, 1993.

195. G.G.F. Mason, A.-M. Witte, M.L. Whitelaw, C. Antonsson, J. McGuire, A. Wilhelmsson, L. Poellinger and J.-Å. Gustafsson: Purification of the DNA binding form of dioxin receptor. J. Biol. Chem., 269, 4438-4449, 1994.

196. M.I. Kleman, L. Poellinger and J.-Å. Gustafsson: Regulation of human dioxin receptor function by indolocarbazoles, receptor ligands of dietary origin. J. Biol. Chem., 269, 5137-5144, 1994.

197. P. Tollet, M. Strömstedt, L. Frøyland, R.K. Berge and J.-Å. Gustafsson: Pretranslational regulation of cytochrome P4504A1 by free fatty acids in primary cultures of rat hepatocytes. J. Lipid. Res., 35, 248-254, 1994.

198. M. Warner and J.-Å. Gustafsson: Effect of ethanol on cytochrome P450 in the rat brain. Proc. Natl. Acad. Sci. USA., 91, 1019-1023, 1994.

199. K. Dahlman-Wright, T. Almlöf, I.J. McEwan, J.-Å. Gustafsson and A.P.H. Wright: Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression. P. Natl. Acad. Sci. USA. 91, 1619-1623, 1994.

200. J. Zilliacus, J. Carlstedt-Duke, J.-Å. Gustafsson and A.P.H. Wright: Evolution of distinct DNA-binding specificities within the nuclear receptor family of transcription factors. Proc.Natl. Acad. Sci. USA., 91, 4175-4179, 1994.

201. T. Lundbäck, J. Zilliacus, J.-Å. Gustafsson, J. Carlstedt-Duke and T. Härd: Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions. Biochemistry, 33, 5955-5965, 1994.

202. A. Wilhelmsson, M.L. Whitelaw, J.-Å. Gustafsson and L. Poellinger: Agonistic and antagonistic effects of -naphtoflavone on dioxin receptor function. J. Biol. Chem., 269, 19028-19033, 1994.

203. J.-Å. Gustafsson: The hypothalamic-pituitary-liver axis growth hormone controls liver sex. In The Liver: Biology and Pathobiology. Third Edition, edited by I. M. Arias, J.L. Boyer, N. Fausto, W.B. Jakoby, D.A. Schachter and D.A. Shafritz. Raven Press, Ltd., New York, 1209-1215, 1994.

204. J.-Å. Gustafsson: Regulation of sexual dimorphism in rat liver. In The Differences between the Sexes. Edited by R.V. Short and E. Balaban, Cambridge University Press, 231-241, 1994.

205. A. Cintra, M. Zoli, L. Rosén, L.F. Agnati, S. Okret, A.-C. Wikström, J.-Å. Gustafsson and K. Fuxe: Mapping and computer assisted morphometry and microdensitometry of glucocorticoid receptor immunoreactive neurons and glial cells in the rat central nervous system. Neuroscience, 62, 843-897, 1994.

206. J. McGuire, M.L. Whitelaw, I. Pongratz, J.-Å. Gustafsson and L. Poellinger: A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor. Mol. Cell. Biol. 14, 2438-2446, 1994.

207. I. J. McEwan, T. Almlöf, A.-C. Wikström, K. Dahlman-Wright, A. P. H. Wright and J.-Å. Gustafsson: The glucocorticoid receptor functions at multiple steps during transcription initiation by RNA polymerase II. J. Biol.Chem. 269, 25629-25636, 1994.

208. M. Whitelaw, J.-Å. Gustafsson, and L. Poellinger: Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: Inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14, 8343-8355, 1994.

209. J. Zilliacus, A.P.H. Wright, J. Carlstedt-Duke, and J.-Å. Gustafsson: Structural determinants of DNA-binding specificity by steroid receptors. Mol. Endocrinol. 9, 389-400, 1995.

210. H. E. Witkowska, C. H. L. Shackleton, K. Dahlman-Wright, J. Y. Kim, and J.-Å. Gustafsson: Mass spectrometric analysis of a native zinc-finger structure: The glucocorticoid receptor DNA binding domain. J. Am. Chem. Society, 117, 3319-3324, 1995.

211. M. Teboul, E. Enmark, Q. Li, A.C. Wikström, M. Pelto-Huikko, and J.-Å. Gustafsson: OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc. Natl. Acad. Sci. USA, 92, 2096-2100, 1995.

212. J. Zilliacus, A. P. H. Wright, J. Carlstedt-Duke, L. Nilsson, and J.-Å. Gustafsson: Modulation of DNA-binding specificity within the nuclear receptor family by substitutions at a single amino acid position. Proteins: Structure, Function, and Genetics, 21, 57-67, 1995.

213. C. Antonsson, M.L. Whitelaw, J. McGuire, J.-Å. Gustafsson, and L. Poellinger: Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains. Mol. Cell. Biol. 15, 756-765, 1995.

214. E. Caldenhoven, J. Lidén, S. Wissink, A. Van de Stolpe, J. Raaijmakers, L. Koenderman, S. Okret, J.-Å. Gustafsson, and P. T. Van der Saag: Negative cross-talk between ReIA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids. Mol. Endocrinol. 9, 401-412, 1995.

215. A. Ström, S. Westin, H. Eguchi, J.-Å. Gustafsson and A. Mode: Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver. J. Biol. Chem., 270, 11276-11281, 1995.

216. K. Dahlman-Wright, H. Baumann, I. J. McEwan, T. Almlöf, A.P.H. Wright, J.-Å. Gustafsson, and T. Härd: Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor. Proc.Natl.Acad.Sci. USA, 92, 1699-1703, 1995.

217. T. J.J. Wood, D. Sliva, P. E. Lobie, T. J. Pircher, F. Gouilleux, H. Wakao, J.-Å. Gustafsson, B. Groner, G. Norstedt, and L.-A. Haldosén: Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/stat 5. J.Biol. Chem., 270, 9448-9453, 1995.

218. K. Grandien, M. Bäckdahl, Ö. Ljunggren, J.-Å. Gustafsson and A. Berkenstam: Estrogen target tissue determines alternative promoter utilization of the human estrogen receptor gene in osteoblasts and tumor cell lines. Endocrinology, 136, 2223-2229, 1995.

219. P. Tollet, M. Hamberg, J.-Å. Gustafsson, and A. Mode: Growth hormone signaling leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2. J.Biol. Chem., 270, 12569-12577, 1995.

220. T. Almlöf, A.P.H. Wright and J.-Å. Gustafsson: Role of acidic and phoshorylated residues in gene activation by the glucocorticoid receptor. J. Biol. Chem. 270, 1-6, 1995.

221. M. Warner and J.-Å. Gustafsson: Cytochrome P450 in the brain: Neuroendocrine functions. Frontiers in Neuroendocrinology, 16, 224-236, 1995.

222. M. L. Whitelaw, J. McGuire, D. Picard, J.-Å. Gustafsson and L. Poellinger: Heat shock protein hsp90 regulates dioxin receptor function
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