Curriculum vitae jan-Åke Gustafsson




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CURRICULUM VITAE

Jan-Åke Gustafsson


Born in 1943, August 4.

Bachelor of Medicine, Karolinska Institute, Stockholm, 1964.

Ph.D. at the Department of Chemistry, Karolinska Institute, 1968.

M.D. 1971.

Associate Professor in Chemistry, Karolinska Institute, 1971.

Professor of Chemistry, Karolinska Institute, 1976.

Professor of Chemistry, University of Gothenburg, 1978.

Professor of Medical Nutrition and Chairman of the Department of Medical Nutrition, Huddinge University Hospital, Karolinska Institute, Stockholm, 1979.

Director of the Center for Biotechnology, Huddinge University Hospital, Karolinska Institute, 1985.

Founder of KaroBio AB 1987 (a campus-situated biotechnology company sponsored by pension and governmental funds with about 130 employees).


Awards and related activities

The Svedberg Prize in Chemistry, Stockholm, 1982.

The Fernström Prize of the Karolinska Institute, 1983.

Member of the Nobel Assembly of the Karolinska Institute, 1986.

Honorary Member of the Japanese Biochemical Society, 1986.

Adjunct Full Professor at the Department of Cell Biology, Baylor College of Medicine, Houston, Texas, since 1987.

Honorary Member of the American Society for Biochemistry and Molecular Biology, 1990.

Consultant to The Rockefeller University Hospital since 1991.

The Anders Jahre Prize, Oslo, 1992.

Medal from Collège de France, Paris, 1992.

Keith Harris Lecture, Australian Endocrine Society, Adelaide, 1992.

Gregory Pincus Medal and Award, Worcester Foundation, 1994.

Sterling Visiting Professor, University of Pennsylvania, Philadephia, 1995.

Member of the Swedish Academy of Sciences, 1997.

Member of the Swedish Academy of Engineering Sciences, 1998.

The Söderberg Prize in Medicine, 1998.

Adjunct Member of the Nobel Committee of the Karolinska Institute, 1998-

Fogarty Scholar NIH, 1999.

Medal of the IngaBritt and Arne Lundberg’s Research Foundation, 1999.

Curt Nicolin’s Prize for Achievements for the Development of South Stockholm, 2000.

European Medal, British Society for Endocrinology, 2000.

Foreign Honorary Member of the American Academy of Arts and Sciences, 2000.

Burroughs Wellcome Fund Lecture, Boston, 2000.

Center for Bioenvironmental Research Distinguished Visiting Professor, Tulane University, New Orleans, 2000.

Garvan International Fellow, November 2000.

One of ISI Top 258 Researchers in Biology & Biochemistry, 2000.

Vice chairman of the Nobel Assembly of the Karolinska Institute, 2001.

Lorenzini Gold Medal, Lorenzini Foundation, 2001.

The AF Group Prize for the creation of Novum Research Park, 2001

Fred Conrad Koch Award (Endocrine Society USA), 2002.

Chairman of the Nobel Assembly of the Karolinska Institute, 2002.

Foreign Honorary Member of the US National Academy of Sciences, 2002.

Commandeur dans l’Ordre des Palmes Académiques, 2002.

Burroughs Wellcome Fund Visiting Professor in the Basic Medical Sciences at the University of Texas Medical Branch School of Medicine, 2002.

McDowell Lecture in Physiology, King´s College, London, U.K., 2003

Marius Tausk Visiting Professor at the Leiden University Medical Centre (LUMC), 2003.

J.G. Moore Visiting Professor, UCLA, USA, 2003.

FEBS Lectureship Datta Award, 2003.

Bristol-Meyers Squibb/Mead Johnson Award for Nutrition Research, 2004.

Medal from Biomedicum Helsinki, 2004.


Other activities

Invited lecturer at more than 400 international symposia since 1970.

Member, currently and/or previously, of the editorial board or similar position in Steroids, The Journal of Steroid Biochemistry and Molecular Biology, Molecular Endocrinology, Breast Cancer Research and Treatment, The Prostate, Anticancer Research, Japanese Journal of Cancer Research, Journal of Molecular Medicine, Molecular Pharmacology and the International Journal of Oncology.

Recipient of three NIH grants for studies on the dioxin receptor, hormonal control of liver carcinogenesis and chemical carcinogenesis of the prostate, respectively.

Has been member of the Faculty Board of the Karolinska Institute and regularly carries out various assignments for the President’s Office of the Karolinska Institute.

Has participated in several international reviewing panels, e.g. as chairman of a board evaluating the Norwegian Biotechnology Program (October/November 1991); member of a board evaluating the Biocenter Oulu (May 1993); member of a board evaluating the Center for Biotechnology, Helsinki, (February 1994); chairman of a board evaluating the Center for Biotechnology, University of Oslo (February 1995).

Has had and has several appointments at and tasks for The Swedish Board for Planning and Coordination of Research, The Swedish Medical Research Council, The Swedish Cancer Society, The Swedish Environmental Protection Agency and The Swedish Fund for Strategic Research.

Regular co-organizer of The Summer School of Signal Transduction held in Spetsai, Greece, every two years since 1990.

Has participated in organizing the following symposia:

1983 Nobel symposium “Steroid hormone receptors: Structure and function”.

1988 2nd CBT Symposium “The steroid/thyroid hormone receptor family and gene regulation”.

1993 5th CBT Symposium “Intracellular hormone receptors and ligan-dependent transcriptional regulation”.

1995 7th CBT Symposium “Nuclear orphan receptors: Novel regulators in physiology and pathology”.

1995 EMBO Workshop; Structure and Function of Steroid and Nuclear Receptors, Alghero, Sardinia, Italy.

1997 9th CBT Symposium “Steroid and orphan nuclear receptors”.

  1. Nobel symposium “Estrogens and women’s health – benefit or threat?”

1999 EMBO Workshop; Steroid and Nuclear receptors, Villefranche, France.

  1. 10th CBT symposium “Nuclear receptors in health and disease”.

  2. EMBO Workshop on Nuclear Receptor Structure and Function, Erice, Italy.

  3. “Nuclear Receptors 2002”, A joint International Symposium arranged by the Center for Biotechnology (CBT), Karolinska Institutet in collaboration with the Summer University of Southern Stockholm.

  4. EMBO Conference, Biology of Nuclear Receptors, Villefranche-sur-Mer, France.

2003 Nobel Conference No 40: “Transcriptional control of lipid homeostasis”.

2003 FEBS Advanced Study Institute, International Summer School on “From Transcription to Physiology: Regulation of Gene Expression and Protein Function in an Integrated Context”, Island of Spetses, Greece.

2004 “Nuclear Receptors 2004” An International Symposium arranged by the Center for Biotechnology (CBT), Karolinska Institutet.

Member of the International Advisory Board of the WHO Center in Oulu since 1995.

Has participated in the supervision of 84 Ph.D. students to the presentation of their thesis.

Has supervised 110 postdocs/visiting scientists.

Has more than 1100 peer-reviewed publications. Can be sent upon request.


SELECTED PUBLICATIONS

This is a list of selected publications. The complete list contains around 1100 publications and can be sent upon request.

1. J.-Å. Gustafsson and J. Sjövall: Steroids in germfree and conventional rats. VI. Identification of 15- and 21-hydroxylated C21 steroids in faeces from germfree rats. Eur. J. Biochem. 6, 236-247, 1968.

2. J.-Å. Gustafsson, R. Ryhage, J. Sjövall and R.M. Moriarty: Migrations of the trimethylsilyl group upon electron impact in steroids. J. Am. Chem. Soc. 91, 1234-1236, 1969.

3. P. Eneroth and J.-Å. Gustafsson: Steroids in newborns and infants. Hydroxylated cholesterol derivatives in the steroid monosulphate fraction from meconium. FEBS Lett. 3, 129-132, 1969.

4. P. Eneroth and J.-Å. Gustafsson: Steroids in newborns and infants. Identification of 20,22-dihydroxycholesterol from the monosulphate and "disulphate" fractions in human meconium. FEBS Lett. 5, 99-103, 1969.

5. I. Björkhem and J.-Å. Gustafsson: Mechanism of microbial transformation of cholesterol into coprostanol. Eur. J. Biochem. 21 428-432, 1971.

6. J.-Å. Gustafsson and A.S. Goldman: Steroid monosulphates in urine from male rat pseudohermaphrodites. Endocrinology 90, 931-935, 1972.

7. C. von Bahr, K. Brandt and J.-Å. Gustafsson: On the participation of cytohrome P-450 in the formation of 16,17-dihydroxylated C19 steroids from 16-dehydro-C19 steroids. FEBS Lett. 25, 64-68, 1972.

8. J.-Å. Gustafsson and M. Ingelman-Sundberg: Sex-specific 15-hydroxylation of sulphoconjugated 15-androstane-3,17 -diol in liver microsomes from female rats. FEBS Lett. 31, 292-296, 1973.

9. K. Einarsson, J.-Å. Gustafsson and B.E. Gustafsson: Differences between germfree and conventional rats in liver microsomal metabolism of steroids. J. Biol. Chem. 248, 3623-3630, 1973.

10. K. Einarsson, J.-Å. Gustafsson and Å. Stenberg: Neonatal imprinting of liver microsomal hydroxylation and reduction of steroids. J. Biol. Chem. 248, 4987-4997, 1973.

11. A. Berg and J.-Å. Gustafsson: Regulation of hydroxylation of 5-androstane-3,17-diol in liver microsomes from male and female rats. J. Biol. Chem. 248, 6559-6567, 1973.

12. J.-Å. Gustafsson and Å. Stenberg: Irreversible androgenic programming at birth of microsomal and soluble liver enzymes active on 4-androstene-3,17-dione and 5-androstane-3,17-diol. J. Biol. Chem. 249, 711-718, 1974.

13. J.-Å. Gustafsson and Å. Stenberg: Neonatal programming of androgen responsiveness of liver of adult rats. J. Biol. Chem. 249, 719-723, 1974.

14. R.-J. Begue, J.-Å. Gustafsson and A.S. Goldman: New potent inhibitors of 3-hydroxy-∆5-steroid oxidoreductase with short duration of action. Endocrinology 95, 238-246, 1974.

15. J.-Å. Gustafsson and M. Ingelman-Sundberg: Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulphates. I. General characteristics. J. Biol. Chem. 249, 1940-1945, 1974.

16. J.-Å. Gustafsson and Å. Pousette: Properties of nuclear 5-reductase in rat liver. Biochemistry 13, 875-881, 1974.

17. J.-Å. Gustafsson and Å. Stenberg: Masculinization of rat liver enzyme activities following hypophysectomy. Endocrinology 95, 891-896, 1974.

18. J. Carlstedt-Duke, J.-Å. Gustafsson and S.A. Gustafsson: Sexual differences in hepatic metabolism and intracellular distribution of corticosterone studies by pulse-labeling with [1,2,6,7-3H]corticosterone. Biochemistry 14, 639-648, 1975.

19. J.-Å. Gustafsson and M. Ingelman-Sundberg: Regulation and substrate specificity of a steroid sulfate-specific hydroxylase system in female rat liver microsomes. J. Biol. Chem. 250, 3451-3458, 1975.

20. M. Ingelman-Sundberg, A. Rane and J.-Å. Gustafsson: Properties of hydroxylase systems in the human fetal liver active on free and sulphoconjugated steroids. Biochemistry 14, 429-437, 1975.

21. J.-Å. Gustafsson, Å. Pousette, Å. Stenberg and Ö. Wrange: High-affinity binding of 4-androstene-3,17-dione in rat liver. Biochemistry 14, 3942-3948, 1975.

22. B.H. Shapiro, A.S. Goldman and J.-Å. Gustafsson: Masculine-like hypothalamic-pituitary axis in the androgen-insensitive genetically male rat pseudohermaphrodite. Endocrinology 97, 487-492, 1975.

23. J.-Å. Gustafsson and Å. Pousette: Demonstration and partial characterization of cytosol receptors for testosterone. Biochemistry 14, 3094-3101, 1975.

24. J.-Å. Gustafsson, A. Larsson, P. Skett and Å. Stenberg: Influence of a novel hypophyseal factor on steroid metabolism in cultured hepatoma cells. Proc. Natl. Acad. Sci. USA 72, 4986-4990, 1975.

25. B.E. Gustafsson, K. Einarsson and J.-Å. Gustafsson: Influence of cholesterol feeding on liver microsomal metabolism of steroids and bile acids in conventional and germ-free rats. J. Biol. Chem. 250, 8496-8502, 1975.

26. J.-Å. Gustafsson and Å. Stenberg: Partial masculinization of rat liver enzyme activities following treatment with FSH. Endocrinology 96, 501-504, 1975.

27. A. Berg, J.-Å. Gustafsson, M. Ingelman-Sundberg and K. Carlström: Characterization of a cytochrome P-450-dependent steroid hydroxylase system present in Bacillus megaterium. J. Biol. Chem. 251, 2831-2838, 1976.

28. J.-Å. Gustafsson and Å. Stenberg: On the obligatory role of the hypophysis in sexual differentiation of hepatic metabolism in rats. Proc. Natl. Acad. Sci. USA 73, 1462-1465, 1976.

29. P. Eneroth, J.-Å. Gustafsson, A. Larsson, P. Skett and Å. Stenberg: Feminization of hepatic steroid metabolism in male rats with a transplanted pituitary tumor (MtT/F4). Cell 7, 413-417, 1976.

30. J.-Å. Gustafsson, M. Ingelman-Sundberg, Å. Stenberg and T. Hökfelt: Feminization of hepatic steroid metabolism in male rats following electrothermic lesion of the hypothalamus. Endocrinology 98, 922-926, 1976.

31. J.-Å. Gustafsson and Å. Stenberg: Specificity of neonatal, androgen-induced imprinting of hepatic steroid metabolism in rats. Science 191, 203-204, 1976.

32. J.-Å. Gustafsson, Å. Pousette and E. Svensson: Sex-specific occurrence of androgen receptors in rat brain. J. Biol. Chem. 251, 4047-4054, 1976.

33. K. Einarsson, J.-Å. Gustafsson, T. Ihre and M. Ingelman-Sundberg: Specific metabolic pathways of steroid sulphates in human liver microsomes. J. Clin. Endocrinol. Metab. 43, 56-63, 1976.

34. J.-Å. Gustafsson and J. Bergman: Iodine- and chlorine-containing oxidation agents as hydroxylating catalysts in cytochrome P-450-dependent fatty acid hydroxylation reactions in rat liver microsomes. FEBS Lett. 70, 276-280, 1976.

35. P. Skett, P. Eneroth, J.-Å. Gustafsson and C. Sonnenschein: Changes in hepatic steroid metabolism in rats following transplantation of four different clones of pituitary tumor cells. Endocrinology 100, 1090-1096, 1977.

36. M. Ingelman-Sundberg and J.-Å. Gustafsson: Resolution of multiple forms of phenobarbital-induced liver microsomal cytochrome P-450 by electrofocusing on granulated gels. FEBS Lett. 74, 103-106, 1977.

37. K. Fuxe, T. Hökfelt, P. Eneroth, J.-Å. Gustafsson and P. Skett: Prolactin-like immunoreactivity: localization in nerve terminals of rat hypothalamus. Science 196, 899-900, 1977.

38. M. Snochowski, Å. Pousette, P. Ekman, D. Bression, L. Andersson, B. Högberg and J.-Å. Gustafsson: Characterization and measurement of the androgen receptor in human benign prostatic hyperplasia and prostatic carcinoma. J. Clin. Endocrinol. Metab. 45, 920-930, 1977.

39. A. Löfström, P. Eneroth, J.-Å. Gustafsson and P. Skett: Effects of estradiol benzoate on catecholamine levels and turnover in discrete areas of the median eminence and the limbic forebrain, and on serum luteinizing hormone, follicle stimulating hormone and prolactin concentrations in the ovariectomized female rat. Endocrinology 101, 1559-1569, 1977.

40. B.E. Gustafsson, B. Angelin, K. Einarsson and J.-Å. Gustafsson: Effects of cholesterol feeding on synthesis and metabolism of cholesterol and bile acids in germfree rats. J. Lipid Res. 18, 717-721, 1977.

41. Ö. Wrange and J.-Å. Gustafsson: Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis. J. Biol. Chem. 253, 856-865, 1978.

42. Ö. Wrange, B. Nordenskjöld and J.-Å. Gustafsson: Cytosol estradiol receptor in human mammary carcinoma: An assay based on isoelectric focusing in polyacrylamide gel. Anal. Biochem. 85, 461-475, 1978.

43. K. Fuxe, B.B. Fredholm, S.-O. Ögren, L.F. Agnati, T. Hökfelt and J.-Å. Gustafsson: Ergot drugs and central monoamine mechanisms: a histochemical, biochemical and behavioral analysis. Fed. Proc. 37, 2181-2191, 1978.

44. J.-Å. Gustafsson, P. Eneroth, T. Hökfelt and P. Skett: Central control of hepatic steroid metabolism: effect of discrete hypothalamic lesions. Endocrinology 103, 141-151, 1978.

45. M. Ingelman-Sundberg, J. Montelius, J. Rydström and J.-Å. Gustafsson: The active form of cytochrome P-45011ß from adrenal cortex mitochondria. J. Biol. Chem. 253, 5042-5047, 1978.

46. B.E. Gustafsson, B. Angelin, K. Einarsson and J.-Å. Gustafsson: Influence of cholestyramine on synthesis of cholesterol and bile acids in germfree rats. J. Lipid Res. 19, 972-977, 1978.

47. Ö. Wrange, J. Carlstedt-Duke and J.-Å. Gustafsson: Purification of the glucocorticoid receptor from rat liver cytosol. J. Biol. Chem. 254, 9284-9290, 1979.

48. J.-Å. Gustafsson, L. Rondahl and J. Bergman: Iodosylbenzene derivatives as oxygen donors in cytochrome-P-450 catalyzed steroid hydroxylations. Biochemistry 18, 865-870, 1979.

49. A. Berg, M. Ingelman-Sundberg and J.-Å. Gustafsson: Purification and characterization of cytochrome P-450meg. J. Biol. Chem. 254, 5264-5271, 1979.

50. J. Carlstedt-Duke, Ö. Wrange, E. Dahlberg, J.-Å. Gustafsson and B. Högberg: Transformation of the glucocorticoid receptor in rat liver cytosol by lysosomal enzymes. J. Biol. Chem. 254, 1537-1539, 1979.

51. Ö. Wrange, J. Carlstedt-Duke and J.-Å. Gustafsson: Purification of the glucocorticoid receptor from rat liver cytosol. J. Biol. Chem. 254, 9284-9290, 1979.

52. P. Ekman, M. Snochowski, E. Dahlberg, D. Bression, B. Högerg and J.-Å. Gustafsson: Steroid receptor content in cytosol from normal and hyperplastic human prostates. J. Clin. Endocrinol. Metab. 49, 205-215, 1979.

53. B. Forsgren, P. Björk, K. Carlström, J.-Å. Gustafsson, Å. Pousette and B. Högberg: Purification and distribution of a major protein in rat prostate that binds estramustine, a nitrogen mustard derivative of estradiol-17. Proc. Natl. Acad. Sci. USA 76, 3149-3153, 1979.

54. K. Fuxe, K. Andersson, T. Hökfelt, V. Mutt, L. Ferland, L.F. Agnati, D. Ganten, S. Said, P. Eneroth and J.-Å. Gustafsson: Localization and possible function of peptidergic neurons and their interactions with central catecholamine neurons, and the central actions of gut hormones. Fed. Proc. 38, 233-234, 1979.

55. Ö. Wrange, G. Norstedt and J.-Å. Gustafsson: The estrogen receptor in rat liver: quantitative and qualitative analysis by isoelectric focusing in polyacrylamide gel. Endocrinology 106, 1455-1462, 1980.

56. J.-Å. Gustafsson, Å. Pousette and Ö. Wrange: Predictive tests in treatment of breast and prostatic carcinoma based on steroid receptor assays. Trends in Pharmacological Sciences, pp. 279-281, June, 1980.

57. E. Dahlberg, M. Snochowski and J.-Å. Gustafsson: Removal of hydrophobic compounds from biological fluids by a simple method. Anal. Biochem. 106, 380-388, 1980.

58. J.E. Bakke, J.-Å. Gustafsson and B.E. Gustafsson: Metabolism of propachlor by the germfree rat. Science 210, 433-435, 1980.

59. S. Okret, J. Carlstedt-Duke, Ö. Wrange, K. Carlström and J.-Å. Gustafsson: Characterization of an antiserum against the glucocorticoid receptor. Biochim. Biophys. Acta 667, 205-219, 1981.

60. E. Dahlberg, M. Snochowski and J.-Å. Gustafsson: Regulation of the androgen and glucocorticoid receptors in rat and mouse skeletal muscle cytosol. Endocrinology 108, 1431-1440, 1981.

61. G. Norstedt, Ö. Wrange and J.-Å. Gustafsson: Multihormonal regulation of the estrogen receptor in rat liver. Endocrinology 108, 1190-1196, 1981.

62. G. Norstedt, A. Mode, P. Eneroth and J.-Å. Gustafsson: Induction of prolactin receptors in rat liver after the administration of growth hormone. Endocrinology 108, 1855-1861, 1981.

63. A. Mode, G. Norstedt, B. Simic, P. Eneroth and J.-Å. Gustafsson: Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat. Endocrinology 108, 2103-2108, 1981.

64. F. Payvar, Ö. Wrange, J. Carlstedt-Duke, S. Okret, J.-Å. Gustafsson and K.R. Yamamoto: Purified glucocorticoid receptors bind selectively
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