Article 13. 1 Drug effects on the nervous system




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Scenario 19.2 Duchenne muscular dystrophy

Stem cells have helped dogs with muscular dystrophy to walk again. Doctors hope a similar approach in humans could lead to more complete improvement than the other leading contender for a cure--an RNA-blocking drug now in clinical trials.


Duchenne muscular dystrophy (DMD) strikes about one in 35 000 children, almost always boys, and is usually fatal by the age of 30. It is caused by mutations in the gene for the muscle protein dystrophin. Without it, muscle contractions shear and kill muscle cells, and victims become progressively weaker, often dying when their breathing muscles fail.


3. Use Scenario 19.2 to answer the following question.


What is the probability that a child born to a mother who is a carrier for muscular dystrophy and a father who does not have the disease run in his family will have the disease?


__________


Scenario 20.1 Fossil DNA

The extraction and sequencing of fossil DNA promises a wealth of information on extinct species. Yet little has been recovered from the most easily accessible sources, those in museum collections. To see why, Eva-Maria Geigl of the Jacques Monod Institute in Paris and colleagues compared DNA recovery from museum samples with those from freshly excavated fossils stored under conditions similar to natural burial. The fresh samples yielded six times as much DNA and twice the number of valid sequences as those from a museum


4. Use Scenario 20.1 to answer the following question.


During the replication of a sample of the DNA found in a fossilized sample the following steps must occur:


Steps Involved in DNA Replication


1. DNA ligase joins nucleotide fragments together

2. DNA polymerase removes incorrect base pairs

3. DNA helicase unzips the double helix

4. DNA polymerase adds nucleotides to the growing strand.


Put the above steps into the order in which they would occur during replication.


__________ __________ __________ __________

Dip questions from nelson

Answer Section


MULTIPLE CHOICE


1. ANS: C PTS: 1 REF: K | STS OBJ: 13.2

LOC: 30-A1.1k | 30-A1.2sts


2. ANS: A PTS: 1 REF: STS OBJ: 13.2

LOC: 30-A1.2sts


3. ANS: B PTS: 1 REF: K OBJ: 13.2

LOC: 30-A1.1k


4. ANS: C PTS: 1 REF: K OBJ: 13.1

LOC: 30-A1.1k


5. ANS: A PTS: 1 REF: K OBJ: 13.3

LOC: 30-A1.2k


6. ANS: D PTS: 1 REF: K OBJ: 14.3

LOC: 30-A1.5k


7. ANS: A PTS: 1 REF: K OBJ: 14.3

LOC: 30-A1.5K


8. ANS: C PTS: 1 REF: K OBJ: 14.1

LOC: 30-A1.6k


9. ANS: A PTS: 1 REF: K | S OBJ: 14.2

LOC: 30-A1.5k | 30-A1.3s


10. ANS: D PTS: 1 REF: K OBJ: 15.1

LOC: 30-A2.4k


11. ANS: B PTS: 1 REF: K OBJ: 15.1

LOC: 30-A2.1k


12. ANS: D PTS: 1 REF: K OBJ: 15.3

LOC: 30-A2.1k


13. ANS: A PTS: 1 REF: K OBJ: 15.4

LOC: 30-A2.3k


14. ANS: C PTS: 1 REF: K OBJ: 16.1 | 16.2

LOC: 30-B2.2k | 30-B2.3k


15. ANS: B PTS: 1 REF: K OBJ: 16.2

LOC: 30-B2.2k


16. ANS: B PTS: 1 REF: K OBJ: 16.3

LOC: 30-B3.1k


17. ANS: B PTS: 1 REF: K OBJ: 16.1 | 16.3

LOC: 30-B3.1k | 30-B3.5k


18. ANS: B PTS: 1 REF: K | S OBJ: 16.2 | 16.3

LOC: 30-K2.2k | 30-B3.5k


19. ANS: B PTS: 1 REF: K OBJ: 17.1

LOC: 30-C1.2k


20. ANS: A PTS: 1 REF: K OBJ: 17.1

LOC: 30-C1.2k


21. ANS: B PTS: 1 REF: STS OBJ: 17.2

LOC: 30-C1.1sts


22. ANS: A PTS: 1 REF: STS OBJ: 17.2

LOC: 30-C1.1sts


23. ANS: D PTS: 1 REF: STS OBJ: 17.2

LOC: 30-C1.1sts


24. ANS: B PTS: 1 REF: K OBJ: 17.1

LOC: 30-C1.1k


25. ANS: A PTS: 1 REF: K OBJ: 17.1

LOC: 30-C1.2k


26. ANS: C PTS: 1 REF: K OBJ: 17.1

LOC: 30-C1.2k


27. ANS: B PTS: 1 REF: K OBJ: 18.1

LOC: 30-C2.2k


28. ANS: C PTS: 1 REF: K OBJ: 18.2

LOC: 30-C2.2k


29. ANS: D PTS: 1 REF: K OBJ: 18.4

LOC: 30-C2.3k


30. ANS: D PTS: 1 REF: K OBJ: 18.2

LOC: 30-C2.2k


31. ANS: D PTS: 1 REF: K OBJ: 18.2

LOC: 30-C2.2k


32. ANS: C PTS: 1 REF: K OBJ: 18.2

LOC: 30-C2.2k


33. ANS: D PTS: 1 REF: K OBJ: 19.1

LOC: 30-C2.5k


34. ANS: C PTS: 1 REF: K OBJ: 19.1

LOC: 30-C2.5k


35. ANS: B PTS: 1 REF: K OBJ: 19.3

LOC: 30-C3.2k


36. ANS: B PTS: 1 REF: K OBJ: 19.1

LOC: 30-C2.5k


37. ANS: B PTS: 1 REF: K OBJ: 19.1

LOC: 30-C2.5k


38. ANS: B PTS: 1 REF: K OBJ: 19.1

LOC: 30-C2.5k


39. ANS: A PTS: 1 REF: K OBJ: 20.1

LOC: 30-C3.2k


40. ANS: B PTS: 1 REF: K OBJ: 20.1

LOC: 30-C3.2k


41. ANS: B PTS: 1 REF: K OBJ: 20.1

LOC: 30-C3.2k


42. ANS: C PTS: 1 REF: K OBJ: 20.2

LOC: 30-C3.2k


43. ANS: A PTS: 1 REF: K OBJ: 20.2

LOC: 30-C3.2k


44. ANS: A PTS: 1 REF: K OBJ: 20.2

LOC: 30-C3.2k


45. ANS: A PTS: 1 REF: K OBJ: 20.2

LOC: 30-C3.2k


46. ANS: B PTS: 1 REF: K OBJ: 21.1

LOC: 30-D1.1k


47. ANS: C PTS: 1 REF: K OBJ: 21.1

LOC: 30-D1.1k


48. ANS: C PTS: 1 REF: K | S OBJ: 21.1

LOC: 30-D1.1k | 30-D1.3s


49. ANS: B PTS: 1 REF: K OBJ: 22.1

LOC: 30-D3.2k


50. ANS: B PTS: 1 REF: K OBJ: 22.1

LOC: 30-D3.2k


51. ANS: C PTS: 1 REF: K OBJ: 22.2

LOC: 30-D1.3k


52. ANS: C PTS: 1 REF: K OBJ: 22.2

LOC: 30-D3.2k


53. ANS: A PTS: 1 REF: K OBJ: 23.1

LOC: 30-D2.1k


54. ANS: A PTS: 1 REF: K OBJ: 23.1

LOC: 30-D2.1k


55. ANS: B PTS: 1 REF: K OBJ: 23.2

LOC: 30-D2.3k


56. ANS: D PTS: 1 REF: K OBJ: 23.1

LOC: 30-D2.2k


NUMERIC RESPONSE


1. ANS: 3, 4, 2, 1


PTS: 1 REF: STS OBJ: 17.2 LOC: 30-C1.1sts


2. ANS: 0.50


PTS: 1 REF: K OBJ: 18.2 LOC: 30-C2.2k


3. ANS: 25%


PTS: 1 REF: K OBJ: 19.1 LOC: 30-C2.5k


4. ANS: 3, 4, 1, 2


PTS: 1 REF: K OBJ: 20.1 LOC: 30-C3.2k
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