School of Biomedical Biomolecular and Chemical Sciences




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School of Biomedical Biomolecular and Chemical Sciences





Unit Outine




INTRODUCTORY IMMUNOLOGY


MICR2203



Semester: Two



Campus: Crawley



Unit Coordinator: Dr Thelma Koppi



This outline is the currently available version for this unit. Detailed Information on unit content and assessment may undergo modification before the time of delivery of the unit. For the most up to date information students must consult material supplied to enrolled students by the unit co-ordinator.


All material reproduced herein has been copied in accordance with and pursuant to a statutory licence administered by Copyright Agency Limited (CAL), granted to the University of Western Australia pursuant to Part VB of the Copyright Act 1968 (Cth).


Copying of this material by students, except for fair dealing purposes under the Copyright Act, is prohibited. For the purposes of this fair dealing exception, students should be aware that the rule allowing copying, for fair dealing purposes, of 10% of the work, or one chapter/article, applies to the original work from which the excerpt in this course material was taken, and not to the course material itself


© The University of Western Australia 2001



Introduction


This stand-alone unit is designed to give students a basic understanding of the mechanisms that have evolved to protect the host against infection. It explores both innate and adaptive immunity and how they interact. The development of a functional immune system during development of the host and the effects of aging on the immune response will be described (ontogeny). The different components of the adaptive immune response, both humoral and cellular, will be described. These sections will include descriptions of the structure and function of immunoglobulins; the generation of immunoglobulin diversity; the role of T and B cells; immune effector functions; the role of complement; antigen presentation; how the immune system deals with bacterial, viral and fungal infections; and the therapeutic modulation of immunity (vaccines). In addition, the phylogeny of both innate and adaptive immunity will be described. This will include an exploration of the diverse mechanisms used by plants, invertebrates and vertebrates to protect themselves against infection. Particular attention will be directed to the study of the evolution of immunoglobulins and cells of the immune system as well as the genetic mechanisms underlying the generation of diversity. In addition to the study of the phylogeny of the immune response, a comparative analysis of the ontogeny of the immune response in birds, amphibians and mammals will be undertaken. The theoretical aspects of immunology will be complemented with a number of laboratory experiments and demonstrations. Further, students will be asked to write an essay in the style of a scientific report to develop their written communication skills. This unit will form the immunological background for several of the units being delivered by UWA in Singapore, including Introductory Microbiology 204, General and Applied Microbiology 205 and Infection and Immunity 302.


Broad Learning Outcomes


Outcomes

Assessment Activity

Students should be able to recall and integrate key knowledge and concepts regarding:

  • Immunoglobulin structure and function

  • Innate and adaptive immunity

  • Cellular immunity

  • Phylogeny

  • Cell Division, Differentiation and Death



Lab write up

Continuous Assessment – MCQ x 2

Final Exam


Students should acquire skills in:

  • Microscopy and cell identification

  • Interpretation of flow cytometric data

  • Bioinformatics including use of searching software such as BLAST

  • Data recording and analysis including use of spreadsheets

  • Simple statistical tests

  • Simple immunochemical assays



Lab worksheets


Students will clearly communicate in writing the results of laboratory work and reading using correct scientific style

Lab assignment


Students will use Word processing and graphing software to generate a document in prescribed scientific format

Lab assignment



Contact Details


Unit web site (may include Web CT URL): http://Webct.uwa.edu.au/

Name of Unit coordinator: Dr Thelma Koppi

e-mail: tkoppi@cyllene.uwa.edu.au

Phone: 93462215

Fax: 93462912

Consultation hours: By appointment


Unit Structure Summary


Lectures

Two x 1-hour lectures per week.


Practical and/or laboratory sessions

One 2 hr laboratory class every week. Attendance is compulsory, and a roll call taken.


Topics


For details of times and venues of all teaching sessions please consult the most recent version of the University timetable at http://www.timetable.uwa.edu.au/


LECTURE TOPICS

1

Introduction to the immune system

2

Cells and tissues involved in immune responses -1

3

Cells and tissues involved in immune responses -2

4

Immunoglobulin structure - 1

5

Immunoglobulin structure - 2

6

Antibody-Antigen interactions

7

Generation of diversity

8

Introduction to bioinformatics and phylogeny

9

Innate immunity in plants

10

Innate immunity in invertebrates

11

Innate immunity in invertebrates

12

Immunity in fish

13

Immunity in reptiles and amphibians

14

Immunity in birds

15

Immunity in marsupials and mammals and amphibians

16

Inflammation and cytokines

17

Complement and phagocytosis

LECTURE TOPICS continued

18

T cells, antigen presentation and MHC

19

Cellular Immunity

20

Defence against bacteria and fungi

21

Defence against viruses

22

Vaccines

23

Immunity from conception to birth

24

Immunity from birth to adult

25

Immunity from adult to old age

26

Review


References, Resources and Reading Materials


Recommended Text

Roitt, I., Brostoff, J. and Male, D. Immunology, 6th ed: Mosby – Year Book Europe, 2001.


Reference Book

Abbas, A.K. and Lichtman, A.H. Basic Immunology: W.B. Saunders Co., 2001.

Janeway, C., Travers, P., Walport, M., Shlomchik, M.J. Immunobiology 6th Edition: Garland Publishing, 2001.


Unit Web Site

All enrolled students have access to the unit WebCT site (http://webct.uwa.edu.au). This site will be used for notices, posting of supplementary course materials, email and discussion. It is strongly recommended that you log onto this site on a daily basis. The website should be used for all remote communication to the unit co-ordinator. Students are encouraged to pose questions about course content on the discussion forum of the site so that all class members can view and contribute to the discussion.


Assessment Details


Assessed Work

% Mark

Timing

Laboratory write up

10%

Due after mid-semester break

MCQ 1

15%

First half of semester

MCQ 2

15%

Second half of semester

Final exam- 2hr exam. Mix of MCQ and short answer questions

60%

End of semester exam period



Plagiarism


The University of Western Australia takes very seriously the matter of academic misconduct by students and has policies in place that define misconduct (including plagiarism) and the penalties that apply. The consequences for misconduct can be severe, including exclusion from the university.


All students are expected to make themselves aware of the definitions and policies relating to academic misconduct, found at the websites below, and with any additional requirements or stipulations that may be provided by individual unit co-ordinators.

http://www.secretariat.uwa.edu.au/__data/page/20839/StuMiscondInfo.rtf

http://www.teachingandlearning.uwa.edu.au/tl/academic_conduct


When you obtain authority to log in to the unit website, you will see an online module on academic conduct which you are strongly advised to complete in your own time.






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