Studie úČinnosti světelné terapie 1981 2008 pramen: PubMed – service of the U. S. National Library of Medicine and the National Institutes of Health




НазваниеStudie úČinnosti světelné terapie 1981 2008 pramen: PubMed – service of the U. S. National Library of Medicine and the National Institutes of Health
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STUDIE ÚČINNOSTI SVĚTELNÉ TERAPIE 1981 - 2008




PRAMEN: PubMed – service of the U.S. National Library of Medicine and the National Institutes of Health

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1: Clin Geriatr Med. 2008 Feb;24(1):139-49, viii.


Light therapy for insomnia in older adults.

Gammack JK.

Division of Geriatric Medicine, Saint Louis University Health Sciences Center,

1402 S. Grand Boulevard, M238, St. Louis, MO 63104, USA. gammackj@slu.edu

Exposure to bright light suppresses the production of melatonin and contributes to the regulation of the circadian rhythm. Because of environmental and medical conditions, older adults are less likely than younger adults to receive the prolonged, high intensity, daily bright light needed to promote a satisfactory sleep-wake cycle. The best available evidence for bright light therapy is in the management of seasonal affective disorder, which is relatively infrequent in the elderly population. For older adults with chronic insomnia, dementia, and nonseasonal depression, there is no consensus on the optimum treatment protocol for bright light therapy. However, in addition to sleep improvement, bright light therapy may be used to reduce unwanted behavioral and cognitive symptoms associated with dementia and depression in the elderly.


Review

PMID: 18035237


2: Bipolar Disord. 2007 Dec;9(8):918-27.


Light therapy for bipolar disorder: a case series in women.

Sit D, Wisner KL, Hanusa BH, Stull S, Terman M.

Women's Behavioral HealthCARE, Department of Psychiatry, Western Psychiatric

Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA

15213, USA. sitdk@upmc.edu

OBJECTIVES: To perform a dose-ranging safety and efficacy study of bright light therapy for depression in women with bipolar disorder (BD). METHODS: Nine women with DSM-IV BD I or II in the depressed phase were exposed to 50 lux (illuminance at the receiving surface) red light for two weeks, after which they received 7,000 lux light therapy for two-week epochs of 15, 30 and 45 min daily. The Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement and the Mania Rating Scale were used to assess mood symptoms. Four patients received morning light and five patients received midday light. RESULTS: Three of the four subjects treated with morning light developed mixed states. The fourth subject achieved a full, sustained response. To decrease the risk of inducing mixed episodes, we changed the time of light exposure to midday. Of the five women who received midday light therapy, two achieved full response and two showed early improvement but required a dose increase to sustain response. One woman remained depressed with 45 min of midday light but responded fully to a switch to morning light, 30 min daily. CONCLUSIONS: Women with bipolar illness are highly sensitive to morning bright light treatment; the induction of mixed states is a substantial risk. Initiating treatment with a brief duration (15 min) of midday light for bipolar depression is advisable.


Research Support, Non-U.S. Gov't

PMID: 18076544 [PubMed - in process]


3: West J Nurs Res. 2007 Dec;29(8):961-75. Epub 2007 Jun 27.

Dowling GA, Graf CL, Hubbard EM, Luxenberg JS. University of California, San Francisco, CA, USA. glenna.dowling@nursing.ucsf.edu


Light treatment for neuropsychiatric behaviors in Alzheimer's disease.

Neuropsychiatric behaviors are common in people with Alzheimer's disease (AD) and make both professional and lay caregiving difficult. Light therapy has been somewhat successful in ameliorating disruptive behaviors. This randomized trial tested the effects of morning or afternoon bright light exposure compared with usual indoor light on the presence, frequency, severity, and occupational disruptiveness of neuropsychiatric behaviors in nursing home residents with AD. Light was administered for 1 hr daily (Monday-Friday) for 10 weeks. The Neuropsychiatric Inventory-Nursing Home was used to assess behavior at baseline and end of the intervention. Analyses revealed statistically significant differences between groups on agitation/aggression, depression/dysphoria, aberrant motor behavior, and appetite/eating disorders. The magnitude of change was small and may not represent clinically significant findings. Agitation/aggression and nighttime behaviors commonly occurred and were highly correlated with occupational disruptiveness. Interventions that decrease the presence and/or severity of neuropsychiatric behaviors have the potential to significantly decrease caregiver burden.


Comparative Study

Multicenter Study

Randomized Controlled Trial

Research Support, N.I.H., Extramural

PMID: 17596638


4: J Affect Disord. 2007 Nov 27 [Epub ahead of print]


Light room therapy effective in mild forms of seasonal affective disorder-A randomised controlled study.

Rastad C, Ulfberg J, Lindberg P.

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; Center for Clinical Research Dalarna, Falun, Sweden.

BACKGROUND: The most common way to provide bright light therapy to Swedish patients with Seasonal Affective Disorder (SAD), is treatment in a light therapy room. Since few studies have evaluated treatment provided in this setting and few have evaluated the effect of bright light in sub-clinical SAD (S-SAD), such a study including a one-month follow-up was designed. METHODS: Fifty adults recruited from a previous prevalence study and clinically assessed as having SAD or S-SAD, were randomised to treatment in a light room or to a three-week waiting-list control group. The Hamilton Depression Rating Scale-Seasonal Affective Disorders Self-rating 29-items Version (SIGH-SAD/SR) was used to measure depressive mood at baseline, directly following treatment and at the one-month follow-up. RESULTS: ANCOVA with adjustment for baseline depression score, showed a significant main effect for the light room therapy group (p<0.001). Fifty-four percent (n=13/24) improved >/=50% while no such improvement was seen in the control condition (n=0/24). After merging the two groups, repeated measures ANOVA confirmed the experimental analysis (p<0.001). At the one-month follow-up, 83.0% (n=39/47) had improved >/=50% and 63.8% (n=30/47) had normal depression scores, i.e.
PMID: 18053580 [PubMed - as supplied by publisher]

5: J Am Geriatr Soc. 2007 Nov;55(11):1817-24. Epub 2007 Oct 16.


The effect of ambient bright light therapy on depressive symptoms in persons with dementia.

Hickman SE, Barrick AL, Williams CS, Zimmerman S, Connell BR, Preisser JS, Mitchell CM, Sloane PD.

School of Nursing, Oregon Health & Science University, Portland, Oregon, USA.

hickmans@ohsu.edu

OBJECTIVES: To assess the effect of ambient bright light therapy on depressive symptoms in persons with dementia. DESIGN: A cluster-unit crossover intervention trial involving four lighting conditions: morning bright light, evening bright light, all-day bright light, and standard light. SETTING: The common areas of two geriatric units in a state-operated psychiatric hospital in North Carolina and in a dementia-specific residential care facility in Oregon. PARTICIPANTS:

Sixty-six older adults with dementia. INTERVENTION: Ambient bright light therapy was delivered through a high-intensity, low-glare lighting system installed in the public areas of study units at both sites. Each lighting condition was provided for multiple 3-week periods in a predetermined sequence. MEASUREMENTS:

Staff caregivers completed the Cornell Scale for Depression in Dementia (CSDD) in the last week of each 3-week period to provide information about participants' moods. RESULTS: Analysis indicated a sex-by-treatment interaction (P=.008). Significant sex differences were found in CSDD scores in response to evening light (P=.003), all-day light (P=.001), and standard light (P

Multicenter Study

Randomized Controlled Trial

Research Support, N.I.H., Extramural

PMID: 17944896


6: J Affect Disord. 2007 Oct 18 [Epub ahead of print]


Efficacy of light therapy in nonseasonal depression: A systematic review.

Even C, Schröder CM, Friedman S, Rouillon F.

Centre Hospitalier Sainte-Anne, Clinique des Maladies Mentales et de l'Encéphale, Université Paris V, Paris, France.

BACKGROUND: The efficacy of bright light therapy is well established for winter depression but its status in depression without seasonal pattern is unclear. METHODS: We systematically evaluated available data on the efficacy of light therapy in nonseasonal depression. RESULTS: We identified 62 reports among which 15 met our predefined selection criteria. The available data show evidence for the efficacy of light therapy as an adjuvant treatment to antidepressants. Trials that evaluated light therapy alone (without antidepressants) in nonseasonal depression yielded inconsistent results. LIMITATIONS: Most of the studies extracted poorly controlled the issue of blindness and were limited by small sample sizes. Publication bias may have distorted our estimation of the effect of light therapy. CONCLUSIONS: Overall, bright light therapy is an excellent candidate for inclusion into the therapeutic inventory available for the treatment of nonseasonal depression today, as adjuvant therapy to antidepressant medication. Future clinical trials of light therapy should distinguish homogenous subgroups of depressed patients in order to evaluate whether light therapy may eventually be considered as stand-alone treatment for specific subgroups of patients with nonseasonal depression.

PMID: 17950467 [PubMed - as supplied by publisher]

7: Intensive Crit Care Nurs. 2007 Oct;23(5):289-97. Epub 2007 Aug 9.


Influence of bright light therapy on postoperative patients: a pilot study.

Taguchi T, Yano M, Kido Y.

School of Nursing Science, Meiji University of Oriental Medicine, Kyoto 629-0392,

Japan. toyoetagu@meiji-u.ac.jp

Bright light therapy is a method of maintaining or restoring the natural circadian rhythm by assisting daytime awakening using bright lights. Postoperative delirium is one of the potential complications encountered by patients receiving postoperative care in the intensive care unit (ICU), but there have been no studies on the use of light for the prevention of postoperative delirium. The objective of this study was to examine whether the circadian rhythms of patients after surgery for oesophageal cancer can be adjusted and whether the postoperative delirium crisis rate can be reduced by bright light therapy. The subjects were 11 patients operated on for oesophageal cancer in Osaka University Hospital. After informed consent was obtained, they were divided into a study group and a control group by a random sampling method. After removal of the endotracheal tube, the study group was exposed to light. The light intensity was about 5000lx immediately before the eyes, and the distance from the light source was about 100 cm. The control group was placed in a natural lighting environment after extubation. In both groups, the rhythms of physical activities and autonomic activities were monitored after surgery, and delirium was evaluated. A significant difference was observed in the delirium score between the study group and control group on the morning of day 3 of bright light therapy by the Mann-Whitney U-test (P=0.014). The study group could begin ambulation about 2 days earlier than the control group. Bright light therapy may reduce the rate of postoperative delirium and make early ambulation possible. However, our study involved a very small sample size. We want to increase the sample in the future after having reviewed clinical application methods.


Randomized Controlled Trial

PMID: 17692522


8: Neuropsychopharmacology. 2007 Sep 19 [Epub ahead of print]


Enhanced Serotonin Transporter Function during Depression in Seasonal Affective Disorder.

Willeit M, Sitte HH, Thierry N, Michalek K, Praschak-Rieder N, Zill P, Winkler D, Brannath W, Fischer MB, Bondy B, Kasper S, Singer EA.

1Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria.

Decreased synaptic serotonin during depressive episodes is a central element of the monoamine hypothesis of depression. The serotonin transporter (5-HTT, SERT) is a key molecule for the control of synaptic serotonin levels. Here we aimed to detect state-related alterations in the efficiency of 5-HTT-mediated inward and outward transport in platelets of drug-free depressed patients suffering from seasonal affective disorder (SAD). 5-HTT turnover rate, a measure for the number of inward transport events per minute, and tyramine-induced, 5-HTT-mediated outward transport were assessed at baseline, after 4 weeks of bright light therapy, and in summer using a case-control design in a consecutive sample of 73 drug-free depressed patients with SAD and 70 nonseasonal healthy controls. Patients were drug-naive or medication-free for at least 6 months prior to study inclusion, females patients were studied in the follicular phase of the menstrual cycle. All participants were genotyped for a 5-HTT-promoter polymorphism (5-HTTLPR) to assess the influence of this polymorphism on 5-HTT parameters. Efficiency of 5-HTT-mediated inward (p=0.014) and outward (p=0.003) transport was enhanced in depressed patients. Both measures normalized toward control levels after therapy and in natural summer remission. Changes in outward transport showed a clear correlation with treatment response (rho=0.421, p=0.001). Changes in inward transport were mediated by changes in 5-HTT transport efficiency rather than affinity or density. 5-HTTLPR was not associated with any of the 5-HTT parameters. In sum, we conclude that the 5-HTT is in a hyperfunctional state during depression in SAD and normalizes after light therapy and in natural summer remission.Neuropsychopharmacology advance online publication, 19 September 2007; doi:10.1038/sj.npp.1301560.

PMID: 17882235 [PubMed - as supplied by publisher]

9: Int J Circumpolar Health. 2007 Sep;66(4):365-9.


Field trial of timed bright light exposure for jet lag among airline cabin crew.

Lahti T, Terttunen J, Leppämäki S, Lönnqvist J, Partonen T.

National Public Health Institute. Department of Mental Health and Alcohol

Research, FI-00300, Helsinki, Finland. tuuli.lahti@ktl.fi

OBJECTIVES: Commercial airlines' flight crew members on transmeridian long-haul flights are constantly exposed to rapid changes in external time. Following rapid changes in circadian rhythm may lead to several symptoms known as jet lag. Our aim was to alleviate jet-lag symptoms by timed exposure to bright light (natural sunlight if present, otherwise artificial bright light). STUDY DESIGN:

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